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Protein

D site-binding protein

Gene

DBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL

GO - Biological processi

  1. liver development Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  3. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  4. rhythmic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
SignaLinkiQ10586.

Names & Taxonomyi

Protein namesi
Recommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Tax-responsive enhancer element-binding protein 302
Short name:
TaxREB302
Gene namesi
Name:DBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:2697. DBP.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325D site-binding proteinPRO_0000076507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ10586.
PRIDEiQ10586.

PTM databases

PhosphoSiteiQ10586.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Gene expression databases

BgeeiQ10586.
CleanExiHS_DBP.
ExpressionAtlasiQ10586. baseline and differential.
GenevestigatoriQ10586.

Organism-specific databases

HPAiHPA034999.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

Protein-protein interaction databases

BioGridi107996. 9 interactions.
IntActiQ10586. 3 interactions.
STRINGi9606.ENSP00000222122.

Structurei

3D structure databases

ProteinModelPortaliQ10586.
SMRiQ10586. Positions 228-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 31864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 27923Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni283 – 29715Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 1357Poly-Pro
Compositional biasi188 – 23952Pro-rich (proline/acidic region (PAR))Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238019.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ10586.
KOiK09056.
OMAiKEPTSCL.
OrthoDBiEOG712TZJ.
PhylomeDBiQ10586.
TreeFamiTF315869.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029830. DBP.
[Graphical view]
PANTHERiPTHR11988:SF7. PTHR11988:SF7. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10586-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK
60 70 80 90 100
EKERKAALPA ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL
110 120 130 140 150
APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGPSP EPSPARTPAP
160 170 180 190 200
SPGPGSCGSA SPRSSPGHAP ARAALGTASG HRAGLTSRDT PSPVDPDTVE
210 220 230 240 250
VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKIQVP
260 270 280 290 300
EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
310 320
VVAVRQELSH YRAVLSRYQA QHGAL
Length:325
Mass (Da):34,349
Last modified:October 1, 1996 - v1
Checksum:iA6933CE21399ECF3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791S → T in AAA81374. (PubMed:7835883)Curated
Sequence conflicti245 – 2451R → K in BAA05833. (PubMed:8482542)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06936 mRNA. Translation: AAA81374.1.
U48213, U48212 Genomic DNA. Translation: AAB18668.1.
EF015902 Genomic DNA. Translation: ABM64213.1.
U79283 mRNA. Translation: AAB50219.1.
BT006836 mRNA. Translation: AAP35482.1.
CH471177 Genomic DNA. Translation: EAW52374.1.
BC011965 mRNA. Translation: AAH11965.1.
D28468 mRNA. Translation: BAA05833.1.
CCDSiCCDS12728.1.
PIRiA55558.
RefSeqiNP_001343.2. NM_001352.4.
UniGeneiHs.414480.
Hs.528006.

Genome annotation databases

EnsembliENST00000222122; ENSP00000222122; ENSG00000105516.
GeneIDi1628.
KEGGihsa:1628.
UCSCiuc002pjx.4. human.

Polymorphism databases

DMDMi1706312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06936 mRNA. Translation: AAA81374.1.
U48213, U48212 Genomic DNA. Translation: AAB18668.1.
EF015902 Genomic DNA. Translation: ABM64213.1.
U79283 mRNA. Translation: AAB50219.1.
BT006836 mRNA. Translation: AAP35482.1.
CH471177 Genomic DNA. Translation: EAW52374.1.
BC011965 mRNA. Translation: AAH11965.1.
D28468 mRNA. Translation: BAA05833.1.
CCDSiCCDS12728.1.
PIRiA55558.
RefSeqiNP_001343.2. NM_001352.4.
UniGeneiHs.414480.
Hs.528006.

3D structure databases

ProteinModelPortaliQ10586.
SMRiQ10586. Positions 228-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107996. 9 interactions.
IntActiQ10586. 3 interactions.
STRINGi9606.ENSP00000222122.

PTM databases

PhosphoSiteiQ10586.

Polymorphism databases

DMDMi1706312.

Proteomic databases

PaxDbiQ10586.
PRIDEiQ10586.

Protocols and materials databases

DNASUi1628.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222122; ENSP00000222122; ENSG00000105516.
GeneIDi1628.
KEGGihsa:1628.
UCSCiuc002pjx.4. human.

Organism-specific databases

CTDi1628.
GeneCardsiGC19M049133.
HGNCiHGNC:2697. DBP.
HPAiHPA034999.
MIMi124097. gene.
neXtProtiNX_Q10586.
PharmGKBiPA27165.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238019.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ10586.
KOiK09056.
OMAiKEPTSCL.
OrthoDBiEOG712TZJ.
PhylomeDBiQ10586.
TreeFamiTF315869.

Enzyme and pathway databases

ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
SignaLinkiQ10586.

Miscellaneous databases

GeneWikiiDBP_(gene).
GenomeRNAii1628.
NextBioi6680.
PROiQ10586.
SOURCEiSearch...

Gene expression databases

BgeeiQ10586.
CleanExiHS_DBP.
ExpressionAtlasiQ10586. baseline and differential.
GenevestigatoriQ10586.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029830. DBP.
[Graphical view]
PANTHERiPTHR11988:SF7. PTHR11988:SF7. 1 hit.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal localization and cDNA cloning of the human DBP and TEF genes."
    Khatib Z.A., Inaba T., Valentine M., Look A.T.
    Genomics 23:344-351(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic structure of the human D-site binding protein (DBP) gene."
    Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R.
    Genomics 34:334-339(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Large-scale concatenation cDNA sequencing."
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  8. "Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I."
    Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K.
    Gene 126:251-255(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
  9. Nyunoya H.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  10. Cited for: REVIEW.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiDBP_HUMAN
AccessioniPrimary (citable) accession number: Q10586
Secondary accession number(s): A2I2P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.