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Q10475

- IF4G_SCHPO

UniProt

Q10475 - IF4G_SCHPO

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Protein

Eukaryotic translation initiation factor 4 gamma

Gene

tif471

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.1 Publication

GO - Molecular functioni

  1. structural molecule activity Source: PomBase
  2. translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. cytoplasmic translational initiation Source: PomBase
  2. ribosomal large subunit biogenesis Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma
Short name:
eIF-4-gamma
Short name:
eIF-4G
Gene namesi
Name:tif471
ORF Names:SPAC17C9.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC17C9.03.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication
Note: Localized to the perinuclear region, the growing tips and septum.

GO - Cellular componenti

  1. cytoplasmic stress granule Source: PomBase
  2. cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14031403Eukaryotic translation initiation factor 4 gammaPRO_0000213333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphoserine1 Publication
Modified residuei452 – 4521Phosphoserine1 Publication
Modified residuei455 – 4551Phosphoserine1 Publication
Modified residuei456 – 4561Phosphoserine1 Publication
Modified residuei459 – 4591Phosphoserine1 Publication
Modified residuei866 – 8661Phosphoserine1 Publication
Modified residuei882 – 8821Phosphoserine1 Publication
Modified residuei884 – 8841Phosphothreonine1 Publication
Modified residuei886 – 8861Phosphoserine1 Publication
Modified residuei911 – 9111Phosphoserine1 Publication
Modified residuei919 – 9191Phosphoserine1 Publication
Modified residuei921 – 9211Phosphoserine1 Publication
Modified residuei923 – 9231Phosphotyrosine1 Publication
Modified residuei1333 – 13331Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10475.
PaxDbiQ10475.
PRIDEiQ10475.

Interactioni

Protein-protein interaction databases

BioGridi278758. 11 interactions.
IntActiQ10475. 2 interactions.
MINTiMINT-4699578.
STRINGi4896.SPAC17C9.03-1.

Structurei

3D structure databases

ProteinModelPortaliQ10475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1009 – 1245237MIF4GAdd
BLAST

Sequence similaritiesi

Contains 1 MIF4G domain.Curated

Phylogenomic databases

eggNOGiNOG301289.
InParanoidiQ10475.
KOiK03260.
OMAiSNTHSHA.
OrthoDBiEOG7VTDWG.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR022745. eIF4G1_eIF4E-bd.
IPR012969. Fibrinogen_BP.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view]
PfamiPF12152. eIF_4G1. 1 hit.
PF08017. Fibrinogen_BP. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view]
SMARTiSM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF101489. SSF101489. 1 hit.
SSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10475-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKPPSNTP KFSYARALAS SQSNKSNSTK ASENNTATAE KQAVKPSGVE
60 70 80 90 100
PTNTSRANAQ KKTESTGKIT SEADTEKYNS SKSPVNKEGS VEKKSSEKSS
110 120 130 140 150
TNNKPWRGDN TSKPSANSSA ERTSSQHQKP ETSSQIGKDN AAPVENVNEK
160 170 180 190 200
STSQETAPPV STVPIQFGSI TRNAAIPSKP KVSGNMQNKS GVSSYSSKSQ
210 220 230 240 250
SVNSSVTSNP PHTEEPVAAK PEASSTATKG PRPTTSASNT NTSPANGAPT
260 270 280 290 300
NKPSTDINTT DPATQTTQVS ASNSPALSGS STPSNTSSRS NRQNHGNFSE
310 320 330 340 350
KRHYDRYGNS HPSYNKYSHY QHGFNYNNSG NNRNESGHPR FRNSRRNYNN
360 370 380 390 400
QGAYPTYMSN GRSANQSPRN NPQNVNNGST PIQIPVSLQT PYGQVYGQPQ
410 420 430 440 450
YIVDPNMVQY GPILQPGYVP QYYPVYHQTP YTQNFPNMSR SGSQVSDQVV
460 470 480 490 500
ESPNSSTLSP RNGFAPIVKQ QKKSSALKIV NPVTHTEVVV PQKNASSPNP
510 520 530 540 550
SETNSRAETP TAAPPQISEE EASQRKDAIK LAIQQRIQEK AEAEAKRKAE
560 570 580 590 600
EKARLEAEEN AKREAEEQAK REAEEKAKRE AEEKAKREAE EKAKREAEEN
610 620 630 640 650
AKREAEEKAK REAEEKAKRE AEEKAKREAE EKAKREAEEK AKREAEEKAK
660 670 680 690 700
REAEEKAKRE AEENAKREAE EKAKREAEEN AKREAEEKVK RETEENAKRK
710 720 730 740 750
AEEEGKREAD KNPEIKSSAP LASSEANVDT SKQTNATEPE VVDKTKVEKL
760 770 780 790 800
KASEGKSTSS LSSPSHSTSS KRDLLSGLES LSLKTNPKSE QCLESLLNSQ
810 820 830 840 850
FITDFSALVY PSTIKPPSTE EALKAGKYEY DVPFLLQFQS VYTDKPMKGW
860 870 880 890 900
DERMKETVAS AFSDKSSRGM YSSSRQSSRS GSNTHSHAGP GFGGPSERKG
910 920 930 940 950
ISRLGIDRGF SSSGAGFGSG SNYKSAPSRG VSHHGHGGMS GSHRGSQRGS
960 970 980 990 1000
RRGGGERDKP DPSSLTIPVD QVAPLQLSAN RWQPKKLTEK PAETKGEDEE
1010 1020 1030 1040 1050
ALLPPEVVQR KVKGSLNKMT LEKFDKISDQ ILEIAMQSRK ENDGRTLKQV
1060 1070 1080 1090 1100
IQLTFEKATD EPNFSNMYAR FARKMMDSID DSIRDEGVLD KNNQPVRGGL
1110 1120 1130 1140 1150
LFRKYLLSRC QEDFERGWKA NLPSGKAGEA EIMSDEYYVA AAIKRRGLGL
1160 1170 1180 1190 1200
VRFIGELFKL SMLSEKIMHE CIKRLLGNVT DPEEEEIESL CRLLMTVGVN
1210 1220 1230 1240 1250
IDATEKGHAA MDVYVLRMET ITKIPNLPSR IKFMLMDVMD SRKNGWAVKN
1260 1270 1280 1290 1300
EVEKGPKTIA EIHEEAERKK ALAESQRPSS GRMHGRDMNR GDSRMGGRGS
1310 1320 1330 1340 1350
NPPFSSSDWS NNKDGYARLG QGIRGLKSGT QGSHGPTSLS SMLKGGSVSR
1360 1370 1380 1390 1400
TPSRQNSALR REQSVRAPPS NVAVTSANSF ELLEEHDHDN DGGQKDSNSK

