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Protein
Submitted name:

Probable peptide synthetase Nrp (Peptide synthase)

Gene

nrp

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Probable peptide synthetase Nrp (Peptide synthase)Imported
Gene namesi
Name:nrpImported
Ordered Locus Names:Rv0101Imported
OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)Imported
Taxonomic identifieri83332 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001584 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: MTBBASE
  • cytosol Source: MTBBASE
  • plasma membrane Source: MTBBASE

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2019O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Proteomic databases

PaxDbiQ10896

Interactioni

Protein-protein interaction databases

STRINGi83332.Rv0101

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DQVX-ray2.30A2056-2512[»]
4U5QX-ray1.81A/B2056-2512[»]
SMRiQ10896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1984 – 2059CarrierInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiCOG1020 LUCA
COG3320 LUCA
HOGENOMiHOG000071412
OMAiRFHYIST

Family and domain databases

CDDicd05235 SDR_e1, 1 hit
Gene3Di1.10.1200.101 hit
3.30.559.102 hits
3.40.50.18201 hit
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR029058 AB_hydrolase
IPR036736 ACP-like_sf
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR013120 Male_sterile_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR010080 Thioester_reductase-like_dom
PfamiView protein in Pfam
PF00501 AMP-binding, 2 hits
PF13193 AMP-binding_C, 1 hit
PF00668 Condensation, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 1 hit
SUPFAMiSSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01733 AA-adenyl-dom, 1 hit
TIGR01746 Thioester-redct, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 2 hits
PS50075 CARRIER, 1 hit
PS00012 PHOSPHOPANTETHEINE, 1 hit

Sequencei

Sequence statusi: Complete.

