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Q10567

- AP1B1_HUMAN

UniProt

Q10567 - AP1B1_HUMAN

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Protein
AP-1 complex subunit beta-1
Gene
AP1B1, ADTB1, BAM22, CLAPB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein kinase binding Source: ParkinsonsUK-UCL
  3. protein transporter activity Source: InterPro
  4. transporter activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. intracellular protein transport Source: InterPro
  3. membrane organization Source: Reactome
  4. post-Golgi vesicle-mediated transport Source: Reactome
  5. regulation of defense response to virus by virus Source: Reactome
  6. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
REACT_121399. MHC class II antigen presentation.
REACT_19287. Lysosome Vesicle Biogenesis.
REACT_19400. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit beta-1
Alternative name(s):
Adaptor protein complex AP-1 subunit beta-1
Adaptor-related protein complex 1 subunit beta-1
Beta-1-adaptin
Beta-adaptin 1
Clathrin assembly protein complex 1 beta large chain
Golgi adaptor HA1/AP1 adaptin beta subunit
Gene namesi
Name:AP1B1
Synonyms:ADTB1, BAM22, CLAPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:554. AP1B1.

Subcellular locationi

Golgi apparatus. Cytoplasmic vesicleclathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side
Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

GO - Cellular componenti

  1. Golgi membrane Source: Reactome
  2. clathrin adaptor complex Source: InterPro
  3. clathrin-coated vesicle membrane Source: UniProtKB-SubCell
  4. cytoplasmic vesicle membrane Source: Reactome
  5. cytosol Source: Reactome
  6. lysosomal membrane Source: Reactome
  7. trans-Golgi network membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24844.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 949948AP-1 complex subunit beta-1
PRO_0000193738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine By similarity
Modified residuei265 – 2651N6-acetyllysine By similarity
Modified residuei318 – 3181N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ10567.
PaxDbiQ10567.
PRIDEiQ10567.

PTM databases

PhosphoSiteiQ10567.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiQ10567.
BgeeiQ10567.
CleanExiHS_AP1B1.
GenevestigatoriQ10567.

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

Binary interactionsi

WithEntry#Exp.IntActNotes
Ap1m1P355853EBI-1171303,EBI-1040251From a different organism.

Protein-protein interaction databases

BioGridi106671. 38 interactions.
DIPiDIP-24207N.
IntActiQ10567. 26 interactions.
MINTiMINT-1540570.
STRINGi9606.ENSP00000350199.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 239
Helixi27 – 4216
Helixi48 – 503
Helixi51 – 555
Helixi63 – 7614
Turni77 – 793
Helixi83 – 875
Helixi88 – 947
Helixi100 – 11011
Helixi116 – 13015
Helixi135 – 15117
Helixi153 – 1597
Helixi161 – 1688
Helixi174 – 19017
Beta strandi191 – 1933
Helixi201 – 21313
Helixi216 – 22813
Helixi234 – 24411
Helixi245 – 2495
Helixi253 – 26614
Helixi267 – 2693
Helixi275 – 29016
Helixi291 – 2933
Helixi296 – 31217
Turni314 – 3196
Helixi321 – 3244
Helixi332 – 34514
Turni348 – 3503
Helixi351 – 36111
Helixi367 – 38317
Helixi387 – 39913
Helixi404 – 42017
Helixi428 – 4314
Helixi432 – 4343
Helixi442 – 45413
Turni455 – 4584
Helixi462 – 4676
Turni471 – 4755
Helixi478 – 49417
Helixi500 – 51112
Helixi517 – 53216
Helixi534 – 5407
Helixi557 – 5648
Turni565 – 5684
Helixi570 – 5745
Helixi578 – 5803

