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Protein

Triosephosphate isomerase

Gene

tpi-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpi-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Binding sitei12SubstrateBy similarity1
Active sitei94ElectrophileBy similarity1
Active sitei164Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: WormBase
  • determination of adult lifespan Source: WormBase
  • gluconeogenesis Source: GO_Central
  • glyceraldehyde-3-phosphate biosynthetic process Source: GO_Central
  • glycerol catabolic process Source: GO_Central
  • glycolytic process Source: GO_Central

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BRENDAi5.3.1.1 1045
ReactomeiR-CEL-70171 Glycolysis
R-CEL-70263 Gluconeogenesis
UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Gene namesi
Name:tpi-1
ORF Names:Y17G7B.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiY17G7B.7 ; CE19040 ; WBGene00006601 ; tpi-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000901271 – 247Triosephosphate isomeraseAdd BLAST247

Proteomic databases

EPDiQ10657
PaxDbiQ10657
PeptideAtlasiQ10657
PRIDEiQ10657

2D gel databases

World-2DPAGE0020:Q10657

Expressioni

Gene expression databases

BgeeiWBGene00006601

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi6239.Y17G7B.7.2

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 10Combined sources6
Helixi17 – 29Combined sources13
Beta strandi36 – 41Combined sources6
Helixi44 – 46Combined sources3
Helixi47 – 53Combined sources7
Beta strandi58 – 63Combined sources6
Beta strandi67 – 72Combined sources6
Helixi79 – 84Combined sources6
Beta strandi89 – 93Combined sources5
Helixi95 – 99Combined sources5
Helixi105 – 117Combined sources13
Beta strandi121 – 126Combined sources6
Helixi130 – 134Combined sources5
Helixi138 – 150Combined sources13
Turni151 – 153Combined sources3
Beta strandi159 – 163Combined sources5
Helixi166 – 168Combined sources3
Turni169 – 171Combined sources3
Helixi177 – 194Combined sources18
Helixi197 – 202Combined sources6
Beta strandi205 – 210Combined sources6
Turni213 – 215Combined sources3
Helixi216 – 219Combined sources4
Beta strandi227 – 231Combined sources5
Helixi232 – 235Combined sources4
Helixi238 – 246Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MO0X-ray1.70A/B2-247[»]
ProteinModelPortaliQ10657
SMRiQ10657
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ10657

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA
GeneTreeiENSGT00390000013354
HOGENOMiHOG000226413
InParanoidiQ10657
KOiK01803
OMAiLCVGEGL
OrthoDBiEOG091G0LEZ
PhylomeDBiQ10657

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q10657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKFFVGGN WKMNGDYASV DGIVTFLNAS ADNSSVDVVV APPAPYLAYA
60 70 80 90 100
KSKLKAGVLV AAQNCYKVPK GAFTGEISPA MIKDLGLEWV ILGHSERRHV
110 120 130 140 150
FGESDALIAE KTVHALEAGI KVVFCIGEKL EEREAGHTKD VNFRQLQAIV
160 170 180 190 200
DKGVSWENIV IAYEPVWAIG TGKTASGEQA QEVHEWIRAF LKEKVSPAVA
210 220 230 240
DATRIIYGGS VTADNAAELG KKPDIDGFLV GGASLKPDFV KIINARS
Length:247
Mass (Da):26,574
Last modified:June 20, 2002 - v2
Checksum:iB4ADF85D0D1A37EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218 – 219EL → DV in AAA79846 (PubMed:7667320).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23081 Genomic DNA Translation: AAA79846.1
AL023828 Genomic DNA Translation: CAA19447.1
PIRiT26493
RefSeqiNP_496563.1, NM_064162.4
UniGeneiCel.6518

Genome annotation databases

EnsemblMetazoaiY17G7B.7; Y17G7B.7; WBGene00006601
GeneIDi174844
KEGGicel:CELE_Y17G7B.7
UCSCiY17G7B.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTPIS_CAEEL
AccessioniPrimary (citable) accession number: Q10657
Secondary accession number(s): Q9U2R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 20, 2002
Last modified: April 25, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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