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Protein
Submitted name:

Peptide synthetase

Gene

nrp

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4218-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptide synthetaseImported
Submitted name:
Probable peptide synthetase Nrp (Peptide synthase)Imported
Gene namesi
Name:nrpImported
Ordered Locus Names:Rv0101Imported
ORF Names:LH57_00575Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome
  • UP000031768 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0101.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DQVX-ray2.30A2056-2512[»]
4U5QX-ray1.81A/B2056-2512[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini930 – 1000Acyl carrierInterPro annotationAdd BLAST71
Domaini1989 – 2056Acyl carrierInterPro annotationAdd BLAST68

Phylogenomic databases

eggNOGiCOG1020. LUCA.
COG3320. LUCA.
HOGENOMiHOG000071412.
OMAiTHRDTEN.

Family and domain databases

CDDicd05235. SDR_e1. 1 hit.
Gene3Di1.10.1200.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR010080. Thioester_reductase-like_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 2 hits.
PF13193. AMP-binding_C. 1 hit.
PF00668. Condensation. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 2 hits.
[Graphical view]
SMARTiSM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 2 hits.
PS00455. AMP_BINDING. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRVRLSRSQ RNLYNGVRQD NNPALYLIGK SYRFRRLELA RFLAALHATV
60 70 80 90 100
LDNPVQLCVL ENSGADYPDL VPRLRFGDIV RVGSADEHLQ STWCSGILGK
110 120 130 140 150
PLVRHTVHTD PNGYVTGLDV HTHHILLDGG ATGTIEADLA RYLTTDPAGE
160 170 180 190 200
TPSVGAGLAK LREAHRRETA KVEESRGRLS AVVQRELADE AYHGGHGHSV
210 220 230 240 250
SDAPGTAAKG VLHESATICG NAFDAILTLS EAQRVPLNVL VAAAAVAVDA
260 270 280 290 300
SLRQNTETLL VHTVDNRFGD SDLNVATCLV NSVAQTVRFP PFASVSDVVR
310 320 330 340 350
TLDRGYVKAV RRRWLREEHY RRMYLAINRT SHVEALTLNF IREPCAPGLR
360 370 380 390 400
PFLSEVPIAT DIGPVEGMTV ASVLDEEQRT LNLAIWNRAD LPACKTHPKV
410 420 430 440 450
AERIAAALES MAAMWDRPIA MIVNDWFGIG PDGTRCQGDW PARQPSTPAW
460 470 480 490 500
FLDSARGVHQ FLGRRRFVYP WVAWLVQRGA APGDVLVFTD DDTDKTIDLL
510 520 530 540 550
IACHLAGCGY SVCDTADEIS VRTNAITEHG DGILVTVVDV AATQLAVVGH
560 570 580 590 600
DELRKVVDER VTQVTHDALL ATKTAYIMPT SGTTGQPKLV RISHGSLAVF
610 620 630 640 650
CDAISRAYGW GAHDTVLQCA PLTSDISVEE IFGGAACGAR LVRSAAMKTG
660 670 680 690 700
DLAALVDDLV ARETTIVDLP TAVWQLLCAD GDAIDAIGRS RLRQIVIGGE
710 720 730 740 750
AIRCSAVDKW LESAASQGIS LLSSYGPTEA TVVATFLPIV CDQTTMDGAL
760 770 780 790 800
LRLGRPILPN TVFLAFGEVV IVGDLVADGY LGIDGDGFGT VTAADGSRRR
810 820 830 840 850
AFATGDRVTV DAEGFPVFSG RKDAVVKISG KRVDIAEVTR RIAEDPAVSD
860 870 880 890 900
VAVELHSGSL GVWFKSQRTR EGEQDAAAAT RIRLVLVSLG VSSFFVVGVP
910 920 930 940 950
NIPRKPNGKI DSDNLPRLPQ WSAAGLNTAE TGQRAAGLSQ IWSRQLGRAI
960 970 980 990 1000
GPDSSLLGEG IGSLDLIRIL PETRRYLGWR LSLLDLIGAD TAANLADYAP
1010 1020 1030 1040 1050
TPDAPTGEDR FRPLVAAQRP AAIPLSFAQR RLWFLDQLQR PAPVYNMAVA
1060 1070 1080 1090 1100
LRLRGYLDTE ALGAAVADVV GRHESLRTVF PAVDGVPRQL VIEARRADLG
1110 1120 1130 1140 1150
CDIVDATAWP ADRLQRAIEE AARHSFDLAT EIPLRTWLFR IADDEHVLVA
1160 1170 1180 1190 1200
VAHHIAADGW SVAPLTADLS AAYASRCAGR APDWAPLPVQ YVDYTLWQRE
1210 1220 1230 1240 1250
ILGDLDDSDS PIAAQLAYWE NALAGMPERL RLPTARPYPP VADQRGASLV
1260 1270 1280 1290 1300
VDWPASVQQQ VRRIARQHNA TSFMVVAAGL AVLLSKLSGS PDVAVGFPIA
1310 1320 1330 1340 1350
GRSDPALDNL VGFFVNTLVL RVNLAGDPSF AELLGQVRAR SLAAYENQDV
1360 1370 1380 1390 1400
PFEVLVDRLK PTRALTHHPL IQVMLAWQDN PVGQLNLGDL QATPMPIDTR
1410 1420 1430 1440 1450
TARMDLVFSL AERFSEGSEP AGIGGAVEYR TDVFEAQAID VLIERLRKVL
1460 1470 1480 1490 1500
VAVAAAPERT VSSIDALDGT ERARLDEWGN RAVLTAPAPT PVSIPQMLAA
1510 1520 1530 1540 1550
QVARIPEAEA VCCGDASMTY RELDEASNRL AHRLAGCGAG PGECVALLFE
1560 1570 1580 1590 1600
RCAPAVVAMV AVLKTGAAYL PIDPANPPPR VAFMLGDAVP VAAVTTAGLR
1610 1620 1630 1640 1650
SRLAGHDLPI IDVVDALAAY PGTPPPMPAA VNLAYILYTS GTTGEPKGVG
1660 1670 1680 1690 1700
ITHRNVTRLF ASLPARLSAA QVWSQCHSYG FDASAWEIWG ALLGGGRLVI
1710 1720 1730 1740 1750
VPESVAASPN DFHGLLVAEH VSVLTQTPAA VAMLPTQGLE SVALVVAGEA
1760 1770 1780 1790 1800
CPAALVDRWA PGRVMLNAYG PTETTICAAI SAPLRPGSGM PPIGVPVSGA
1810 1820 1830 1840 1850
ALFVLDSWLR PVPAGVAGEL YIAGAGVGVG YWRRAGLTAS RFVACPFGGS
1860 1870 1880 1890 1900
GARMYRTGDL VCWRADGQLE FLGRTDDQVK IRGYRIELGE VATALAELAG
1910 1920 1930 1940 1950
VGQAVVIARE DRPGDKRLVG YATEIAPGAV DPAGLRAQLA QRLPGYLVPA
1960 1970 1980 1990 2000
AVVVIDALPL TVNGKLDHRA LPAPEYGDTN GYRAPAGPVE KTVAGIFARV
2010 2020 2030 2040 2050
LGLERVGVDD SFFELGGDSL AAMRVIAAIN TTLNADLPVR ALLHASSTRG
2060 2070 2080 2090 2100
LSQLLGRDAR PTSDPRLVSV HGDNPTEVHA SDLTLDRFID ADTLATAVNL
2110 2120 2130 2140 2150
PGPSPELRTV LLTGATGFLG RYLVLELLRR LDVDGRLICL VRAESDEDAR
2160 2170 2180 2190 2200
RRLEKTFDSG DPELLRHFKE LAADRLEVVA GDKSEPDLGL DQPMWRRLAE
2210 2220 2230 2240 2250
TVDLIVDSAA MVNAFPYHEL FGPNVAGTAE LIRIALTTKL KPFTYVSTAD
2260 2270 2280 2290 2300
VGAAIEPSAF TEDADIRVIS PTRTVDGGWA GGYGTSKWAG EVLLREANDL
2310 2320 2330 2340 2350
CALPVAVFRC GMILADTSYA GQLNMSDWVT RMVLSLMATG IAPRSFYEPD
2360 2370 2380 2390 2400
SEGNRQRAHF DGLPVTFVAE AIAVLGARVA GSSLAGFATY HVMNPHDDGI
2410 2420 2430 2440 2450
GLDEYVDWLI EAGYPIRRID DFAEWLQRFE ASLGALPDRQ RRHSVLPMLL
2460 2470 2480 2490 2500
ASNSQRLQPL KPTRGCSAPT DRFRAAVRAA KVGSDKDNPD IPHVSAPTII
2510
NYVTNLQLLG LL
Length:2,512
Mass (Da):269,409
Last modified:November 1, 1996 - v1
Checksum:i86B9FA3ABA17D6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12822.1.
AL123456 Genomic DNA. Translation: CCP42826.1.
RefSeqiNP_214615.1. NC_000962.3.
WP_003400794.1. NZ_KK339370.1.

