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Protein

G2/mitotic-specific cyclin-B3

Gene

cyb-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II (PubMed:20599902).Curated1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome cycle Source: WormBase
  • kinetochore organization Source: WormBase
  • meiotic cell cycle Source: UniProtKB
  • meiotic sister chromatid segregation Source: WormBase
  • mitotic cell cycle Source: WormBase
  • mitotic sister chromatid segregation Source: WormBase
  • oocyte maturation Source: WormBase
  • positive regulation of mitotic metaphase/anaphase transition Source: WormBase
  • positive regulation of protein phosphorylation Source: WormBase
  • pronuclear migration Source: WormBase
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  • regulation of G2/M transition of mitotic cell cycle Source: InterPro
  • regulation of meiotic cell cycle Source: UniProtKB

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B3
Gene namesi
Name:cyb-3
Synonyms:cyb-2
ORF Names:T06E6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT06E6.2a ; CE45171 ; WBGene00000868 ; cyb-3
T06E6.2b ; CE45189 ; WBGene00000868 ; cyb-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown causes a longer meiosis II in 1-cell embryos without affecting meiotic exit timing. In a pam-1 (or282) mutant background, restores normal timing for meiotic exit.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803811 – 385G2/mitotic-specific cyclin-B3Add BLAST385

Proteomic databases

EPDiQ10654
PaxDbiQ10654
PeptideAtlasiQ10654

Expressioni

Gene expression databases

BgeeiWBGene00000868

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi45035, 2 interactors
DIPiDIP-25112N
IntActiQ10654, 3 interactors
STRINGi6239.T06E6.2a.2

Structurei

3D structure databases

ProteinModelPortaliQ10654
SMRiQ10654
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000017816
InParanoidiQ10654
KOiK21771
OMAiLQFHSGY
OrthoDBiEOG091G0L84

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR015452 Cyclin_B3
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF214 PTHR10177:SF214, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q10654-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLRSQAKNV DLTSQADSRH QQKRKQAEQL DALKNPSEPA AKKQHSKGLT
60 70 80 90 100
ELRAHISGFK IDSAKRDPLG KSRTSRRDVE NLPPQKSRYV DPCPHYDYDL
110 120 130 140 150
EEAGNPDSIS DYAQGIFDYY RHREVHFRVR KYLHKHPEVD VKTRAILIDW
160 170 180 190 200
MVEIQETFEL NHETLYNAVK LTDMYLCKTK NVDKNTIQKL ACVAIFIAAK
210 220 230 240 250
YDERSPPLVD DLIYLSGDRF SRDELLAMER ELFATVGYDL GSPLSYRYLR
260 270 280 290 300
RFGRVCRVDM KTLTMGRFIL ETSLMVYEYA MVSQSRLAAA AFVLAMRMLD
310 320 330 340 350
KNNEYEWNPV LEKYSGFTGE EVMPLVEHMN HILHFSKDKW AQLTSVRQKY
360 370 380
SHEVFFHVAS IPMLPDTLKV VDSHTYAPVP MLSYP
Length:385
Mass (Da):44,757
Last modified:July 27, 2011 - v3
Checksum:i74CEDA847A76E695
GO
Isoform b (identifier: Q10654-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: Missing.

Show »
Length:384
Mass (Da):44,686
Checksum:iA2774489931F1AB5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04164416Missing in isoform b. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21282 mRNA Translation: AAA84395.1
Z81117 Genomic DNA Translation: CAB03311.2
Z81117 Genomic DNA Translation: CAC42336.2
PIRiT24596
RefSeqiNP_001024112.2, NM_001028941.3 [Q10654-2]
NP_506825.4, NM_074424.6 [Q10654-1]
UniGeneiCel.7608

Genome annotation databases

EnsemblMetazoaiT06E6.2a.1; T06E6.2a.1; WBGene00000868 [Q10654-1]
T06E6.2a.2; T06E6.2a.2; WBGene00000868 [Q10654-1]
GeneIDi180040
KEGGicel:CELE_T06E6.2
UCSCiT06E6.2a.1 c. elegans [Q10654-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCNB3_CAEEL
AccessioniPrimary (citable) accession number: Q10654
Secondary accession number(s): Q95ZP8, Q9U378
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health