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Protein

Myoblast growth factor receptor egl-15

Gene

egl-15

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase required for larval development (PubMed:7585964). May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2 (PubMed:11689700). May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1 (PubMed:11689700). Acts in the hypodermis to regulate axon growth and fluid homeostasis (PubMed:12835392, PubMed:7585964). Activates protein degradation in muscles (PubMed:14517244). Probably following interaction with ligand let-756, regulates negatively membrane protrusion from body wall muscles during larval development (PubMed:16495308). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAChR subunit lev-1 in the nerve cord (PubMed:15990870).6 Publications
Isoform b: Affects the maintenance of axon position without affecting axon growth. Interaction with egl-17 is required for the guidance of sex myoblast migration during gonad development.1 Publication
Isoform a: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Isoform c: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Isoform d: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Isoform e: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei672ATPPROSITE-ProRule annotation1
Active sitei797Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi646 – 654ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: WormBase
  • digestive tract morphogenesis Source: WormBase
  • fibroblast growth factor receptor signaling pathway Source: WormBase
  • muscle organ development Source: WormBase
  • nematode larval development Source: WormBase
  • oviposition Source: WormBase
  • protein phosphorylation Source: WormBase
  • regulation of cell projection organization Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1045.
ReactomeiR-CEL-109704. PI3K Cascade.
R-CEL-1257604. PIP3 activates AKT signaling.
R-CEL-190322. FGFR4 ligand binding and activation.
R-CEL-190370. FGFR1b ligand binding and activation.
R-CEL-190371. FGFR3b ligand binding and activation.
R-CEL-190372. FGFR3c ligand binding and activation.
R-CEL-190373. FGFR1c ligand binding and activation.
R-CEL-190375. FGFR2c ligand binding and activation.
R-CEL-190377. FGFR2b ligand binding and activation.
R-CEL-445144. Signal transduction by L1.
R-CEL-5654219. Phospholipase C-mediated cascade: FGFR1.
R-CEL-5654221. Phospholipase C-mediated cascade, FGFR2.
R-CEL-5654227. Phospholipase C-mediated cascade, FGFR3.
R-CEL-5654228. Phospholipase C-mediated cascade, FGFR4.
R-CEL-5654688. SHC-mediated cascade:FGFR1.
R-CEL-5654689. PI-3K cascade:FGFR1.
R-CEL-5654693. FRS-mediated FGFR1 signaling.
R-CEL-5654695. PI-3K cascade:FGFR2.
R-CEL-5654699. SHC-mediated cascade:FGFR2.
R-CEL-5654700. FRS-mediated FGFR2 signaling.
R-CEL-5654704. SHC-mediated cascade:FGFR3.
R-CEL-5654706. FRS-mediated FGFR3 signaling.
R-CEL-5654710. PI-3K cascade:FGFR3.
R-CEL-5654712. FRS-mediated FGFR4 signaling.
R-CEL-5654719. SHC-mediated cascade:FGFR4.
R-CEL-5654720. PI-3K cascade:FGFR4.
R-CEL-5654726. Negative regulation of FGFR1 signaling.
R-CEL-5654727. Negative regulation of FGFR2 signaling.
R-CEL-5654732. Negative regulation of FGFR3 signaling.
R-CEL-5654733. Negative regulation of FGFR4 signaling.
R-CEL-5673001. RAF/MAP kinase cascade.
R-CEL-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiQ10656.

Names & Taxonomyi

Protein namesi
Recommended name:
Myoblast growth factor receptor egl-15 (EC:2.7.10.1)
Alternative name(s):
Egg-laying defective protein 15
Gene namesi
Name:egl-15
ORF Names:F58A3.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF58A3.2a; CE28238; WBGene00001184; egl-15.
F58A3.2b; CE35726; WBGene00001184; egl-15.
F58A3.2c; CE50149; WBGene00001184; egl-15.
F58A3.2d; CE50303; WBGene00001184; egl-15.
F58A3.2e; CE50247; WBGene00001184; egl-15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 525ExtracellularSequence analysisAdd BLAST506
Transmembranei526 – 549HelicalSequence analysisAdd BLAST24
Topological domaini550 – 1040CytoplasmicSequence analysisAdd BLAST491