Genome annotation databases

EnsemblBacteriaiAIR12822; AIR12822; LH57_00575.
CCP42826; CCP42826; Rv0101.
GeneIDi886951.
KEGGimtu:Rv0101.
mtv:RVBD_0101.
PATRICi18148724. VBIMycTub87468_0115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009480 Genomic DNA. Translation: AIR12822.1.
AL123456 Genomic DNA. Translation: CCP42826.1.
RefSeqiNP_214615.1. NC_000962.3.
WP_003400794.1. NZ_KK339370.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DQVX-ray2.30A2056-2512[»]
4U5QX-ray1.81A/B2056-2512[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi83332.Rv0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIR12822; AIR12822; LH57_00575.
CCP42826; CCP42826; Rv0101.
GeneIDi886951.
KEGGimtu:Rv0101.
mtv:RVBD_0101.
PATRICi18148724. VBIMycTub87468_0115.

Phylogenomic databases

eggNOGiCOG1020. LUCA.
COG3320. LUCA.
HOGENOMiHOG000071412.
OMAiTHRDTEN.

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-4218-MONOMER.

Family and domain databases

CDDicd05235. SDR_e1. 1 hit.
Gene3Di1.10.1200.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR010080. Thioester_reductase-like_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 2 hits.
PF13193. AMP-binding_C. 1 hit.
PF00668. Condensation. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 2 hits.
[Graphical view]
SMARTiSM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 2 hits.
PS00455. AMP_BINDING. 2 hits.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ10896_MYCTU
AccessioniPrimary (citable) accession number: Q10896
Secondary accession number(s): I6XUF1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.