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Protein

G2/mitotic-specific cyclin-B1

Gene

cyb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.By similarity

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: WormBase
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic cell cycle Source: WormBase
  • oocyte maturation Source: WormBase
  • positive regulation of protein phosphorylation Source: WormBase

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-CEL-176408 Regulation of APC/C activators between G1/S and early anaphase
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2500257 Resolution of Sister Chromatid Cohesion
R-CEL-4419969 Depolymerisation of the Nuclear Lamina
R-CEL-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-CEL-69478 G2/M DNA replication checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B1
Gene namesi
Name:cyb-1
ORF Names:ZC168.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiZC168.4 ; CE06570 ; WBGene00000865 ; cyb-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803801 – 361G2/mitotic-specific cyclin-B1Add BLAST361

Post-translational modificationi

Ubiquitinated by etc-1 likely during meiosis, resulting in its degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ10653
PaxDbiQ10653
PeptideAtlasiQ10653

Expressioni

Developmental stagei

Expressed in mature oocytes followed by a severe reduction in protein levels as meiotic division progresses (PubMed:23578927).1 Publication

Gene expression databases

BgeeiWBGene00000865

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF) (By similarity). The cyclin subunit imparts substrate specificity to the complex (By similarity). Interacts with E3 ubiquitin-protein ligase etc-1 (PubMed:23578927).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
puf-3Q9U2G43EBI-330851,EBI-330810

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi430663 interactors.
IntActiQ10653 2 interactors.
STRINGi6239.ZC168.4.2

Structurei

3D structure databases

ProteinModelPortaliQ10653
SMRiQ10653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000021215
InParanoidiQ10653
KOiK05868
OMAiTLHLTVF
OrthoDBiEOG091G0E9B
PhylomeDBiQ10653

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

Q10653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRATNNRRT SNNVEKDSLQ MAKHGNGPLK PVNAQGLQTK REAREILALK
60 70 80 90 100
PSNPAPVETA QKSQRINLQD AETKCLAMAD DIYKYLVHHE KKYLLEECFM
110 120 130 140 150
EGGEPTPKMR RILVDWLVQV HVRFHLTPET LHLTVFILDR MLQKKVTSKA
160 170 180 190 200
DLQLLGISAM FVASKFEEVY LPDIHDYEFI TENTYSKKQI LAMEQTILNS
210 220 230 240 250
LNFDLSCPSS LVFLRCLSRI LSENDASPID NQAFCYTYNI SKCLGELALL
260 270 280 290 300
DSVMASTPRS HIASASMIIA LEVHPVDGIE AENAVSVICK QLGASKKVIE
310 320 330 340 350
DAVALLAEVS YKNFKQGKLV AIKNKYQSSK LAQVSNLMTD DVLEKINRMG
360
QNAKVDASEM E
Length:361
Mass (Da):40,519
Last modified:October 1, 1996 - v1
Checksum:i2B76FE39E0248C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20903 mRNA Translation: AAA84394.1
Z70312 Genomic DNA Translation: CAA94384.1
PIRiT27504
RefSeqiNP_501987.1, NM_069586.5
UniGeneiCel.19740

Genome annotation databases

EnsemblMetazoaiZC168.4.1; ZC168.4.1; WBGene00000865
ZC168.4.2; ZC168.4.2; WBGene00000865
ZC168.4.3; ZC168.4.3; WBGene00000865
ZC168.4.4; ZC168.4.4; WBGene00000865
GeneIDi177965
KEGGicel:CELE_ZC168.4
UCSCiZC168.4.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiCCNB1_CAEEL
AccessioniPrimary (citable) accession number: Q10653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome