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Q10586

- DBP_HUMAN

UniProt

Q10586 - DBP_HUMAN

Protein

D site-binding protein

Gene

DBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL

    GO - Biological processi

    1. liver development Source: Ensembl
    2. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    3. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    4. rhythmic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    SignaLinkiQ10586.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D site-binding protein
    Alternative name(s):
    Albumin D box-binding protein
    Albumin D-element-binding protein
    Tax-responsive enhancer element-binding protein 302
    Short name:
    TaxREB302
    Gene namesi
    Name:DBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:2697. DBP.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27165.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325D site-binding proteinPRO_0000076507Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei86 – 861Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ10586.
    PRIDEiQ10586.

    PTM databases

    PhosphoSiteiQ10586.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

    Gene expression databases

    ArrayExpressiQ10586.
    BgeeiQ10586.
    CleanExiHS_DBP.
    GenevestigatoriQ10586.

    Organism-specific databases

    HPAiHPA034999.

    Interactioni

    Subunit structurei

    Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

    Protein-protein interaction databases

    BioGridi107996. 9 interactions.
    IntActiQ10586. 3 interactions.
    STRINGi9606.ENSP00000222122.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10586.
    SMRiQ10586. Positions 228-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini255 – 31864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni257 – 27923Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni283 – 29715Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi129 – 1357Poly-Pro
    Compositional biasi188 – 23952Pro-rich (proline/acidic region (PAR))Add
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. PAR subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238019.
    HOGENOMiHOG000234383.
    HOVERGENiHBG004983.
    InParanoidiQ10586.
    KOiK09056.
    OMAiKEPTSCL.
    OrthoDBiEOG712TZJ.
    PhylomeDBiQ10586.
    TreeFamiTF315869.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10586-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK    50
    EKERKAALPA ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL 100
    APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGPSP EPSPARTPAP 150
    SPGPGSCGSA SPRSSPGHAP ARAALGTASG HRAGLTSRDT PSPVDPDTVE 200
    VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKIQVP 250
    EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 300
    VVAVRQELSH YRAVLSRYQA QHGAL 325
    Length:325
    Mass (Da):34,349
    Last modified:October 1, 1996 - v1
    Checksum:iA6933CE21399ECF3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti179 – 1791S → T in AAA81374. (PubMed:7835883)Curated
    Sequence conflicti245 – 2451R → K in BAA05833. (PubMed:8482542)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06936 mRNA. Translation: AAA81374.1.
    U48213, U48212 Genomic DNA. Translation: AAB18668.1.
    EF015902 Genomic DNA. Translation: ABM64213.1.
    U79283 mRNA. Translation: AAB50219.1.
    BT006836 mRNA. Translation: AAP35482.1.
    CH471177 Genomic DNA. Translation: EAW52374.1.
    BC011965 mRNA. Translation: AAH11965.1.
    D28468 mRNA. Translation: BAA05833.1.
    CCDSiCCDS12728.1.
    PIRiA55558.
    RefSeqiNP_001343.2. NM_001352.4.
    UniGeneiHs.414480.
    Hs.528006.

    Genome annotation databases

    EnsembliENST00000222122; ENSP00000222122; ENSG00000105516.
    GeneIDi1628.
    KEGGihsa:1628.
    UCSCiuc002pjx.4. human.

    Polymorphism databases

    DMDMi1706312.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06936 mRNA. Translation: AAA81374.1 .
    U48213 , U48212 Genomic DNA. Translation: AAB18668.1 .
    EF015902 Genomic DNA. Translation: ABM64213.1 .
    U79283 mRNA. Translation: AAB50219.1 .
    BT006836 mRNA. Translation: AAP35482.1 .
    CH471177 Genomic DNA. Translation: EAW52374.1 .
    BC011965 mRNA. Translation: AAH11965.1 .
    D28468 mRNA. Translation: BAA05833.1 .
    CCDSi CCDS12728.1.
    PIRi A55558.
    RefSeqi NP_001343.2. NM_001352.4.
    UniGenei Hs.414480.
    Hs.528006.

    3D structure databases

    ProteinModelPortali Q10586.
    SMRi Q10586. Positions 228-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107996. 9 interactions.
    IntActi Q10586. 3 interactions.
    STRINGi 9606.ENSP00000222122.

    PTM databases

    PhosphoSitei Q10586.

    Polymorphism databases

    DMDMi 1706312.

    Proteomic databases

    PaxDbi Q10586.
    PRIDEi Q10586.

    Protocols and materials databases

    DNASUi 1628.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222122 ; ENSP00000222122 ; ENSG00000105516 .
    GeneIDi 1628.
    KEGGi hsa:1628.
    UCSCi uc002pjx.4. human.

    Organism-specific databases

    CTDi 1628.
    GeneCardsi GC19M049133.
    HGNCi HGNC:2697. DBP.
    HPAi HPA034999.
    MIMi 124097. gene.
    neXtProti NX_Q10586.
    PharmGKBi PA27165.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238019.
    HOGENOMi HOG000234383.
    HOVERGENi HBG004983.
    InParanoidi Q10586.
    KOi K09056.
    OMAi KEPTSCL.
    OrthoDBi EOG712TZJ.
    PhylomeDBi Q10586.
    TreeFami TF315869.

    Enzyme and pathway databases

    Reactomei REACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
    SignaLinki Q10586.

    Miscellaneous databases

    GeneWikii DBP_(gene).
    GenomeRNAii 1628.
    NextBioi 6680.
    PROi Q10586.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q10586.
    Bgeei Q10586.
    CleanExi HS_DBP.
    Genevestigatori Q10586.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal localization and cDNA cloning of the human DBP and TEF genes."
      Khatib Z.A., Inaba T., Valentine M., Look A.T.
      Genomics 23:344-351(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic structure of the human D-site binding protein (DBP) gene."
      Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R.
      Genomics 34:334-339(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. NHLBI resequencing and genotyping service (RS&G)
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Large-scale concatenation cDNA sequencing."
      Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
      Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    8. "Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I."
      Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K.
      Gene 126:251-255(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
    9. Nyunoya H.
      Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    10. Cited for: REVIEW.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiDBP_HUMAN
    AccessioniPrimary (citable) accession number: Q10586
    Secondary accession number(s): A2I2P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3