Reviewed, UniProtKB/Swiss-Prot Q10656 (EGL15_CAEEL)

Names and origin

Protein names

Recommended name:
    Myoblast growth factor receptor egl-15
    EC=2.7.10.1
Alternative name(s):
    Egg-laying defective protein 15

Gene names

Name:	egl-15
ORF Names:	F58A3.2

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1040 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Activation leads to the phosphorylation of SOC-1 on Tyr-408 triggering PTP-2 recruitment and/or activation. Activates the SEM-5/SOS-1/RAS/MAPK pathway. Acts in the hypodermis to regulate axon growth. Isoform 2 has no effect on axon growth but affects the maintenance of axon position. Isoform b acts as a receptor for an extracellular signal required for the guidance of sex myoblast migration during gonad development. Isoforms 1, 3, 4 and 5 appear to play a role in maintaining body morphology at higher temperatures. Ref.1 Ref.2 Ref.4
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Cofactor	Manganese By similarity.
Subunit structure	Interaction of egl-17 with isoform b is required for sex myoblast chemoattraction. Isoforms a, c, d and e interact with let-756 and play a role in the regulation of temperature-dependent growth.
Subcellular location	Membrane; Single-pass type I membrane protein.
Developmental stage	Expressed in the hypodermal membrane during the larval stage. Ref.4
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Ligand	ATP-binding Manganese Metal-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase oviposition Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro receptor-mediated endocytosis Inferred from mutant phenotype. Source: WormBase secretion by cell Inferred from mutant phenotype. Source: WormBase
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform a (identifier: Q10656-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform b (identifier: Q10656-2)

Also known as: EGL-15(5A);

The sequence of this isoform differs from the canonical sequence as follows:
     129-245: FCDYFLFPDI...DSEESPSESR → PLKLFDWLTE...RLRQINHALG

Isoform c (identifier: Q10656-3)

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEP...NPLPTKETIV

Isoform d (identifier: Q10656-4)

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEP...DDEKHHYYYS

Isoform e (identifier: Q10656-5)

