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Protein

Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Gene

etr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NADP+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton donorBy similarity1
Binding sitei157NADPBy similarity1
Binding sitei365NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi183 – 186NADPBy similarity4
Nucleotide bindingi206 – 208NADPBy similarity3
Nucleotide bindingi279 – 282NADPBy similarity4
Nucleotide bindingi304 – 306NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-SPO-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrialBy similarity (EC:1.3.1.104By similarity)
Alternative name(s):
2-enoyl thioester reductaseBy similarity
Gene namesi
Name:etr1
ORF Names:SPAC26F1.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26F1.04c.
PomBaseiSPAC26F1.04c. etr1.

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: PomBase

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000000090319 – 372Enoyl-[acyl-carrier-protein] reductase, mitochondrialSequence analysisAdd BLAST354

Proteomic databases

MaxQBiQ10488.
PRIDEiQ10488.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4699670.

Structurei

3D structure databases

ProteinModelPortaliQ10488.
SMRiQ10488.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000294683.
InParanoidiQ10488.
KOiK07512.
OMAiAFRGFWM.
OrthoDBiEOG092C2NJA.
PhylomeDBiQ10488.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFKTAVRR FSSTSITRGM AKAIAYSEYG NPKEVLRAVS YNVPKCSKNQ
60 70 80 90 100
VNVRFLASPI NPSDINQIQG VYPSKPPFTN DVCSSKPSAV AGNEGLVEVV
110 120 130 140 150
DVGDQFKGTF SPGQWAILGS VNLGSWRTEM NIDGRSLVPV DKSAFPSIAE
160 170 180 190 200
AATLSVNPCT AYCLLQHVVQ LNKGDWFIQD GANSMVGIAT IQLAKHFGYK
210 220 230 240 250
SINVVRNRPD IEKLKEQLKS LGATIVITDE ELMDRKTMKQ KVPEWIQGGE
260 270 280 290 300
VKLGIDCVSG RVAAEMAKYM SKGATMATFG GMSRQPLPVP VSLLIFKNLK
310 320 330 340 350
FHGFWVTKWK SEHPEEFLKI IHKVEDFYRN GTLKTVNTEL VSLKEDADEK
360 370
TFLDTFLNAI EGHGKKIIKF EH
Length:372
Mass (Da):41,230
Last modified:October 1, 1996 - v1
Checksum:iF0ECE4624829A428
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA97361.1.
PIRiT38416.
RefSeqiNP_594891.1. NM_001020320.2.

Genome annotation databases

EnsemblFungiiSPAC26F1.04c.1; SPAC26F1.04c.1:pep; SPAC26F1.04c.
GeneIDi2542100.
KEGGispo:SPAC26F1.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA97361.1.
PIRiT38416.
RefSeqiNP_594891.1. NM_001020320.2.

3D structure databases

ProteinModelPortaliQ10488.
SMRiQ10488.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4699670.

Proteomic databases

MaxQBiQ10488.
PRIDEiQ10488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC26F1.04c.1; SPAC26F1.04c.1:pep; SPAC26F1.04c.
GeneIDi2542100.
KEGGispo:SPAC26F1.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC26F1.04c.
PomBaseiSPAC26F1.04c. etr1.

Phylogenomic databases

HOGENOMiHOG000294683.
InParanoidiQ10488.
KOiK07512.
OMAiAFRGFWM.
OrthoDBiEOG092C2NJA.
PhylomeDBiQ10488.

Enzyme and pathway databases

ReactomeiR-SPO-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.

Miscellaneous databases

PROiPR:Q10488.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiETR1_SCHPO
AccessioniPrimary (citable) accession number: Q10488
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 7, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.