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Protein

Cell fusion protein fus1

Gene

fus1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for cell fusion. It associates with the pre-zygotic projection tips in conjugating cells.

GO - Biological processi

  • actin cytoskeleton organization Source: PomBase
  • actin fusion focus assembly Source: PomBase
  • plasma membrane fusion involved in cytogamy Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-SPO-5663220. RHO GTPases Activate Formins.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell fusion protein fus1
Gene namesi
Name:fus1
ORF Names:SPAC20G4.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G4.02c.
PomBaseiSPAC20G4.02c. fus1.

Subcellular locationi

GO - Cellular componenti

  • actin fusion focus Source: PomBase
  • cell division site Source: PomBase
  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mating projection Source: PomBase
  • mating projection tip Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001949021 – 1372Cell fusion protein fus1Add BLAST1372

Proteomic databases

PRIDEiQ10719.

Expressioni

Inductioni

By nitrogen starvation and by a pheromone signal in both P and M cell types. Essentially unexpressed in vegetative cells.

Interactioni

Subunit structurei

Interacts with actin at the FH2 domain.By similarity

Protein-protein interaction databases

BioGridi278235. 26 interactors.
MINTiMINT-4699818.

Structurei

3D structure databases

ProteinModelPortaliQ10719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 522GBD/FH3PROSITE-ProRule annotationAdd BLAST419
Domaini868 – 1278FH2PROSITE-ProRule annotationAdd BLAST411

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi802 – 817SH3-bindingAdd BLAST16

Sequence similaritiesi

Belongs to the formin homology family. BNI1 subfamily.Curated
Contains 1 FH2 (formin homology 2) domain.PROSITE-ProRule annotation
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

