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Protein

G2/mitotic-specific cyclin-B1

Gene

cyb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: WormBase

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic nuclear division Source: UniProtKB-KW
  • oocyte maturation Source: WormBase
  • positive regulation of protein phosphorylation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-CEL-113507. E2F-enabled inhibition of pre-replication complex formation.
R-CEL-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-CEL-2500257. Resolution of Sister Chromatid Cohesion.
R-CEL-4419969. Depolymerisation of the Nuclear Lamina.
R-CEL-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-CEL-69273. Cyclin A/B1 associated events during G2/M transition.
R-CEL-69478. G2/M DNA replication checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B1
Gene namesi
Name:cyb-1
ORF Names:ZC168.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZC168.4; CE06570; WBGene00000865; cyb-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361G2/mitotic-specific cyclin-B1PRO_0000080380Add
BLAST

Proteomic databases

EPDiQ10653.
PaxDbiQ10653.

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
puf-3Q9U2G43EBI-330851,EBI-330810

Protein-protein interaction databases

BioGridi43066. 3 interactions.
IntActiQ10653. 2 interactions.
MINTiMINT-251174.
STRINGi6239.ZC168.4.2.

Structurei

3D structure databases

ProteinModelPortaliQ10653.
SMRiQ10653. Positions 80-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000021215.
InParanoidiQ10653.
KOiK05868.
OMAiTLHLTVF.
OrthoDBiEOG7ZGX3C.
PhylomeDBiQ10653.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRATNNRRT SNNVEKDSLQ MAKHGNGPLK PVNAQGLQTK REAREILALK
60 70 80 90 100
PSNPAPVETA QKSQRINLQD AETKCLAMAD DIYKYLVHHE KKYLLEECFM
110 120 130 140 150
EGGEPTPKMR RILVDWLVQV HVRFHLTPET LHLTVFILDR MLQKKVTSKA
160 170 180 190 200
DLQLLGISAM FVASKFEEVY LPDIHDYEFI TENTYSKKQI LAMEQTILNS
210 220 230 240 250
LNFDLSCPSS LVFLRCLSRI LSENDASPID NQAFCYTYNI SKCLGELALL
260 270 280 290 300
DSVMASTPRS HIASASMIIA LEVHPVDGIE AENAVSVICK QLGASKKVIE
310 320 330 340 350
DAVALLAEVS YKNFKQGKLV AIKNKYQSSK LAQVSNLMTD DVLEKINRMG
360
QNAKVDASEM E
Length:361
Mass (Da):40,519
Last modified:October 1, 1996 - v1
Checksum:i2B76FE39E0248C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20903 mRNA. Translation: AAA84394.1.
Z70312 Genomic DNA. Translation: CAA94384.1.
PIRiT27504.
RefSeqiNP_501987.1. NM_069586.5.
UniGeneiCel.19740.

Genome annotation databases

EnsemblMetazoaiZC168.4.1; ZC168.4.1; WBGene00000865.
ZC168.4.2; ZC168.4.2; WBGene00000865.
ZC168.4.3; ZC168.4.3; WBGene00000865.
GeneIDi177965.
KEGGicel:CELE_ZC168.4.
UCSCiZC168.4.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20903 mRNA. Translation: AAA84394.1.
Z70312 Genomic DNA. Translation: CAA94384.1.
PIRiT27504.
RefSeqiNP_501987.1. NM_069586.5.
UniGeneiCel.19740.

3D structure databases

ProteinModelPortaliQ10653.
SMRiQ10653. Positions 80-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43066. 3 interactions.
IntActiQ10653. 2 interactions.
MINTiMINT-251174.
STRINGi6239.ZC168.4.2.

Proteomic databases

EPDiQ10653.
PaxDbiQ10653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZC168.4.1; ZC168.4.1; WBGene00000865.
ZC168.4.2; ZC168.4.2; WBGene00000865.
ZC168.4.3; ZC168.4.3; WBGene00000865.
GeneIDi177965.
KEGGicel:CELE_ZC168.4.
UCSCiZC168.4.2. c. elegans.

Organism-specific databases

CTDi177965.
WormBaseiZC168.4; CE06570; WBGene00000865; cyb-1.

Phylogenomic databases

eggNOGiKOG0653. Eukaryota.
COG5024. LUCA.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000021215.
InParanoidiQ10653.
KOiK05868.
OMAiTLHLTVF.
OrthoDBiEOG7ZGX3C.
PhylomeDBiQ10653.

Enzyme and pathway databases

ReactomeiR-CEL-113507. E2F-enabled inhibition of pre-replication complex formation.
R-CEL-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-CEL-2500257. Resolution of Sister Chromatid Cohesion.
R-CEL-4419969. Depolymerisation of the Nuclear Lamina.
R-CEL-6804114. TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
R-CEL-69273. Cyclin A/B1 associated events during G2/M transition.
R-CEL-69478. G2/M DNA replication checkpoint.

Miscellaneous databases

PROiQ10653.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression."
    Kreutzer M.A., Richards J.P., de Silva-Udawatta M.N., Temenak J.J., Knoblich J.A., Lehner C.F., Bennett K.L.
    J. Cell Sci. 108:2415-2424(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCCNB1_CAEEL
AccessioniPrimary (citable) accession number: Q10653
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.