GO - Cellular componenti

  • cell Source: WormBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Early arrest in larval development. Impaired guided migration of sex myoblasts (PubMed:7585964). RNAi-mediated knockdown causes ectopic membrane extension from body wall muscles (PubMed:16495308).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi680E → K in n1775; loss of activity. 1 Publication1
Mutagenesisi714P → L in n1783; loss of activity. Ectopic membrane extension in body wall muscles. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001679620 – 1040Myoblast growth factor receptor egl-15Add BLAST1021

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 109PROSITE-ProRule annotation
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi314 ↔ 367PROSITE-ProRule annotation
Glycosylationi401N-linked (GlcNAc...)Sequence analysis1
Glycosylationi407N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi414 ↔ 485PROSITE-ProRule annotation
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi440N-linked (GlcNAc...)Sequence analysis1
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Modified residuei828Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Activity is regulated by the phosphatase clr-1, however it is not known whether clr-1 acts directly on egl-15.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ10656.
PeptideAtlasiQ10656.

PTM databases

iPTMnetiQ10656.

Expressioni

Gene expression databases

BgeeiWBGene00001184.
ExpressionAtlasiQ10656. differential.

Interactioni

Protein-protein interaction databases

BioGridi46202. 148 interactors.
IntActiQ10656. 1 interactor.
STRINGi6239.F58A3.2c.

Structurei

3D structure databases

ProteinModelPortaliQ10656.
SMRiQ10656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 125Ig-like C2-type 1Add BLAST93
Domaini287 – 383Ig-like C2-type 2Add BLAST97
Domaini391 – 501Ig-like C2-type 3Add BLAST111
Domaini640 – 931Protein kinasePROSITE-ProRule annotationAdd BLAST292

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
InParanoidiQ10656.
OMAiVELCKHG.
OrthoDBiEOG091G0CQZ.
PhylomeDBiQ10656.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q10656-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE
60 70 80 90 100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID
110 120 130 140 150
VSDQGLWSCR VHNAYGQISR NFTVEVIDFC DYFLFPDIHH LNIPMECVCL
160 170 180 190 200
WKYNKEAKRS DVNYAAVTGE VCSKYASRMI NRARKPLPMI PCFGDHCKEF
210 220 230 240 250
DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES PSESRTEFIN
260 270 280 290 300
ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE
310 320 330 340 350
THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW
360 370 380 390 400
SLEVEDAVVA DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA
410 420 430 440 450
NQSVNINDTA TFHCKVVSDL LPHIIWVRIN KINGSYSYYN NSAEEYMFNY
460 470 480 490 500
TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ GIYACLSGNS LGMSMANATL
510 520 530 540 550
TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT LFGILFMVCK
560 570 580 590 600
QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET
610 620 630 640 650
PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA
660 670 680 690 700
FGEVWKATYK ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE
710 720 730 740 750
NVLRLIGCCT GAGPLYVVVE LCKHGNLRDF LRAHRPKEEK AKKSSQELTD
760 770 780 790 800
YLEPRKASDK DDIELIPNLT QRHLVQFAWQ VAQGMNFLAS KKIIHRDLAA
810 820 830 840 850
RNVLVGDGHV LKISDFGLSR DVHCNDYYRK RGNGRLPIKW MALEALDSNV
860 870 880 890 900
YTVESDVWSY GVLLWEIMTL GGTPYPTIAM PELYANLKEG YRMEPPHLCP
910 920 930 940 950
QEVYHLMCSC WREKLEERPS FKTIVDYLDW MLTMTNETIE GSQEFNDQFF
960 970 980 990 1000
SERSTASGPV SPMESFQKKR KHRPLSAPVN LPSEPQHTIC DDYESNFSVE
1010 1020 1030 1040
PPNDPNHLYC NDNMLKNHII TPETSQRIPS NNNSMSKPEF
Length:1,040
Mass (Da):118,956
Last modified:November 1, 1997 - v1
Checksum:i8CA227195DDBCD69
GO
Isoform b (identifier: Q10656-2) [UniParc]FASTAAdd to basket
Also known as: EGL-15(5A)

