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Q10488

- ETR1_SCHPO

UniProt

Q10488 - ETR1_SCHPO

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Protein
Probable trans-2-enoyl-CoA reductase, mitochondrial
Gene
etr1, SPAC26F1.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571NADP By similarity
Binding sitei365 – 3651NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi183 – 1864NADP By similarity
Nucleotide bindingi206 – 2083NADP By similarity
Nucleotide bindingi279 – 2824NADP By similarity
Nucleotide bindingi304 – 3063NADP By similarity

GO - Molecular functioni

  1. alcohol dehydrogenase activity, zinc-dependent Source: PomBase
  2. enoyl-[acyl-carrier-protein] reductase activity Source: PomBase
  3. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: PomBase
  2. fatty acid biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:etr1
ORF Names:SPAC26F1.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC26F1.04c.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. mitochondrial matrix Source: UniProtKB-SubCell
  3. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 372Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000903
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiQ10488.

Interactioni

Protein-protein interaction databases

MINTiMINT-4699670.
STRINGi4896.SPAC26F1.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10488.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
HOGENOMiHOG000294683.
KOiK07512.
OMAiCSTLWRV.
OrthoDBiEOG7PS1RH.
PhylomeDBiQ10488.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10488-1 [UniParc]FASTAAdd to Basket

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MSFFKTAVRR FSSTSITRGM AKAIAYSEYG NPKEVLRAVS YNVPKCSKNQ    50
VNVRFLASPI NPSDINQIQG VYPSKPPFTN DVCSSKPSAV AGNEGLVEVV 100
DVGDQFKGTF SPGQWAILGS VNLGSWRTEM NIDGRSLVPV DKSAFPSIAE 150
AATLSVNPCT AYCLLQHVVQ LNKGDWFIQD GANSMVGIAT IQLAKHFGYK 200
SINVVRNRPD IEKLKEQLKS LGATIVITDE ELMDRKTMKQ KVPEWIQGGE 250
VKLGIDCVSG RVAAEMAKYM SKGATMATFG GMSRQPLPVP VSLLIFKNLK 300
FHGFWVTKWK SEHPEEFLKI IHKVEDFYRN GTLKTVNTEL VSLKEDADEK 350
TFLDTFLNAI EGHGKKIIKF EH 372
Length:372
Mass (Da):41,230
Last modified:October 1, 1996 - v1
Checksum:iF0ECE4624829A428
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA97361.1.
PIRiT38416.
RefSeqiNP_594891.1. NM_001020320.2.

Genome annotation databases

EnsemblFungiiSPAC26F1.04c.1; SPAC26F1.04c.1:pep; SPAC26F1.04c.
GeneIDi2542100.
KEGGispo:SPAC26F1.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA97361.1 .
PIRi T38416.
RefSeqi NP_594891.1. NM_001020320.2.

3D structure databases

ProteinModelPortali Q10488.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4699670.
STRINGi 4896.SPAC26F1.04c-1.

Proteomic databases

MaxQBi Q10488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC26F1.04c.1 ; SPAC26F1.04c.1:pep ; SPAC26F1.04c .
GeneIDi 2542100.
KEGGi spo:SPAC26F1.04c.

Organism-specific databases

PomBasei SPAC26F1.04c.

Phylogenomic databases

eggNOGi COG0604.
HOGENOMi HOG000294683.
KOi K07512.
OMAi CSTLWRV.
OrthoDBi EOG7PS1RH.
PhylomeDBi Q10488.

Miscellaneous databases

NextBioi 20803172.
PROi Q10488.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiETR1_SCHPO
AccessioniPrimary (citable) accession number: Q10488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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