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Q10488

- ETR1_SCHPO

UniProt

Q10488 - ETR1_SCHPO

Protein

Probable trans-2-enoyl-CoA reductase, mitochondrial

Gene

etr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei157 – 1571NADPBy similarity
    Binding sitei365 – 3651NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi183 – 1864NADPBy similarity
    Nucleotide bindingi206 – 2083NADPBy similarity
    Nucleotide bindingi279 – 2824NADPBy similarity
    Nucleotide bindingi304 – 3063NADPBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase activity, zinc-dependent Source: PomBase
    2. enoyl-[acyl-carrier-protein] reductase activity Source: PomBase
    3. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: PomBase
    2. fatty acid biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
    Gene namesi
    Name:etr1
    ORF Names:SPAC26F1.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC26F1.04c.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 372Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000903
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ10488.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4699670.
    STRINGi4896.SPAC26F1.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10488.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    HOGENOMiHOG000294683.
    KOiK07512.
    OMAiCSTLWRV.
    OrthoDBiEOG7PS1RH.
    PhylomeDBiQ10488.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10488-1 [UniParc]FASTAAdd to Basket

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    MSFFKTAVRR FSSTSITRGM AKAIAYSEYG NPKEVLRAVS YNVPKCSKNQ    50
    VNVRFLASPI NPSDINQIQG VYPSKPPFTN DVCSSKPSAV AGNEGLVEVV 100
    DVGDQFKGTF SPGQWAILGS VNLGSWRTEM NIDGRSLVPV DKSAFPSIAE 150
    AATLSVNPCT AYCLLQHVVQ LNKGDWFIQD GANSMVGIAT IQLAKHFGYK 200
    SINVVRNRPD IEKLKEQLKS LGATIVITDE ELMDRKTMKQ KVPEWIQGGE 250
    VKLGIDCVSG RVAAEMAKYM SKGATMATFG GMSRQPLPVP VSLLIFKNLK 300
    FHGFWVTKWK SEHPEEFLKI IHKVEDFYRN GTLKTVNTEL VSLKEDADEK 350
    TFLDTFLNAI EGHGKKIIKF EH 372
    Length:372
    Mass (Da):41,230
    Last modified:October 1, 1996 - v1
    Checksum:iF0ECE4624829A428
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA97361.1.
    PIRiT38416.
    RefSeqiNP_594891.1. NM_001020320.2.

    Genome annotation databases

    EnsemblFungiiSPAC26F1.04c.1; SPAC26F1.04c.1:pep; SPAC26F1.04c.
    GeneIDi2542100.
    KEGGispo:SPAC26F1.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA97361.1 .
    PIRi T38416.
    RefSeqi NP_594891.1. NM_001020320.2.

    3D structure databases

    ProteinModelPortali Q10488.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4699670.
    STRINGi 4896.SPAC26F1.04c-1.

    Proteomic databases

    MaxQBi Q10488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC26F1.04c.1 ; SPAC26F1.04c.1:pep ; SPAC26F1.04c .
    GeneIDi 2542100.
    KEGGi spo:SPAC26F1.04c.

    Organism-specific databases

    PomBasei SPAC26F1.04c.

    Phylogenomic databases

    eggNOGi COG0604.
    HOGENOMi HOG000294683.
    KOi K07512.
    OMAi CSTLWRV.
    OrthoDBi EOG7PS1RH.
    PhylomeDBi Q10488.

    Miscellaneous databases

    NextBioi 20803172.
    PROi Q10488.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiETR1_SCHPO
    AccessioniPrimary (citable) accession number: Q10488
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3