Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q10715

- ACE_HAEIX

UniProt

Q10715 - ACE_HAEIX

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Haematobia irritans exigua (Buffalo fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the specific maturation or degradation of a number of bioactive peptides.

Catalytic activityi

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi367 – 3671Zinc; catalyticPROSITE-ProRule annotation
Active sitei368 – 3681PROSITE-ProRule annotation
Metal bindingi371 – 3711Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallopeptidase activity Source: UniProtKB-KW
  4. peptidyl-dipeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM02.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzyme (EC:3.4.15.1)
Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II
Gene namesi
Name:ACE
OrganismiHaematobia irritans exigua (Buffalo fly)
Taxonomic identifieri34678 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeHaematobia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 611594Angiotensin-converting enzymePRO_0000028565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in the compound ganglion and in the posterior region of the midgut.

Structurei

3D structure databases

ProteinModelPortaliQ10715.
SMRiQ10715. Positions 23-603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 1 hit.
[Graphical view]
PRINTSiPR00791. PEPDIPTASEA.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10715-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLVVTILA GLAVCHGATK EEIVATEYLQ NINKELAKHT NVETEVSWAY
60 70 80 90 100
ASNITDENER LRNEISAENA KFLKEVAKDI QKFNWRTYGS ADVRRQFKSL
110 120 130 140 150
SKTGYSALPA EDYAELLEVL SAMESNFAKV RVCDYKNSAK CDLSLDPEIE
160 170 180 190 200
EIITKSRDPE ELKYYWTQFY DKAGTPTRSN FEKYVELNTK SAKLNNFTDG
210 220 230 240 250
AEVWLDEYED ATFEDQLEAI FEDIKPLYDQ VHGYVRYRLN KFYGDEVVSK
260 270 280 290 300
TGPLPMHLLG NMWAQQWSSI ADIVSPFPEK PLVDVSDEMV AQGYTPLKMF
310 320 330 340 350
QMGDDFFQSM GLKKLPQEFW DKSILEKPDD GRDLVCHASA WDFYLTDDVR
360 370 380 390 400
IKQCTRVTQD QFFTVHHEMG HIQYFLQYQH QPFVYRTGAN PGFHEAVGDV
410 420 430 440 450
LSLSVSTPKH LERVGLLKNY VSDNEARINQ LFLTALDKIV FLPFAFTMDK
460 470 480 490 500
YRWALFRGQA DKSEWNCAFW KLREEYSGIE PPVVRTEKDF DAPAKYHVSA
510 520 530 540 550
DVEYLRYLVS FIIQFQFYKS ACITAGEYVP NQTEYPLDNC DIYGSKEAGK
560 570 580 590 600
LFENMLSLGA SKPWPDALEA FNGERTMTGK AIAEYFEPLR VWLEAVAVES
610
LCHQRYKNVD L
Length:611
Mass (Da):70,506
Last modified:November 1, 1997 - v1
Checksum:iA43D6DF5A83ECB53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43965 Genomic DNA. Translation: AAA70427.1.
PIRiS65472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43965 Genomic DNA. Translation: AAA70427.1 .
PIRi S65472.

3D structure databases

ProteinModelPortali Q10715.
SMRi Q10715. Positions 23-603.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M02.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01401. Peptidase_M2. 1 hit.
[Graphical view ]
PRINTSi PR00791. PEPDIPTASEA.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterisation of angiotensin-converting enzyme from the dipteran species, Haematobia irritans exigua, and its expression in the maturing male reproductive system."
    Wijffels G.L., Fitzgerald C., Gough J., Riding G.A., Elvin C., Kemp D.J., Willadsen P.
    Eur. J. Biochem. 237:414-423(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiACE_HAEIX
AccessioniPrimary (citable) accession number: Q10715
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3