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEPIGNGSNSPVL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 1040	1021	Myoblast growth factor receptor egl-15		PRO_0000016796
Regions
	Topological domain	20 – 525	506	Extracellular Potential
	Transmembrane	526 – 549	24	Potential
	Topological domain	550 – 1040	491	Cytoplasmic Potential
	Domain	33 – 125	93	Ig-like C2-type 1
	Domain	287 – 383	97	Ig-like C2-type 2
	Domain	391 – 501	111	Ig-like C2-type 3
	Domain	640 – 931	292	Protein kinase
	Nucleotide binding	646 – 654	9	ATP By similarity
Sites
	Active site	797	1	Proton acceptor By similarity
	Binding site	672	1	ATP By similarity
Amino acid modifications
	Modified residue	828	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Glycosylation	280	1	N-linked (GlcNAc...) Potential
	Glycosylation	299	1	N-linked (GlcNAc...) Potential
	Glycosylation	401	1	N-linked (GlcNAc...) Potential
	Glycosylation	407	1	N-linked (GlcNAc...) Potential
	Glycosylation	433	1	N-linked (GlcNAc...) Potential
	Glycosylation	440	1	N-linked (GlcNAc...) Potential
	Glycosylation	449	1	N-linked (GlcNAc...) Potential
	Glycosylation	474	1	N-linked (GlcNAc...) Potential
	Glycosylation	497	1	N-linked (GlcNAc...) Potential
	Disulfide bond	55 ↔ 109		Potential
	Disulfide bond	314 ↔ 367		Potential
	Disulfide bond	414 ↔ 485		Potential
Natural variations
	Alternative sequence	129 – 245	117	FCDYF…PSESR → PLKLFDWLTEHRVFDISHLL PKLLPPAEMRRVKSQLGGWE KMNNEQKIVRARHILRLRQI NHALG in isoform b.		VSP_019861
	Alternative sequence	829	1	R → RL in isoform c, isoform d and isoform e.		VSP_002991
	Alternative sequence	984	1	E → EVDQN in isoform c, isoform d and isoform e.		VSP_002992
	Alternative sequence	1027 – 1040	14	RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDQTHQ YYNTTSKIQYLHFTFDDPDC MTRSRDSAIFEESYHPNYIQ SHPLYSKIIIKKNMTPRNPL PTKETIV in isoform c.		VSP_002994
	Alternative sequence	1027 – 1040	14	RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDDEKH HYYYS in isoform d.		VSP_019862
	Alternative sequence	1027 – 1040	14	RIPSN…SKPEF → LYIHKVLNEPIGNGSNSPVL in isoform e.		VSP_019863
Experimental info
	Mutagenesis	680	1	E → K in N1775; loss of activity. Ref.1
	Mutagenesis	714	1	P → L in N1783; loss of activity. Ref.1
	Mutagenesis	930	1	W → in N1477ts; loss of activity. Ref.1
	Sequence conflict	551	1	Q → G in AAP44084. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform a [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 8CA227195DDBCD69	FASTA	1,040	118,956
	10 20 30 40 50 60 MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE IKFDCQTAAS 70 80 90 100 110 120 KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID VSDQGLWSCR VHNAYGQISR 130 140 150 160 170 180 NFTVEVIDFC DYFLFPDIHH LNIPMECVCL WKYNKEAKRS DVNYAAVTGE VCSKYASRMI 190 200 210 220 230 240 NRARKPLPMI PCFGDHCKEF DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES 250 260 270 280 290 300 PSESRTEFIN ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE 310 320 330 340 350 360 THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW SLEVEDAVVA 370 380 390 400 410 420 DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA NQSVNINDTA TFHCKVVSDL 430 440 450 460 470 480 LPHIIWVRIN KINGSYSYYN NSAEEYMFNY TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ 490 500 510 520 530 540 GIYACLSGNS LGMSMANATL TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT 550 560 570 580 590 600 LFGILFMVCK QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET 610 620 630 640 650 660 PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA FGEVWKATYK 670 680 690 700 710 720 ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE NVLRLIGCCT GAGPLYVVVE 730 740 750 760 770 780 LCKHGNLRDF LRAHRPKEEK AKKSSQELTD YLEPRKASDK DDIELIPNLT QRHLVQFAWQ 790 800 810 820 830 840 VAQGMNFLAS KKIIHRDLAA RNVLVGDGHV LKISDFGLSR DVHCNDYYRK RGNGRLPIKW 850 860 870 880 890 900 MALEALDSNV YTVESDVWSY GVLLWEIMTL GGTPYPTIAM PELYANLKEG YRMEPPHLCP 910 920 930 940 950 960 QEVYHLMCSC WREKLEERPS FKTIVDYLDW MLTMTNETIE GSQEFNDQFF SERSTASGPV 970 980 990 1000 1010 1020 SPMESFQKKR KHRPLSAPVN LPSEPQHTIC DDYESNFSVE PPNDPNHLYC NDNMLKNHII 1030 1040 TPETSQRIPS NNNSMSKPEF
	Isoform b (EGL-15(5A)). Checksum: A7365D218C082E49	FASTA	988	113,327
	10 20 30 40 50 60 MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE IKFDCQTAAS 70 80 90 100 110 120 KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID VSDQGLWSCR VHNAYGQISR 130 140 150 160 170 180 NFTVEVIDPL KLFDWLTEHR VFDISHLLPK LLPPAEMRRV KSQLGGWEKM NNEQKIVRAR 190 200 210 220 230 240 HILRLRQINH ALGTEFINAD EKENKEDEEE DYSVSQPVAP DAGLTELNIT AEEPPYFKSN 250 260 270 280 290 300 DNIVLFNETH ALPAGRTLKL NCRAKGYPEP QIIWYKNGKM LKKSSARSGG YEFKFNRWSL 310 320 330 340 350 360 EVEDAVVADS GEFHCEALNK VGSAKKYFHV IIVNRMRRPP IIVPNILANQ SVNINDTATF 370 380 390 400 410 420 HCKVVSDLLP HIIWVRINKI NGSYSYYNNS AEEYMFNYTE MDTFDKAHVH HVGDESTLTI 430 440 450 460 470 480 FNVSLDDQGI YACLSGNSLG MSMANATLTV NEFMAIHLLT GDEPKIDRWT TSDYIFTTIL 490 500 510 520 530 540 LFLLLAATLF GILFMVCKQT LHKKGFMDDT VGLVARKKRV VVSKRPMNED NENSDDEPSP 550 560 570 580 590 600 YQIQIIETPI TKKEAARKQR KRMNSENTVL SEYEVDSDPV WEVERSKLSL VHMLGEGAFG 610 620 630 640 650 660 EVWKATYKET ENNEIAVAVK KLKMSAHEKE LIDLVSEMET FKVIGEHENV LRLIGCCTGA 670 680 690 700 710 720 GPLYVVVELC KHGNLRDFLR AHRPKEEKAK KSSQELTDYL EPRKASDKDD IELIPNLTQR 730 740 750 760 770 780 HLVQFAWQVA QGMNFLASKK IIHRDLAARN VLVGDGHVLK ISDFGLSRDV HCNDYYRKRG 790 800 810 820 830 840 NGRLPIKWMA LEALDSNVYT VESDVWSYGV LLWEIMTLGG TPYPTIAMPE LYANLKEGYR 850 860 870 880 890 900 MEPPHLCPQE VYHLMCSCWR EKLEERPSFK TIVDYLDWML TMTNETIEGS QEFNDQFFSE 910 920 930 940 950 960 RSTASGPVSP MESFQKKRKH RPLSAPVNLP SEPQHTICDD YESNFSVEPP NDPNHLYCND 970 980 NMLKNHIITP ETSQRIPSNN NSMSKPEF
	Isoform c. Checksum: 2159D2E7C6564685	FASTA	1,158	132,425
	10 20 30 40 50 60 MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE IKFDCQTAAS 70 80 90 100 110 120 KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID VSDQGLWSCR VHNAYGQISR 130 140 150 160 170 180 NFTVEVIDFC DYFLFPDIHH LNIPMECVCL WKYNKEAKRS DVNYAAVTGE VCSKYASRMI 190 200 210 220 230 240 NRARKPLPMI PCFGDHCKEF DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES 250 260 270 280 290 300 PSESRTEFIN ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE 310 320 330 340 350 360 THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW SLEVEDAVVA 370 380 390 400 410 420 DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA NQSVNINDTA TFHCKVVSDL 430 440 450 460 470 480 LPHIIWVRIN KINGSYSYYN NSAEEYMFNY TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ 490 500 510 520 530 540 GIYACLSGNS LGMSMANATL TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT 550 560 570 580 590 600 LFGILFMVCK QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET 610 620 630 640 650 660 PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA FGEVWKATYK 670 680 690 700 710 720 ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE NVLRLIGCCT GAGPLYVVVE 730 740 750 760 770 780 LCKHGNLRDF LRAHRPKEEK AKKSSQELTD YLEPRKASDK DDIELIPNLT QRHLVQFAWQ 790 800 810 820 830 840 VAQGMNFLAS KKIIHRDLAA RNVLVGDGHV LKISDFGLSR DVHCNDYYRL KRGNGRLPIK 850 860 870 880 890 900 WMALEALDSN VYTVESDVWS YGVLLWEIMT LGGTPYPTIA MPELYANLKE GYRMEPPHLC 910 920 930 940 950 960 PQEVYHLMCS CWREKLEERP SFKTIVDYLD WMLTMTNETI EGSQEFNDQF FSERSTASGP 970 980 990 1000 1010 1020 VSPMESFQKK RKHRPLSAPV NLPSEVDQNP QHTICDDYES NFSVEPPNDP NHLYCNDNML 1030 1040 1050 1060 1070 1080 KNHIITPETS QLYIHKVLNE PIGNGYVRQD KLARAVSGVA NQSLDSALGS PAWPSYDRPS 1090 1100 1110 1120 1130 1140 NKASCLDQTH QYYNTTSKIQ YLHFTFDDPD CMTRSRDSAI FEESYHPNYI QSHPLYSKII 1150 IKKNMTPRNP LPTKETIV
	Isoform d. Checksum: C76B0B8A20852F80	FASTA	1,096	125,172
	10 20 30 40 50 60 MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE IKFDCQTAAS 70 80 90 100 110 120 KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID VSDQGLWSCR VHNAYGQISR 130 140 150 160 170 180 NFTVEVIDFC DYFLFPDIHH LNIPMECVCL WKYNKEAKRS DVNYAAVTGE VCSKYASRMI 190 200 210 220 230 240 NRARKPLPMI PCFGDHCKEF DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES 250 260 270 280 290 300 PSESRTEFIN ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE 310 320 330 340 350 360 THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW SLEVEDAVVA 370 380 390 400 410 420 DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA NQSVNINDTA TFHCKVVSDL 430 440 450 460 470 480 LPHIIWVRIN KINGSYSYYN NSAEEYMFNY TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ 490 500 510 520 530 540 GIYACLSGNS LGMSMANATL TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT 550 560 570 580 590 600 LFGILFMVCK QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET 610 620 630 640 650 660 PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA FGEVWKATYK 670 680 690 700 710 720 ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE NVLRLIGCCT GAGPLYVVVE 730 740 750 760 770 780 LCKHGNLRDF LRAHRPKEEK AKKSSQELTD YLEPRKASDK DDIELIPNLT QRHLVQFAWQ 790 800 810 820 830 840 VAQGMNFLAS KKIIHRDLAA RNVLVGDGHV LKISDFGLSR DVHCNDYYRL KRGNGRLPIK 850 860 870 880 890 900 WMALEALDSN VYTVESDVWS YGVLLWEIMT LGGTPYPTIA MPELYANLKE GYRMEPPHLC 910 920 930 940 950 960 PQEVYHLMCS CWREKLEERP SFKTIVDYLD WMLTMTNETI EGSQEFNDQF FSERSTASGP 970 980 990 1000 1010 1020 VSPMESFQKK RKHRPLSAPV NLPSEVDQNP QHTICDDYES NFSVEPPNDP NHLYCNDNML 1030 1040 1050 1060 1070 1080 KNHIITPETS QLYIHKVLNE PIGNGYVRQD KLARAVSGVA NQSLDSALGS PAWPSYDRPS 1090 NKASCLDDEK HHYYYS
	Isoform e. Checksum: A9616D4CAEA14AEE	FASTA	1,051	120,070
	10 20 30 40 50 60 MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE IKFDCQTAAS 70 80 90 100 110 120 KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID VSDQGLWSCR VHNAYGQISR 130 140 150 160 170 180 NFTVEVIDFC DYFLFPDIHH LNIPMECVCL WKYNKEAKRS DVNYAAVTGE VCSKYASRMI 190 200 210 220 230 240 NRARKPLPMI PCFGDHCKEF DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES 250 260 270 280 290 300 PSESRTEFIN ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE 310 320 330 340 350 360 THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW SLEVEDAVVA 370 380 390 400 410 420 DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA NQSVNINDTA TFHCKVVSDL 430 440 450 460 470 480 LPHIIWVRIN KINGSYSYYN NSAEEYMFNY TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ 490 500 510 520 530 540 GIYACLSGNS LGMSMANATL TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT 550 560 570 580 590 600 LFGILFMVCK QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET 610 620 630 640 650 660 PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA