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Q10738

- MMP7_MOUSE

UniProt

Q10738 - MMP7_MOUSE

Protein

Matrilysin

Gene

Mmp7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase By similarity.By similarity
    May play a role in tissue reorganization.

    Catalytic activityi

    Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).

    Cofactori

    Binds 2 calcium ions per subunit.By similarity
    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Zinc 2; in inhibited formBy similarity
    Metal bindingi153 – 1531Calcium 1By similarity
    Metal bindingi163 – 1631Zinc 1By similarity
    Metal bindingi165 – 1651Zinc 1By similarity
    Metal bindingi170 – 1701Calcium 2By similarity
    Metal bindingi171 – 1711Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi173 – 1731Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi175 – 1751Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi178 – 1781Zinc 1By similarity
    Metal bindingi185 – 1851Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi187 – 1871Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi189 – 1891Calcium 1By similarity
    Metal bindingi191 – 1911Zinc 1By similarity
    Metal bindingi193 – 1931Calcium 2By similarity
    Metal bindingi196 – 1961Calcium 2By similarity
    Metal bindingi214 – 2141Zinc 2; catalyticBy similarity
    Active sitei215 – 2151PROSITE-ProRule annotation
    Metal bindingi218 – 2181Zinc 2; catalyticBy similarity
    Metal bindingi224 – 2241Zinc 2; catalyticBy similarity

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. antibacterial peptide secretion Source: MGI
    2. collagen catabolic process Source: UniProtKB-KW
    3. defense response to bacterium Source: MGI
    4. defense response to Gram-negative bacterium Source: MGI
    5. defense response to Gram-positive bacterium Source: MGI
    6. regulation of cell proliferation Source: MGI
    7. response to drug Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Biological processi

    Collagen degradation

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi3.4.24.23. 3474.
    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.
    REACT_199052. Degradation of the extracellular matrix.
    REACT_199055. Collagen degradation.

    Protein family/group databases

    MEROPSiM10.008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrilysin (EC:3.4.24.23)
    Alternative name(s):
    Matrin
    Matrix metalloproteinase-7
    Short name:
    MMP-7
    Pump-1 protease
    Uterine metalloproteinase
    Gene namesi
    Name:Mmp7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:103189. Mmp7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 9477Activation peptideBy similarityPRO_0000028740Add
    BLAST
    Chaini95 – 264170MatrilysinPRO_0000028741Add
    BLAST

    Keywords - PTMi

    Zymogen

    Proteomic databases

    PRIDEiQ10738.

    PTM databases

    PhosphoSiteiQ10738.

    Expressioni

    Gene expression databases

    ArrayExpressiQ10738.
    BgeeiQ10738.
    CleanExiMM_MMP7.
    GenevestigatoriQ10738.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10738.
    SMRiQ10738. Positions 36-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi85 – 928Cysteine switchBy similarity

    Domaini

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

    Sequence similaritiesi

    Belongs to the peptidase M10A family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG312228.
    HOVERGENiHBG052484.
    InParanoidiQ10738.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR028707. Matrilysin.
    IPR024079. MetalloPept_cat_dom.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR021158. Pept_M10A_Zn_BS.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view]
    PANTHERiPTHR10201:SF128. PTHR10201:SF128. 1 hit.
    PfamiPF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view]
    PRINTSiPR00138. MATRIXIN.
    SMARTiSM00235. ZnMc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47090. SSF47090. 1 hit.
    PROSITEiPS00546. CYSTEINE_SWITCH. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10738-1 [UniParc]FASTAAdd to Basket

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    MQLTLFCFVC LLPGHLALPL SQEAGDVSAH QWEQAQNYLR KFYPHDSKTK    50
    KVNSLVDNLK EMQKFFGLPM TGKLSPYIME IMQKPRCGVP DVAEYSLMPN 100
    SPKWHSRIVT YRIVSYTSDL PRIVVDQIVK KALRMWSMQI PLNFKRVSWG 150
    TADIIIGFAR RDHGDSFPFD GPGNTLGHAF APGPGLGGDA HFDKDEYWTD 200
    GEDAGVNFLF AATHEFGHSL GLSHSSVPGT VMYPTYQRDY SEDFSLTKDD 250
    IAGIQKLYGK RNTL 264
    Length:264
    Mass (Da):29,755
    Last modified:October 1, 1996 - v1
    Checksum:iEDA31A5EBAC63342
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti201 – 2011G → D in AAA99983. (PubMed:7579699)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36238
    , L36243, L36242, L36241, L36240, L36239 Genomic DNA. Translation: AAA99984.1.
    L36244 mRNA. Translation: AAA99983.1.
    UniGeneiMm.4825.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36238
    , L36243 , L36242 , L36241 , L36240 , L36239 Genomic DNA. Translation: AAA99984.1 .
    L36244 mRNA. Translation: AAA99983.1 .
    UniGenei Mm.4825.

    3D structure databases

    ProteinModelPortali Q10738.
    SMRi Q10738. Positions 36-260.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M10.008.

    PTM databases

    PhosphoSitei Q10738.

    Proteomic databases

    PRIDEi Q10738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:103189. Mmp7.

    Phylogenomic databases

    eggNOGi NOG312228.
    HOVERGENi HBG052484.
    InParanoidi Q10738.

    Enzyme and pathway databases

    BRENDAi 3.4.24.23. 3474.
    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.
    REACT_199052. Degradation of the extracellular matrix.
    REACT_199055. Collagen degradation.

    Miscellaneous databases

    PROi Q10738.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q10738.
    Bgeei Q10738.
    CleanExi MM_MMP7.
    Genevestigatori Q10738.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR028707. Matrilysin.
    IPR024079. MetalloPept_cat_dom.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR021158. Pept_M10A_Zn_BS.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view ]
    PANTHERi PTHR10201:SF128. PTHR10201:SF128. 1 hit.
    Pfami PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00138. MATRIXIN.
    SMARTi SM00235. ZnMc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47090. SSF47090. 1 hit.
    PROSITEi PS00546. CYSTEINE_SWITCH. 1 hit.
    PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse."
      Wilson C.L., Heppner K.J., Rudolph L.A., Matrisian L.M.
      Mol. Biol. Cell 6:851-869(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: ICR.
      Tissue: Uterus.

    Entry informationi

    Entry nameiMMP7_MOUSE
    AccessioniPrimary (citable) accession number: Q10738
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3