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Q10628 (RNPH_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonuclease PH
Short name=RNase PH
EC=2.7.7.56
Alternative name(s):
tRNA nucleotidyltransferase
Gene names
Name:rph
Synonyms:rphA
Ordered Locus Names:Rv1340, MT1381
ORF Names:MTCY130.25, MTCY02B10.04
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates By similarity. HAMAP MF_00564

Catalytic activity

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. HAMAP MF_00564

Sequence similarities

Belongs to the RNase PH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Ribonuclease PH HAMAP MF_00564
PRO_0000139912

Secondary structure

1 ........................................ 259
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q10628 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: D8461B3089929F9F

FASTA25927,351
        10         20         30         40         50         60 
MSKREDGRLD HELRPVIITR GFTENPAGSV LIEFGHTKVL CTASVTEGVP RWRKATGLGW 

        70         80         90        100        110        120 
LTAEYAMLPS ATHSRSDRES VRGRLSGRTQ EISRLIGRSL RACIDLAALG ENTIAIDCDV 

       130        140        150        160        170        180 
LQADGGTRTA AITGAYVALA DAVTYLSAAG KLSDPRPLSC AIAAVSVGVV DGRIRVDLPY 

       190        200        210        220        230        240 
EEDSRAEVDM NVVATDTGTL VEIQGTGEGA TFARSTLDKL LDMALGACDT LFAAQRDALA 

       250 
LPYPGVLPQG PPPPKAFGT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842576 Genomic DNA. Translation: CAA99973.1.
AE000516 Genomic DNA. Translation: AAK45646.1.
PIRC70739.
RefSeqNP_215856.1. NC_000962.2.
NP_335832.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3B4TX-ray2.10A/B/C/D/E/F2-259[»]
ProteinModelPortalQ10628.
SMRQ10628. Positions 3-248.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000003516; EBMYCP00000003516; EBMYCG00000003514.
EBMYCT00000071385; EBMYCP00000069444; EBMYCG00000071380.
GeneID886864.
924657.
GenomeReviewsGene locus MT1381 in contig AE000516_GR.
Gene locus Rv1340 in contig AL123456_GR.
KEGGmtc:MT1381.
mtu:Rv1340.
PATRIC18124810. VBIMycTub22151_1520.
TIGRMT1381.

Organism-specific databases

TubercuListRv1340.

Phylogenomic databases

GeneTreeEBGT00050000017525.
HOGENOMHBG737187.
OMAMLPRATG.
PhylomeDBQ10628.
ProtClustDBPRK00173.

Family and domain databases

HAMAPMF_00564. RNase_PH.
[Tree]
InterProIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
KOK00989.
PfamPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMSSF55666. 3_ExoRNase. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR01966. RNasePH. 1 hit.
PROSITEPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNPH_MYCTU
AccessionPrimary (citable) accession number: Q10628
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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