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Q10641 (PNCB1_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase pncB1
Short name=NAPRTase pncB1
EC=2.4.2.11
Gene names
Name:pncB1
Ordered Locus Names:Rv1330c, MT1372
ORF Names:MTCY130.15c
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.

Catalytic activity

Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Nicotinate phosphoribosyltransferase pncB1
PRO_0000103804

Experimental info

Sequence conflict4291G → A in AAK45636. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q10641 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: E3F926EAA5835CE9

FASTA44847,227
        10         20         30         40         50         60 
MGPPPAARRR EGEPDNQDPA GLLTDKYELT MLAAALRDGS ANRPTTFEVF ARRLPTGRRY 

        70         80         90        100        110        120 
GVVAGTGRLL EALPQFRFDA DACELLAQFL DPATVRYLRE FRFRGDIDGY AEGELYFPGS 

       130        140        150        160        170        180 
PVLSVRGSFA ECVLLETLVL SIFNHDTAIA SAAARMVSAA GGRPLIEMGS RRTHERAAVA 

       190        200        210        220        230        240 
AARAAYIAGF AASSNLAAQR RYGVPAHGTA AHAFTMLHAQ HGGPTELAER AAFRAQVEAL 

       250        260        270        280        290        300 
GPGTTLLVDT YDVTTGVANA VAAAGAELGA IRIDSGELGV LARQAREQLD RLGATRTRIV 

       310        320        330        340        350        360 
VSGDLDEFSI AALRGEPVDS YGVGTSLVTG SGAPTANMVY KLVEVDGVPV QKRSSYKESP 

       370        380        390        400        410        420 
GGRKEALRRS RATGTITEEL VHPAGRPPVI VEPHRVLTLP LVRAGQPVAD TSLAAARQLV 

       430        440 
ASGLRSLPGD GLKLAPGEPA IPTRTIPA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842576 Genomic DNA. Translation: CAA98094.2.
AE000516 Genomic DNA. Translation: AAK45636.1.
AL123456 Genomic DNA. Translation: CCP44088.1.
PIRF70770.
RefSeqNP_215846.2. NC_000962.3.
NP_335822.1. NC_002755.2.
YP_006514708.1. NC_018143.1.

3D structure databases

ProteinModelPortalQ10641.
SMRQ10641. Positions 18-378.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv1330c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK45636; AAK45636; MT1372.
GeneID13319916.
886884.
924689.
KEGGmtc:MT1372.
mtu:Rv1330c.
mtv:RVBD_1330c.
PATRIC18124790. VBIMycTub22151_1510.

Organism-specific databases

TubercuListRv1330c.

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000001113.
KOK00763.
OMAEVYFPGS.
ProtClustDBPRK09243.

Enzyme and pathway databases

UniPathwayUPA00253; UER00457.

Family and domain databases

InterProIPR015977. Nic_PRibTrfase-like.
IPR007229. Nic_PRibTrfase-rel.
IPR006405. Nic_PRibTrfase_put.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. Q_phspho_trans. 1 hit.
TIGRFAMsTIGR01513. NAPRTase_put. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB1_MYCTU
AccessionPrimary (citable) accession number: Q10641
Secondary accession number(s): L0T9B3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 10, 2003
Last modified: May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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