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Q10587

- TEF_HUMAN

UniProt

Q10587 - TEF_HUMAN

Protein

Thyrotroph embryonic factor

Gene

TEF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.

    GO - Molecular functioni

    1. double-stranded DNA binding Source: Ensembl
    2. sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    3. rhythmic process Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ10587.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyrotroph embryonic factor
    Gene namesi
    Name:TEF
    Synonyms:KIAA1655
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:11722. TEF.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36439.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Thyrotroph embryonic factorPRO_0000076512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei32 – 321Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ10587.
    PRIDEiQ10587.

    PTM databases

    PhosphoSiteiQ10587.

    Expressioni

    Inductioni

    Accumulates according to a robust circadian rhythm.By similarity

    Gene expression databases

    ArrayExpressiQ10587.
    BgeeiQ10587.
    CleanExiHS_TEF.
    GenevestigatoriQ10587.

    Organism-specific databases

    HPAiHPA028868.

    Interactioni

    Subunit structurei

    Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.

    Protein-protein interaction databases

    IntActiQ10587. 30 interactions.
    STRINGi9606.ENSP00000266304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10587.
    SMRiQ10587. Positions 232-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini233 – 29664bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni235 – 25521Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni256 – 2638Leucine-zipperPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi166 – 21752Pro-rich (proline/acidic region (PAR))Add
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. PAR subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG323431.
    HOVERGENiHBG004983.
    InParanoidiQ10587.
    KOiK09058.
    OMAiCKNIVSK.
    OrthoDBiEOG712TZJ.
    PhylomeDBiQ10587.
    TreeFamiTF315869.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q10587-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDAGGGKKP PVDPQAGPGP GPGRAAGERG LSGSFPLVLK KLMENPPREA    50
    RLDKEKGKEK LEEDEAAAAS TMAVSASLMP PIWDKTIPYD GESFHLEYMD 100
    LDEFLLENGI PASPTHLAHN LLLPVAELEG KESASSSTAS PPSSSTAIFQ 150
    PSETVSSTES SLEKERETPS PIDPNCVEVD VNFNPDPADL VLSSVPGGEL 200
    FNPRKHKFAE EDLKPQPMIK KAKKVFVPDE QKDEKYWTRR KKNNVAAKRS 250
    RDARRLKENQ ITIRAAFLEK ENTALRTEVA ELRKEVGKCK TIVSKYETKY 300
    GPL 303
    Length:303
    Mass (Da):33,248
    Last modified:August 16, 2004 - v3
    Checksum:i4A87B7BFA7248C6F
    GO
    Isoform 2 (identifier: Q10587-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-52: MSDAGGGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENPPREARL → MDMPEVLKSLLEHSLPWPEKRT

    Note: No experimental confirmation available.

    Show »
    Length:273
    Mass (Da):30,635
    Checksum:iB1A956839CBC4AC4
    GO

    Sequence cautioni

    The sequence AAA81373.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541K → E in AAA81373. (PubMed:7835883)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5252MSDAG…REARL → MDMPEVLKSLLEHSLPWPEK RT in isoform 2. 1 PublicationVSP_041376Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06935 mRNA. Translation: AAA81373.1. Different initiation.
    U44059 mRNA. Translation: AAB06497.1.
    CR456592 mRNA. Translation: CAG30478.1.
    CR541827 mRNA. Translation: CAG46626.1.
    AK091916 mRNA. Translation: BAG52441.1.
    AK314906 mRNA. Translation: BAG37419.1.
    AL035659 Genomic DNA. Translation: CAI23516.1.
    AL035659 Genomic DNA. Translation: CAQ08872.1.
    CH471095 Genomic DNA. Translation: EAW60430.1.
    CH471095 Genomic DNA. Translation: EAW60431.1.
    BC039258 mRNA. Translation: AAH39258.1.
    BC042476 mRNA. Translation: AAH42476.1.
    BX537848 mRNA. Translation: CAD97856.1.
    CCDSiCCDS14014.1. [Q10587-1]
    CCDS46716.1. [Q10587-2]
    PIRiG02360.
    RefSeqiNP_001138870.1. NM_001145398.2. [Q10587-2]
    NP_003207.1. NM_003216.3. [Q10587-1]
    UniGeneiHs.181159.

    Genome annotation databases

    EnsembliENST00000266304; ENSP00000266304; ENSG00000167074. [Q10587-1]
    ENST00000406644; ENSP00000385256; ENSG00000167074. [Q10587-2]
    GeneIDi7008.
    KEGGihsa:7008.
    UCSCiuc003azx.4. human. [Q10587-2]
    uc003azy.4. human. [Q10587-1]

    Polymorphism databases

    DMDMi51338730.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06935 mRNA. Translation: AAA81373.1 . Different initiation.
    U44059 mRNA. Translation: AAB06497.1 .
    CR456592 mRNA. Translation: CAG30478.1 .
    CR541827 mRNA. Translation: CAG46626.1 .
    AK091916 mRNA. Translation: BAG52441.1 .
    AK314906 mRNA. Translation: BAG37419.1 .
    AL035659 Genomic DNA. Translation: CAI23516.1 .
    AL035659 Genomic DNA. Translation: CAQ08872.1 .
    CH471095 Genomic DNA. Translation: EAW60430.1 .
    CH471095 Genomic DNA. Translation: EAW60431.1 .
    BC039258 mRNA. Translation: AAH39258.1 .
    BC042476 mRNA. Translation: AAH42476.1 .
    BX537848 mRNA. Translation: CAD97856.1 .
    CCDSi CCDS14014.1. [Q10587-1 ]
    CCDS46716.1. [Q10587-2 ]
    PIRi G02360.
    RefSeqi NP_001138870.1. NM_001145398.2. [Q10587-2 ]
    NP_003207.1. NM_003216.3. [Q10587-1 ]
    UniGenei Hs.181159.

    3D structure databases

    ProteinModelPortali Q10587.
    SMRi Q10587. Positions 232-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q10587. 30 interactions.
    STRINGi 9606.ENSP00000266304.

    PTM databases

    PhosphoSitei Q10587.

    Polymorphism databases

    DMDMi 51338730.

    Proteomic databases

    PaxDbi Q10587.
    PRIDEi Q10587.

    Protocols and materials databases

    DNASUi 7008.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266304 ; ENSP00000266304 ; ENSG00000167074 . [Q10587-1 ]
    ENST00000406644 ; ENSP00000385256 ; ENSG00000167074 . [Q10587-2 ]
    GeneIDi 7008.
    KEGGi hsa:7008.
    UCSCi uc003azx.4. human. [Q10587-2 ]
    uc003azy.4. human. [Q10587-1 ]

    Organism-specific databases

    CTDi 7008.
    GeneCardsi GC22P041763.
    HGNCi HGNC:11722. TEF.
    HPAi HPA028868.
    MIMi 188595. gene.
    neXtProti NX_Q10587.
    PharmGKBi PA36439.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323431.
    HOVERGENi HBG004983.
    InParanoidi Q10587.
    KOi K09058.
    OMAi CKNIVSK.
    OrthoDBi EOG712TZJ.
    PhylomeDBi Q10587.
    TreeFami TF315869.

    Enzyme and pathway databases

    SignaLinki Q10587.

    Miscellaneous databases

    ChiTaRSi TEF. human.
    GeneWikii TEF_(gene).
    GenomeRNAii 7008.
    NextBioi 27374.
    PROi Q10587.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q10587.
    Bgeei Q10587.
    CleanExi HS_TEF.
    Genevestigatori Q10587.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization and cDNA cloning of the human DBP and TEF genes."
      Khatib Z.A., Inaba T., Valentine M., Look A.T.
      Genomics 23:344-351(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties."
      Hunger S.P., Li S., Fall M.Z., Naumovski L., Cleary M.L.
      Blood 87:4607-4617(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum and Kidney.
    6. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-303.
      Tissue: Retina.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiTEF_HUMAN
    AccessioniPrimary (citable) accession number: Q10587
    Secondary accession number(s): B0QYS8
    , B2RC22, Q15729, Q7Z3J7, Q8IU94, Q96TG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3