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Q10751

- ACE_CHICK

UniProt

Q10751 - ACE_CHICK

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Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.

Catalytic activityi

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi288 – 2881Zinc 1; catalyticBy similarity
Active sitei289 – 28911PROSITE-ProRule annotation
Metal bindingi292 – 2921Zinc 1; catalyticBy similarity
Metal bindingi886 – 8861Zinc 2; catalyticBy similarity
Active sitei887 – 88712PROSITE-ProRule annotation
Metal bindingi890 – 8901Zinc 2; catalyticBy similarity

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB
  4. peptidyl-dipeptidase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM02.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
Short name:
ACE
Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II
Gene namesi
Name:ACE
Synonyms:DCP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 1156›1156ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1157 – 117317HelicalSequence AnalysisAdd
BLAST
Topological domaini1174 – 119320CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 1193›1193Angiotensin-converting enzymePRO_0000078152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi513 – 5131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi555 – 5551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi575 – 5751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1089 – 10891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ10751.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039731.

Structurei

3D structure databases

ProteinModelPortaliQ10751.
SMRiQ10751. Positions 1-539, 543-1120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati125 – 481357Add
BLAST
Repeati723 – 1079357Add
BLAST

Sequence similaritiesi

Belongs to the peptidase M2 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71044.
HOGENOMiHOG000007838.
HOVERGENiHBG000264.
InParanoidiQ10751.
PhylomeDBiQ10751.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
PROSITEiPS00142. ZINC_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q10751-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AKELYGNIWS NFSDPQLKKI IGSIQTLGPS NLPLDKRQQY NTILSDMDKI
60 70 80 90 100
YSTAKVCLDN GTCWDLEPDI SDIMATSRSY KKLLYAWEGW HNAAGNPLRA
110 120 130 140 150
KYQEFVTLSN EAYQMDGFED TGSYWRSWYD STTFEDDLEH LYNQLEPLYL
160 170 180 190 200
NLHAFVRRKL YDRYGPKYIN LKGPIPAHLL GNMWAQQWNN IYDLMVPYPD
210 220 230 240 250
KPNLDVTNTM VNQGWNATHM FRVSEEFFTS LGLLEMPPEF WEKSMLEKPA
260 270 280 290 300
DGREVVCHAS AWDFYNRKDF RIKQCTTVTM EQLFTVHHEM GHVQYYLQYK
310 320 330 340 350
DQPVSFRGGA NPGFHEAIGD VLSLSVSTPS HLQKIGLLSS AVEDEESNIN
360 370 380 390 400
YLLKMALEKI AFLPFGYLID QWRWNVFSGR TPPSRYNYDW WYLRTKYQGI
410 420 430 440 450
CAPVSRNESN FDPGAKYHIP GNTPYIRYFV SFILQFQFHK ALCQAANHTG
460 470 480 490 500
PLHTCDIYMS KEAGAKLREV LKAGSSKSWQ EILFNLTGTD KMDAGALLEY
510 520 530 540 550
FSPVTTWLQE QNNKTNEVLG WPEFDWRSPI PEGYPEGIDK IVDEAQAKEF
560 570 580 590 600
LSEYNSTAEV VWNAYTEASW EYNTNITDHN KEVMLEKNLA MSKHTIEYGM
610 620 630 640 650
RARQFDPSDF QDETVTRILN KLSVLERAAL PEDELKEYNT LLSDMETTYS
660 670 680 690 700
VAKVCRENNT FHPLDPDLTD ILATSRDYNE LLFAWKGWWD ASGAKIKDKY
710 720 730 740 750
KRYVELSNKA AVLNGYTDNG AYWRSLYETP TFEEDLERLY LQLQPLYLNL
760 770 780 790 800
HAYVRRALYN KYGAEHISLK GPIPAHLLGN MWAQSWSNIF DLVMPFPDAT
810 820 830 840 850
KVDATPAMKQ QGWTPKMMFE ESDRFFTSLG LIPMPQEFWD KSMIEKPADG
860 870 880 890 900
REVVCHASAW DFYNRKDFRI KQCTVVNMDD LITVHHEMGH VQYFLQYMDQ
910 920 930 940 950
PISFRDGANP GFHEAIGDVM ALSVSTPKHL HSINLLDQVT ENEESDINYL
960 970 980 990 1000
MSIALDKIAF LPFGYLMDQW RWKVFDGRIK EDEYNQQWWN LRLKYQGLCP
1010 1020 1030 1040 1050
PVPRSEDDFD PGAKFHIPAN VPYIRYFVSF VIQFQFHQAL CKAAGHTGPL
1060 1070 1080 1090 1100
HTCDIYQSKE AGKLLGDAMK LGFSKPWPEA MQLITGQPNM SAEALMSYFE
1110 1120 1130 1140 1150
PLMTWLVKKN TENGEVLGWP EYSWTPYAVT EFHAATDTAD FLGMSVGTKQ
1160 1170 1180 1190
ATAGAWVLLA LALVFLITSI FLGVKLFSSR RKAFKSSSEM ELK
Length:1,193
Mass (Da):137,821
Last modified:October 1, 1996 - v1
Checksum:i954472A18EA471C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40175 mRNA. Translation: AAA75554.1.
PIRiJC2489.
UniGeneiGga.3781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40175 mRNA. Translation: AAA75554.1 .
PIRi JC2489.
UniGenei Gga.3781.

3D structure databases

ProteinModelPortali Q10751.
SMRi Q10751. Positions 1-539, 543-1120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000039731.

Protein family/group databases

MEROPSi M02.001.

Proteomic databases

PaxDbi Q10751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG71044.
HOGENOMi HOG000007838.
HOVERGENi HBG000264.
InParanoidi Q10751.
PhylomeDBi Q10751.

Family and domain databases

InterProi IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01401. Peptidase_M2. 2 hits.
[Graphical view ]
PRINTSi PR00791. PEPDIPTASEA.
PROSITEi PS00142. ZINC_PROTEASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals."
    Esther C.R., Thomas K.E., Bernstein K.E.
    Biochem. Biophys. Res. Commun. 205:1916-1921(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiACE_CHICK
AccessioniPrimary (citable) accession number: Q10751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3