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HMYX-ray7.00B1-584[»]
4P6ZX-ray3.00B1-584[»]
ProteinModelPortaliQ10567.
SMRiQ10567. Positions 12-574, 714-949.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi576 – 725150Pro-rich (stalk region)
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5096.
HOGENOMiHOG000163270.
HOVERGENiHBG050515.
InParanoidiQ10567.
KOiK12392.
OMAiQPGNPSC.
OrthoDBiEOG7BGHK0.
PhylomeDBiQ10567.
TreeFamiTF300318.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1150. 1 hit.
3.30.310.10. 1 hit.
InterProiIPR026739. AP_beta.
IPR016342. AP_complex_bsu_1_2_4.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015151. B-adaptin_app_sub_C.
IPR012295. Beta2_adaptin/TBP_C_dom.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR013037. Clathrin_b-adaptin_app_Ig-like.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PANTHERiPTHR11134. PTHR11134. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
PF09066. B2-adapt-app_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002291. AP_complex_beta. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
SM01020. B2-adapt-app_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform A (identifier: Q10567-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL    50
FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP 100
LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD 150
INAQLVEDQG FLDTLKDLIS DSNPMVVANA VAALSEIAES HPSSNLLDLN 200
PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI CERVTPRLSH 250
ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY 300
VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN 350
IAQVLAELKE YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ 400
TKVNYVVQEA IVVIKDIFRK YPNKYESVIA TLCENLDSLD EPEARAAMIW 450
IVGEYAERID NADELLESFL EGFHDESTQV QLQLLTAIVK LFLKKPTETQ 500
ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV VLAEKPLISE 550
ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS 600
ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS 650
VQMGAVDLLG GGLDSLMGDE PEGIGGTNFV APPTAAVPAN LGAPIGSGLS 700
DLFDLTSGVG TLSGSYVAPK AVWLPAMKAK GLEISGTFTR QVGSISMDLQ 750
LTNKALQVMT DFAIQFNRNS FGLAPATPLQ VHAPLSPNQT VEISLPLSTV 800
GSVMKMEPLN NLQVAVKNNI DVFYFSTLYP LHILFVEDGK MDRQMFLATW 850
KDIPNENEAQ FQIRDCPLNA EAASSKLQSS NIFTVAKRNV EGQDMLYQSL 900
KLTNGIWVLA ELRIQPGNPS CTDLELSLKC RAPEVSQHVY QAYETILKN 949
Length:949
Mass (Da):104,637
Last modified:March 2, 2010 - v2
Checksum:iFE1BA762F9318585
GO
Isoform B (identifier: Q10567-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-673: Missing.

Show »
Length:942
Mass (Da):103,921
Checksum:i2DB97E5FBB283A38
GO
Isoform C (identifier: Q10567-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-673: Missing.
     923-925: Missing.

Show »
Length:939
Mass (Da):103,564
Checksum:iD8817293C15BD8E4
GO
Isoform 4 (identifier: Q10567-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-673: Missing.
     722-741: Missing.
     923-925: Missing.

Note: No experimental confirmation available.

Show »
Length:919
Mass (Da):101,348
Checksum:iAC046601DF0170D3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti777 – 7771T → A.4 Publications
Corresponds to variant rs2857465 [ dbSNP | Ensembl ].
VAR_062816

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei667 – 6737Missing in isoform B, isoform C and isoform 4.
VSP_000163
Alternative sequencei722 – 74120Missing in isoform 4.
VSP_044928Add
BLAST
Alternative sequencei923 – 9253Missing in isoform C and isoform 4.
VSP_038753

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13939 mRNA. Translation: AAC98702.1.
CT841508 mRNA. Translation: CAJ86438.1.
AC000041 Genomic DNA. No translation available.
AC002059 Genomic DNA. No translation available.
BC046242 mRNA. Translation: AAH46242.1.
U36268
, U36250, U36251, U36252, U36253, U36254, U36255, U36256, U36257, U36258, U36259, U36260, U36261, U36262, U36263, U36264, U36265, U36266, U36267, AF379038, AF379039 Genomic DNA. Translation: AAC50684.2.
L48038 Genomic DNA. No translation available.
CCDSiCCDS13855.1. [Q10567-1]
CCDS13856.2. [Q10567-3]
CCDS54515.1. [Q10567-4]
PIRiI54360.
RefSeqiNP_001118.3. NM_001127.3.
NP_001159491.1. NM_001166019.1.
NP_663782.2. NM_145730.2.
UniGeneiHs.368794.

Genome annotation databases

EnsembliENST00000317368; ENSP00000319361; ENSG00000100280. [Q10567-4]
ENST00000356015; ENSP00000348297; ENSG00000100280. [Q10567-2]
ENST00000357586; ENSP00000350199; ENSG00000100280. [Q10567-1]
ENST00000402502; ENSP00000386071; ENSG00000100280. [Q10567-3]
ENST00000405198; ENSP00000384194; ENSG00000100280. [Q10567-1]
ENST00000415447; ENSP00000387612; ENSG00000100280. [Q10567-3]
ENST00000432560; ENSP00000400065; ENSG00000100280. [Q10567-3]
GeneIDi162.
KEGGihsa:162.
UCSCiuc003afi.3. human. [Q10567-3]
uc003afj.3. human. [Q10567-1]