InParanoidiQ10719.
KOiK17971.
OMAiINERRHI.
OrthoDBiEOG092C03J2.
PhylomeDBiQ10719.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR015425. FH2_Formin.
IPR014768. GBD/FH3_dom.
IPR010473. GTPase-bd.
[Graphical view]
PfamiPF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM01140. Drf_GBD. 1 hit.
SM00498. FH2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTASFKGIR ISKPIVKEIS SFGSLTNIDL HTDPYEKVEA KALSRSRLKN
60 70 80 90 100
QSVKKTDLRI TNDYSSLFVS IENKKNTIPD IHCNNLSKRP VGFTDSYVPG
110 120 130 140 150
EALLCPDDPN LVNELFDDVL KRLREEKSDS GEQFHWDANV TLSQENKWSF
160 170 180 190 200
ITGYLSRNDK FLKISSNDSE LNVKASVISY IEKLSCTPLK LKYVESLAVA
210 220 230 240 250
LRTESVTWVR YFLLMGGHIV LAKILQAIHE KKHLKSPDIT LEIAILKSMR
260 270 280 290 300
CIIGQKIGTD FYLSNKYPID SVVHCLLSTK LLVRKLAAEL LTFLCYSEKP
310 320 330 340 350
NGINAIMKCM KNFANLKVES MNVFDLWLSQ WKRTLLEKVV TEEKKVLEEA
360 370 380 390 400
ALHDKITIEY IISQMLLINA FLENIPSKTA LLQFKESLRI GNFKSILLIL
410 420 430 440 450
KKINDEGVLK QLEKCVKLVS LDTANEKHFL KHTPNSAAHQ SLLNTNMFND
460 470 480 490 500
ANFEFMVKEH IKNFLKLLKE HNNPVRIIKL LDCLVLTLQA DKGNGNSNND
510 520 530 540 550
IDCFYKELKI GNEQGNNAPG YSSVTSGYGT TNSKKVVASY DNTDDNEYSV
560 570 580 590 600
SKSELYATGD TNNTTNQGYE NSERKYVESS KYETDLKNIF DCLCLLFPSE
610 620 630 640 650
FDPQSSFSAE KIFSKLKHLL TRTRDSYISE DTKILRLLNR SSSKLQDRDQ
660 670 680 690 700
EYLISKNNVN GNGNRDWVQP VNTTSSVSAF ASPRIKPKLL FQPNQDEKLK
710 720 730 740 750
LCKLDLAKAN SITLKSEPSS AVSTHSFEVH LSMPGTQIKS ANLAEKMETS
760 770 780 790 800
KHKVFNPKRI DVVSDLPLDY RKSYYGRFSI TDTKRFSKIE NMRIKEVIDG
810 820 830 840 850
NPFKAPPPAP LPPPAPPLPT AMSSLQKFEK NDSQIFRKTI IIPENISIDD
860 870 880 890 900
IFKFCSGSES EVYASKIPGE LCNPSKRLKQ LHWKRLEVPF EKTLWNIVVA
910 920 930 940 950
DPYLLTLKLT AEGIFKQLED CYPLREVTVS NKKVKEYTGF MPVDLQQMVS
960 970 980 990 1000
IRLHRFNSLT PIEIAKKFFH CDHDIMELVD FFNDRKFFRQ EGLKKQLKPY
1010 1020 1030 1040 1050
MSSRNEEVME VSEKLLELSR FDQIYTLIVV DIDTYYEKRM AALKIKSFLA
1060 1070 1080 1090 1100
NNFRDFRRQI RKLHCASLEL KSSLHFKYFL NLVLHIGNFM NDAPRRAKGY
1110 1120 1130 1140 1150
RLESLLRASM IKNDKTGLTL LHTIEKIVRT HFPQLEAFLV DLKAIPEISR
1160 1170 1180 1190 1200
FNLEQLEQDC NDICERMKNV EKDFSNEGIF SNHKALHPDD HICEVMVPWI
1210 1220 1230 1240 1250
PSGKSMVDEL NSDITELKTT LKTTLLMYGE NPDEPTSSAR FFNNLNEIIL
1260 1270 1280 1290 1300
EYKKASTVNQ KMEKEEELAF LRLQALKASV KSNNAENSGS SKNEEVSATM
1310 1320 1330 1340 1350
ENLISQLQKG LCDDSLSNKT DCTESSKQTI ETLMNYENDK QTLEGSNKKR
1360 1370
QTVVLKAECM LKQLENNNEL KR
Length:1,372
Mass (Da):157,074
Last modified:October 1, 1996 - v1
Checksum:i52349B4E1B9D6B98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37838 Genomic DNA. Translation: AAA99003.1.
CU329670 Genomic DNA. Translation: CAB11252.1.
PIRiT43296.
RefSeqiNP_594737.1. NM_001020165.2.

Genome annotation databases

EnsemblFungiiSPAC20G4.02c.1; SPAC20G4.02c.1:pep; SPAC20G4.02c.
GeneIDi2541741.
KEGGispo:SPAC20G4.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37838 Genomic DNA. Translation: AAA99003.1.
CU329670 Genomic DNA. Translation: CAB11252.1.
PIRiT43296.
RefSeqiNP_594737.1. NM_001020165.2.

3D structure databases

ProteinModelPortaliQ10719.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278235. 26 interactors.
MINTiMINT-4699818.

Proteomic databases

PRIDEiQ10719.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC20G4.02c.1; SPAC20G4.02c.1:pep; SPAC20G4.02c.
GeneIDi2541741.
KEGGispo:SPAC20G4.02c.

Organism-specific databases

EuPathDBiFungiDB:SPAC20G4.02c.
PomBaseiSPAC20G4.02c. fus1.

Phylogenomic databases

InParanoidiQ10719.
KOiK17971.
OMAiINERRHI.
OrthoDBiEOG092C03J2.
PhylomeDBiQ10719.

Enzyme and pathway databases

ReactomeiR-SPO-5663220. RHO GTPases Activate Formins.

Miscellaneous databases

PROiQ10719.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR015425. FH2_Formin.
IPR014768. GBD/FH3_dom.
IPR010473. GTPase-bd.
[Graphical view]
PfamiPF06371. Drf_GBD. 1 hit.
PF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM01140. Drf_GBD. 1 hit.
SM00498. FH2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51444. FH2. 1 hit.
PS51232. GBD_FH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUS1_SCHPO
AccessioniPrimary (citable) accession number: Q10719
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.