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Q10737

- AMPN_HAECO

UniProt

Q10737 - AMPN_HAECO

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Protein
Aminopeptidase N
Gene
N/A
Organism
Haemonchus contortus (Barber pole worm)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081Substrate By similarity
Metal bindingi379 – 3791Zinc; catalytic By similarity
Active sitei380 – 3801Proton acceptor By similarity
Metal bindingi383 – 3831Zinc; catalytic By similarity
Metal bindingi402 – 4021Zinc; catalytic By similarity
Sitei466 – 4661Transition state stabilizer By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metallopeptidase activity Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM01.015.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminopeptidase N (EC:3.4.11.2)
Short name:
AP-N
Alternative name(s):
Membrane glycoprotein H11
Microsomal aminopeptidase
OrganismiHaemonchus contortus (Barber pole worm)
Taxonomic identifieri6289 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaHaemonchidaeHaemonchinaeHaemonchus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1716Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei18 – 3922Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini40 – 972933Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 972971Aminopeptidase N
PRO_0000095087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi549 – 5491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi759 ↔ 766 By similarity
Disulfide bondi804 ↔ 840 By similarity
Glycosylationi858 – 8581N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ10737.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni343 – 3475Substrate binding By similarity

Sequence similaritiesi

Belongs to the peptidase M1 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10737-1 [UniParc]FASTAAdd to Basket

« Hide

MTSQGRTRTL LNLTPIRLIV ALFLVAAAVG LSIGLTYYFT RKAFDTSEKP    50
GKDDTGGKDK DNSPSAAELL LPSNIKPLSY DLTIKTYLPG YVDFPPEKNL 100
TFDGRVEISM VVIEPTKSIV LNSKKISVIP QECELVSGDK KLEIESVKEH 150
PRLEKVEFLI KSQLEKDQQI LLKVGYIGLI SNSFGGIYQT TYTTPDGTPK 200
IAAVSQNEPI DARRMVPCMD EPKYKANWTV TVIHPKGTKA VSNGIEVNGD 250
GEISGDWITS KFLTTPRMSS YLLAVMVSEF EYIEGETKTG VRFRIWSRPE 300
AKKMTQYALQ SGIKCIEFYE DFFDIRFPLK KQDMIALPDF SAGAMENWGL 350
ITYRENSLLY DDRFYAPMNK QRIARIVAHE LAHQWFGDLV TMKWWDNLWL 400
NEGFARFTEF IGAGQITQDD ARMRNYFLID VLERALKADS VASSHPLSFR 450
IDKAAEVEEA FDDITYAKGA SVLTMLRALI GEEKHKHAVS QYLKKFSYSN 500
AEATDLWAVF DEVVTDVEGP DGKPMKTTEF ASQWTTQMGF PVISVAEFNS 550
TTLKLTQSRY EANKDAVEKE KYRHPKYGFK WDIPLWYQEG DKKEIKRTWL 600
RRDEPLYLHV SDAGAPFVVN ADRYGFYRQN HDANGWKKII KQLKDNHEVY 650
SPRTRNAIIS DAFAAAATDA IEYETVFELL NYAEKETEYL PLEIAMSGIS 700
SILKYFGTEP EAKPAQTYMM NILKPMYEKS SIDFIANNYR NDKLFFQINL 750
QKDVIDMFCA LGSQDCRKKY KKLFDDEVMN KCRDGQAATE CVRIAAPLRS 800
SVYCYGVKEG GDYASDKVME LYTAETLALE KDFLRLALGC HKDVTALKGL 850
LLRALDRNSS FVRMQDIPSA FNDVAANPIG GEFIFNFLIE RWPDIIESIG 900
TKHTYVEKVI PACTSGIRSQ QQIDQLKNLQ KNGMNARQFG AFDKAIERAQ 950
NRVDWIKKHF QKLAAFFKKA TL 972
Length:972
Mass (Da):110,674
Last modified:January 23, 2007 - v2
Checksum:i5964328CC3C80E43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94187 mRNA. Translation: CAA63897.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94187 mRNA. Translation: CAA63897.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M01.015.

Proteomic databases

PRIDEi Q10737.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view ]
PANTHERi PTHR11533. PTHR11533. 1 hit.
Pfami PF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view ]
PRINTSi PR00756. ALADIPTASE.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a microsomal aminopeptidase from the intestine of the nematode Haemonchus contortus."
    Smith T.S., Graham M., Munn E.A., Newton S.E., Knox D.P., Coadwell W.J., McMichael-Phillips D., Smith H., Smith W.D., Oliver J.J.
    Biochim. Biophys. Acta 1338:295-306(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAMPN_HAECO
AccessioniPrimary (citable) accession number: Q10737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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