Polymorphism databases

DMDMi290457628.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13939 mRNA. Translation: AAC98702.1 .
CT841508 mRNA. Translation: CAJ86438.1 .
AC000041 Genomic DNA. No translation available.
AC002059 Genomic DNA. No translation available.
BC046242 mRNA. Translation: AAH46242.1 .
U36268
, U36250 , U36251 , U36252 , U36253 , U36254 , U36255 , U36256 , U36257 , U36258 , U36259 , U36260 , U36261 , U36262 , U36263 , U36264 , U36265 , U36266 , U36267 , AF379038 , AF379039 Genomic DNA. Translation: AAC50684.2 .
L48038 Genomic DNA. No translation available.
CCDSi CCDS13855.1. [Q10567-1 ]
CCDS13856.2. [Q10567-3 ]
CCDS54515.1. [Q10567-4 ]
PIRi I54360.
RefSeqi NP_001118.3. NM_001127.3.
NP_001159491.1. NM_001166019.1.
NP_663782.2. NM_145730.2.
UniGenei Hs.368794.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HMY X-ray 7.00 B 1-584 [» ]
4P6Z X-ray 3.00 B 1-584 [» ]
ProteinModelPortali Q10567.
SMRi Q10567. Positions 12-574, 714-949.
ModBasei Search...

Protein-protein interaction databases

BioGridi 106671. 38 interactions.
DIPi DIP-24207N.
IntActi Q10567. 26 interactions.
MINTi MINT-1540570.
STRINGi 9606.ENSP00000350199.

PTM databases

PhosphoSitei Q10567.

Polymorphism databases

DMDMi 290457628.

Proteomic databases

MaxQBi Q10567.
PaxDbi Q10567.
PRIDEi Q10567.

Protocols and materials databases

DNASUi 162.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317368 ; ENSP00000319361 ; ENSG00000100280 . [Q10567-4 ]
ENST00000356015 ; ENSP00000348297 ; ENSG00000100280 . [Q10567-2 ]
ENST00000357586 ; ENSP00000350199 ; ENSG00000100280 . [Q10567-1 ]
ENST00000402502 ; ENSP00000386071 ; ENSG00000100280 . [Q10567-3 ]
ENST00000405198 ; ENSP00000384194 ; ENSG00000100280 . [Q10567-1 ]
ENST00000415447 ; ENSP00000387612 ; ENSG00000100280 . [Q10567-3 ]
ENST00000432560 ; ENSP00000400065 ; ENSG00000100280 . [Q10567-3 ]
GeneIDi 162.
KEGGi hsa:162.
UCSCi uc003afi.3. human. [Q10567-3 ]
uc003afj.3. human. [Q10567-1 ]

Organism-specific databases

CTDi 162.
GeneCardsi GC22M029723.
HGNCi HGNC:554. AP1B1.
MIMi 600157. gene.
neXtProti NX_Q10567.
PharmGKBi PA24844.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5096.
HOGENOMi HOG000163270.
HOVERGENi HBG050515.
InParanoidi Q10567.
KOi K12392.
OMAi QPGNPSC.
OrthoDBi EOG7BGHK0.
PhylomeDBi Q10567.
TreeFami TF300318.

Enzyme and pathway databases

Reactomei REACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
REACT_121399. MHC class II antigen presentation.
REACT_19287. Lysosome Vesicle Biogenesis.
REACT_19400. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSi AP1B1. human.
GeneWikii AP1B1.
GenomeRNAii 162.
NextBioi 35514080.
PROi Q10567.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q10567.
Bgeei Q10567.
CleanExi HS_AP1B1.
Genevestigatori Q10567.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
2.60.40.1150. 1 hit.
3.30.310.10. 1 hit.
InterProi IPR026739. AP_beta.
IPR016342. AP_complex_bsu_1_2_4.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR015151. B-adaptin_app_sub_C.
IPR012295. Beta2_adaptin/TBP_C_dom.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR013037. Clathrin_b-adaptin_app_Ig-like.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view ]
PANTHERi PTHR11134. PTHR11134. 1 hit.
Pfami PF01602. Adaptin_N. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
PF09066. B2-adapt-app_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF002291. AP_complex_beta. 1 hit.
SMARTi SM00809. Alpha_adaptinC2. 1 hit.
SM01020. B2-adapt-app_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene."
    Peyrard M., Fransson I., Xie Y.-G., Han F.-Y., Ruttledge M.H., Swahn S., Collins J.E., Dunham I., Collins V.P., Dumanski J.P.
    Hum. Mol. Genet. 3:1393-1399(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), VARIANT ALA-777.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C), VARIANT ALA-777.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT ALA-777.
    Tissue: Lymph.
  5. "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12."
    Peyrard M., Pan H.-Q., Kedra D., Fransson I., Swahn S., Hartman K., Clifton S.W., Roe B.A., Dumanski J.P.
    Genomics 36:112-117(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-922, VARIANT ALA-777.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-318, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAP1B1_HUMAN
AccessioniPrimary (citable) accession number: Q10567
Secondary accession number(s): C9JRD1
, F8WDL0, P78436, Q20WL3, Q86X54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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