Q10896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRVRLSRSQ RNLYNGVRQD NNPALYLIGK SYRFRRLELA RFLAALHATV
60 70 80 90 100
LDNPVQLCVL ENSGADYPDL VPRLRFGDIV RVGSADEHLQ STWCSGILGK
110 120 130 140 150
PLVRHTVHTD PNGYVTGLDV HTHHILLDGG ATGTIEADLA RYLTTDPAGE
160 170 180 190 200
TPSVGAGLAK LREAHRRETA KVEESRGRLS AVVQRELADE AYHGGHGHSV
210 220 230 240 250
SDAPGTAAKG VLHESATICG NAFDAILTLS EAQRVPLNVL VAAAAVAVDA
260 270 280 290 300
SLRQNTETLL VHTVDNRFGD SDLNVATCLV NSVAQTVRFP PFASVSDVVR
310 320 330 340 350
TLDRGYVKAV RRRWLREEHY RRMYLAINRT SHVEALTLNF IREPCAPGLR
360 370 380 390 400
PFLSEVPIAT DIGPVEGMTV ASVLDEEQRT LNLAIWNRAD LPACKTHPKV
410 420 430 440 450
AERIAAALES MAAMWDRPIA MIVNDWFGIG PDGTRCQGDW PARQPSTPAW
460 470 480 490 500
FLDSARGVHQ FLGRRRFVYP WVAWLVQRGA APGDVLVFTD DDTDKTIDLL
510 520 530 540 550
IACHLAGCGY SVCDTADEIS VRTNAITEHG DGILVTVVDV AATQLAVVGH
560 570 580 590 600
DELRKVVDER VTQVTHDALL ATKTAYIMPT SGTTGQPKLV RISHGSLAVF
610 620 630 640 650
CDAISRAYGW GAHDTVLQCA PLTSDISVEE IFGGAACGAR LVRSAAMKTG
660 670 680 690 700
DLAALVDDLV ARETTIVDLP TAVWQLLCAD GDAIDAIGRS RLRQIVIGGE
710 720 730 740 750
AIRCSAVDKW LESAASQGIS LLSSYGPTEA TVVATFLPIV CDQTTMDGAL
760 770 780 790 800
LRLGRPILPN TVFLAFGEVV IVGDLVADGY LGIDGDGFGT VTAADGSRRR
810 820 830 840 850
AFATGDRVTV DAEGFPVFSG RKDAVVKISG KRVDIAEVTR RIAEDPAVSD
860 870 880 890 900
VAVELHSGSL GVWFKSQRTR EGEQDAAAAT RIRLVLVSLG VSSFFVVGVP
910 920 930 940 950
NIPRKPNGKI DSDNLPRLPQ WSAAGLNTAE TGQRAAGLSQ IWSRQLGRAI
960 970 980 990 1000
GPDSSLLGEG IGSLDLIRIL PETRRYLGWR LSLLDLIGAD TAANLADYAP
1010 1020 1030 1040 1050
TPDAPTGEDR FRPLVAAQRP AAIPLSFAQR RLWFLDQLQR PAPVYNMAVA
1060 1070 1080 1090 1100
LRLRGYLDTE ALGAAVADVV GRHESLRTVF PAVDGVPRQL VIEARRADLG
1110 1120 1130 1140 1150
CDIVDATAWP ADRLQRAIEE AARHSFDLAT EIPLRTWLFR IADDEHVLVA
1160 1170 1180 1190 1200
VAHHIAADGW SVAPLTADLS AAYASRCAGR APDWAPLPVQ YVDYTLWQRE
1210 1220 1230 1240 1250
ILGDLDDSDS PIAAQLAYWE NALAGMPERL RLPTARPYPP VADQRGASLV
1260 1270 1280 1290 1300
VDWPASVQQQ VRRIARQHNA TSFMVVAAGL AVLLSKLSGS PDVAVGFPIA
1310 1320 1330 1340 1350
GRSDPALDNL VGFFVNTLVL RVNLAGDPSF AELLGQVRAR SLAAYENQDV
1360 1370 1380 1390 1400
PFEVLVDRLK PTRALTHHPL IQVMLAWQDN PVGQLNLGDL QATPMPIDTR
1410 1420 1430 1440 1450
TARMDLVFSL AERFSEGSEP AGIGGAVEYR TDVFEAQAID VLIERLRKVL
1460 1470 1480 1490 1500
VAVAAAPERT VSSIDALDGT ERARLDEWGN RAVLTAPAPT PVSIPQMLAA
1510 1520 1530 1540 1550
QVARIPEAEA VCCGDASMTY RELDEASNRL AHRLAGCGAG PGECVALLFE
1560 1570 1580 1590 1600
RCAPAVVAMV AVLKTGAAYL PIDPANPPPR VAFMLGDAVP VAAVTTAGLR
1610 1620 1630 1640 1650
SRLAGHDLPI IDVVDALAAY PGTPPPMPAA VNLAYILYTS GTTGEPKGVG
1660 1670 1680 1690 1700
ITHRNVTRLF ASLPARLSAA QVWSQCHSYG FDASAWEIWG ALLGGGRLVI
1710 1720 1730 1740 1750
VPESVAASPN DFHGLLVAEH VSVLTQTPAA VAMLPTQGLE SVALVVAGEA
1760 1770 1780 1790 1800
CPAALVDRWA PGRVMLNAYG PTETTICAAI SAPLRPGSGM PPIGVPVSGA
1810 1820 1830 1840 1850
ALFVLDSWLR PVPAGVAGEL YIAGAGVGVG YWRRAGLTAS RFVACPFGGS
1860 1870 1880 1890 1900
GARMYRTGDL VCWRADGQLE FLGRTDDQVK IRGYRIELGE VATALAELAG
1910 1920 1930 1940 1950
VGQAVVIARE DRPGDKRLVG YATEIAPGAV DPAGLRAQLA QRLPGYLVPA
1960 1970 1980 1990 2000
AVVVIDALPL TVNGKLDHRA LPAPEYGDTN GYRAPAGPVE KTVAGIFARV
2010 2020 2030 2040 2050
LGLERVGVDD SFFELGGDSL AAMRVIAAIN TTLNADLPVR ALLHASSTRG
2060 2070 2080 2090 2100
LSQLLGRDAR PTSDPRLVSV HGDNPTEVHA SDLTLDRFID ADTLATAVNL
2110 2120 2130 2140 2150
PGPSPELRTV LLTGATGFLG RYLVLELLRR LDVDGRLICL VRAESDEDAR
2160 2170 2180 2190 2200
RRLEKTFDSG DPELLRHFKE LAADRLEVVA GDKSEPDLGL DQPMWRRLAE
2210 2220 2230 2240 2250
TVDLIVDSAA MVNAFPYHEL FGPNVAGTAE LIRIALTTKL KPFTYVSTAD
2260 2270 2280 2290 2300
VGAAIEPSAF TEDADIRVIS PTRTVDGGWA GGYGTSKWAG EVLLREANDL
2310 2320 2330 2340 2350
CALPVAVFRC GMILADTSYA GQLNMSDWVT RMVLSLMATG IAPRSFYEPD
2360 2370 2380 2390 2400
SEGNRQRAHF DGLPVTFVAE AIAVLGARVA GSSLAGFATY HVMNPHDDGI
2410 2420 2430 2440 2450
GLDEYVDWLI EAGYPIRRID DFAEWLQRFE ASLGALPDRQ RRHSVLPMLL
2460 2470 2480 2490 2500
ASNSQRLQPL KPTRGCSAPT DRFRAAVRAA KVGSDKDNPD IPHVSAPTII
2510
NYVTNLQLLG LL
Length:2,512
Mass (Da):269,409
Last modified:November 1, 1996 - v1
Checksum:i86B9FA3ABA17D6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP42826.1
RefSeqiNP_214615.1, NC_000962.3
WP_003400794.1, NZ_KK339370.1

Genome annotation databases

EnsemblBacteriaiAIR12822; AIR12822; LH57_00575
CCP42826; CCP42826; Rv0101
GeneIDi886951
KEGGimtu:Rv0101
mtv:RVBD_0101
PATRICifig|83332.111.peg.115

Similar proteinsi

Entry informationi

Entry nameiQ10896_MYCTU
AccessioniPrimary (citable) accession number: Q10896
Secondary accession number(s): I6XUF1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported