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Protein

Arf guanine nucleotide exchange factor sec74

Gene

sec74

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Involved in vesicular transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Arf guanine nucleotide exchange factor sec74
Gene namesi
Name:sec74
ORF Names:SPAC26F1.01, SPAPJ691.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26F1.01.
PomBaseiSPAC26F1.01. sec74.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell septum Source: UniProtKB-SubCell
  • cell tip Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202211 – 928Arf guanine nucleotide exchange factor sec74Add BLAST928

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10491.
PRIDEiQ10491.

PTM databases

iPTMnetiQ10491.

Interactioni

Protein-protein interaction databases

BioGridi278550. 15 interactors.
MINTiMINT-4699705.

Structurei

3D structure databases

ProteinModelPortaliQ10491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 420SEC7PROSITE-ProRule annotationAdd BLAST193
Domaini548 – 677PHPROSITE-ProRule annotationAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 230Ser-richAdd BLAST227

Domaini

The SEC7 domain is sufficient for nucleotide exchange activity.By similarity

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ10491.
OrthoDBiEOG092C066Z.
PhylomeDBiQ10491.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDESSRIASS SALHGLDEMV SAHKPSPPLP SRRKGKSALR SALEKKNRKS
60 70 80 90 100
KSKPKVTITS DTPKVSSQHS PVSSAYTGDS TTDLDSKSGH SSSQKLSNKV
110 120 130 140 150
SSALKLTIPK RWRSSKSSSS QCSSPFLPTS SSNGHGDDAS LNLPDKKSRP
160 170 180 190 200
SSQSSIFLSN WSTIFSSNAS PTDSQLSPTH TSTIAELAAS TLSIFPSGSY
210 220 230 240 250
AGSTFGSPSR SSIDSSTYLP RSKSVNSLSS NFSARTPASN QSSVSEDFGA
260 270 280 290 300
APNCDHKHNS VTLSDFALPD IDQHDTVETI LEKVEFTIPK QFTPAILSQG
310 320 330 340 350
TSSLLKLCLR KYLSVVNFKC ISLDMALRKF LAVYVLPNET QQIDRVLSTF
360 370 380 390 400
SDQYFHCNPD LYDSSDECYI LTFSLMILHT DFFNIHNRQK MTRAEFISNT
410 420 430 440 450
NLPTILPEIL ECFYDNITYT PFVHVEHIGC VVTSPSNEKP SLSQRLGDSQ
460 470 480 490 500
FRLTKRNTFA TESDHQALQE QLTGFRINLD SILDLKKIDS VRTSIESPTR
510 520 530 540 550
TADDLYKEFA RAPFLQIVSH RSQPQAFSYH FEPSAESEST NPAIINVKVF
560 570 580 590 600
KLGILIQNEK VRKDRLLSNR EVGVILTSSQ LMFFKNVYWI SGLLDQLEDF
610 620 630 640 650
KRSHSFSPCY FSPHLTSLSA DYIIPLSDLV AYGDGSRIEN ELYSFSVKQK
660 670 680 690 700
NQRTHVFSVT NVDELNDWLV KINFVSTFAT AGLAPRERLP CVESSDKSIK
710 720 730 740 750
ASVSVLPDIY EDSDAMSKAS KETRSEVLEC SKVRVYIVQN RIYKLEEALR
760 770 780 790 800
QGESKMTVQR RNAANILHLE PIQSRTRIRL ARCSNTLKKN MLAQMIEIQK
810 820 830 840 850
FKISIKFLKE DLEMDSHLQD YLRSVFPSSV MGKENASEDT ILESNFRNHS
860 870 880 890 900
NPSVRRSNLR VGKTVESVQN TKLKSVENDS GKAETETVGK NPEVVRKSPA
910 920
KLPNIANIMT VNGHRYSVVE LPDDFLRE
Length:928
Mass (Da):103,633
Last modified:March 27, 2002 - v2
Checksum:i6D9EA3CA411B8E80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA97358.1.
AB027773 Genomic DNA. Translation: BAA87077.1.
PIRiT38419.
RefSeqiNP_594894.2. NM_001020323.2.

Genome annotation databases

EnsemblFungiiSPAC26F1.01.1; SPAC26F1.01.1:pep; SPAC26F1.01.
GeneIDi2542073.
KEGGispo:SPAC26F1.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA97358.1.
AB027773 Genomic DNA. Translation: BAA87077.1.
PIRiT38419.
RefSeqiNP_594894.2. NM_001020323.2.

3D structure databases

ProteinModelPortaliQ10491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278550. 15 interactors.
MINTiMINT-4699705.

PTM databases

iPTMnetiQ10491.

Proteomic databases

MaxQBiQ10491.
PRIDEiQ10491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC26F1.01.1; SPAC26F1.01.1:pep; SPAC26F1.01.
GeneIDi2542073.
KEGGispo:SPAC26F1.01.

Organism-specific databases

EuPathDBiFungiDB:SPAC26F1.01.
PomBaseiSPAC26F1.01. sec74.

Phylogenomic databases

InParanoidiQ10491.
OrthoDBiEOG092C066Z.
PhylomeDBiQ10491.

Miscellaneous databases

PROiQ10491.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC74_SCHPO
AccessioniPrimary (citable) accession number: Q10491
Secondary accession number(s): Q9URW4, Q9UU74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 27, 2002
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.