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Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.

Catalytic activityi

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi288Zinc 1; catalyticBy similarity1
Active sitei2891PROSITE-ProRule annotation1
Metal bindingi292Zinc 1; catalyticBy similarity1
Metal bindingi886Zinc 2; catalyticBy similarity1
Active sitei8872PROSITE-ProRule annotation1
Metal bindingi890Zinc 2; catalyticBy similarity1

GO - Molecular functioni

  • carboxypeptidase activity Source: UniProtKB-KW
  • dipeptidyl-peptidase activity Source: AgBase
  • metallopeptidase activity Source: UniProtKB
  • peptidyl-dipeptidase activity Source: UniProtKB
  • zinc ion binding Source: AgBase

GO - Biological processi

  • cell proliferation Source: AgBase
  • primitive erythrocyte differentiation Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM02.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
Short name:
ACE
Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II
Gene namesi
Name:ACE
Synonyms:DCP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 1156ExtracellularSequence analysisAdd BLAST›1156
Transmembranei1157 – 1173HelicalSequence analysisAdd BLAST17
Topological domaini1174 – 1193CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000078152‹1 – 1193Angiotensin-converting enzymeAdd BLAST›1193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1
Glycosylationi407N-linked (GlcNAc...)Sequence analysis1
Glycosylationi447N-linked (GlcNAc...)Sequence analysis1
Glycosylationi485N-linked (GlcNAc...)Sequence analysis1
Glycosylationi513N-linked (GlcNAc...)Sequence analysis1
Glycosylationi555N-linked (GlcNAc...)Sequence analysis1
Glycosylationi575N-linked (GlcNAc...)Sequence analysis1
Glycosylationi658N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1089N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ10751.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039731.

Structurei

3D structure databases

ProteinModelPortaliQ10751.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati125 – 481Add BLAST357
Repeati723 – 1079Add BLAST357

Sequence similaritiesi

Belongs to the peptidase M2 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
HOGENOMiHOG000007838.
HOVERGENiHBG000264.
InParanoidiQ10751.
PhylomeDBiQ10751.

Family and domain databases

CDDicd06461. M2_ACE. 2 hits.
InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
PROSITEiPS00142. ZINC_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q10751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKELYGNIWS NFSDPQLKKI IGSIQTLGPS NLPLDKRQQY NTILSDMDKI
60 70 80 90 100
YSTAKVCLDN GTCWDLEPDI SDIMATSRSY KKLLYAWEGW HNAAGNPLRA
110 120 130 140 150
KYQEFVTLSN EAYQMDGFED TGSYWRSWYD STTFEDDLEH LYNQLEPLYL
160 170 180 190 200
NLHAFVRRKL YDRYGPKYIN LKGPIPAHLL GNMWAQQWNN IYDLMVPYPD
210 220 230 240 250
KPNLDVTNTM VNQGWNATHM FRVSEEFFTS LGLLEMPPEF WEKSMLEKPA
260 270 280 290 300
DGREVVCHAS AWDFYNRKDF RIKQCTTVTM EQLFTVHHEM GHVQYYLQYK
310 320 330 340 350
DQPVSFRGGA NPGFHEAIGD VLSLSVSTPS HLQKIGLLSS AVEDEESNIN
360 370 380 390 400
YLLKMALEKI AFLPFGYLID QWRWNVFSGR TPPSRYNYDW WYLRTKYQGI
410 420 430 440 450
CAPVSRNESN FDPGAKYHIP GNTPYIRYFV SFILQFQFHK ALCQAANHTG
460 470 480 490 500
PLHTCDIYMS KEAGAKLREV LKAGSSKSWQ EILFNLTGTD KMDAGALLEY
510 520 530 540 550
FSPVTTWLQE QNNKTNEVLG WPEFDWRSPI PEGYPEGIDK IVDEAQAKEF
560 570 580 590 600
LSEYNSTAEV VWNAYTEASW EYNTNITDHN KEVMLEKNLA MSKHTIEYGM
610 620 630 640 650
RARQFDPSDF QDETVTRILN KLSVLERAAL PEDELKEYNT LLSDMETTYS
660 670 680 690 700
VAKVCRENNT FHPLDPDLTD ILATSRDYNE LLFAWKGWWD ASGAKIKDKY
710 720 730 740 750
KRYVELSNKA AVLNGYTDNG AYWRSLYETP TFEEDLERLY LQLQPLYLNL
760 770 780 790 800
HAYVRRALYN KYGAEHISLK GPIPAHLLGN MWAQSWSNIF DLVMPFPDAT
810 820 830 840 850
KVDATPAMKQ QGWTPKMMFE ESDRFFTSLG LIPMPQEFWD KSMIEKPADG
860 870 880 890 900
REVVCHASAW DFYNRKDFRI KQCTVVNMDD LITVHHEMGH VQYFLQYMDQ
910 920 930 940 950
PISFRDGANP GFHEAIGDVM ALSVSTPKHL HSINLLDQVT ENEESDINYL
960 970 980 990 1000
MSIALDKIAF LPFGYLMDQW RWKVFDGRIK EDEYNQQWWN LRLKYQGLCP
1010 1020 1030 1040 1050
PVPRSEDDFD PGAKFHIPAN VPYIRYFVSF VIQFQFHQAL CKAAGHTGPL
1060 1070 1080 1090 1100
HTCDIYQSKE AGKLLGDAMK LGFSKPWPEA MQLITGQPNM SAEALMSYFE
1110 1120 1130 1140 1150
PLMTWLVKKN TENGEVLGWP EYSWTPYAVT EFHAATDTAD FLGMSVGTKQ
1160 1170 1180 1190
ATAGAWVLLA LALVFLITSI FLGVKLFSSR RKAFKSSSEM ELK
Length:1,193
Mass (Da):137,821
Last modified:October 1, 1996 - v1
Checksum:i954472A18EA471C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40175 mRNA. Translation: AAA75554.1.
PIRiJC2489.
UniGeneiGga.3781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40175 mRNA. Translation: AAA75554.1.
PIRiJC2489.
UniGeneiGga.3781.

3D structure databases

ProteinModelPortaliQ10751.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039731.

Protein family/group databases

MEROPSiM02.001.

Proteomic databases

PaxDbiQ10751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3690. Eukaryota.
ENOG410XPJ3. LUCA.
HOGENOMiHOG000007838.
HOVERGENiHBG000264.
InParanoidiQ10751.
PhylomeDBiQ10751.

Family and domain databases

CDDicd06461. M2_ACE. 2 hits.
InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 2 hits.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
PROSITEiPS00142. ZINC_PROTEASE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACE_CHICK
AccessioniPrimary (citable) accession number: Q10751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.