Reviewed, UniProtKB/Swiss-Prot Q10586 (DBP_HUMAN)

Names and origin

Protein names

Recommended name:
    D site-binding protein
Alternative name(s):
    Albumin D box-binding protein
    Albumin D-element-binding protein
    TAXREB302

Gene names

Name:

DBP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
Subunit structure	Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.
Subcellular location	Nucleus.
Tissue specificity	Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.
Sequence similarities	Belongs to the bZIP family. PAR subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Biological process	Biological rhythms Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	regulation of transcription from RNA polymerase II promoter Ref.2 Traceable author statement. Source: ProtInc rhythmic process Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA polymerase II transcription factor activity Ref.2 Traceable author statement. Source: ProtInc protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	D site-binding protein		PRO_0000076507
Regions
	Domain	290 – 304	15	Leucine-zipper
	DNA binding	258 – 277	20	Basic motif
	Compositional bias	129 – 135	7	Poly-Pro
	Compositional bias	188 – 239	52	Pro-rich (proline/acidic region (PAR))
Experimental info
	Sequence conflict	179	1	S → T in AAA81374. Ref.1
	Sequence conflict	245	1	R → K in BAA05833. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q10586-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: A6933CE21399ECF3	FASTA	325	34,349
	10 20 30 40 50 60 MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA 70 80 90 100 110 120 ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD 130 140 150 160 170 180 AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG 190 200 210 220 230 240 HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI 250 260 270 280 290 300 MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 310 320 VVAVRQELSH YRAVLSRYQA QHGAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chromosomal localization and cDNA cloning of the human DBP and TEF genes." Khatib Z.A., Inaba T., Valentine M., Look A.T. Genomics 23:344-351(1994) [PubMed: 7835883] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic structure of the human D-site binding protein (DBP) gene." Shutler G., Glassco T., Kang X., Korneluk R., Mueller C.R. Genomics 34:334-339(1996) [PubMed: 8786133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Large-scale concatenation cDNA sequencing." Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Genome Res. 7:353-358(1997) [PubMed: 9110174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[6]	"Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I." Nyunoya H., Morita T., Sato T., Honma S., Tsujimoto A., Shimotohno K. Gene 126:251-255(1993) [PubMed: 8482542] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-325.
[7]	Nyunoya H. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[8]	"The ins and outs of circadian timekeeping." Brown S.A., Schibler U. Curr. Opin. Genet. Dev. 9:588-594(1999) [PubMed: 10508692] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U06936 mRNA. Translation: AAA81374.1. U48213, U48212 Genomic DNA. Translation: AAB18668.1. U79283 mRNA. Translation: AAB50219.1. BT006836 mRNA. Translation: AAP35482.1. BC011965 mRNA. Translation: AAH11965.1. D28468 mRNA. Translation: BAA05833.1.
IPI	IPI00305559.
PIR	A55558.
RefSeq	NP_001343.2.
UniGene	Hs.414480 Hs.528006
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q10586.
Genome annotation databases
Ensembl	ENSG00000105516. Homo sapiens. [Contig view]
GeneID	1628.
KEGG	hsa:1628.
Organism-specific databases
GeneCards	GC19M053825.
H-InvDB	HIX0015298.
HGNC	HGNC:2697. DBP.
MIM	124097. gene.
PharmGKB	PA27165.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q10586.
HOVERGEN	Q10586.
OMA	Q10586. FAPLLWE.
Gene expression databases
ArrayExpress	Q10586.
Bgee	Q10586.
CleanEx	HS_DBP.
GermOnline	ENSG00000105516. Homo sapiens.
Family and domain databases
InterPro	IPR011700. bZIP_2. IPR004827. TF_bZIP. [Graphical view]
Pfam	PF07716. bZIP_2. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	6680.
SOURCE	Search...

Entry information

Entry name

DBP_HUMAN

Accession

Primary (citable) accession number: Q10586

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)