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Protein

Putative leucine--tRNA ligase, cytoplasmic

Gene

lrs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei740ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:lrs1
ORF Names:SPAC26F1.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26F1.13c
PomBaseiSPAC26F1.13c lrs1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521541 – 1111Putative leucine--tRNA ligase, cytoplasmicAdd BLAST1111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei460Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10490
PaxDbiQ10490
PRIDEiQ10490

PTM databases

iPTMnetiQ10490

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC26F1.13c.1

Structurei

3D structure databases

ProteinModelPortaliQ10490
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 84"HIGH" regionAdd BLAST11
Motifi737 – 741"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000216621
InParanoidiQ10490
KOiK01869
OMAiHVTGTPI
OrthoDBiEOG092C097K
PhylomeDBiQ10490

Family and domain databases

InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q10490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTEPSVEQ LETKTAKLKL ENTTKRDTLI ELEKKYQQKW QEEKAFEVDA
60 70 80 90 100
PLEDVPIDEL RKKYPKFFGN MPYPYMNGAL HLGHAFTLSK VEFTTAFERL
110 120 130 140 150
NGKRVLFPMG FHCTGMPICA SADRLSREIE MFGPSFDVPE EKEEEVEVEV
160 170 180 190 200
KTPNAREDVT KHSGKKSKAA AKTAAVKYQF QIMESLGVPR TEIHKFADAK
210 220 230 240 250
YWLSYFPPLC QRDCTEFGLG IDWRRSFITT DVNPYYDSFV RWQVNHLHDS
260 270 280 290 300
GKIKFGERYT VYSIKDGQPC MDHDRKSGEG VGPQEYTGIK MEVLEFPEAA
310 320 330 340 350
RKALQSIDLS NKKVCMIAAT LRPETMYGQT NCYVGPNITY GIYESNVPNE
360 370 380 390 400
LFICTRRAAN NMAYQKLSKE RGVVSELGTI KGQDLIGALV NAPLSVHKQV
410 420 430 440 450
YVLPMETVLA TKGTGVVTSV PSDSPDDFAT LTELRKKAEF YHLNPEWMKY
460 470 480 490 500
EAVPIIRTPS YGDMCAEFLC KKLKIQSPKD VKQLAQAKEL AYKECFYQGT
510 520 530 540 550
MIIGKYSGEK VETAKPKVRK ELIDQGLAFV YNEPEGQVIS RSGDDCIVAL
560 570 580 590 600
CDQWFLDYGE ASWKAVTEKA LDRLNTFSPE VRNGFLKTLD WLSQWACARS
610 620 630 640 650
YGLGTRLPWD PQFLVESLTD STIYMAYYTI CHLLHSDVYG KVPGALNIKP
660 670 680 690 700
EQMTPEVWDH VFRQAPKPKN TSISDEALAR LCREFQYFYP FDIRASGKDL
710 720 730 740 750
VPNHLTFCLY THTAIFDEKY WPKGIRANGH LLMNGEKMSK STGNFMTLHE
760 770 780 790 800
ATKKFGADAT RLALADAGDT VDDANFEEAL ANSAILRLYT QEAWCKEMME
810 820 830 840 850
NLDNLRTGPY NFHDKVFENE INQLIESSRE AFSATLFKAA LKSCFYDLQN
860 870 880 890 900
ARDWYREVTA DRKMHRDLVC RWIETQVLLL ATFAPHWSEH IWLTTLKKPQ
910 920 930 940 950
SIHVSGRFPQ VSSPVNTALS NSLLYIRTLS RVIREAEAAQ LKRQKKGKGM
960 970 980 990 1000
LFDPSKPKRL TVFVAEKFPE WQAQYVALLQ KYYNESENKF DDKAIISSVD
1010 1020 1030 1040 1050
KKEMKRAMPF IQQFKQSVIN RGEHVSANSI FSRELGFNEL EVLREVKPYL
1060 1070 1080 1090 1100
VRNVGIQELR IVLLQKPADK SSAAIGLVES GSDAGATVEI APNFANTVPG
1110
QPTFLFENVS A
Length:1,111
Mass (Da):126,452
Last modified:October 1, 1996 - v1
Checksum:i88D654634F0415A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA97370.1
D89170 mRNA Translation: BAA13832.1
PIRiT38407
T42535
RefSeqiNP_594882.1, NM_001020311.2

Genome annotation databases

EnsemblFungiiSPAC26F1.13c.1; SPAC26F1.13c.1:pep; SPAC26F1.13c
GeneIDi2542670
KEGGispo:SPAC26F1.13c

Similar proteinsi

Entry informationi

Entry nameiSYLC_SCHPO
AccessioniPrimary (citable) accession number: Q10490
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health