AP-1 complex subunit beta-1 - Homo sapiens (Human)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Amino acid modifications

Natural variations

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Protein names

Recommended name:
    AP-1 complex subunit beta-1
Alternative name(s):
    Adapter-related protein complex 1 subunit beta-1
    Adaptor protein complex AP-1 subunit beta-1
    Beta-adaptin 1
    Beta1-adaptin
    Golgi adaptor HA1/AP1 adaptin beta subunit
    Clathrin assembly protein complex 1 beta large chain

Gene names

Name:	AP1B1
Synonyms:	ADTB1, BAM22, CLAPB2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Sequence length	949 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

Function	Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subunit structure	Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).
Subcellular location	Golgi apparatus. Cytoplasmic vesicle › clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Tissue specificity	Widely expressed.
Involvement in disease	Deletion of the AP1B1 gene may play a role in the tumorigenesis of meningiomas.
Sequence similarities	Belongs to the adaptor complexes large subunit family.

Hide | Top

Keywords
Biological process	Endocytosis Protein transport Transport
Cellular component	Cytoplasmic vesicle Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell clathrin adaptor complex Inferred from electronic annotation. Source: InterPro clathrin coated vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from Experiment. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Hide | Top

Hide | Top

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 949

949

AP-1 complex subunit beta-1

PRO_0000193738

Compositional bias

576 – 725

150

Pro-rich (stalk region)

Modified residue

897

1

Phosphotyrosine Ref.3

Alternative sequence

667 – 673

7

Missing in isoform B.

VSP_000163

Hide | Top

Sequence		Length	Mass (Da)
Isoform A [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0B010DD2F29B248E Show »	FASTA	949	104,607
10 20 30 40 50 60 MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT 70 80 90 100 110 120 DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE 130 140 150 160 170 180 YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA 190 200 210 220 230 240 VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI 250 260 270 280 290 300 CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY 310 320 330 340 350 360 VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 370 380 390 400 410 420 YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK 430 440 450 460 470 480 YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 490 500 510 520 530 540 QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV 550 560 570 580 590 600 VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS 610 620 630 640 650 660 ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS VQMGAVDLLG 670 680 690 700 710 720 GGLDSLMGDE PEGIGGTNFV APPTAAVPAN LGAPIGSGLS DLFDLTSGVG TLSGSYVAPK 730 740 750 760 770 780 AVWLPAMKAK GLEISGTFTR QVGSISMDLQ LTNKALQVMT DFAIQFNRNS FGLAPAAPLQ 790 800 810 820 830 840 VHAPLSPNQT VEISLPLSTV GSVMKMEPLN NLQVAVKNNI DVFYFSTLYP LHILFVEDGK 850 860 870 880 890 900 MDRQMFLATW KDIPNENEAQ FQIRDCPLNA EAASSKLQSS NIFTVAKRNV EGQDMLYQSL 910 920 930 940 KLTNGIWVLA ELRIQPGNPS CTDLELSLKC RAPEVSQHVY QAYETILKN « Hide
Isoform B. Checksum: D8A3D4EFB0829B33 Show »	FASTA	942	103,891
10 20 30 40 50 60 MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT 70 80 90 100 110 120 DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE 130 140 150 160 170 180 YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA 190 200 210 220 230 240 VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI 250 260 270 280 290 300 CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY 310 320 330 340 350 360 VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 370 380 390 400 410 420 YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK 430 440 450 460 470 480 YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 490 500 510 520 530 540 QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV 550 560 570 580 590 600 VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS 610 620 630 640 650 660 ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS VQMGAVDLLG 670 680 690 700 710 720 GGLDSLIGGT NFVAPPTAAV PANLGAPIGS GLSDLFDLTS GVGTLSGSYV APKAVWLPAM 730 740 750 760 770 780 KAKGLEISGT FTRQVGSISM DLQLTNKALQ VMTDFAIQFN RNSFGLAPAA PLQVHAPLSP 790 800 810 820 830 840 NQTVEISLPL STVGSVMKME PLNNLQVAVK NNIDVFYFST LYPLHILFVE DGKMDRQMFL 850 860 870 880 890 900 ATWKDIPNEN EAQFQIRDCP LNAEAASSKL QSSNIFTVAK RNVEGQDMLY QSLKLTNGIW 910 920 930 940 VLAELRIQPG NPSCTDLELS LKCRAPEVSQ HVYQAYETIL KN « Hide

