ID   FOX1_CAEEL              Reviewed;         415 AA.
AC   Q10572; Q22304;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2002, sequence version 2.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Sex determination protein fox-1;
DE   AltName: Full=Feminizing locus on X protein 1;
GN   Name=fox-1; ORFNames=T07D1.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=CB1489; TISSUE=Embryo;
RX   MEDLINE=95121221; PubMed=7821230;
RA   Hodgkin J., Zellan J.D., Albertson D.G.;
RT   "Identification of a candidate primary sex determination locus, fox-1,
RT   on the X chromosome of Caenorhabditis elegans.";
RL   Development 120:3681-3689(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION.
RX   PubMed=17060915; DOI=10.1038/nmeth944;
RA   Kuroyanagi H., Kobayashi T., Mitani S., Hagiwara M.;
RT   "Transgenic alternative-splicing reporters reveal tissue-specific
RT   expression profiles and regulation mechanisms in vivo.";
RL   Nat. Methods 3:909-915(2006).
RN   [4]
RP   FUNCTION, INTERACTION WITH SUP-12, AND TISSUE-SPECIFICITY.
RX   PubMed=17923701; DOI=10.1128/MCB.01508-07;
RA   Kuroyanagi H., Ohno G., Mitani S., Hagiwara M.;
RT   "The Fox-1 family and SUP-12 coordinately regulate tissue-specific
RT   alternative splicing in vivo.";
RL   Mol. Cell. Biol. 27:8612-8621(2007).
CC   -!- FUNCTION: A member of the sex determination pathway involved in
CC       making the distinction between one and two X-chromosomes. RNA-
CC       binding protein that regulates alternative splicing events by
CC       binding to 5'-UGCAUG-3' elements. Regulates alternative splicing
CC       of tissue-specific exons. Promotes binding of sup-12 to target
CC       RNA.
CC   -!- SUBUNIT: Interacts with sup-12.
CC   -!- INTERACTION:
CC       O17670:eya-1; NbExp=1; IntAct=EBI-317821, EBI-311862;
CC       Q17381:pha-4; NbExp=1; IntAct=EBI-317821, EBI-321384;
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: Detected in pharynx, intestine and in muscle
CC       from vulva and body wall. Widely expressed in early embryos before
CC       morphogenesis.
CC   -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
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DR   EMBL; U14946; AAA67723.1; -; mRNA.
DR   EMBL; U41531; AAA83161.2; -; Genomic_DNA.
DR   PIR; T16825; T16825.
DR   RefSeq; NP_508446.1; -.
DR   UniGene; Cel.6361; -.
DR   HSSP; Q61474; 2MST.
DR   SMR; Q10572; 152-240.
DR   IntAct; Q10572; 2.
DR   Ensembl; T07D1.4; Caenorhabditis elegans.
DR   GeneID; 180549; -.
DR   KEGG; cel:T07D1.4; -.
DR   WormBase; WBGene00001484; fox-1.
DR   WormPep; T07D1.4; CE25105.
DR   OMA; Q10572; VNCATAR.
DR   NextBio; 909832; -.
DR   ArrayExpress; Q10572; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0018991; P:oviposition; IMP:WormBase.
DR   InterPro; IPR012677; a_b_plait_nuc_bd.
DR   InterPro; IPR000504; RRM_RNP1.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Nucleus; RNA-binding.
FT   CHAIN         1    415       Sex determination protein fox-1.
FT                                /FTId=PRO_0000081589.
FT   DOMAIN      153    229       RRM.
FT   COMPBIAS      1    122       Gln-rich.
FT   COMPBIAS    251    354       Ala-rich.
FT   CONFLICT     97     97       Q -> R (in Ref. 1; AAA67723).
FT   CONFLICT    281    281       A -> P (in Ref. 1; AAA67723).
FT   CONFLICT    336    336       Q -> L (in Ref. 1; AAA67723).
SQ   SEQUENCE   415 AA;  44339 MW;  2792E15219454754 CRC64;
     MQALYQLSAT GAQQQNQQIP IGLSNSLLYQ QLAAHQQIAA QQHQQQLAVS AAHQTQNNIM
     LATSAPSLIN HMENSTDGKV KDDPNSDYDL QLSIQQQLAA AAQAAQMGQT QIGPQIVGQQ
     GQPVVATTAG STNGSAAVTQ PDPSTSSGPD GPKRLHVSNI PFRFRDPDLK TMFEKFGVVS
     DVEIIFNERG SKGFGFVTME RPQDAERARQ ELHGSMIEGR KIEVNCATAR VHSKKVKPTG
     GILDQMNPLM AQSALAAQAQ MNRALLLRSP LVAQSLLGRG AALIPGMQQP AFQLQAALAG
     NPLAQLQGQP LLFNAAALQT NALQQSAFGM DPAAVQAALL ANEQARFQLA AAAAQGNEYI
     MYHQAKQQEL PGRIPSSGNA SAFGEQYLSN ALATASLPSY QMNPALRTLN RFTPY
//