Reviewed, UniProtKB/Swiss-Prot Q10902 (NHR2_CAEEL)

Names and origin

Protein names

Recommended name:
    Nuclear hormone receptor family member nhr-2

Gene names

Name:	nhr-2
ORF Names:	C32F10.6

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Orphan nuclear receptor.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase meiotic chromosome segregation Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ligand-dependent nuclear receptor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	O02043	1	EBI-312197,EBI-328211
	Q18488	1	EBI-312197,EBI-316782
	Q9N3X3	1	EBI-312197,EBI-330787
	Q9NAE1	1	EBI-312197,EBI-315053
	Q9XTS1	1	EBI-312197,EBI-312192
aak-2	Q95ZQ4	1	EBI-312197,EBI-326514
lgc-42	Q9N517	1	EBI-312197,EBI-330336
nhr-67	Q9XVV3	1	EBI-312197,EBI-314697

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Nuclear hormone receptor family member nhr-2		PRO_0000053756
Regions
	DNA binding	102 – 184	83	Nuclear receptor
	Zinc finger	105 – 125	21	NR C4-type
	Zinc finger	154 – 172	19	NR C4-type

Sequences

	Sequence		Length	Mass (Da)
	Q10902-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: C91F5E0B315EB28B	FASTA	359	39,764
	10 20 30 40 50 60 MQLTPLQQAK PEKEEISPYA INNILSSTQS SPDNGNEADD KENSSVRRNT FPASSASTKK 70 80 90 100 110 120 PRGTPYDRTN TPMTVVPQMP QFAPDFSNYN LTMNAWSEFF KKDRCMVCGD NSTGYHYGVQ 130 140 150 160 170 180 SCEGCKGFFR RSVHKNIAYV CTKGENCTFS YENCAANRGV RTRCQACRFA KCLAVGMNRD 190 200 210 220 230 240 NVRVNKETDK DVKPSVASPN FEMTSQVKEL TAAFVANMPC STHLTSGTHA IGAIKKFIES 250 260 270 280 290 300 VPALSSLLPK DEKALEMSIQ KVMSGILAIR AAFTFDPITF YSCENPVNLL RGGIRNTVFN 310 320 330 340 350 DCEVALLSGI HILQIVNGGV AEIFTSYCQG LRHQLSQTHL QEIGLCDRLL MRLGPYLNQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes." Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V. Genome Res. 9:103-120(1999) [PubMed: 10022975] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U37424 Genomic DNA. Translation: AAA80355.1. AF000195 Genomic DNA. Translation: AAC24271.2.
PIR	T34026.
3D structure databases
HSSP	HSSP built from PDB template 1HCQ based on UniProtKB P03372.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q10902. 12 interactions.
Genome annotation databases
Ensembl	C32F10.6. Caenorhabditis elegans. [Contig view]
Organism-specific databases
WormBase	WBGene00003601. nhr-2.
WormPep	C32F10.6. CE17488. [WorfDB]
Gene expression databases
ArrayExpress	Q10902.
Family and domain databases
InterPro	IPR000324. VitD_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00047. STROIDFINGER. PR00350. VITAMINDR.
ProDom	PD000035. Znf_C4steroid. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NHR2_CAEEL

Accession

Primary (citable) accession number: Q10902

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project