Hide | Top

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene." Peyrard M., Fransson I., Xie Y.-G., Han F.-Y., Ruttledge M.H., Swahn S., Collins J.E., Dunham I., Collins V.P., Dumanski J.P. Hum. Mol. Genet. 3:1393-1399(1994) [PubMed: 7987321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). Tissue: Brain.
[2]	"Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12." Peyrard M., Pan H.-Q., Kedra D., Fransson I., Swahn S., Hartman K., Clifton S.W., Roe B.A., Dumanski J.P. Genomics 36:112-117(1996) [PubMed: 8812422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-922.
[3]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-897, MASS SPECTROMETRY. Tissue: Lung.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Hide | Top

Sequence databases
	L13939 mRNA. Translation: AAC98702.1. U36268 AF379039 Genomic DNA. Translation: AAC50684.2. L48038 Genomic DNA. No translation available.
IPI	IPI00328257. IPI00413947.
PIR	I54360.
RefSeq	NP_001118.2. NP_663782.1.
UniGene	Hs.368794
3D structure databases
HSSP	HSSP built from PDB template 1GW5 based on UniProtKB P21851.
SMR	Q10567. Positions 714-949.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:24207N.
PTM databases
PhosphoSite	Q10567.
Proteomic databases
PRIDE	Q10567.
Genome annotation databases
Ensembl	ENSG00000100280. Homo sapiens. [Contig view]
GeneID	162.
KEGG	hsa:162.
Organism-specific databases
GeneCards	GC22M028048.
H-InvDB	HIX0027860.
HGNC	HGNC:554. AP1B1.
MIM	600157. gene.
PharmGKB	PA24844.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q10567.
HOVERGEN	Q10567.
Enzyme and pathway databases
Pathway_Interaction_DB	hnf3apathway. FOXA1 transcription factor network.
Reactome	REACT_11123. Membrane Trafficking. REACT_6185. HIV Infection.
Gene expression databases
ArrayExpress	Q10567.
Bgee	Q10567.
CleanEx	HS_AP1B1.
GermOnline	ENSG00000100280. Homo sapiens.
Family and domain databases
InterPro	IPR016342. AP_complex_bsu. IPR012295. b_Adaptin_TBP_C. IPR002553. Clathrin/coatomer_adapt-like_N. IPR008152. Clathrin_a/b/g-adaptin_app_Ig. IPR013037. Clathrin_b-adaptin_app_Ig-like. IPR015151. Clathrin_b-adaptin_app_sub_C. [Graphical view]
Gene3D	G3DSA:3.30.310.10. b_Adaptin_TBP_C. 1 hit. G3DSA:2.60.40.1150. Clathrin_b-adaptin_app_Ig-like. 1 hit.
Pfam	PF01602. Adaptin_N. 1 hit. PF02883. Alpha_adaptinC2. 1 hit. PF09066. B2-adapt-app_C. 1 hit. [Graphical view]
PIRSF	PIRSF002291. AP_complex_beta. 1 hit.
SMART	SM00809. Alpha_adaptinC2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	647.
SOURCE	Search...

Hide | Top

Entry name

AP1B1_HUMAN

Accession

Primary (citable) accession number: Q10567
Secondary accession number(s): P78436

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q10567-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q10567-2)

The sequence of this isoform differs from the canonical sequence as follows:
667-673: Missing.