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Q10586

- DBP_HUMAN

UniProt

Q10586 - DBP_HUMAN

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Protein
D site-binding protein
Gene
DBP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL

GO - Biological processi

  1. liver development Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  3. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  4. rhythmic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
SignaLinkiQ10586.

Names & Taxonomyi

Protein namesi
Recommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Tax-responsive enhancer element-binding protein 302
Short name:
TaxREB302
Gene namesi
Name:DBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:2697. DBP.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325D site-binding protein
PRO_0000076507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ10586.
PRIDEiQ10586.

PTM databases

PhosphoSiteiQ10586.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Gene expression databases

ArrayExpressiQ10586.
BgeeiQ10586.
CleanExiHS_DBP.
GenevestigatoriQ10586.

Organism-specific databases

HPAiHPA034999.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

Protein-protein interaction databases

BioGridi107996. 9 interactions.
IntActiQ10586. 3 interactions.
STRINGi9606.ENSP00000222122.

Structurei

3D structure databases

ProteinModelPortaliQ10586.
SMRiQ10586. Positions 228-313.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 31864bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 27923Basic motif By similarity
Add
BLAST
Regioni283 – 29715Leucine-zipper By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 1357Poly-Pro
Compositional biasi188 – 23952Pro-rich (proline/acidic region (PAR))
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.

Phylogenomic databases

eggNOGiNOG238019.
HOGENOMiHOG000234383.
HOVERGENiHBG004983.
InParanoidiQ10586.
KOiK09056.
OMAiKEPTSCL.
OrthoDBiEOG712TZJ.
PhylomeDBiQ10586.
TreeFamiTF315869.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10586-1 [UniParc]FASTAAdd to Basket

« Hide

MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK    50
EKERKAALPA ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL 100
APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGPSP EPSPARTPAP 150
SPGPGSCGSA SPRSSPGHAP ARAALGTASG HRAGLTSRDT PSPVDPDTVE 200
VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKIQVP 250
EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 300
VVAVRQELSH YRAVLSRYQA QHGAL 325
Length:325
Mass (Da):34,349
Last modified:October 1, 1996 - v1
Checksum:iA6933CE21399ECF3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791S → T in AAA81374. 1 Publication
Sequence conflicti245 – 2451R → K in BAA05833. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06936 mRNA. Translation: AAA81374.1.
U48213, U48212 Genomic DNA. Translation: AAB18668.1.
EF015902 Genomic DNA. Translation: ABM64213.1.
U79283 mRNA. Translation: AAB50219.1.
BT006836 mRNA. Translation: AAP35482.1.
CH471177 Genomic DNA. Translation: EAW52374.1.
BC011965 mRNA. Translation: AAH11965.1.
D28468 mRNA. Translation: BAA05833.1.
CCDSiCCDS12728.1.
PIRiA55558.
RefSeqiNP_001343.2. NM_001352.4.
UniGeneiHs.414480.
Hs.528006.

Genome annotation databases

EnsembliENST00000222122; ENSP00000222122; ENSG00000105516.
GeneIDi1628.
KEGGihsa:1628.
UCSCiuc002pjx.4. human.

Polymorphism databases

DMDMi1706312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U06936 mRNA. Translation: AAA81374.1 .
U48213 , U48212 Genomic DNA. Translation: AAB18668.1 .
EF015902 Genomic DNA. Translation: ABM64213.1 .
U79283 mRNA. Translation: AAB50219.1 .
BT006836 mRNA. Translation: AAP35482.1 .
CH471177 Genomic DNA. Translation: EAW52374.1 .
BC011965 mRNA. Translation: AAH11965.1 .
D28468 mRNA. Translation: BAA05833.1 .
CCDSi CCDS12728.1.
PIRi A55558.
RefSeqi NP_001343.2. NM_001352.4.
UniGenei Hs.414480.
Hs.528006.

3D structure databases

ProteinModelPortali Q10586.
SMRi Q10586. Positions 228-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107996. 9 interactions.
IntActi Q10586. 3 interactions.
STRINGi 9606.ENSP00000222122.

PTM databases

PhosphoSitei Q10586.

Polymorphism databases

DMDMi 1706312.

Proteomic databases

PaxDbi Q10586.
PRIDEi Q10586.

Protocols and materials databases

DNASUi 1628.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222122 ; ENSP00000222122 ; ENSG00000105516 .
GeneIDi 1628.
KEGGi hsa:1628.
UCSCi uc002pjx.4. human.

Organism-specific databases

CTDi 1628.
GeneCardsi GC19M049133.
HGNCi HGNC:2697. DBP.
HPAi HPA034999.
MIMi 124097. gene.
neXtProti NX_Q10586.
PharmGKBi PA27165.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238019.
HOGENOMi HOG000234383.
HOVERGENi HBG004983.
InParanoidi Q10586.
KOi K09056.
OMAi KEPTSCL.
OrthoDBi EOG712TZJ.
PhylomeDBi Q10586.
TreeFami TF315869.

Enzyme and pathway databases

Reactomei REACT_111118. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
SignaLinki Q10586.

Miscellaneous databases

GeneWikii DBP_(gene).
GenomeRNAii 1628.
NextBioi 6680.
PROi Q10586.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q10586.
Bgeei Q10586.
CleanExi HS_DBP.
Genevestigatori Q10586.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF07716. bZIP_2. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chromosomal localization and cDNA cloning of the human DBP and TEF genes."
    Khatib Z.A., Inaba T., Valentine M., Look A.T.
    Genomics 23:344-351(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic structure of the human D-site binding protein (DBP) gene."
    Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R.
    Genomics 34:334-339(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Large-scale concatenation cDNA sequencing."
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  8. "Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I."
    Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K.
    Gene 126:251-255(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
  9. Nyunoya H.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  10. Cited for: REVIEW.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiDBP_HUMAN
AccessioniPrimary (citable) accession number: Q10586
Secondary accession number(s): A2I2P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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