Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C motif chemokine 3

Gene

Cxcl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion.By similarity2 Publications

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR chemokine receptor binding Source: GO_Central

GO - Biological processi

  • cellular response to lipopolysaccharide Source: RGD
  • chemokine-mediated signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: RGD
  • neutrophil chemotaxis Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of neutrophil chemotaxis Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to lipopolysaccharide Source: RGD

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-RNO-380108 Chemokine receptors bind chemokines
R-RNO-418594 G alpha (i) signalling events
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 3
Alternative name(s):
Cytokine-induced neutrophil chemoattractant 2
Short name:
CINC-2
Macrophage inflammatory protein 2-alpha/beta
Short name:
MIP2-alpha/beta
Gene namesi
Name:Cxcl3
Synonyms:Cinc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi621812 Cxcl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 322 PublicationsAdd BLAST32
ChainiPRO_000014429733 – 101C-X-C motif chemokine 3Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 63By similarity
Disulfide bondi39 ↔ 79By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ10746
PRIDEiQ10746

PTM databases

PhosphoSitePlusiQ10746

Expressioni

Inductioni

By lipopolysaccharide. Expression increases until 4 hours after treatment and then gradually decreases, remaining high 24 hours after stimulation.1 Publication

Gene expression databases

BgeeiENSRNOG00000028043
GenevisibleiQ10746 RN

Interactioni

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR chemokine receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038520

Structurei

3D structure databases

ProteinModelPortaliQ10746
SMRiQ10746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiQ10746
KOiK05505
OMAiEVCLNPQ
PhylomeDBiQ10746
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q10746-1) [UniParc]FASTAAdd to basket
Also known as: CINC-2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPTRRLLN AALLLLLLLM ATSHQPSGTV VARELRCQCL KTLPRVDFEN
60 70 80 90 100
IQSLTVTPPG PHCTQTEVIA TLKDGQEVCL NPQAPRLQKI IQKLLKSDKS

S
Length:101
Mass (Da):11,109
Last modified:November 25, 2008 - v2
Checksum:iD949D5712FE30909
GO
Isoform 2 (identifier: Q10746-2) [UniParc]FASTAAdd to basket
Also known as: CINC-2B

The sequence of this isoform differs from the canonical sequence as follows:
     98-101: DKSS → PSL

Show »
Length:100
Mass (Da):10,989
Checksum:iEB53ECEFE30909D2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03573598 – 101DKSS → PSL in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21095 mRNA Translation: BAA04657.1
D87926 Genomic DNA Translation: BAB12336.1
D87926 Genomic DNA Translation: BAB12279.1
D87927 mRNA Translation: BAB12280.1
PIRiS46198
RefSeqiNP_612531.1, NM_138522.1 [Q10746-2]
XP_006250783.1, XM_006250721.3 [Q10746-1]
UniGeneiRn.10525

Genome annotation databases

EnsembliENSRNOT00000034090; ENSRNOP00000038520; ENSRNOG00000028043 [Q10746-2]
ENSRNOT00000078746; ENSRNOP00000070985; ENSRNOG00000028043 [Q10746-1]
GeneIDi171551
KEGGirno:171551
UCSCiRGD:621812 rat [Q10746-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCXCL3_RAT
AccessioniPrimary (citable) accession number: Q10746
Secondary accession number(s): Q10747, Q5CZ55, Q9EP62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health