Reviewed, UniProtKB/Swiss-Prot Q10587 (TEF_HUMAN)

Names and origin

Protein names

Recommended name:
    Thyrotroph embryonic factor

Gene names

Name:	TEF
Synonyms:	KIAA1655

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
Subunit structure	Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.
Subcellular location	Nucleus.
Induction	Accumulates according to a robust circadian rhythm By similarity.
Sequence similarities	Belongs to the bZIP family. PAR subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Biological process	Biological rhythms Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc rhythmic process Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Thyrotroph embryonic factor		PRO_0000076512
Regions
	Domain	268 – 282	15	Leucine-zipper
	DNA binding	239 – 257	19	Basic motif
	Compositional bias	166 – 217	52	Pro-rich (proline/acidic region (PAR))
Experimental info
	Sequence conflict	54	1	K → E in AAA81373. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q10587-1 [UniParc]. Last modified August 16, 2004. Version 3. Checksum: 4A87B7BFA7248C6F	FASTA	303	33,248
	10 20 30 40 50 60 MSDAGGGKKP PVDPQAGPGP GPGRAAGERG LSGSFPLVLK KLMENPPREA RLDKEKGKEK 70 80 90 100 110 120 LEEDEAAAAS TMAVSASLMP PIWDKTIPYD GESFHLEYMD LDEFLLENGI PASPTHLAHN 130 140 150 160 170 180 LLLPVAELEG KESASSSTAS PPSSSTAIFQ PSETVSSTES SLEKERETPS PIDPNCVEVD 190 200 210 220 230 240 VNFNPDPADL VLSSVPGGEL FNPRKHKFAE EDLKPQPMIK KAKKVFVPDE QKDEKYWTRR 250 260 270 280 290 300 KKNNVAAKRS RDARRLKENQ ITIRAAFLEK ENTALRTEVA ELRKEVGKCK TIVSKYETKY GPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chromosomal localization and cDNA cloning of the human DBP and TEF genes." Khatib Z.A., Inaba T., Valentine M., Look A.T. Genomics 23:344-351(1994) [PubMed: 7835883] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties." Hunger S.P., Li S., Fall M.Z., Naumovski L., Cleary M.L. Blood 87:4607-4617(1996) [PubMed: 8639829] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-303. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U06935 mRNA. Translation: AAA81373.1. Different initiation. U44059 mRNA. Translation: AAB06497.1. CR456592 mRNA. Translation: CAG30478.1. CR541827 mRNA. Translation: CAG46626.1. AL035659 Genomic DNA. Translation: CAI23516.1. BC039258 mRNA. Translation: AAH39258.1. BC042476 mRNA. Translation: AAH42476.1. BX537848 mRNA. Translation: CAD97856.1.
IPI	IPI00216670.
PIR	G02360.
RefSeq	NP_001138870.1. NP_003207.1.
UniGene	Hs.181159
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q10587.
Proteomic databases
PRIDE	Q10587.
Genome annotation databases
Ensembl	ENSG00000167074. Homo sapiens. [Contig view]
GeneID	7008.
KEGG	hsa:7008.
Organism-specific databases
GeneCards	GC22P040102.
H-InvDB	HIX0016516.
HGNC	HGNC:11722. TEF.
MIM	188595. gene.
PharmGKB	PA36439.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q10587.
HOVERGEN	Q10587.
OMA	Q10587. WSEKKAD.
Gene expression databases
ArrayExpress	Q10587.
Bgee	Q10587.
CleanEx	HS_TEF.
GermOnline	ENSG00000167074. Homo sapiens.
Family and domain databases
InterPro	IPR011700. bZIP_2. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF07716. bZIP_2. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	27374.
SOURCE	Search...

Entry information

Entry name

TEF_HUMAN

Accession

Primary (citable) accession number: Q10587
Secondary accession number(s): Q15729 , Q7Z3J7, Q8IU94, Q96TG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	August 16, 2004
Last modified:	June 16, 2009
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)