ID   TREY_MYCTU              Reviewed;         765 AA.
AC   Q10768;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Putative maltooligosyl trehalose synthase;
DE            EC=5.4.99.15;
DE   AltName: Full=(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase;
GN   Name=treY; OrderedLocusNames=Rv1563c, MT1614; ORFNames=MTCY48.02;
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   MEDLINE=98295987; PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA   Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA   Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA   Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA   Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA   Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA   Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the
RT   complete genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   MEDLINE=22206494; PubMed=12218036;
RX   DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA   Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA   Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA   Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA   Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Catalyzes the conversion of maltooligosaccharide into
CC       the non-reducing saccharide, maltooligosyl trehalose (alpha-
CC       maltooligosyl alpha-D-glucoside) by intramolecular
CC       transglycosylation (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4-((1->4)-alpha-D-glucosyl)(n-1)-D-glucose =
CC       1-alpha-D-((1->4)-alpha-D-glucosyl)(n-1)-alpha-D-glucopyranoside.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
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DR   EMBL; BX842577; CAE55404.1; -; Genomic_DNA.
DR   EMBL; AE000516; AAK45881.1; -; Genomic_DNA.
DR   PIR; H70763; H70763.
DR   RefSeq; NP_336067.1; -.
DR   RefSeq; YP_177820.1; -.
DR   HSSP; Q53688; 1IV8.
DR   CAZy; GH13; Glycoside Hydrolase Family 13.
DR   GeneID; 886357; -.
DR   GeneID; 924320; -.
DR   GenomeReviews; AE000516_GR; MT1614.
DR   GenomeReviews; AL123456_GR; Rv1563c.
DR   KEGG; mtc:MT1614; -.
DR   KEGG; mtu:Rv1563c; -.
DR   TIGR; MT1614; -.
DR   TubercuList; Rv1563c; -.
DR   HOGENOM; Q10768; -.
DR   OMA; Q10768; LLERQHY.
DR   BRENDA; 5.4.99.15; 809.
DR   GO; GO:0047470; F:(1,4)-alpha-D-glucan 1-alpha-D-glucosylmuta...; IEA:EC.
DR   GO; GO:0043169; F:cation binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   InterPro; IPR006047; Glyco_hydro_13_cat.
DR   InterPro; IPR013781; Glyco_hydro_sg_catalytic.
DR   InterPro; IPR012767; Trehalose_TreY.
DR   Gene3D; G3DSA:3.20.20.80; Glyco_hydro_cat; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   TIGRFAMs; TIGR02401; trehalose_TreY; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase.
FT   CHAIN         1    765       Putative maltooligosyl trehalose
FT                                synthase.
FT                                /FTId=PRO_0000054342.
SQ   SEQUENCE   765 AA;  82707 MW;  34E9A5CB53624D6A CRC64;
     MAFPVISTYR VQMRGRSNGF GFTFADAENL LDYLDDLGVS HLYLSPILTA VGGSTHGYDV
     TDPTTVSPEL GGSDGLARLS AAARSRGMGL IVDIVPSHVG VGKPEQNAWW WDVLKFGRSS
     AYAEFFDIDW ELGDGRIILP LLGSDSDVAN LRVDGDLLRL GDLALPVAPG SGDGTGPAVH
     DRQHYRLVGW RHGLCGYRRF FSITSLAGLR QEDRAVFDAS HAEVARWFTE GLVDGVRVDH
     LDGLSDPSGY LAQLRELLGP NAWIVVEKIL AVDEALEPTL PVDGSTGYDV LREIGGVLVD
     PQGESPLTAL VESAGVDYQE MPAMLADLKV HAAVHTLASE LRRLRRCIAA AAGADHPLLP
     AAVAALLRHI GRYRCDYPGQ AAVLPCALAE THSTTPQLAP GLQLIAAAVA RGGEPAVRLQ
     QLCGAVSAKA VEDCMFYRDA RLVSLNEVGG EPRRFGVGAA EFHHRAATRA RLWPRSMTTL
     STHDTKRGED VRARIGVLSQ VPWLWAKFIG HAQAIAPAPD AVTGQFLWQN VFGVWPVSGE
     VSAALRGRLH TYAEKAIREA AWHTSWHNPN RAFEDDVHGW LDLVLDGPLA SELTGLVAHL
     NSHAESDALA AKLLALTVPG VPDVYQGSEL WDDSLVDPDN RRPVDYGTRR VALKALQHPK
     IRVLAAALRL RRTHPESFLG GAYHPVFAAG PAADHVVAFR RGDDILVAVT RWTVRLQQTG
     WDHTVLPLPD GSWTDALTGF TASGHTPAVE LFADLPVVLL VRDNA
//