Reviewed,
UniProtKB/Swiss-Prot Q10587 (TEF_HUMAN)
Last modified
June 16, 2009.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Thyrotroph embryonic factor | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 303 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'. |
| Subunit structure | Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP. |
| Subcellular location | |
| Induction | Accumulates according to a robust circadian rhythm By similarity. |
| Sequence similarities | Belongs to the bZIP family. PAR subfamily. Contains 1 bZIP domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Biological rhythms Transcription Transcription regulation |
| Cellular component | Nucleus |
| Ligand | DNA-binding |
| Molecular function | Activator |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc rhythmic processInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc protein dimerization activityInferred from electronic annotation. Source: InterPro sequence-specific DNA bindingInferred from electronic annotation. Source: InterPro transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 303 | 303 | Thyrotroph embryonic factor | PRO_0000076512 | |||||
Regions | |||||||||
| Domain | 268 – 282 | 15 | Leucine-zipper | ||||||
| DNA binding | 239 – 257 | 19 | Basic motif | ||||||
| Compositional bias | 166 – 217 | 52 | Pro-rich (proline/acidic region (PAR)) | ||||||
Experimental info | |||||||||
| Sequence conflict | 54 | 1 | K → E in AAA81373. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Chromosomal localization and cDNA cloning of the human DBP and TEF genes." Khatib Z.A., Inaba T., Valentine M., Look A.T. Genomics 23:344-351(1994) [PubMed: 7835883] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties." Hunger S.P., Li S., Fall M.Z., Naumovski L., Cleary M.L. Blood 87:4607-4617(1996) [PubMed: 8639829] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. Wright H.Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [7] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-303. Tissue: Retina. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U06935 mRNA. Translation: AAA81373.1. Different initiation. U44059 mRNA. Translation: AAB06497.1. CR456592 mRNA. Translation: CAG30478.1. CR541827 mRNA. Translation: CAG46626.1. AL035659 Genomic DNA. Translation: CAI23516.1. BC039258 mRNA. Translation: AAH39258.1. BC042476 mRNA. Translation: AAH42476.1. BX537848 mRNA. Translation: CAD97856.1. | |
| IPI | IPI00216670. |
| PIR | G02360. |
| RefSeq | NP_001138870.1. NP_003207.1. |
| UniGene | Hs.181159 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q10587. |
Proteomic databases | |
| PRIDE | Q10587. |
Genome annotation databases | |
| Ensembl | ENSG00000167074. Homo sapiens. [Contig view] |
| GeneID | 7008. |
| KEGG | hsa:7008. |
Organism-specific databases | |
| GeneCards | GC22P040102. |
| H-InvDB | HIX0016516. |
| HGNC | HGNC:11722. TEF. |
| MIM | 188595. gene. |
| PharmGKB | PA36439. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q10587. |
| HOVERGEN | Q10587. |
| OMA | Q10587. WSEKKAD. |
Gene expression databases | |
| ArrayExpress | Q10587. |
| Bgee | Q10587. |
| CleanEx | HS_TEF. |
| GermOnline | ENSG00000167074. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011700. bZIP_2. IPR004827. TF_bZIP. [Graphical view] |
| Pfam | PF07716. bZIP_2. 1 hit. [Graphical view] |
| SMART | SM00338. BRLZ. 1 hit. [Graphical view] |
| PROSITE | PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 27374. |
| SOURCE | Search... |
Entry information
| Entry name | TEF_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q10587 Secondary accession number(s): Q15729 Q96TG4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 22 Human chromosome 22: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


