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Q10475

- IF4G_SCHPO

UniProt

Q10475 - IF4G_SCHPO

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Protein

Eukaryotic translation initiation factor 4 gamma

Gene
tif471, SPAC17C9.03
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.1 Publication

GO - Molecular functioni

  1. protein binding Source: PomBase
  2. structural molecule activity Source: PomBase
  3. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. cytoplasmic translational initiation Source: PomBase
  2. ribosomal large subunit biogenesis Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma
Short name:
eIF-4-gamma
Short name:
eIF-4G
Gene namesi
Name:tif471
ORF Names:SPAC17C9.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC17C9.03.

Subcellular locationi

Cytoplasmperinuclear region
Note: Localized to the perinuclear region, the growing tips and septum.1 Publication

GO - Cellular componenti

  1. cytoplasmic stress granule Source: PomBase
  2. cytosol Source: PomBase
  3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14031403Eukaryotic translation initiation factor 4 gammaPRO_0000213333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphoserine1 Publication
Modified residuei452 – 4521Phosphoserine1 Publication
Modified residuei455 – 4551Phosphoserine1 Publication
Modified residuei456 – 4561Phosphoserine1 Publication
Modified residuei459 – 4591Phosphoserine1 Publication
Modified residuei866 – 8661Phosphoserine1 Publication
Modified residuei882 – 8821Phosphoserine1 Publication
Modified residuei884 – 8841Phosphothreonine1 Publication
Modified residuei886 – 8861Phosphoserine1 Publication
Modified residuei911 – 9111Phosphoserine1 Publication
Modified residuei919 – 9191Phosphoserine1 Publication
Modified residuei921 – 9211Phosphoserine1 Publication
Modified residuei923 – 9231Phosphotyrosine1 Publication
Modified residuei1333 – 13331Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10475.
PaxDbiQ10475.
PRIDEiQ10475.

Interactioni

Protein-protein interaction databases

BioGridi278758. 9 interactions.
IntActiQ10475. 2 interactions.
MINTiMINT-4699578.
STRINGi4896.SPAC17C9.03-1.

Structurei

3D structure databases

ProteinModelPortaliQ10475.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1009 – 1245237MIF4GAdd
BLAST

Sequence similaritiesi

Contains 1 MIF4G domain.

Phylogenomic databases

eggNOGiNOG301289.
KOiK03260.
OMAiSNTHSHA.
OrthoDBiEOG7VTDWG.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR022745. eIF4G1_eIF4E-bd.
IPR012969. Fibrinogen_BP.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF12152. eIF_4G1. 1 hit.
PF08017. Fibrinogen_BP. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF101489. SSF101489. 1 hit.
SSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10475-1 [UniParc]FASTAAdd to Basket

