Reviewed, UniProtKB/Swiss-Prot Q10641 (PNCB_MYCTU)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Ordered Locus Names:	Rv1330c, MT1372
ORF Names:	MTCY130.15c

Organism

Mycobacterium tuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Nicotinate phosphoribosyltransferase		PRO_0000103804
Experimental info
	Sequence conflict	429	1	G → A in AAK45636. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q10641-1 [UniParc]. Last modified January 10, 2003. Version 2. Checksum: E3F926EAA5835CE9	FASTA	448	47,227
	10 20 30 40 50 60 MGPPPAARRR EGEPDNQDPA GLLTDKYELT MLAAALRDGS ANRPTTFEVF ARRLPTGRRY 70 80 90 100 110 120 GVVAGTGRLL EALPQFRFDA DACELLAQFL DPATVRYLRE FRFRGDIDGY AEGELYFPGS 130 140 150 160 170 180 PVLSVRGSFA ECVLLETLVL SIFNHDTAIA SAAARMVSAA GGRPLIEMGS RRTHERAAVA 190 200 210 220 230 240 AARAAYIAGF AASSNLAAQR RYGVPAHGTA AHAFTMLHAQ HGGPTELAER AAFRAQVEAL 250 260 270 280 290 300 GPGTTLLVDT YDVTTGVANA VAAAGAELGA IRIDSGELGV LARQAREQLD RLGATRTRIV 310 320 330 340 350 360 VSGDLDEFSI AALRGEPVDS YGVGTSLVTG SGAPTANMVY KLVEVDGVPV QKRSSYKESP 370 380 390 400 410 420 GGRKEALRRS RATGTITEEL VHPAGRPPVI VEPHRVLTLP LVRAGQPVAD TSLAAARQLV 430 440 ASGLRSLPGD GLKLAPGEPA IPTRTIPA

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842576 Genomic DNA. Translation: CAA98094.2. AE000516 Genomic DNA. Translation: AAK45636.1.
PIR	F70770.
RefSeq	NP_215846.2. NP_335822.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	886884. 924689.
GenomeReviews	Gene locus MT1372 in contig AE000516_GR. Gene locus Rv1330c in contig AL123456_GR.
KEGG	mtc:MT1372. mtu:Rv1330c.
TIGR	MT1372.
Organism-specific databases
TubercuList	Rv1330c.
Phylogenomic databases
HOGENOM	Q10641.
OMA	LPEGRRY.
Family and domain databases
InterPro	IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR006405. Nic_PRibTrfase_put. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01513. NAPRTase_put. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_MYCTU

Accession

Primary (citable) accession number: Q10641

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 10, 2003
Last modified:	November 3, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)