Reviewed, UniProtKB/Swiss-Prot Q10768 (TREY_MYCTU)

Names and origin

Protein names

Recommended name:
    Putative maltooligosyl trehalose synthase
    EC=5.4.99.15
Alternative name(s):
    (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase

Gene names

Name:	treY
Ordered Locus Names:	Rv1563c, MT1614
ORF Names:	MTCY48.02

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	765 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of maltooligosaccharide into the non-reducing saccharide, maltooligosyl trehalose (alpha-maltooligosyl alpha-D-glucoside) by intramolecular transglycosylation By similarity.
Catalytic activity	4-((1->4)-alpha-D-glucosyl)(n-1)-D-glucose = 1-alpha-D-((1->4)-alpha-D-glucosyl)(n-1)-alpha-D-glucopyranoside.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 13 family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 765	765	Putative maltooligosyl trehalose synthase		PRO_0000054342

Sequences

	Sequence		Length	Mass (Da)
	Q10768-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 34E9A5CB53624D6A	FASTA	765	82,707
	10 20 30 40 50 60 MAFPVISTYR VQMRGRSNGF GFTFADAENL LDYLDDLGVS HLYLSPILTA VGGSTHGYDV 70 80 90 100 110 120 TDPTTVSPEL GGSDGLARLS AAARSRGMGL IVDIVPSHVG VGKPEQNAWW WDVLKFGRSS 130 140 150 160 170 180 AYAEFFDIDW ELGDGRIILP LLGSDSDVAN LRVDGDLLRL GDLALPVAPG SGDGTGPAVH 190 200 210 220 230 240 DRQHYRLVGW RHGLCGYRRF FSITSLAGLR QEDRAVFDAS HAEVARWFTE GLVDGVRVDH 250 260 270 280 290 300 LDGLSDPSGY LAQLRELLGP NAWIVVEKIL AVDEALEPTL PVDGSTGYDV LREIGGVLVD 310 320 330 340 350 360 PQGESPLTAL VESAGVDYQE MPAMLADLKV HAAVHTLASE LRRLRRCIAA AAGADHPLLP 370 380 390 400 410 420 AAVAALLRHI GRYRCDYPGQ AAVLPCALAE THSTTPQLAP GLQLIAAAVA RGGEPAVRLQ 430 440 450 460 470 480 QLCGAVSAKA VEDCMFYRDA RLVSLNEVGG EPRRFGVGAA EFHHRAATRA RLWPRSMTTL 490 500 510 520 530 540 STHDTKRGED VRARIGVLSQ VPWLWAKFIG HAQAIAPAPD AVTGQFLWQN VFGVWPVSGE 550 560 570 580 590 600 VSAALRGRLH TYAEKAIREA AWHTSWHNPN RAFEDDVHGW LDLVLDGPLA SELTGLVAHL 610 620 630 640 650 660 NSHAESDALA AKLLALTVPG VPDVYQGSEL WDDSLVDPDN RRPVDYGTRR VALKALQHPK 670 680 690 700 710 720 IRVLAAALRL RRTHPESFLG GAYHPVFAAG PAADHVVAFR RGDDILVAVT RWTVRLQQTG 730 740 750 760 WDHTVLPLPD GSWTDALTGF TASGHTPAVE LFADLPVVLL VRDNA

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842577 Genomic DNA. Translation: CAE55404.1. AE000516 Genomic DNA. Translation: AAK45881.1.
PIR	H70763.
RefSeq	NP_336067.1. YP_177820.1.
3D structure databases
HSSP	HSSP built from PDB template 1IV8 based on UniProtKB Q53688.
ModBase	Search...
Protein family/group databases
CAZy	GH13. Glycoside Hydrolase Family 13.
Genome annotation databases
GeneID	886357. 924320.
GenomeReviews	Gene locus MT1614 in contig AE000516_GR. Gene locus Rv1563c in contig AL123456_GR.
KEGG	mtc:MT1614. mtu:Rv1563c.
TIGR	MT1614.
Organism-specific databases
TubercuList	Rv1563c.
Phylogenomic databases
HOGENOM	Q10768.
OMA	Q10768. LLERQHY.
Enzyme and pathway databases
BRENDA	5.4.99.15. 809.
Family and domain databases
InterPro	IPR006047. Glyco_hydro_13_cat. IPR013781. Glyco_hydro_sg_catalytic. IPR012767. Trehalose_TreY. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF00128. Alpha-amylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02401. trehalose_TreY. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TREY_MYCTU

Accession

Primary (citable) accession number: Q10768

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)