FGEVWKATYK 670 680 690 700 710 720 ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE NVLRLIGCCT GAGPLYVVVE 730 740 750 760 770 780 LCKHGNLRDF LRAHRPKEEK AKKSSQELTD YLEPRKASDK DDIELIPNLT QRHLVQFAWQ 790 800 810 820 830 840 VAQGMNFLAS KKIIHRDLAA RNVLVGDGHV LKISDFGLSR DVHCNDYYRL KRGNGRLPIK 850 860 870 880 890 900 WMALEALDSN VYTVESDVWS YGVLLWEIMT LGGTPYPTIA MPELYANLKE GYRMEPPHLC 910 920 930 940 950 960 PQEVYHLMCS CWREKLEERP SFKTIVDYLD WMLTMTNETI EGSQEFNDQF FSERSTASGP 970 980 990 1000 1010 1020 VSPMESFQKK RKHRPLSAPV NLPSEVDQNP QHTICDDYES NFSVEPPNDP NHLYCNDNML 1030 1040 1050 KNHIITPETS QLYIHKVLNE PIGNGSNSPV L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites." Devore D.L., Horvitz H.R., Stern M.J. Cell 83:611-620(1995) [PubMed: 7585964] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, MUTAGENESIS OF GLU-680; PRO-714 AND TRP-930. Strain: Bristol N2.
[2]	"Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity." Goodman S.J., Branda C.S., Robinson M.K., Burdine R.D., Stern M.J. Development 130:3757-3766(2003) [PubMed: 12835392] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), NUCLEOTIDE SEQUENCE [MRNA] OF 932-1040 (ISOFORMS A; C; D AND E), FUNCTION, INTERACTION WITH EGL-17 AND LET-756.
[3]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
[4]	"The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction." Schutzman J.L., Borland C.Z., Newman J.C., Robinson M.K., Kokel M., Stern M.J. Mol. Cell. Biol. 21:8104-8116(2001) [PubMed: 11689700] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U39761 mRNA. Translation: AAC46934.1. AY268435 mRNA. Translation: AAP31029.1. AY268436 mRNA. Translation: AAP31030.1. AY288941 mRNA. Translation: AAP44084.1. AY288942 mRNA. Translation: AAP44085.1. AY292532 mRNA. Translation: AAP74805.1. Z81017 Genomic DNA. Translation: CAB02673.2. Z81017 Genomic DNA. Translation: CAC70094.2. Z81017 Genomic DNA. Translation: CAC70095.2. Z81017 Genomic DNA. Translation: CAD44136.1. Z81017 Genomic DNA. Translation: CAE47468.1.
PIR	A57638. T22889.
RefSeq	NP_001024723.1. NP_001024724.2. NP_001024725.1. NP_001024726.1. NP_509842.2.
UniGene	Cel.17140
3D structure databases
SMR	Q10656. Positions 32-503, 626-935, 637-961.
ModBase	Search...
Protein-protein interaction databases
STRING	Q10656.
Genome annotation databases
Ensembl	F58A3.2a; F58A3.2a; F58A3.2; Caenorhabditis elegans. [Genome view]
GeneID	181291.
KEGG	cel:F58A3.2.
UCSC	F58A3.2e. c. elegans.
Organism-specific databases
CTD	181291.
WormBase	WBGene00001184. egl-15.
WormPep	F58A3.2a. CE28238. [WorfDB] F58A3.2b. CE35726. [WorfDB] F58A3.2c. CE41325. [WorfDB] F58A3.2d. CE31549. [WorfDB] F58A3.2e. CE35727. [WorfDB]
Phylogenomic databases
eggNOG	meNOG04870.
InParanoid	Q10656.
Enzyme and pathway databases
BRENDA	2.7.10.1. 672.
Gene expression databases
ArrayExpress	Q10656.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR020725. Tyr_kinase_Egl15_rcpt. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PANTHER	PTHR23256:SF231. Tyr_kinase_Egl15_rcpt. 1 hit. PTHR23256. Tyr_prot_kinase. 1 hit.
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 2 hits. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	913304.

Entry information

Entry name

EGL15_CAEEL

Accession

Primary (citable) accession number: Q10656
Secondary accession number(s): Q7JL68 , Q7YZM7, Q7YZM8, Q7YZN0, Q7YZN1, Q7Z025, Q8MQ14, Q93804, Q95QE0, Q95QE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	February 9, 2010
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project