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Q10586 (DBP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Tax-responsive enhancer element-binding protein 302
Short name=TaxREB302
Gene names
Name:DBP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

Subunit structure

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

Subcellular location

Nucleus.

Tissue specificity

Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Sequence similarities

Belongs to the bZIP family. PAR subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325D site-binding protein
PRO_0000076507

Regions

Domain255 – 31864bZIP
Region257 – 27923Basic motif By similarity
Region283 – 29715Leucine-zipper By similarity
Compositional bias129 – 1357Poly-Pro
Compositional bias188 – 23952Pro-rich (proline/acidic region (PAR))

Amino acid modifications

Modified residue861Phosphoserine Ref.11

Experimental info

Sequence conflict1791S → T in AAA81374. Ref.1
Sequence conflict2451R → K in BAA05833. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q10586 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A6933CE21399ECF3

FASTA32534,349
        10         20         30         40         50         60 
MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA 

        70         80         90        100        110        120 
ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD 

       130        140        150        160        170        180 
AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG 

       190        200        210        220        230        240 
HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI 

       250        260        270        280        290        300 
MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 

       310        320 
VVAVRQELSH YRAVLSRYQA QHGAL 

« Hide

References

« Hide 'large scale' references
[1]"Chromosomal localization and cDNA cloning of the human DBP and TEF genes."
Khatib Z.A., Inaba T., Valentine M., Look A.T.
Genomics 23:344-351(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure of the human D-site binding protein (DBP) gene."
Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R.
Genomics 34:334-339(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]NHLBI resequencing and genotyping service (RS&G)
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Large-scale concatenation cDNA sequencing."
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[8]"Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I."
Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K.
Gene 126:251-255(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
[9]Nyunoya H.
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[10]"The ins and outs of circadian timekeeping."
Brown S.A., Schibler U.
Curr. Opin. Genet. Dev. 9:588-594(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06936 mRNA. Translation: AAA81374.1.
U48213, U48212 Genomic DNA. Translation: AAB18668.1.
EF015902 Genomic DNA. Translation: ABM64213.1.
U79283 mRNA. Translation: AAB50219.1.
BT006836 mRNA. Translation: AAP35482.1.
CH471177 Genomic DNA. Translation: EAW52374.1.
BC011965 mRNA. Translation: AAH11965.1.
D28468 mRNA. Translation: BAA05833.1.
CCDSCCDS12728.1.
PIRA55558.
RefSeqNP_001343.2. NM_001352.4.
UniGeneHs.414480.
Hs.528006.

3D structure databases

ProteinModelPortalQ10586.
SMRQ10586. Positions 228-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107996. 9 interactions.
IntActQ10586. 3 interactions.
STRING9606.ENSP00000222122.

PTM databases

PhosphoSiteQ10586.

Polymorphism databases

DMDM1706312.

Proteomic databases

PaxDbQ10586.
PRIDEQ10586.

Protocols and materials databases

DNASU1628.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222122; ENSP00000222122; ENSG00000105516.
GeneID1628.
KEGGhsa:1628.
UCSCuc002pjx.4. human.

Organism-specific databases

CTD1628.
GeneCardsGC19M049133.
HGNCHGNC:2697. DBP.
HPAHPA034999.
MIM124097. gene.
neXtProtNX_Q10586.
PharmGKBPA27165.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238019.
HOGENOMHOG000234383.
HOVERGENHBG004983.
InParanoidQ10586.
KOK09056.
OMAKEPTSCL.
OrthoDBEOG712TZJ.
PhylomeDBQ10586.
TreeFamTF315869.

Enzyme and pathway databases

ReactomeREACT_24941. Circadian Clock.
SignaLinkQ10586.

Gene expression databases

ArrayExpressQ10586.
BgeeQ10586.
CleanExHS_DBP.
GenevestigatorQ10586.

Family and domain databases

InterProIPR004827. bZIP.
[Graphical view]
PfamPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDBP_(gene).
GenomeRNAi1628.
NextBio6680.
PROQ10586.
SOURCESearch...

Entry information

Entry nameDBP_HUMAN
AccessionPrimary (citable) accession number: Q10586
Secondary accession number(s): A2I2P4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM