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Reviewed, UniProtKB/Swiss-Prot Q10586 (DBP_HUMAN)

Last modified June 16, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    D site-binding protein
Alternative name(s):
    Albumin D box-binding protein
    Albumin D-element-binding protein
    TAXREB302
Gene names
Name: DBP
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

Subunit structure

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

Subcellular location

Nucleus.

Tissue specificity

Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Sequence similarities

Belongs to the bZIP family. PAR subfamily.

Contains 1 bZIP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325D site-binding protein
PRO_0000076507

Regions

Domain290 – 30415Leucine-zipper
DNA binding258 – 27720Basic motif
Compositional bias129 – 1357Poly-Pro
Compositional bias188 – 23952Pro-rich (proline/acidic region (PAR))

Experimental info

Sequence conflict1791S → T in AAA81374. Ref.1
Sequence conflict2451R → K in BAA05833. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q10586-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A6933CE21399ECF3

FASTA32534,349
        10         20         30         40         50         60 
MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA 

        70         80         90        100        110        120 
ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD 

       130        140        150        160        170        180 
AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG 

       190        200        210        220        230        240 
HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI 

       250        260        270        280        290        300 
MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 

       310        320 
VVAVRQELSH YRAVLSRYQA QHGAL 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal localization and cDNA cloning of the human DBP and TEF genes."
Khatib Z.A., Inaba T., Valentine M., Look A.T.
Genomics 23:344-351(1994) [PubMed: 7835883] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure of the human D-site binding protein (DBP) gene."
Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R.
Genomics 34:334-339(1996) [PubMed: 8786133] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Large-scale concatenation cDNA sequencing."
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
Genome Res. 7:353-358(1997) [PubMed: 9110174] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[6]"Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I."
Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K.
Gene 126:251-255(1993) [PubMed: 8482542] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
[7]Nyunoya H.
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[8]"The ins and outs of circadian timekeeping."
Brown S.A., Schibler U.
Curr. Opin. Genet. Dev. 9:588-594(1999) [PubMed: 10508692] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

U06936 mRNA. Translation: AAA81374.1.
U48213, U48212 Genomic DNA. Translation: AAB18668.1.
U79283 mRNA. Translation: AAB50219.1.
BT006836 mRNA. Translation: AAP35482.1.
BC011965 mRNA. Translation: AAH11965.1.
D28468 mRNA. Translation: BAA05833.1.
IPIIPI00305559.
PIRA55558.
RefSeqNP_001343.2.
UniGeneHs.414480
Hs.528006

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ10586.

Genome annotation databases

EnsemblENSG00000105516. Homo sapiens. [Contig view]
GeneID1628.
KEGGhsa:1628.

Organism-specific databases

GeneCardsGC19M053825.
H-InvDBHIX0015298.
HGNCHGNC:2697. DBP.
MIM124097. gene.
PharmGKBPA27165.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ10586.
HOVERGENQ10586.
OMAQ10586. FAPLLWE.

Gene expression databases

ArrayExpressQ10586.
BgeeQ10586.
CleanExHS_DBP.
GermOnlineENSG00000105516. Homo sapiens.

Family and domain databases

InterProIPR011700. bZIP_2.
IPR004827. TF_bZIP.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio6680.
SOURCESearch...

Entry information

Entry nameDBP_HUMAN
AccessionPrimary (citable) accession number: Q10586
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents