Reviewed, UniProtKB/Swiss-Prot Q107X0 (KRIP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein KRIP1
Alternative name(s):
    Kallikrein-related in prostate protein 1
    Kallikrein-related mRNA protein
      Short name=KARMA

Gene names

Name:	KLKP1
Synonyms:	KLK31P

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Cytoplasm. Nucleus.
Tissue specificity	Abundant expression is found in prostate, restricted to cells of epithelial origin in normal and diseased glands. Very low expression is detected in pancreas and ovary.
Induction	By androgens.
Caution	Was named (Ref.2) 'Kallikrein-related in prostate protein 1' because this protein is encoded by a transcript from the KLKP1 gene region. It is encoded in an exon which is similar to the intronic region between exons 1 and 2 of KLK1, KLK2 and KLK3.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	Protein KRIP1		PRO_0000341220
Regions
	Compositional bias	27 – 130	104	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q107X0-1 [UniParc]. Last modified August 22, 2006. Version 1. Checksum: 29EECF9BB8351706	FASTA	134	14,401
	10 20 30 40 50 60 MSPVHRSRTS QTQEAHKPTS TLSFISPPQP PRQDPKSPHI LCSQPNACSR QSHVSYPNPW 70 80 90 100 110 120 GLPCSQSKVS PPGTATNPNP KEWSRISGPP VSLDPQPWSS APFKPTAQLP LLAQSLGPPA 130 KPALPDPALP LQML

References

[1]

"KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that is expressed at lower levels in prostate cancer cells than in normal prostate cells." Lu W., Zhou D., Glusman G., Utleg A.G., White J.T., Nelson P.S., Vasicek T.J., Hood L., Lin B. Prostate 66:936-944(2006) [PubMed: 16541416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

[2]

"A novel transcript from the KLKP1 gene is androgen regulated, down-regulated during prostate cancer progression and encodes the first non-serine protease identified from the human kallikrein gene locus." Kaushal A., Myers S.A., Dong Y., Lai J., Tan O.L., Bui L.T., Hunt M.L., Digby M.R., Samaratunga H., Gardiner R.A., Clements J.A., Hooper J.D. Prostate 68:381-399(2008) [PubMed: 18196551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ211698 mRNA. No translation available. DQ086829 mRNA. Translation: AAZ78651.1. DQ086830 Genomic DNA. Translation: AAZ78652.1.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000197588. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:21260. KLKP1.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q107X0.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

KRIP1_HUMAN

Accession

Primary (citable) accession number: Q107X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	August 22, 2006
Last modified:	November 4, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)