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Q10751

- ACE_CHICK

UniProt

Q10751 - ACE_CHICK

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Protein

Angiotensin-converting enzyme

Gene
ACE, DCP1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.

Catalytic activityi

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi288 – 2881Zinc 1; catalytic By similarity
Active sitei289 – 28911 By similarity
Metal bindingi292 – 2921Zinc 1; catalytic By similarity
Metal bindingi886 – 8861Zinc 2; catalytic By similarity
Active sitei887 – 88712 By similarity
Metal bindingi890 – 8901Zinc 2; catalytic By similarity

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB
  4. peptidyl-dipeptidase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM02.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
Short name:
ACE
Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II
Gene namesi
Name:ACE
Synonyms:DCP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 1156›1156Extracellular Reviewed predictionAdd
BLAST
Transmembranei1157 – 117317Helical; Reviewed predictionAdd
BLAST
Topological domaini1174 – 119320Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 1193›1193Angiotensin-converting enzymePRO_0000078152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi60 – 601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi407 – 4071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi447 – 4471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi485 – 4851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi555 – 5551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi575 – 5751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi658 – 6581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1089 – 10891N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ10751.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039731.

Structurei

3D structure databases

ProteinModelPortaliQ10751.
SMRiQ10751. Positions 1-539, 543-1120.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati125 – 481357Add
BLAST
Repeati723 – 1079357Add
BLAST

Sequence similaritiesi

Belongs to the peptidase M2 family.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71044.
HOGENOMiHOG000007838.
HOVERGENiHBG000264.
PhylomeDBiQ10751.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
PROSITEiPS00142. ZINC_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q10751-1 [UniParc]FASTAAdd to Basket

« Hide

AKELYGNIWS NFSDPQLKKI IGSIQTLGPS NLPLDKRQQY NTILSDMDKI     50
YSTAKVCLDN GTCWDLEPDI SDIMATSRSY KKLLYAWEGW HNAAGNPLRA 100
KYQEFVTLSN EAYQMDGFED TGSYWRSWYD STTFEDDLEH LYNQLEPLYL 150
NLHAFVRRKL YDRYGPKYIN LKGPIPAHLL GNMWAQQWNN IYDLMVPYPD 200
KPNLDVTNTM VNQGWNATHM FRVSEEFFTS LGLLEMPPEF WEKSMLEKPA 250
DGREVVCHAS AWDFYNRKDF RIKQCTTVTM EQLFTVHHEM GHVQYYLQYK 300
DQPVSFRGGA NPGFHEAIGD VLSLSVSTPS HLQKIGLLSS AVEDEESNIN 350
YLLKMALEKI AFLPFGYLID QWRWNVFSGR TPPSRYNYDW WYLRTKYQGI 400
CAPVSRNESN FDPGAKYHIP GNTPYIRYFV SFILQFQFHK ALCQAANHTG 450
PLHTCDIYMS KEAGAKLREV LKAGSSKSWQ EILFNLTGTD KMDAGALLEY 500
FSPVTTWLQE QNNKTNEVLG WPEFDWRSPI PEGYPEGIDK IVDEAQAKEF 550
LSEYNSTAEV VWNAYTEASW EYNTNITDHN KEVMLEKNLA MSKHTIEYGM 600
RARQFDPSDF QDETVTRILN KLSVLERAAL PEDELKEYNT LLSDMETTYS 650
VAKVCRENNT FHPLDPDLTD ILATSRDYNE LLFAWKGWWD ASGAKIKDKY 700
KRYVELSNKA AVLNGYTDNG AYWRSLYETP TFEEDLERLY LQLQPLYLNL 750
HAYVRRALYN KYGAEHISLK GPIPAHLLGN MWAQSWSNIF DLVMPFPDAT 800
KVDATPAMKQ QGWTPKMMFE ESDRFFTSLG LIPMPQEFWD KSMIEKPADG 850
REVVCHASAW DFYNRKDFRI KQCTVVNMDD LITVHHEMGH VQYFLQYMDQ 900
PISFRDGANP GFHEAIGDVM ALSVSTPKHL HSINLLDQVT ENEESDINYL 950
MSIALDKIAF LPFGYLMDQW RWKVFDGRIK EDEYNQQWWN LRLKYQGLCP 1000
PVPRSEDDFD PGAKFHIPAN VPYIRYFVSF VIQFQFHQAL CKAAGHTGPL 1050
HTCDIYQSKE AGKLLGDAMK LGFSKPWPEA MQLITGQPNM SAEALMSYFE 1100
PLMTWLVKKN TENGEVLGWP EYSWTPYAVT EFHAATDTAD FLGMSVGTKQ 1150
ATAGAWVLLA LALVFLITSI FLGVKLFSSR RKAFKSSSEM ELK 1193
Length:1,193
Mass (Da):137,821
Last modified:October 1, 1996 - v1
Checksum:i954472A18EA471C7
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L40175 mRNA. Translation: AAA75554.1.
PIRiJC2489.
UniGeneiGga.3781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L40175 mRNA. Translation: AAA75554.1 .
PIRi JC2489.
UniGenei Gga.3781.

3D structure databases

ProteinModelPortali Q10751.
SMRi Q10751. Positions 1-539, 543-1120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000039731.

Protein family/group databases

MEROPSi M02.001.

Proteomic databases

PaxDbi Q10751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG71044.
HOGENOMi HOG000007838.
HOVERGENi HBG000264.
PhylomeDBi Q10751.

Family and domain databases

InterProi IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01401. Peptidase_M2. 2 hits.
[Graphical view ]
PRINTSi PR00791. PEPDIPTASEA.
PROSITEi PS00142. ZINC_PROTEASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals."
    Esther C.R., Thomas K.E., Bernstein K.E.
    Biochem. Biophys. Res. Commun. 205:1916-1921(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiACE_CHICK
AccessioniPrimary (citable) accession number: Q10751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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