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Q10751

- ACE_CHICK

UniProt

Q10751 - ACE_CHICK

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Protein
Angiotensin-converting enzyme
Gene
ACE, DCP1
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.

Catalytic activityi

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi288 – 2881Zinc 1; catalytic By similarity
Active sitei289 – 28911 By similarity
Metal bindingi292 – 2921Zinc 1; catalytic By similarity
Metal bindingi886 – 8861Zinc 2; catalytic By similarity
Active sitei887 – 88712 By similarity
Metal bindingi890 – 8901Zinc 2; catalytic By similarity

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB
  4. peptidyl-dipeptidase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM02.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
    Short name:
    ACE
    Alternative name(s):
    Dipeptidyl carboxypeptidase I
    Kininase II
    Gene namesi
    Name:ACE
    Synonyms:DCP1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini‹1 – 1156›1156Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei1157 – 117317Helical; Reviewed prediction
    Add
    BLAST
    Topological domaini1174 – 119320Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 1193›1193Angiotensin-converting enzyme
    PRO_0000078152Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi60 – 601N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi407 – 4071N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi447 – 4471N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi485 – 4851N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi555 – 5551N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi575 – 5751N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi658 – 6581N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi1089 – 10891N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ10751.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000039731.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10751.
    SMRiQ10751. Positions 1-539, 543-1120.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati125 – 481357
    Add
    BLAST
    Repeati723 – 1079357
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M2 family.

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71044.
    HOGENOMiHOG000007838.
    HOVERGENiHBG000264.
    PhylomeDBiQ10751.

    Family and domain databases

    InterProiIPR001548. Peptidase_M2.
    [Graphical view]
    PANTHERiPTHR10514. PTHR10514. 1 hit.
    PfamiPF01401. Peptidase_M2. 2 hits.
    [Graphical view]
    PRINTSiPR00791. PEPDIPTASEA.
    PROSITEiPS00142. ZINC_PROTEASE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q10751-1 [UniParc]FASTAAdd to Basket

    « Hide

    AKELYGNIWS NFSDPQLKKI IGSIQTLGPS NLPLDKRQQY NTILSDMDKI     50
    YSTAKVCLDN GTCWDLEPDI SDIMATSRSY KKLLYAWEGW HNAAGNPLRA 100
    KYQEFVTLSN EAYQMDGFED TGSYWRSWYD STTFEDDLEH LYNQLEPLYL 150
    NLHAFVRRKL YDRYGPKYIN LKGPIPAHLL GNMWAQQWNN IYDLMVPYPD 200
    KPNLDVTNTM VNQGWNATHM FRVSEEFFTS LGLLEMPPEF WEKSMLEKPA 250
    DGREVVCHAS AWDFYNRKDF RIKQCTTVTM EQLFTVHHEM GHVQYYLQYK 300
    DQPVSFRGGA NPGFHEAIGD VLSLSVSTPS HLQKIGLLSS AVEDEESNIN 350
    YLLKMALEKI AFLPFGYLID QWRWNVFSGR TPPSRYNYDW WYLRTKYQGI 400
    CAPVSRNESN FDPGAKYHIP GNTPYIRYFV SFILQFQFHK ALCQAANHTG 450
    PLHTCDIYMS KEAGAKLREV LKAGSSKSWQ EILFNLTGTD KMDAGALLEY 500
    FSPVTTWLQE QNNKTNEVLG WPEFDWRSPI PEGYPEGIDK IVDEAQAKEF 550
    LSEYNSTAEV VWNAYTEASW EYNTNITDHN KEVMLEKNLA MSKHTIEYGM 600
    RARQFDPSDF QDETVTRILN KLSVLERAAL PEDELKEYNT LLSDMETTYS 650
    VAKVCRENNT FHPLDPDLTD ILATSRDYNE LLFAWKGWWD ASGAKIKDKY 700
    KRYVELSNKA AVLNGYTDNG AYWRSLYETP TFEEDLERLY LQLQPLYLNL 750
    HAYVRRALYN KYGAEHISLK GPIPAHLLGN MWAQSWSNIF DLVMPFPDAT 800
    KVDATPAMKQ QGWTPKMMFE ESDRFFTSLG LIPMPQEFWD KSMIEKPADG 850
    REVVCHASAW DFYNRKDFRI KQCTVVNMDD LITVHHEMGH VQYFLQYMDQ 900
    PISFRDGANP GFHEAIGDVM ALSVSTPKHL HSINLLDQVT ENEESDINYL 950
    MSIALDKIAF LPFGYLMDQW RWKVFDGRIK EDEYNQQWWN LRLKYQGLCP 1000
    PVPRSEDDFD PGAKFHIPAN VPYIRYFVSF VIQFQFHQAL CKAAGHTGPL 1050
    HTCDIYQSKE AGKLLGDAMK LGFSKPWPEA MQLITGQPNM SAEALMSYFE 1100
    PLMTWLVKKN TENGEVLGWP EYSWTPYAVT EFHAATDTAD FLGMSVGTKQ 1150
    ATAGAWVLLA LALVFLITSI FLGVKLFSSR RKAFKSSSEM ELK 1193
    Length:1,193
    Mass (Da):137,821
    Last modified:October 1, 1996 - v1
    Checksum:i954472A18EA471C7
    GO

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L40175 mRNA. Translation: AAA75554.1.
    PIRiJC2489.
    UniGeneiGga.3781.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L40175 mRNA. Translation: AAA75554.1 .
    PIRi JC2489.
    UniGenei Gga.3781.

    3D structure databases

    ProteinModelPortali Q10751.
    SMRi Q10751. Positions 1-539, 543-1120.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000039731.

    Protein family/group databases

    MEROPSi M02.001.

    Proteomic databases

    PaxDbi Q10751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG71044.
    HOGENOMi HOG000007838.
    HOVERGENi HBG000264.
    PhylomeDBi Q10751.

    Family and domain databases

    InterProi IPR001548. Peptidase_M2.
    [Graphical view ]
    PANTHERi PTHR10514. PTHR10514. 1 hit.
    Pfami PF01401. Peptidase_M2. 2 hits.
    [Graphical view ]
    PRINTSi PR00791. PEPDIPTASEA.
    PROSITEi PS00142. ZINC_PROTEASE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals."
      Esther C.R., Thomas K.E., Bernstein K.E.
      Biochem. Biophys. Res. Commun. 205:1916-1921(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiACE_CHICK
    AccessioniPrimary (citable) accession number: Q10751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: May 14, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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