TSS
Length:1,403
Mass (Da):154,035
Last modified:October 1, 1996 - v1
Checksum:i0317EE65BE2A1E63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1017 – 10171N → T in BAA13842. (PubMed:9501991)Curated
Sequence conflicti1249 – 12491K → L in BAA13842. (PubMed:9501991)Curated
Sequence conflicti1253 – 12531E → G in BAA13842. (PubMed:9501991)Curated
Sequence conflicti1257 – 12571K → G in BAA13842. (PubMed:9501991)Curated
Sequence conflicti1301 – 13011N → T in BAA13842. (PubMed:9501991)Curated
Sequence conflicti1304 – 13041F → P in BAA13842. (PubMed:9501991)Curated
Sequence conflicti1353 – 13531S → Y in BAA13842. (PubMed:9501991)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA97349.1.
D89180 mRNA. Translation: BAA13842.1.
PIRiT11583.
T42624.
RefSeqiNP_594602.1. NM_001020030.2.

Genome annotation databases

EnsemblFungiiSPAC17C9.03.1; SPAC17C9.03.1:pep; SPAC17C9.03.
GeneIDi2542290.
KEGGispo:SPAC17C9.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA97349.1 .
D89180 mRNA. Translation: BAA13842.1 .
PIRi T11583.
T42624.
RefSeqi NP_594602.1. NM_001020030.2.

3D structure databases

ProteinModelPortali Q10475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278758. 11 interactions.
IntActi Q10475. 2 interactions.
MINTi MINT-4699578.
STRINGi 4896.SPAC17C9.03-1.

Proteomic databases

MaxQBi Q10475.
PaxDbi Q10475.
PRIDEi Q10475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC17C9.03.1 ; SPAC17C9.03.1:pep ; SPAC17C9.03 .
GeneIDi 2542290.
KEGGi spo:SPAC17C9.03.

Organism-specific databases

PomBasei SPAC17C9.03.

Phylogenomic databases

eggNOGi NOG301289.
InParanoidi Q10475.
KOi K03260.
OMAi SNTHSHA.
OrthoDBi EOG7VTDWG.

Miscellaneous databases

NextBioi 20803353.
PROi Q10475.

Family and domain databases

Gene3Di 1.25.40.180. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR022745. eIF4G1_eIF4E-bd.
IPR012969. Fibrinogen_BP.
IPR016021. MIF4-like_typ_1/2/3.
IPR003890. MIF4G-like_typ-3.
[Graphical view ]
Pfami PF12152. eIF_4G1. 1 hit.
PF08017. Fibrinogen_BP. 1 hit.
PF02854. MIF4G. 1 hit.
[Graphical view ]
SMARTi SM00543. MIF4G. 1 hit.
[Graphical view ]
SUPFAMi SSF101489. SSF101489. 1 hit.
SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules."
    Hashemzadeh-Bonehi L., Curtis P.S., Morley S.J., Thorpe J.R., Pain V.M.
    Genes Cells 8:163-178(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, FUNCTION, SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 865-1403.
    Strain: PR745.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-452; SER-455; SER-456; SER-459; SER-866; SER-882; THR-884; SER-886; SER-911; SER-919; SER-921; TYR-923 AND SER-1333, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiIF4G_SCHPO
AccessioniPrimary (citable) accession number: Q10475
Secondary accession number(s): P78832
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3