ID   NHR2_CAEEL              Reviewed;         359 AA.
AC   Q10902;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Nuclear hormone receptor family member nhr-2;
GN   Name=nhr-2; ORFNames=C32F10.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99148134; PubMed=10022975;
RA   Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT   "The nuclear receptor superfamily has undergone extensive
RT   proliferation and diversification in nematodes.";
RL   Genome Res. 9:103-120(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- INTERACTION:
CC       O02043:-; NbExp=1; IntAct=EBI-312197, EBI-328211;
CC       Q18488:-; NbExp=1; IntAct=EBI-312197, EBI-316782;
CC       Q9N3X3:-; NbExp=1; IntAct=EBI-312197, EBI-330787;
CC       Q9NAE1:-; NbExp=1; IntAct=EBI-312197, EBI-315053;
CC       Q9XTS1:-; NbExp=1; IntAct=EBI-312197, EBI-312192;
CC       Q95ZQ4:aak-2; NbExp=1; IntAct=EBI-312197, EBI-326514;
CC       Q9N517:lgc-42; NbExp=1; IntAct=EBI-312197, EBI-330336;
CC       Q9XVV3:nhr-67; NbExp=1; IntAct=EBI-312197, EBI-314697;
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; U37424; AAA80355.1; -; Genomic_DNA.
DR   EMBL; AF000195; AAC24271.2; -; Genomic_DNA.
DR   PIR; T34026; T34026.
DR   HSSP; P03372; 1HCQ.
DR   IntAct; Q10902; 12.
DR   Ensembl; C32F10.6; Caenorhabditis elegans.
DR   WormBase; WBGene00003601; nhr-2.
DR   WormPep; C32F10.6; CE17488.
DR   ArrayExpress; Q10902; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:ligand-dependent nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009792; P:embryonic development ending in birth or eg...; IMP:WormBase.
DR   GO; GO:0040007; P:growth; IMP:WormBase.
DR   GO; GO:0040011; P:locomotion; IMP:WormBase.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IMP:WormBase.
DR   GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR000324; VitD_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Gene3D; G3DSA:3.30.50.10; Znf_NHR/GATA; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00350; VITAMINDR.
DR   ProDom; PD000035; Znf_C4steroid; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    359       Nuclear hormone receptor family member
FT                                nhr-2.
FT                                /FTId=PRO_0000053756.
FT   DNA_BIND    102    184       Nuclear receptor.
FT   ZN_FING     105    125       NR C4-type.
FT   ZN_FING     154    172       NR C4-type.
SQ   SEQUENCE   359 AA;  39764 MW;  C91F5E0B315EB28B CRC64;
     MQLTPLQQAK PEKEEISPYA INNILSSTQS SPDNGNEADD KENSSVRRNT FPASSASTKK
     PRGTPYDRTN TPMTVVPQMP QFAPDFSNYN LTMNAWSEFF KKDRCMVCGD NSTGYHYGVQ
     SCEGCKGFFR RSVHKNIAYV CTKGENCTFS YENCAANRGV RTRCQACRFA KCLAVGMNRD
     NVRVNKETDK DVKPSVASPN FEMTSQVKEL TAAFVANMPC STHLTSGTHA IGAIKKFIES
     VPALSSLLPK DEKALEMSIQ KVMSGILAIR AAFTFDPITF YSCENPVNLL RGGIRNTVFN
     DCEVALLSGI HILQIVNGGV AEIFTSYCQG LRHQLSQTHL QEIGLCDRLL MRLGPYLNQ
//