Cation-transporting P-type ATPase A - Mycobacterium tuberculosis

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Q10876 (CTPA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cation-transporting P-type ATPase A
EC=3.6.3.-

Gene names

Name:	ctpA
Ordered Locus Names:	Rv0092, MT0101
ORF Names:	MTCY251.11

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	761 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity

ATP + H₂O = ADP + phosphate.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Contains 1 HMA domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 761

761

Cation-transporting P-type ATPase A

PRO_0000046165

Regions

Transmembrane

102 – 122

Helical; Potential

Transmembrane

129 – 149

Helical; Potential

Transmembrane

164 – 184

Helical; Potential

Transmembrane

199 – 219

Helical; Potential

Transmembrane

361 – 381

Helical; Potential

Transmembrane

387 – 407

Helical; Potential

Transmembrane

548 – 568

Helical; Potential

Transmembrane

650 – 670

Helical; Potential

Transmembrane

703 – 723

Helical; Potential

Domain

15 – 79

HMA

Sites

Active site

443

4-aspartylphosphate intermediate By similarity

Metal binding

By similarity

Metal binding

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q10876 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D397901EC5C513BE
Show »

FASTA

761

78,851

        10         20         30         40         50         60 
MTTAVTGEHH ASVQRIQLRI SGMSCSACAH RVESTLNKLP GVRAAVNFGT RVATIDTSEA 

        70         80         90        100        110        120 
VDAAALCQAV RRAGYQADLC TDDGRSASDP DADHARQLLI RLAIAAVLFV PVADLSVMFG 

       130        140        150        160        170        180 
VVPATRFTGW QWVLSALALP VVTWAAWPFH RVAMRNARHH AASMETLISV GITAATIWSL 

       190        200        210        220        230        240 
YTVFGNHSPI ERSGIWQALL GSDAIYFEVA AGVTVFVLVG RYFEARAKSQ AGSALRALAA 

       250        260        270        280        290        300 
LSAKEVAVLL PDGSEMVIPA DELKEQQRFV VRPGQIVAAD GLAVDGSAAV DMSAMTGEAK 

       310        320        330        340        350        360 
PTRVRPGGQV IGGTTVLDGR LIVEAAAVGA DTQFAGMVRL VEQAQAQKAD AQRLADRISS 

       370        380        390        400        410        420 
VFVPAVLVIA ALTAAGWLIA GGQPDRAVSA ALAVLVIACP CALGLATPTA MMVASGRGAQ 

       430        440        450        460        470        480 
LGIFLKGYKS LEATRAVDTV VFDKTGTLTT GRLQVSAVTA APGWEADQVL ALAATVEAAS 

       490        500        510        520        530        540 
EHSVALAIAA ATTRRDAVTD FRAIPGRGVS GTVSGRAVRV GKPSWIGSSS CHPNMRAARR 

       550        560        570        580        590        600 
HAESLGETAV FVEVDGEPCG VIAVADAVKD SARDAVAALA DRGLRTMLLT GDNPESAAAV 

       610        620        630        640        650        660 
ATRVGIDEVI ADILPEGKVD VIEQLRDRGH VVAMVGDGIN DGPALARADL GMAIGRGTDV 

       670        680        690        700        710        720 
AIGAADIILV RDHLDVVPLA LDLARATMRT VKLNMVWAFG YNIAAIPVAA AGLLNPLVAG 

       730        740        750        760 
AAMAFSSFFV VSNSLRLRKF GRYPLGCGTV GGPQMTAPSS A

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References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence."
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.

Barrell B.G.
Nature 393:537-544(1998) [PubMed: 9634230] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains."
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R.

Fraser C.M.
J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842572 Genomic DNA. Translation: CAA98928.1. AE000516 Genomic DNA. Translation: AAK44324.1.
PIR	D70750.
RefSeq	NP_214606.1. NC_000962.2. NP_334510.1. NC_002755.2.
3D structure databases
ProteinModelPortal	Q10876.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000003703; EBMYCP00000003703; EBMYCG00000003701. EBMYCT00000070418; EBMYCP00000068477; EBMYCG00000070413.
GeneID	886946. 922913.
GenomeReviews	Gene locus MT0101 in contig AE000516_GR. Gene locus Rv0092 in contig AL123456_GR.
KEGG	mtc:MT0101. mtu:Rv0092.
PATRIC	18121946. VBIMycTub22151_0107.
TIGR	MT0101.
Organism-specific databases
TubercuList	Rv0092.
Phylogenomic databases
GeneTree	EBGT00050000016190.
HOGENOM	HBG507745.
OMA	MSTTIVT.
PhylomeDB	Q10876.
ProtClustDB	CLSK790257.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR000579. ATPase_P-typ_cation-transptr. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe-assoc_HMA. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K12949.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00940. CATPATPASEA.
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF55008. HeavyMe_transpt. 1 hit.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTPA_MYCTU

Accession

Primary (citable) accession number: Q10876

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents