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Protein

D site-binding protein

Gene

DBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105516-MONOMER.
ReactomeiR-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
SignaLinkiQ10586.

Names & Taxonomyi

Protein namesi
Recommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Tax-responsive enhancer element-binding protein 302
Short name:
TaxREB302
Gene namesi
Name:DBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:2697. DBP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1628.
OpenTargetsiENSG00000105516.
PharmGKBiPA27165.

Polymorphism and mutation databases

BioMutaiDBP.
DMDMi1706312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765071 – 325D site-binding proteinAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ10586.
PaxDbiQ10586.
PeptideAtlasiQ10586.
PRIDEiQ10586.

PTM databases

iPTMnetiQ10586.
PhosphoSitePlusiQ10586.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Gene expression databases

BgeeiENSG00000105516.
CleanExiHS_DBP.
ExpressionAtlasiQ10586. baseline and differential.
GenevisibleiQ10586. HS.

Organism-specific databases

HPAiHPA034999.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

Protein-protein interaction databases

BioGridi107996. 11 interactors.
IntActiQ10586. 3 interactors.
STRINGi9606.ENSP00000222122.

Structurei

3D structure databases

ProteinModelPortaliQ10586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 318bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni257 – 279Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni283 – 297Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 135Poly-Pro7
Compositional biasi188 – 239Pro-rich (proline/acidic region (PAR))Add BLAST52

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ10586.
KOiK09056.
OMAiKEPTSCL.
OrthoDBiEOG091G0EO0.
PhylomeDBiQ10586.
TreeFamiTF315869.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029830. DBP.
[Graphical view]
PANTHERiPTHR11988:SF7. PTHR11988:SF7. 2 hits.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK
60 70 80 90 100
EKERKAALPA ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL
110 120 130 140 150
APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGPSP EPSPARTPAP
160 170 180 190 200
SPGPGSCGSA SPRSSPGHAP ARAALGTASG HRAGLTSRDT PSPVDPDTVE
210 220 230 240 250
VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKIQVP
260 270 280 290 300
EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
310 320
VVAVRQELSH YRAVLSRYQA QHGAL
Length:325
Mass (Da):34,349
Last modified:October 1, 1996 - v1
Checksum:iA6933CE21399ECF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179S → T in AAA81374 (PubMed:7835883).Curated1
Sequence conflicti245R → K in BAA05833 (PubMed:8482542).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06936 mRNA. Translation: AAA81374.1.
U48213, U48212 Genomic DNA. Translation: AAB18668.1.
EF015902 Genomic DNA. Translation: ABM64213.1.
U79283 mRNA. Translation: AAB50219.1.
BT006836 mRNA. Translation: AAP35482.1.
CH471177 Genomic DNA. Translation: EAW52374.1.
BC011965 mRNA. Translation: AAH11965.1.
D28468 mRNA. Translation: BAA05833.1.
CCDSiCCDS12728.1.
PIRiA55558.
RefSeqiNP_001343.2. NM_001352.4.
UniGeneiHs.414480.
Hs.528006.

Genome annotation databases

EnsembliENST00000222122; ENSP00000222122; ENSG00000105516.
GeneIDi1628.
KEGGihsa:1628.
UCSCiuc002pjx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06936 mRNA. Translation: AAA81374.1.
U48213, U48212 Genomic DNA. Translation: AAB18668.1.
EF015902 Genomic DNA. Translation: ABM64213.1.
U79283 mRNA. Translation: AAB50219.1.
BT006836 mRNA. Translation: AAP35482.1.
CH471177 Genomic DNA. Translation: EAW52374.1.
BC011965 mRNA. Translation: AAH11965.1.
D28468 mRNA. Translation: BAA05833.1.
CCDSiCCDS12728.1.
PIRiA55558.
RefSeqiNP_001343.2. NM_001352.4.
UniGeneiHs.414480.
Hs.528006.

3D structure databases

ProteinModelPortaliQ10586.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107996. 11 interactors.
IntActiQ10586. 3 interactors.
STRINGi9606.ENSP00000222122.

PTM databases

iPTMnetiQ10586.
PhosphoSitePlusiQ10586.

Polymorphism and mutation databases

BioMutaiDBP.
DMDMi1706312.

Proteomic databases

EPDiQ10586.
PaxDbiQ10586.
PeptideAtlasiQ10586.
PRIDEiQ10586.

Protocols and materials databases

DNASUi1628.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222122; ENSP00000222122; ENSG00000105516.
GeneIDi1628.
KEGGihsa:1628.
UCSCiuc002pjx.5. human.

Organism-specific databases

CTDi1628.
DisGeNETi1628.
GeneCardsiDBP.
HGNCiHGNC:2697. DBP.
HPAiHPA034999.
MIMi124097. gene.
neXtProtiNX_Q10586.
OpenTargetsiENSG00000105516.
PharmGKBiPA27165.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3119. Eukaryota.
ENOG410YJ8G. LUCA.
GeneTreeiENSGT00440000039070.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ10586.
KOiK09056.
OMAiKEPTSCL.
OrthoDBiEOG091G0EO0.
PhylomeDBiQ10586.
TreeFamiTF315869.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105516-MONOMER.
ReactomeiR-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
SignaLinkiQ10586.

Miscellaneous databases

GeneWikiiDBP_(gene).
GenomeRNAii1628.
PROiQ10586.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105516.
CleanExiHS_DBP.
ExpressionAtlasiQ10586. baseline and differential.
GenevisibleiQ10586. HS.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029830. DBP.
[Graphical view]
PANTHERiPTHR11988:SF7. PTHR11988:SF7. 2 hits.
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBP_HUMAN
AccessioniPrimary (citable) accession number: Q10586
Secondary accession number(s): A2I2P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.