Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q10768 (TREY_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative maltooligosyl trehalose synthase
EC=5.4.99.15
Alternative name(s):
(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase
Gene names
Name:treY
Ordered Locus Names:Rv1563c, MT1614
ORF Names:MTCY48.02
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length765 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of maltooligosaccharide into the non-reducing saccharide, maltooligosyl trehalose (alpha-maltooligosyl alpha-D-glucoside) by intramolecular transglycosylation By similarity.

Catalytic activity

4-((1->4)-alpha-D-glucosyl)(n-1)-D-glucose = 1-alpha-D-((1->4)-alpha-D-glucosyl)(n-1)-alpha-D-glucopyranoside.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 13 family.

Ontologies

Keywords
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processalpha-glucan catabolic process

Inferred from direct assay. Source: MTBBASE

trehalose biosynthetic process

Inferred from direct assay. Source: MTBBASE

   Cellular componentcytosol

Traceable author statement. Source: Reactome

   Molecular function(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity

Inferred from direct assay. Source: MTBBASE

cation binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 765765Putative maltooligosyl trehalose synthase
PRO_0000054342

Sequences

Sequence LengthMass (Da)Tools
Q10768 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 34E9A5CB53624D6A

FASTA76582,707
        10         20         30         40         50         60 
MAFPVISTYR VQMRGRSNGF GFTFADAENL LDYLDDLGVS HLYLSPILTA VGGSTHGYDV 

        70         80         90        100        110        120 
TDPTTVSPEL GGSDGLARLS AAARSRGMGL IVDIVPSHVG VGKPEQNAWW WDVLKFGRSS 

       130        140        150        160        170        180 
AYAEFFDIDW ELGDGRIILP LLGSDSDVAN LRVDGDLLRL GDLALPVAPG SGDGTGPAVH 

       190        200        210        220        230        240 
DRQHYRLVGW RHGLCGYRRF FSITSLAGLR QEDRAVFDAS HAEVARWFTE GLVDGVRVDH 

       250        260        270        280        290        300 
LDGLSDPSGY LAQLRELLGP NAWIVVEKIL AVDEALEPTL PVDGSTGYDV LREIGGVLVD 

       310        320        330        340        350        360 
PQGESPLTAL VESAGVDYQE MPAMLADLKV HAAVHTLASE LRRLRRCIAA AAGADHPLLP 

       370        380        390        400        410        420 
AAVAALLRHI GRYRCDYPGQ AAVLPCALAE THSTTPQLAP GLQLIAAAVA RGGEPAVRLQ 

       430        440        450        460        470        480 
QLCGAVSAKA VEDCMFYRDA RLVSLNEVGG EPRRFGVGAA EFHHRAATRA RLWPRSMTTL 

       490        500        510        520        530        540 
STHDTKRGED VRARIGVLSQ VPWLWAKFIG HAQAIAPAPD AVTGQFLWQN VFGVWPVSGE 

       550        560        570        580        590        600 
VSAALRGRLH TYAEKAIREA AWHTSWHNPN RAFEDDVHGW LDLVLDGPLA SELTGLVAHL 

       610        620        630        640        650        660 
NSHAESDALA AKLLALTVPG VPDVYQGSEL WDDSLVDPDN RRPVDYGTRR VALKALQHPK 

       670        680        690        700        710        720 
IRVLAAALRL RRTHPESFLG GAYHPVFAAG PAADHVVAFR RGDDILVAVT RWTVRLQQTG 

       730        740        750        760 
WDHTVLPLPD GSWTDALTGF TASGHTPAVE LFADLPVVLL VRDNA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842577 Genomic DNA. Translation: CAE55404.1.
AE000516 Genomic DNA. Translation: AAK45881.1.
PIRH70763.
RefSeqNP_336067.1. NC_002755.2.
YP_177820.1. NC_000962.2.

3D structure databases

ProteinModelPortalQ10768.
ModBaseSearch...

Protein family/group databases

CAZyGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000000887; EBMYCP00000000887; EBMYCG00000000887.
EBMYCT00000073002; EBMYCP00000071061; EBMYCG00000072997.
GeneID886357.
924320.
GenomeReviewsGene locus MT1614 in contig AE000516_GR.
Gene locus Rv1563c in contig AL123456_GR.
KEGGmtc:MT1614.
mtu:Rv1563c.
PATRIC18125316. VBIMycTub22151_1772.
TIGRMT1614.

Organism-specific databases

TubercuListRv1563c.

Phylogenomic databases

GeneTreeEBGT00050000016660.
HOGENOMHBG542942.
OMAQGTELWD.
ProtClustDBCLSK799817.

Enzyme and pathway databases

ReactomeREACT_27295. Mycobacterium tuberculosis biological processes.

Family and domain databases

InterProIPR015902. Alpha_amylase.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_subgr_catalytic.
IPR017853. Glycoside_hydrolase_SF.
IPR013797. Maltooligo_trehalose_synth_N.
IPR012767. Trehalose_TreY.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 4 hits.
G3DSA:1.10.10.470. Maltooligo_trehalose_synth_N. 1 hit.
KOK06044.
PANTHERPTHR10357. Alpha_amylase. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
TIGRFAMsTIGR02401. Trehalose_TreY. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTREY_MYCTU
AccessionPrimary (citable) accession number: Q10768
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents