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Protein

G2/mitotic-specific cyclin-B3

Gene

cyb-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could be involved at the G2/M (mitosis) transition. Interacts with the CDK1 and CDK2 protein kinases. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: WormBase

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome cycle Source: WormBase
  • kinetochore organization Source: WormBase
  • meiotic sister chromatid segregation Source: WormBase
  • mitotic sister chromatid segregation Source: WormBase
  • oocyte maturation Source: WormBase
  • positive regulation of mitotic metaphase/anaphase transition Source: WormBase
  • positive regulation of protein phosphorylation Source: WormBase
  • pronuclear migration Source: WormBase
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  • regulation of G2/M transition of mitotic cell cycle Source: InterPro
  • regulation of meiotic cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B3
Gene namesi
Name:cyb-3
Synonyms:cyb-2
ORF Names:T06E6.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT06E6.2a; CE45171; WBGene00000868; cyb-3.
T06E6.2b; CE45189; WBGene00000868; cyb-3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385G2/mitotic-specific cyclin-B3PRO_0000080381Add
BLAST

Proteomic databases

EPDiQ10654.
PaxDbiQ10654.
PRIDEiQ10654.

Interactioni

Protein-protein interaction databases

BioGridi45035. 2 interactions.
DIPiDIP-25112N.
IntActiQ10654. 1 interaction.
MINTiMINT-1116033.
STRINGi6239.T06E6.2a.2.

Structurei

3D structure databases

ProteinModelPortaliQ10654.
SMRiQ10654. Positions 110-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000017816.
InParanoidiQ10654.
KOiK05868.
OMAiNHETLYN.
OrthoDBiEOG7P2XST.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015452. Cyclin_B3.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF214. PTHR10177:SF214. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q10654-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLRSQAKNV DLTSQADSRH QQKRKQAEQL DALKNPSEPA AKKQHSKGLT
60 70 80 90 100
ELRAHISGFK IDSAKRDPLG KSRTSRRDVE NLPPQKSRYV DPCPHYDYDL
110 120 130 140 150
EEAGNPDSIS DYAQGIFDYY RHREVHFRVR KYLHKHPEVD VKTRAILIDW
160 170 180 190 200
MVEIQETFEL NHETLYNAVK LTDMYLCKTK NVDKNTIQKL ACVAIFIAAK
210 220 230 240 250
YDERSPPLVD DLIYLSGDRF SRDELLAMER ELFATVGYDL GSPLSYRYLR
260 270 280 290 300
RFGRVCRVDM KTLTMGRFIL ETSLMVYEYA MVSQSRLAAA AFVLAMRMLD
310 320 330 340 350
KNNEYEWNPV LEKYSGFTGE EVMPLVEHMN HILHFSKDKW AQLTSVRQKY
360 370 380
SHEVFFHVAS IPMLPDTLKV VDSHTYAPVP MLSYP
Length:385
Mass (Da):44,757
Last modified:July 27, 2011 - v3
Checksum:i74CEDA847A76E695
GO
Isoform b (identifier: Q10654-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: Missing.

Show »
Length:384
Mass (Da):44,686
Checksum:iA2774489931F1AB5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 161Missing in isoform b. CuratedVSP_041644

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21282 mRNA. Translation: AAA84395.1.
Z81117 Genomic DNA. Translation: CAB03311.2.
Z81117 Genomic DNA. Translation: CAC42336.2.
PIRiT24596.
RefSeqiNP_001024112.2. NM_001028941.3. [Q10654-2]
NP_506825.4. NM_074424.6. [Q10654-1]
UniGeneiCel.7608.

Genome annotation databases

EnsemblMetazoaiT06E6.2a.1; T06E6.2a.1; WBGene00000868. [Q10654-1]
T06E6.2a.2; T06E6.2a.2; WBGene00000868. [Q10654-1]
GeneIDi180040.
KEGGicel:CELE_T06E6.2.
UCSCiT06E6.2a.1. c. elegans. [Q10654-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21282 mRNA. Translation: AAA84395.1.
Z81117 Genomic DNA. Translation: CAB03311.2.
Z81117 Genomic DNA. Translation: CAC42336.2.
PIRiT24596.
RefSeqiNP_001024112.2. NM_001028941.3. [Q10654-2]
NP_506825.4. NM_074424.6. [Q10654-1]
UniGeneiCel.7608.

3D structure databases

ProteinModelPortaliQ10654.
SMRiQ10654. Positions 110-368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45035. 2 interactions.
DIPiDIP-25112N.
IntActiQ10654. 1 interaction.
MINTiMINT-1116033.
STRINGi6239.T06E6.2a.2.

Proteomic databases

EPDiQ10654.
PaxDbiQ10654.
PRIDEiQ10654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT06E6.2a.1; T06E6.2a.1; WBGene00000868. [Q10654-1]
T06E6.2a.2; T06E6.2a.2; WBGene00000868. [Q10654-1]
GeneIDi180040.
KEGGicel:CELE_T06E6.2.
UCSCiT06E6.2a.1. c. elegans. [Q10654-1]

Organism-specific databases

CTDi180040.
WormBaseiT06E6.2a; CE45171; WBGene00000868; cyb-3.
T06E6.2b; CE45189; WBGene00000868; cyb-3.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000017816.
InParanoidiQ10654.
KOiK05868.
OMAiNHETLYN.
OrthoDBiEOG7P2XST.

Miscellaneous databases

PROiQ10654.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR015452. Cyclin_B3.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF214. PTHR10177:SF214. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression."
    Kreutzer M.A., Richards J.P., de Silva-Udawatta M.N., Temenak J.J., Knoblich J.A., Lehner C.F., Bennett K.L.
    J. Cell Sci. 108:2415-2424(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiCCNB3_CAEEL
AccessioniPrimary (citable) accession number: Q10654
Secondary accession number(s): Q95ZP8, Q9U378
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.