Reviewed, UniProtKB/Swiss-Prot Q10941 (UGT46_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative UDP-glucuronosyltransferase ugt-46
      Short name=UDPGT 46
    EC=2.4.1.17

Gene names

Name:	ugt-46
Synonyms:	ugt14
ORF Names:	B0310.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9XVA3	1	EBI-319068,EBI-319064

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 531	514	Putative UDP-glucuronosyltransferase ugt-46		PRO_0000036053
Regions
	Transmembrane	493 – 513	21	Potential
Amino acid modifications
	Glycosylation	304	1	N-linked (GlcNAc...) Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q10941-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 1C498A4385E272C4	FASTA	531	60,204
	10 20 30 40 50 60 MRLIFVLLAT FVNAAFSYKI LVFSPATSKS HLISNGRLAD ELARAGHDVT VLELDFLGIS 70 80 90 100 110 120 QTTNSVKVAK KRIIDGFQES TNFKNVLHGF SETVMEEPSF TDEIKGWWAY QNVYNDLCAE 130 140 150 160 170 180 FLKMDDIFNE LKNAKFDGFF AEQINLCGFG YAHALEIPRH FLISSCPFAA PVYDFTGLPM 190 200 210 220 230 240 PTSTVAFAAD LSISPTYTER ARNLFVAVLT KLEFTLLNNR LQAHFQHKFG EHFPSLYSVT 250 260 270 280 290 300 SDVDVIFVAT DEIIDISTTT LQNIVHVGGL GVDDDVAEMD NVFASEMSKG KEGVIYFSLG 310 320 330 340 350 360 TIANTTKIDS KVMRTVLDIV KKFPDYHFVI RADKYDLSTR EYAKSVSNAF VSDWLPQPAI 370 380 390 400 410 420 LHHPRLKLFI THSGYNSIVE AARAGVPLIN IPFMFDQNLN SRAVEKKGWG IRRHKKQLLT 430 440 450 460 470 480 EPEEIEKAIS EIIHNKKYSL KAQRIRDLIK SKPLSSSQLL IKTTEWAIKN HGLDEIKFES 490 500 510 520 530 RGQTTWTYYN LDVIIPVFWL SISLVIPTIF GWYKFSCFGH VEEKKGKSKR D

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Identification of the hydrophobic glycoproteins of Caenorhabditis elegans." Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H., Mahuran D.J. Glycobiology 15:952-964(2005) [PubMed: 15888633] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-304, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U40959 Genomic DNA. Translation: AAA81769.1.
PIR	T15329.
RefSeq	NP_508112.1.
UniGene	Cel.11527
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:26251N.
IntAct	Q10941. 1 interaction.
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	B0310.5. Caenorhabditis elegans. [Contig view]
GeneID	180404.
KEGG	cel:B0310.5.
Organism-specific databases
WormBase	WBGene00015141. ugt-46.
WormPep	B0310.5. CE03878. [WorfDB]
Phylogenomic databases
OMA	Q10941. TTEWAIK.
Enzyme and pathway databases
BRENDA	2.4.1.17. 672.
Gene expression databases
ArrayExpress	Q10941.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	909208.

Entry information

Entry name

UGT46_CAEEL

Accession

Primary (citable) accession number: Q10941

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 5, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project