ADP-ribosylation factor 1-like 2 - Caenorhabditis elegans

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Q10943 (ARF12_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
ADP-ribosylation factor 1-like 2

Alternative name(s):
ADP-ribosylation factor-related protein 1.2

Gene names

Name:	arf-1.2
Synonyms:	arf-1
ORF Names:	B0336.2

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Ref.2 Ref.3
Subcellular location	Golgi apparatus By similarity.
Tissue specificity	Expressed in hypodermis, intestine, spermatheca, uterus, gonadal sheath, vulva cells, pharynx muscle, body wall muscle, head neurons, ventral nerve cord. Ref.2
Developmental stage	First detected in very young embryos with as little as 48-64 cells. Ref.2
Disruption phenotype	Death during embryogenesis. Some muscle differentiation occurs although it is poorly organized and little elongation or morphogenesis is evident. Ref.3
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Golgi apparatus
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryo development ending in birth or egg hatching Inferred from mutant phenotype Ref.2. Source: UniProtKB intracellular protein transport Inferred from mutant phenotype PubMed 10588660. Source: WormBase oocyte development Inferred from mutant phenotype PubMed 10588660. Source: WormBase regulation of receptor-mediated endocytosis Inferred from genetic interaction PubMed 21596567. Source: WormBase small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from direct assay Ref.2. Source: UniProtKB
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Potential

Chain

2 – 181

180

ADP-ribosylation factor 1-like 2

PRO_0000207405

Regions

Nucleotide binding

24 – 31

GTP By similarity

Nucleotide binding

67 – 71

GTP By similarity

Nucleotide binding

126 – 129

GTP By similarity

Sites

Binding site

GTP; via amide nitrogen By similarity

Amino acid modifications

Lipidation

N-myristoyl glycine Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q10943 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 98FD0886AD9A2459
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FASTA

181

20,522

        10         20         30         40         50         60 
MGNVFGSLFK GLFGKREMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN 

        70         80         90        100        110        120 
ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV GEAREELMRM LAEDELRDAV 

       130        140        150        160        170        180 
LLVFANKQDL PQAMNAAEVT DKLGLHSLRN RSWYIQATCA TSGDGLYEGL DWLSNQLKNR 


S

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans." Li Y., Kelly W.G., Logsdon J.M. Jr., Schurko A.M., Harfe B.D., Hill-Harfe K.L., Kahn R.A. FASEB J. 18:1834-1850(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[3]	"Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans." Poteryaev D., Squirrell J.M., Campbell J.M., White J.G., Spang A. Mol. Biol. Cell 16:2139-2153(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080138 Genomic DNA. Translation: CCD61516.1.
PIR	T15341.
RefSeq	NP_498235.1. NM_065834.3.
3D structure databases
ProteinModelPortal	Q10943.
SMR	Q10943. Positions 18-177.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-24528N.
IntAct	Q10943. 3 interactions.
MINT	MINT-212315.
STRING	6239.B0336.2.1.
Proteomic databases
PaxDb	Q10943.
PRIDE	Q10943.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0336.2.1; B0336.2.1; B0336.2. B0336.2.2; B0336.2.2; B0336.2. B0336.2.3; B0336.2.3; B0336.2.
GeneID	175801.
KEGG	cel:CELE_B0336.2.
UCSC	B0336.2.1. c. elegans.
Organism-specific databases
CTD	175801.
WormBase	B0336.2; CE00696; WBGene00000182; arf-1.2.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00650000093078.
HOGENOM	HOG000163691.
InParanoid	Q10943.
KO	K07977.
OMA	NDRDRMR.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR024156. Small_GTPase_ARF. IPR006689. Small_GTPase_ARF/SAR. [Graphical view]
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
SMART	SM00177. ARF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51417. ARF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	889734.

Entry information

Entry name

ARF12_CAEEL

Accession

Primary (citable) accession number: Q10943

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents