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Q10588 (BST1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP-ribosyl cyclase 2

EC=3.2.2.5
Alternative name(s):
Bone marrow stromal antigen 1
Short name=BST-1
Cyclic ADP-ribose hydrolase 2
Short name=cADPr hydrolase 2
CD_antigen=CD157
Gene names
Name:BST1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Catalytic activity

NAD+ + H2O = ADP-D-ribose + nicotinamide.

Subunit structure

Homodimer.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the ADP-ribosyl cyclase family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainSignal
   LigandNAD
   Molecular functionHydrolase
   PTMDisulfide bond
Glycoprotein
GPI-anchor
Lipoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhumoral immune response

Traceable author statement Ref.1. Source: ProtInc

multicellular organismal development

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentanchored component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

extrinsic component of membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNAD+ nucleosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 293265ADP-ribosyl cyclase 2
PRO_0000004032
Propeptide294 – 31825Removed in mature form Potential
PRO_0000004033

Sites

Site1091Crucial for NAD binding and catalysis
Site1721Crucial for NAD binding and catalysis
Site2101Crucial for NAD binding and catalysis

Amino acid modifications

Lipidation2931GPI-anchor amidated alanine Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation951N-linked (GlcNAc...) Ref.8
Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1921N-linked (GlcNAc...) Ref.7
Disulfide bond51 ↔ 67
Disulfide bond83 ↔ 163
Disulfide bond144 ↔ 157
Disulfide bond238 ↔ 259
Disulfide bond271 ↔ 280

Natural variations

Natural variant771A → V.
Corresponds to variant rs2302466 [ dbSNP | Ensembl ].
VAR_028438
Natural variant1011I → V.
Corresponds to variant rs6840615 [ dbSNP | Ensembl ].
VAR_028439
Natural variant1251R → H.
Corresponds to variant rs2302465 [ dbSNP | Ensembl ].
VAR_021964
Natural variant1451R → Q.
Corresponds to variant rs2302464 [ dbSNP | Ensembl ].
VAR_021965

Experimental info

Sequence conflict361G → A in BAA04885. Ref.1

Secondary structure

............................................... 318
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q10588 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: E0DD04C89A8F4215

FASTA31835,724
        10         20         30         40         50         60 
MAAQGCAASR LLQLLLQLLL LLLLLAAGGA RARWRGEGTS AHLRDIFLGR CAEYRALLSP 

        70         80         90        100        110        120 
EQRNKNCTAI WEAFKVALDK DPCSVLPSDY DLFINLSRHS IPRDKSLFWE NSHLLVNSFA 

       130        140        150        160        170        180 
DNTRRFMPLS DVLYGRVADF LSWCRQKNDS GLDYQSCPTS EDCENNPVDS FWKRASIQYS 

       190        200        210        220        230        240 
KDSSGVIHVM LNGSEPTGAY PIKGFFADYE IPNLQKEKIT RIEIWVMHEI GGPNVESCGE 

       250        260        270        280        290        300 
GSMKVLEKRL KDMGFQYSCI NDYRPVKLLQ CVDHSTHPDC ALKSAAAATQ RKAPSLYTEQ 

       310 
RAGLIIPLFL VLASRTQL 

« Hide

References

« Hide 'large scale' references
[1]"BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth."
Kaisho T., Ishikawa J., Oritani K., Inazawa J., Tomizawa H., Muraoka O., Ochi T., Hirano T.
Proc. Natl. Acad. Sci. U.S.A. 91:5325-5329(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thalamus.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[7]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-192.
Tissue: Plasma.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-95.
Tissue: Liver.
[9]"Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities."
Yamamoto-Katayama S., Ariyoshi M., Ishihara K., Hirano T., Jingami H., Morikawa K.
J. Mol. Biol. 316:711-723(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 33-297.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D21878 mRNA. Translation: BAA04885.1.
BT019502 mRNA. Translation: AAV38309.1.
AK312497 mRNA. Translation: BAG35399.1.
AC114744 Genomic DNA. Translation: AAY40930.1.
CH471069 Genomic DNA. Translation: EAW92744.1.
BC012095 mRNA. Translation: AAH12095.1.
PIRI59301.
RefSeqNP_004325.2. NM_004334.2.
UniGeneHs.720344.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ISFX-ray2.50A/B33-297[»]
1ISGX-ray2.60A/B33-297[»]
1ISHX-ray2.40A/B33-297[»]
1ISIX-ray2.10A/B33-297[»]
1ISJX-ray2.30A/B33-297[»]
1ISMX-ray3.00A/B33-297[»]
ProteinModelPortalQ10588.
SMRQ10588. Positions 34-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107148. 2 interactions.
IntActQ10588. 1 interaction.
STRING9606.ENSP00000265016.

PTM databases

PhosphoSiteQ10588.

Polymorphism databases

DMDM116241273.

Proteomic databases

PaxDbQ10588.
PRIDEQ10588.

Protocols and materials databases

DNASU683.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265016; ENSP00000265016; ENSG00000109743.
GeneID683.
KEGGhsa:683.
UCSCuc003goh.4. human.

Organism-specific databases

CTD683.
GeneCardsGC04P015704.
HGNCHGNC:1118. BST1.
HPAHPA050121.
MIM600387. gene.
neXtProtNX_Q10588.
PharmGKBPA25435.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42584.
HOGENOMHOG000293141.
HOVERGENHBG097049.
KOK01242.
OrthoDBEOG7RBZ9B.
PhylomeDBQ10588.
TreeFamTF332530.

Gene expression databases

ArrayExpressQ10588.
BgeeQ10588.
CleanExHS_BST1.
GenevestigatorQ10588.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR10912. PTHR10912. 1 hit.
PfamPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBST1. human.
EvolutionaryTraceQ10588.
GeneWikiBST1.
GenomeRNAi683.
NextBio2812.
PROQ10588.
SOURCESearch...

Entry information

Entry nameBST1_HUMAN
AccessionPrimary (citable) accession number: Q10588
Secondary accession number(s): B2R6A2, Q5U0K0, Q96EN3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries