Reviewed, UniProtKB/Swiss-Prot Q10801 (DIPZ_MYCTU)

Names and origin

Protein names

Recommended name:
    Protein dipZ

Gene names

Name:	dipZ
Ordered Locus Names:	Rv2874, MT2942
ORF Names:	MTCY274.05

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	695 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro cytochrome complex assembly Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antioxidant activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 695

695

Protein dipZ

PRO_0000079911

Regions

Transmembrane

123 – 143

21

Potential

Transmembrane

179 – 199

21

Potential

Transmembrane

205 – 225

21

Potential

Transmembrane

254 – 274

21

Potential

Transmembrane

285 – 305

21

Potential

Transmembrane

325 – 345

21

Potential

Domain

394 – 542

149

Thioredoxin

Experimental info

Sequence conflict

672

1

Y → D in AAK47267. Ref.3

Secondary structure

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695

Helix Strand Turn

Details...

Turn

379 – 383

5

Helix

384 – 386

3

Beta strand

408 – 412

5

Helix

413 – 415

3

Helix

420 – 423

4

Beta strand

426 – 433

8

Helix

438 – 454

17

Helix

455 – 457

3

Beta strand

459 – 465

7

Helix

470 – 473

4

Helix

475 – 485

11

Beta strand

491 – 493

3

Helix

498 – 502

5

Beta strand

507 – 514

8

Beta strand

518 – 527

10

Helix

530 – 544

15

Helix

554 – 556

3

Turn

575 – 577

3

Beta strand

589 – 594

6

Beta strand

604 – 613

10

Beta strand

618 – 620

3

Beta strand

622 – 624

3

Beta strand

626 – 650

25

Beta strand

653 – 659

7

Beta strand

664 – 683

20

Sequences

	Sequence		Length	Mass (Da)
	Q10801-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: B775ADEE33FF73CF	FASTA	695	74,168
	10 20 30 40 50 60 MVESRRAAAA ASAYASRCGI APATSQRSLA TPPTISVPSG EGRCRCHVAR GAGRDPRRRL 70 80 90 100 110 120 RRRRWCGRCG YHSHLTGGEF DVNRLCQQRS RERSCQLVAV PADPRPKRQR ITDVLTLALV 130 140 150 160 170 180 GFLGGLITGI SPCILPVLPV IFFSGAQSVD AAQVAKPEGA VAVRRKRALS ATLRPYRVIG 190 200 210 220 230 240 GLVLSFGMVT LLGSALLSVL HLPQDAIRWA ALVALVAIGA GLIFPRFEQL LEKPFSRIPQ 250 260 270 280 290 300 KQIVTRSNGF GLGLALGVLY VPCAGPILAA IVVAGATATI GLGTVVLTAT FALGAALPLL 310 320 330 340 350 360 FFALAGQRIA ERVGAFRRRQ REIRIATGSV TILLAVALVF DLPAALQRAI PDYTASLQQQ 370 380 390 400 410 420 ISTGTEIREQ LNLGGIVNAQ NAQLSNCSDG AAQLESCGTA PDLKGITGWL NTPGNKPIDL 430 440 450 460 470 480 KSLRGKVVLI DFWAYSCINC QRAIPHVVGW YQAYKDSGLA VIGVHTPEYA FEKVPGNVAK 490 500 510 520 530 540 GAANLGISYP IALDNNYATW TNYRNRYWPA EYLIDATGTV RHIKFGEGDY NVTETLVRQL 550 560 570 580 590 600 LNDAKPGVKL PQPSSTTTPD LTPRAALTPE TYFGVGKVVN YGGGGAYDEG SAVFDYPPSL 610 620 630 640 650 660 AANSFALRGR WALDYQGATS DGNDAAIKLN YHAKDVYIVV GGTGTLTVVR DGKPATLPIS 670 680 690 GPPTTHQVVA GYRLASETLE VRPSKGLQVF SFTYG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mycobacterium tuberculosis mpt83 and dipZ/thioredoxin genes are part of the same translational unit." Juarez M.D., Torres A., Bigi F., Espitia C. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[3]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF189006 Genomic DNA. Translation: AAF13401.1.
BX842581 Genomic DNA. Translation: CAA98351.1.
AE000516 Genomic DNA. Translation: AAK47267.1.

PIR

E70923.

RefSeq

NP_217390.1.
NP_337453.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HYX	X-ray	1.90	A/B/C/D	366-695	[»]

ModBase

Search...

Genome annotation databases

GeneID

888162.
925334.

GenomeReviews

Gene locus MT2942 in contig AE000516_GR.
Gene locus Rv2874 in contig AL123456_GR.

KEGG

mtc:MT2942.
mtu:Rv2874.

TIGR

MT2942.

Organism-specific databases

TubercuList

Rv2874.

Phylogenomic databases

HOGENOM

Q10801.

OMA

Q10801. QAYAFTF.

Family and domain databases

InterPro

IPR000866. Alkyl_hydroperoxide_Rdtase.
IPR003834. Cyt_c_assmbl_TM.
IPR017936. Thioredoxin-like.
IPR012335. Thioredoxin_fold.
[Graphical view]

Gene3D

G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.

Pfam

PF00578. AhpC-TSA. 1 hit.
PF02683. DsbD. 1 hit.
[Graphical view]

ProDom

PD003679. Thioredoxin_like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

DIPZ_MYCTU

Accession

Primary (citable) accession number: Q10801

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)