ID   CAH5_CAEEL              Reviewed;         310 AA.
AC   Q10462;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 3.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Putative carbonic anhydrase 5;
DE            EC=4.2.1.1;
DE   AltName: Full=Carbonate dehydratase 5;
DE   Flags: Precursor;
GN   Name=cah-5; ORFNames=R173.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Reversible hydration of carbon dioxide.
CC   -!- CATALYTIC ACTIVITY: H(2)CO(3) = CO(2) + H(2)O.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; U39743; AAA80437.6; -; Genomic_DNA.
DR   PIR; T16772; T16772.
DR   RefSeq; NP_509186.3; -.
DR   UniGene; Cel.20861; -.
DR   HSSP; P00918; 1CIM.
DR   Ensembl; R173.1; Caenorhabditis elegans.
DR   GeneID; 180972; -.
DR   KEGG; cel:R173.1; -.
DR   NMPDR; fig|6239.3.peg.23672; -.
DR   WormBase; WBGene00000283; cah-5.
DR   WormPep; R173.1; CE36560.
DR   OMA; Q10462; DSITISE.
DR   BRENDA; 4.2.1.1; 672.
DR   NextBio; 911796; -.
DR   ArrayExpress; Q10462; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:InterPro.
DR   InterPro; IPR001148; Carbonic_anhydrase_a-class_cat.
DR   InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR   Gene3D; G3DSA:3.10.200.10; Euk_COanhd; 1.
DR   PANTHER; PTHR18952; Euk_COanhd; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   ProDom; PD000865; Euk_COanhd; 1.
DR   PROSITE; PS00162; ALPHA_CA_1; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Lyase; Metal-binding; Secreted; Signal; Zinc.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    310       Putative carbonic anhydrase 5.
FT                                /FTId=PRO_0000004256.
FT   METAL       117    117       Zinc; catalytic.
FT   METAL       119    119       Zinc; catalytic.
FT   METAL       142    142       Zinc; catalytic.
SQ   SEQUENCE   310 AA;  34862 MW;  696A8ED5355DB186 CRC64;
     MPSHLLVLSL LVALLVVVSC GPGSDHGWGY DENNGPDTWQ GKCQNHLKQS PIDIRAPDVD
     YALLHRMHFL NYDMDGKIEL SNTGRTLFAG GFESWQHKQP MIQGGGLKHR YKLAQFHLHW
     GQNDAVGSEH AMGSLHYPAE LHLVHVREGL TLKEALSRPD GLAVVGVFLA KTNDPVANKF
     SPISERLHDL RHSGNKTELK NFRTKYVLPL DTEAFYRYEG SLTTPDCSEA VIWTVLAEPM
     AISSHQLHLL RQLHNKELVK SDKNYRPLQP LNGRRIQYRP SKLDRAMICS SFATTSVIIT
     YVAILSAMLI
//