« Hide

MSSKPPSNTP KFSYARALAS SQSNKSNSTK ASENNTATAE KQAVKPSGVE     50
PTNTSRANAQ KKTESTGKIT SEADTEKYNS SKSPVNKEGS VEKKSSEKSS 100
TNNKPWRGDN TSKPSANSSA ERTSSQHQKP ETSSQIGKDN AAPVENVNEK 150
STSQETAPPV STVPIQFGSI TRNAAIPSKP KVSGNMQNKS GVSSYSSKSQ 200
SVNSSVTSNP PHTEEPVAAK PEASSTATKG PRPTTSASNT NTSPANGAPT 250
NKPSTDINTT DPATQTTQVS ASNSPALSGS STPSNTSSRS NRQNHGNFSE 300
KRHYDRYGNS HPSYNKYSHY QHGFNYNNSG NNRNESGHPR FRNSRRNYNN 350
QGAYPTYMSN GRSANQSPRN NPQNVNNGST PIQIPVSLQT PYGQVYGQPQ 400
YIVDPNMVQY GPILQPGYVP QYYPVYHQTP YTQNFPNMSR SGSQVSDQVV 450
ESPNSSTLSP RNGFAPIVKQ QKKSSALKIV NPVTHTEVVV PQKNASSPNP 500
SETNSRAETP TAAPPQISEE EASQRKDAIK LAIQQRIQEK AEAEAKRKAE 550
EKARLEAEEN AKREAEEQAK REAEEKAKRE AEEKAKREAE EKAKREAEEN 600
AKREAEEKAK REAEEKAKRE AEEKAKREAE EKAKREAEEK AKREAEEKAK 650
REAEEKAKRE AEENAKREAE EKAKREAEEN AKREAEEKVK RETEENAKRK 700
AEEEGKREAD KNPEIKSSAP LASSEANVDT SKQTNATEPE VVDKTKVEKL 750
KASEGKSTSS LSSPSHSTSS KRDLLSGLES LSLKTNPKSE QCLESLLNSQ 800
FITDFSALVY PSTIKPPSTE EALKAGKYEY DVPFLLQFQS VYTDKPMKGW 850
DERMKETVAS AFSDKSSRGM YSSSRQSSRS GSNTHSHAGP GFGGPSERKG 900
ISRLGIDRGF SSSGAGFGSG SNYKSAPSRG VSHHGHGGMS GSHRGSQRGS 950
RRGGGERDKP DPSSLTIPVD QVAPLQLSAN RWQPKKLTEK PAETKGEDEE 1000
ALLPPEVVQR KVKGSLNKMT LEKFDKISDQ ILEIAMQSRK ENDGRTLKQV 1050
IQLTFEKATD EPNFSNMYAR FARKMMDSID DSIRDEGVLD KNNQPVRGGL 1100
LFRKYLLSRC QEDFERGWKA NLPSGKAGEA EIMSDEYYVA AAIKRRGLGL 1150
VRFIGELFKL SMLSEKIMHE CIKRLLGNVT DPEEEEIESL CRLLMTVGVN 1200
IDATEKGHAA MDVYVLRMET ITKIPNLPSR IKFMLMDVMD SRKNGWAVKN 1250
EVEKGPKTIA EIHEEAERKK ALAESQRPSS GRMHGRDMNR GDSRMGGRGS 1300
NPPFSSSDWS NNKDGYARLG QGIRGLKSGT QGSHGPTSLS SMLKGGSVSR 1350
TPSRQNSALR REQSVRAPPS NVAVTSANSF ELLEEHDHDN DGGQKDSNSK 1400
TSS 1403
Length:1,403
Mass (Da):154,035
Last modified:October 1, 1996 - v1
Checksum:i0317EE65BE2A1E63
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1017 – 10171N → T in BAA13842. 1 Publication
Sequence conflicti1249 – 12491K → L in BAA13842. 1 Publication
Sequence conflicti1253 – 12531E → G in BAA13842. 1 Publication
Sequence conflicti1257 – 12571K → G in BAA13842. 1 Publication
Sequence conflicti1301 – 13011N → T in BAA13842. 1 Publication
Sequence conflicti1304 – 13041F → P in BAA13842. 1 Publication
Sequence conflicti1353 – 13531S → Y in BAA13842. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA97349.1.
D89180 mRNA. Translation: BAA13842.1.
PIRiT11583.
T42624.
RefSeqiNP_594602.1. NM_001020030.2.

Genome annotation databases

EnsemblFungiiSPAC17C9.03.1; SPAC17C9.03.1:pep; SPAC17C9.03.
GeneIDi2542290.
KEGGispo:SPAC17C9.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA97349.1 .
D89180 mRNA. Translation: BAA13842.1 .
PIRi T11583.
T42624.
RefSeqi NP_594602.1. NM_001020030.2.

3D structure databases

ProteinModelPortali Q10475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278758. 9 interactions.
IntActi Q10475. 2 interactions.
MINTi MINT-4699578.
STRINGi 4896.SPAC17C9.03-1.

Proteomic databases

MaxQBi Q10475.
PaxDbi Q10475.
PRIDEi Q10475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC17C9.03.1 ; SPAC17C9.03.1:pep ; SPAC17C9.03 .
GeneIDi 2542290.
KEGGi spo:SPAC17C9.03.

Organism-specific databases

PomBasei SPAC17C9.03.

Phylogenomic databases

eggNOGi NOG301289.
KOi K03260.
OMAi SNTHSHA.
OrthoDBi EOG7VTDWG.

Miscellaneous databases

NextBioi 20803353.
PROi Q10475.

Family and domain databases

Gene3Di 1.25.40.180. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR022745. eIF4G1_eIF4E-bd.
IPR012969. Fibrinogen_BP.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view ]
Pfami PF12152. eIF_4G1. 1 hit.
PF08017. Fibrinogen_BP. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view ]
SMARTi SM00543. MIF4G. 1 hit.
[Graphical view ]
SUPFAMi SSF101489. SSF101489. 1 hit.
SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules."
    Hashemzadeh-Bonehi L., Curtis P.S., Morley S.J., Thorpe J.R., Pain V.M.
    Genes Cells 8:163-178(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 865-1403.
    Strain: PR745.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-452; SER-455; SER-456; SER-459; SER-866; SER-882; THR-884; SER-886; SER-911; SER-919; SER-921; TYR-923 AND SER-1333, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiIF4G_SCHPO
AccessioniPrimary (citable) accession number: Q10475
Secondary accession number(s): P78832
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi