Q10586 (DBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D site-binding protein

Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Tax-responsive enhancer element-binding protein 302
Short name=TaxREB302

Gene names

Name:

DBP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
Subunit structure	Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.
Subcellular location	Nucleus.
Tissue specificity	Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.
Sequence similarities	Belongs to the bZIP family. PAR subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Biological rhythms Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	liver development Inferred from electronic annotation. Source: Compara rhythmic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 20093779. Source: BHF-UCL RNA polymerase II regulatory region sequence-specific DNA binding Inferred from direct assay PubMed 20093779. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	D site-binding protein		PRO_0000076507
Regions
	Domain	255 – 318	64	bZIP
	Region	257 – 279	23	Basic motif By similarity
	Region	283 – 297	15	Leucine-zipper By similarity
	Compositional bias	129 – 135	7	Poly-Pro
	Compositional bias	188 – 239	52	Pro-rich (proline/acidic region (PAR))
Amino acid modifications
	Modified residue	86	1	Phosphoserine Ref.11
Experimental info
	Sequence conflict	179	1	S → T in AAA81374. Ref.1
	Sequence conflict	245	1	R → K in BAA05833. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Q10586 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: A6933CE21399ECF3	FASTA	325	34,349
	10 20 30 40 50 60 MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA 70 80 90 100 110 120 ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD 130 140 150 160 170 180 AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG 190 200 210 220 230 240 HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI 250 260 270 280 290 300 MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 310 320 VVAVRQELSH YRAVLSRYQA QHGAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chromosomal localization and cDNA cloning of the human DBP and TEF genes." Khatib Z.A., Inaba T., Valentine M., Look A.T. Genomics 23:344-351(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic structure of the human D-site binding protein (DBP) gene." Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R. Genomics 34:334-339(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	NHLBI resequencing and genotyping service (RS&G) Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Large-scale concatenation cDNA sequencing." Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[8]	"Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I." Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K. Gene 126:251-255(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
[9]	Nyunoya H. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[10]	"The ins and outs of circadian timekeeping." Brown S.A., Schibler U. Curr. Opin. Genet. Dev. 9:588-594(1999) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U06936 mRNA. Translation: AAA81374.1. U48213, U48212 Genomic DNA. Translation: AAB18668.1. EF015902 Genomic DNA. Translation: ABM64213.1. U79283 mRNA. Translation: AAB50219.1. BT006836 mRNA. Translation: AAP35482.1. CH471177 Genomic DNA. Translation: EAW52374.1. BC011965 mRNA. Translation: AAH11965.1. D28468 mRNA. Translation: BAA05833.1.
IPI	IPI00305559.
PIR	A55558.
RefSeq	NP_001343.2. NM_001352.3.
UniGene	Hs.414480. Hs.528006.
3D structure databases
ProteinModelPortal	Q10586.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q10586. 3 interactions.
STRING	9606.ENSP00000222122.
PTM databases
PhosphoSite	Q10586.
Polymorphism databases
DMDM	1706312.
Proteomic databases
PaxDb	Q10586.
PRIDE	Q10586.
Protocols and materials databases
DNASU	1628.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222122; ENSP00000222122; ENSG00000105516.
GeneID	1628.
KEGG	hsa:1628.
UCSC	uc002pjx.4. human.
Organism-specific databases
CTD	1628.
GeneCards	GC19M049133.
HGNC	HGNC:2697. DBP.
HPA	HPA034999.
MIM	124097. gene.
neXtProt	NX_Q10586.
PharmGKB	PA27165.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG238019.
HOGENOM	HOG000234383.
HOVERGEN	HBG004983.
InParanoid	Q10586.
KO	K09056.
OMA	KEPTSCL.
OrthoDB	EOG4PRSRN.
PhylomeDB	Q10586.
Enzyme and pathway databases
Reactome	REACT_24941. Circadian Clock.
Gene expression databases
Bgee	Q10586.
CleanEx	HS_DBP.
Genevestigator	Q10586.
GermOnline	ENSG00000105516. Homo sapiens.
Family and domain databases
InterPro	IPR004827. bZIP. [Graphical view]
Pfam	PF07716. bZIP_2. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1628.
NextBio	6680.
SOURCE	Search...

Entry information

Entry name

DBP_HUMAN

Accession

Primary (citable) accession number: Q10586
Secondary accession number(s): A2I2P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.