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Protein

Cysteine proteinase 1

Gene

CCP1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the degradation of the storage protein zein. May play a role in proteolysis during emergencies.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611By similarity
Active sitei303 – 3031By similarity
Active sitei330 – 3301By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteinase 1 (EC:3.4.22.-)
Gene namesi
Name:CCP1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi25431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 136118Activation peptideSequence analysisPRO_0000026428Add
BLAST
Chaini137 – 371235Cysteine proteinase 1PRO_0000026429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi158 ↔ 208By similarity
Disulfide bondi196 ↔ 241By similarity
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi297 ↔ 345By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ10716.
PRIDEiQ10716.

Expressioni

Tissue specificityi

Expressed during the late stages of seed ripening, in mature seeds and during germination.

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G098298_P01.

Structurei

3D structure databases

ProteinModelPortaliQ10716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230774.
KOiK01373.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRVLLLLS LASAAAVAAA VDAEDPLIRQ VVPGGDDNDL ELNAESHFLS
60 70 80 90 100
FVQRFGKSYK DADEHAYRLS VFKDNLRRAR RHQLLDPSAE HGVTKFSDLT
110 120 130 140 150
PAEFRRTYLG LRKSRRALLR ELGESAHEAP VLPTDGLPDD FDWRDHGAVG
160 170 180 190 200
PVKNQGSCGS CWSFSASGAL EGAHYLATGK LEVLSEQQFV DCDHECDSSE
210 220 230 240 250
PDSCDSGCNG GLMTTAFSYL QKAGGLESEK DYPYTGSDGK CKFDKSKIVA
260 270 280 290 300
SVQNFSVVSV DEAQISANLI KHGPLAIGIN AAYMQTYIGG VSCPYICGRH
310 320 330 340 350
LDHGVLLVGY GASGFAPIRL KDKPYWIIKN SWGENWGENG YYKICRGSNV
360 370
RNKCGVDSMV STVSAVHASK E
Length:371
Mass (Da):40,347
Last modified:October 1, 1996 - v1
Checksum:i59042B03266E6058
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti269 – 2691L → R in CAA57675 (PubMed:7632917).Curated
Sequence conflicti318 – 3181I → M in CAA57675 (PubMed:7632917).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45402 mRNA. Translation: BAA08244.1.
X82185 mRNA. Translation: CAA57675.1.
PIRiS59597.
S60456.
RefSeqiNP_001105685.1. NM_001112215.1.
UniGeneiZm.5565.

Genome annotation databases

GeneIDi542701.
KEGGizma:542701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45402 mRNA. Translation: BAA08244.1.
X82185 mRNA. Translation: CAA57675.1.
PIRiS59597.
S60456.
RefSeqiNP_001105685.1. NM_001112215.1.
UniGeneiZm.5565.

3D structure databases

ProteinModelPortaliQ10716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G098298_P01.

Protein family/group databases

MEROPSiC01.022.

Proteomic databases

PaxDbiQ10716.
PRIDEiQ10716.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi542701.
KEGGizma:542701.

Organism-specific databases

MaizeGDBi25431.

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230774.
KOiK01373.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYSP1_MAIZE
AccessioniPrimary (citable) accession number: Q10716
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 17, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.