The sequence of this isoform differs from the canonical sequence as follows:
     129-245: FCDYFLFPDI...DSEESPSESR → PLKLFDWLTE...RLRQINHALG

Show »
Length:988
Mass (Da):113,327
Checksum:iA7365D218C082E49
GO
Isoform c (identifier: Q10656-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEP...NPLPTKETIV

Show »
Length:1,158
Mass (Da):132,425
Checksum:i2159D2E7C6564685
GO
Isoform d (identifier: Q10656-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEP...DDEKHHYYYS

Show »
Length:1,096
Mass (Da):125,172
Checksum:iC76B0B8A20852F80
GO
Isoform e (identifier: Q10656-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEPIGNGSNSPVL

Show »
Length:1,051
Mass (Da):120,070
Checksum:iA9616D4CAEA14AEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti551Q → G in AAP44084 (PubMed:12835392).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019861129 – 245FCDYF…PSESR → PLKLFDWLTEHRVFDISHLL PKLLPPAEMRRVKSQLGGWE KMNNEQKIVRARHILRLRQI NHALG in isoform b. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_002991829R → RL in isoform c, isoform d and isoform e. 1 Publication1
Alternative sequenceiVSP_002992984E → EVDQN in isoform c, isoform d and isoform e. 1 Publication1
Alternative sequenceiVSP_0029941027 – 1040RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDQTHQ YYNTTSKIQYLHFTFDDPDC MTRSRDSAIFEESYHPNYIQ SHPLYSKIIIKKNMTPRNPL PTKETIV in isoform c. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0198621027 – 1040RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDDEKH HYYYS in isoform d. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0198631027 – 1040RIPSN…SKPEF → LYIHKVLNEPIGNGSNSPVL in isoform e. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39761 mRNA. Translation: AAC46934.1.
AY268435 mRNA. Translation: AAP31029.1.
AY268436 mRNA. Translation: AAP31030.1.
AY288941 mRNA. Translation: AAP44084.1.
AY288942 mRNA. Translation: AAP44085.1.
AY292532 mRNA. Translation: AAP74805.1.
Z81017 Genomic DNA. Translation: CAB02673.2.
Z81017 Genomic DNA. Translation: CAC70094.2.
Z81017 Genomic DNA. Translation: CAC70095.2.
Z81017 Genomic DNA. Translation: CAD44136.1.
Z81017 Genomic DNA. Translation: CAE47468.1.
PIRiA57638.
T22889.
RefSeqiNP_001024723.1. NM_001029552.2. [Q10656-2]
NP_001024724.3. NM_001029553.5.
NP_001024725.2. NM_001029554.4.
NP_001024726.2. NM_001029555.4.
NP_509842.2. NM_077441.6. [Q10656-1]
UniGeneiCel.17140.

Genome annotation databases

EnsemblMetazoaiF58A3.2a.1; F58A3.2a.1; WBGene00001184. [Q10656-1]
F58A3.2a.2; F58A3.2a.2; WBGene00001184. [Q10656-1]
F58A3.2a.3; F58A3.2a.3; WBGene00001184. [Q10656-1]
F58A3.2a.4; F58A3.2a.4; WBGene00001184. [Q10656-1]
GeneIDi181291.
KEGGicel:CELE_F58A3.2.
UCSCiF58A3.2e. c. elegans. [Q10656-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39761 mRNA. Translation: AAC46934.1.
AY268435 mRNA. Translation: AAP31029.1.
AY268436 mRNA. Translation: AAP31030.1.
AY288941 mRNA. Translation: AAP44084.1.
AY288942 mRNA. Translation: AAP44085.1.
AY292532 mRNA. Translation: AAP74805.1.
Z81017 Genomic DNA. Translation: CAB02673.2.
Z81017 Genomic DNA. Translation: CAC70094.2.
Z81017 Genomic DNA. Translation: CAC70095.2.
Z81017 Genomic DNA. Translation: CAD44136.1.
Z81017 Genomic DNA. Translation: CAE47468.1.
PIRiA57638.
T22889.
RefSeqiNP_001024723.1. NM_001029552.2. [Q10656-2]
NP_001024724.3. NM_001029553.5.
NP_001024725.2. NM_001029554.4.
NP_001024726.2. NM_001029555.4.
NP_509842.2. NM_077441.6. [Q10656-1]
UniGeneiCel.17140.

3D structure databases

ProteinModelPortaliQ10656.
SMRiQ10656.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46202. 148 interactors.
IntActiQ10656. 1 interactor.
STRINGi6239.F58A3.2c.

PTM databases

iPTMnetiQ10656.

Proteomic databases

PaxDbiQ10656.
PeptideAtlasiQ10656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58A3.2a.1; F58A3.2a.1; WBGene00001184. [Q10656-1]
F58A3.2a.2; F58A3.2a.2; WBGene00001184. [Q10656-1]
F58A3.2a.3; F58A3.2a.3; WBGene00001184. [Q10656-1]
F58A3.2a.4; F58A3.2a.4; WBGene00001184. [Q10656-1]
GeneIDi181291.
KEGGicel:CELE_F58A3.2.
UCSCiF58A3.2e. c. elegans. [Q10656-1]

Organism-specific databases

CTDi181291.
WormBaseiF58A3.2a; CE28238; WBGene00001184; egl-15.
F58A3.2b; CE35726; WBGene00001184; egl-15.
F58A3.2c; CE50149; WBGene00001184; egl-15.
F58A3.2d; CE50303; WBGene00001184; egl-15.
F58A3.2e; CE50247; WBGene00001184; egl-15.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
InParanoidiQ10656.
OMAiVELCKHG.
OrthoDBiEOG091G0CQZ.
PhylomeDBiQ10656.

Enzyme and pathway databases

BRENDAi2.7.10.1. 1045.
ReactomeiR-CEL-109704. PI3K Cascade.
R-CEL-1257604. PIP3 activates AKT signaling.
R-CEL-190322. FGFR4 ligand binding and activation.
R-CEL-190370. FGFR1b ligand binding and activation.
R-CEL-190371. FGFR3b ligand binding and activation.
R-CEL-190372. FGFR3c ligand binding and activation.
R-CEL-190373. FGFR1c ligand binding and activation.
R-CEL-190375. FGFR2c ligand binding and activation.
R-CEL-190377. FGFR2b ligand binding and activation.
R-CEL-445144. Signal transduction by L1.
R-CEL-5654219. Phospholipase C-mediated cascade: FGFR1.
R-CEL-5654221. Phospholipase C-mediated cascade, FGFR2.
R-CEL-5654227. Phospholipase C-mediated cascade, FGFR3.
R-CEL-5654228. Phospholipase C-mediated cascade, FGFR4.
R-CEL-5654688. SHC-mediated cascade:FGFR1.
R-CEL-5654689. PI-3K cascade:FGFR1.
R-CEL-5654693. FRS-mediated FGFR1 signaling.
R-CEL-5654695. PI-3K cascade:FGFR2.
R-CEL-5654699. SHC-mediated cascade:FGFR2.
R-CEL-5654700. FRS-mediated FGFR2 signaling.
R-CEL-5654704. SHC-mediated cascade:FGFR3.
R-CEL-5654706. FRS-mediated FGFR3 signaling.
R-CEL-5654710. PI-3K cascade:FGFR3.
R-CEL-5654712. FRS-mediated FGFR4 signaling.
R-CEL-5654719. SHC-mediated cascade:FGFR4.
R-CEL-5654720. PI-3K cascade:FGFR4.
R-CEL-5654726. Negative regulation of FGFR1 signaling.
R-CEL-5654727. Negative regulation of FGFR2 signaling.
R-CEL-5654732. Negative regulation of FGFR3 signaling.
R-CEL-5654733. Negative regulation of FGFR4 signaling.
R-CEL-5673001. RAF/MAP kinase cascade.
R-CEL-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
SignaLinkiQ10656.

Miscellaneous databases

PROiQ10656.

Gene expression databases

BgeeiWBGene00001184.
ExpressionAtlasiQ10656. differential.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGL15_CAEEL
AccessioniPrimary (citable) accession number: Q10656
Secondary accession number(s): Q7JL68
, Q7YZM7, Q7YZM8, Q7YZN0, Q7YZN1, Q7Z025, Q8MQ14, Q93804, Q95QE0, Q95QE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.