ID   DBP_HUMAN               Reviewed;         325 AA.
AC   Q10586;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   07-JUL-2009, entry version 74.
DE   RecName: Full=D site-binding protein;
DE   AltName: Full=Albumin D box-binding protein;
DE   AltName: Full=Albumin D-element-binding protein;
DE   AltName: Full=TAXREB302;
GN   Name=DBP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=95137580; PubMed=7835883; DOI=10.1006/geno.1994.1510;
RA   Khatib Z.A., Inaba T., Valentine M., Look A.T.;
RT   "Chromosomal localization and cDNA cloning of the human DBP and TEF
RT   genes.";
RL   Genomics 23:344-351(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96374825; PubMed=8786133; DOI=10.1006/geno.1996.0295;
RA   Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R.;
RT   "Genomic structure of the human D-site binding protein (DBP) gene.";
RL   Genomics 34:334-339(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=97264341; PubMed=9110174;
RA   Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
RA   Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
RT   "Large-scale concatenation cDNA sequencing.";
RL   Genome Res. 7:353-358(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
RX   MEDLINE=93246252; PubMed=8482542; DOI=10.1016/0378-1119(93)90375-D;
RA   Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K.;
RT   "Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is
RT   specific for the tax-responsive enhancer of HTLV-I.";
RL   Gene 126:251-255(1993).
RN   [7]
RP   SEQUENCE REVISION.
RA   Nyunoya H.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   REVIEW.
RX   MEDLINE=99439627; PubMed=10508692; DOI=10.1016/S0959-437X(99)00009-X;
RA   Brown S.A., Schibler U.;
RT   "The ins and outs of circadian timekeeping.";
RL   Curr. Opin. Genet. Dev. 9:588-594(1999).
CC   -!- FUNCTION: This transcriptional activator recognizes and binds to
CC       the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such
CC       as albumin, CYP2A4 and CYP2A5. It is not essential for circadian
CC       rhythm generation, but modulates important clock output genes. May
CC       be a direct target for regulation by the circadian pacemaker
CC       component clock. May affect circadian period and sleep regulation.
CC   -!- SUBUNIT: Binds DNA as a homodimer or a heterodimer. Can form a
CC       heterodimer with TEF.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in the
CC       suprachiasmatic nuclei (SCN) and in most peripheral tissues, with
CC       a strong circadian rhythmicity.
CC   -!- SIMILARITY: Belongs to the bZIP family. PAR subfamily.
CC   -!- SIMILARITY: Contains 1 bZIP domain.
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DR   EMBL; U06936; AAA81374.1; -; mRNA.
DR   EMBL; U48213; AAB18668.1; -; Genomic_DNA.
DR   EMBL; U48212; AAB18668.1; JOINED; Genomic_DNA.
DR   EMBL; U79283; AAB50219.1; -; mRNA.
DR   EMBL; BT006836; AAP35482.1; -; mRNA.
DR   EMBL; BC011965; AAH11965.1; -; mRNA.
DR   EMBL; D28468; BAA05833.1; -; mRNA.
DR   IPI; IPI00305559; -.
DR   PIR; A55558; A55558.
DR   RefSeq; NP_001343.2; -.
DR   UniGene; Hs.414480; -.
DR   UniGene; Hs.528006; -.
DR   PRIDE; Q10586; -.
DR   Ensembl; ENSG00000105516; Homo sapiens.
DR   GeneID; 1628; -.
DR   KEGG; hsa:1628; -.
DR   UCSC; uc002pjx.2; human.
DR   GeneCards; GC19M053825; -.
DR   H-InvDB; HIX0015298; -.
DR   HGNC; HGNC:2697; DBP.
DR   MIM; 124097; gene.
DR   PharmGKB; PA27165; -.
DR   HOGENOM; Q10586; -.
DR   HOVERGEN; Q10586; -.
DR   OMA; Q10586; FAPLLWE.
DR   NextBio; 6680; -.
DR   ArrayExpress; Q10586; -.
DR   Bgee; Q10586; -.
DR   CleanEx; HS_DBP; -.
DR   GermOnline; ENSG00000105516; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0003702; F:RNA polymerase II transcription factor acti...; TAS:ProtInc.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription from RNA polyme...; TAS:ProtInc.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR011700; bZIP_2.
DR   InterPro; IPR004827; TF_bZIP.
DR   Pfam; PF07716; bZIP_2; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Activator; Biological rhythms; Complete proteome; DNA-binding;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN         1    325       D site-binding protein.
FT                                /FTId=PRO_0000076507.
FT   DOMAIN      290    304       Leucine-zipper.
FT   DNA_BIND    258    277       Basic motif.
FT   COMPBIAS    129    135       Poly-Pro.
FT   COMPBIAS    188    239       Pro-rich (proline/acidic region (PAR)).
FT   CONFLICT    179    179       S -> T (in Ref. 1; AAA81374).
FT   CONFLICT    245    245       R -> K (in Ref. 6; BAA05833).
SQ   SEQUENCE   325 AA;  34349 MW;  A6933CE21399ECF3 CRC64;
     MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA
     ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD
     AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG
     HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI
     MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
     VVAVRQELSH YRAVLSRYQA QHGAL
//