Angiotensin-converting enzyme - Gallus gallus (Chicken)

Contribute

Read comments (?) or add your own

Q10751 (ACE_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Angiotensin-converting enzyme
Short name=ACE
EC=3.2.1.-
EC=3.4.15.1

Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II

Gene names

Name:	ACE
Synonyms:	DCP1

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	1193 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.
Catalytic activity	Release of a C-terminal dipeptide, oligopeptide-\|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the peptidase M2 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Metal-binding Zinc
Molecular function	Carboxypeptidase Hydrolase Metalloprotease Protease
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	carboxypeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Non-traceable author statement Ref.1. Source: UniProtKB peptidyl-dipeptidase activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

›1193

Angiotensin-converting enzyme

PRO_0000078152

Regions

Topological domain

›1156

Extracellular Potential

Transmembrane

17

Helical; Potential

Topological domain

20

Cytoplasmic Potential

Repeat

357

Repeat

357

Sites

Active site

1

1 By similarity

Active site

1

2 By similarity

Metal binding

1

Zinc 1; catalytic By similarity

Metal binding

1

Zinc 1; catalytic By similarity

Metal binding

1

Zinc 2; catalytic By similarity

Metal binding

1

Zinc 2; catalytic By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue

1

Sequences

Sequence

Length

Mass (Da)

Tools

Q10751 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 954472A18EA471C7
Show »

1,193

137,821

        10         20         30         40         50         60 
AKELYGNIWS NFSDPQLKKI IGSIQTLGPS NLPLDKRQQY NTILSDMDKI YSTAKVCLDN 

        70         80         90        100        110        120 
GTCWDLEPDI SDIMATSRSY KKLLYAWEGW HNAAGNPLRA KYQEFVTLSN EAYQMDGFED 

       130        140        150        160        170        180 
TGSYWRSWYD STTFEDDLEH LYNQLEPLYL NLHAFVRRKL YDRYGPKYIN LKGPIPAHLL 

       190        200        210        220        230        240 
GNMWAQQWNN IYDLMVPYPD KPNLDVTNTM VNQGWNATHM FRVSEEFFTS LGLLEMPPEF 

       250        260        270        280        290        300 
WEKSMLEKPA DGREVVCHAS AWDFYNRKDF RIKQCTTVTM EQLFTVHHEM GHVQYYLQYK 

       310        320        330        340        350        360 
DQPVSFRGGA NPGFHEAIGD VLSLSVSTPS HLQKIGLLSS AVEDEESNIN YLLKMALEKI 

       370        380        390        400        410        420 
AFLPFGYLID QWRWNVFSGR TPPSRYNYDW WYLRTKYQGI CAPVSRNESN FDPGAKYHIP 

       430        440        450        460        470        480 
GNTPYIRYFV SFILQFQFHK ALCQAANHTG PLHTCDIYMS KEAGAKLREV LKAGSSKSWQ 

       490        500        510        520        530        540 
EILFNLTGTD KMDAGALLEY FSPVTTWLQE QNNKTNEVLG WPEFDWRSPI PEGYPEGIDK 

       550        560        570        580        590        600 
IVDEAQAKEF LSEYNSTAEV VWNAYTEASW EYNTNITDHN KEVMLEKNLA MSKHTIEYGM 

       610        620        630        640        650        660 
RARQFDPSDF QDETVTRILN KLSVLERAAL PEDELKEYNT LLSDMETTYS VAKVCRENNT 

       670        680        690        700        710        720 
FHPLDPDLTD ILATSRDYNE LLFAWKGWWD ASGAKIKDKY KRYVELSNKA AVLNGYTDNG 

       730        740        750        760        770        780 
AYWRSLYETP TFEEDLERLY LQLQPLYLNL HAYVRRALYN KYGAEHISLK GPIPAHLLGN 

       790        800        810        820        830        840 
MWAQSWSNIF DLVMPFPDAT KVDATPAMKQ QGWTPKMMFE ESDRFFTSLG LIPMPQEFWD 

       850        860        870        880        890        900 
KSMIEKPADG REVVCHASAW DFYNRKDFRI KQCTVVNMDD LITVHHEMGH VQYFLQYMDQ 

       910        920        930        940        950        960 
PISFRDGANP GFHEAIGDVM ALSVSTPKHL HSINLLDQVT ENEESDINYL MSIALDKIAF 

       970        980        990       1000       1010       1020 
LPFGYLMDQW RWKVFDGRIK EDEYNQQWWN LRLKYQGLCP PVPRSEDDFD PGAKFHIPAN 

      1030       1040       1050       1060       1070       1080 
VPYIRYFVSF VIQFQFHQAL CKAAGHTGPL HTCDIYQSKE AGKLLGDAMK LGFSKPWPEA 

      1090       1100       1110       1120       1130       1140 
MQLITGQPNM SAEALMSYFE PLMTWLVKKN TENGEVLGWP EYSWTPYAVT EFHAATDTAD 

      1150       1160       1170       1180       1190 
FLGMSVGTKQ ATAGAWVLLA LALVFLITSI FLGVKLFSSR RKAFKSSSEM ELK

References

[1]	"Chicken lacks the testis specific isozyme of angiotensin converting enzyme found in mammals." Esther C.R., Thomas K.E., Bernstein K.E. Biochem. Biophys. Res. Commun. 205:1916-1921(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L40175 mRNA. Translation: AAA75554.1.
IPI	IPI00601768.
PIR	JC2489.
UniGene	Gga.3781.
3D structure databases
ProteinModelPortal	Q10751.
SMR	Q10751. Positions 1-539, 543-1120.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000039731.
Protein family/group databases
MEROPS	M02.001.
Proteomic databases
PaxDb	Q10751.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG71044.
HOGENOM	HOG000007838.
HOVERGEN	HBG000264.
Family and domain databases
InterPro	IPR001548. Peptidase_M2. [Graphical view]
PANTHER	PTHR10514. PTHR10514. 1 hit.
Pfam	PF01401. Peptidase_M2. 2 hits. [Graphical view]
PRINTS	PR00791. PEPDIPTASEA.
PROSITE	PS00142. ZINC_PROTEASE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACE_CHICK

Accession

Primary (citable) accession number: Q10751

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

to top of page

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents