Q10462 (CAH5_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative carbonic anhydrase 5
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase 5

Gene names

Name:	cah-5
ORF Names:	R173.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 310	290	Putative carbonic anhydrase 5		PRO_0000004256
Regions
	Region	223 – 224	2	Substrate binding By similarity
Sites
	Metal binding	117	1	Zinc; catalytic
	Metal binding	119	1	Zinc; catalytic
	Metal binding	142	1	Zinc; catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q10462 [UniParc]. Last modified July 19, 2004. Version 3. Checksum: 696A8ED5355DB186	FASTA	310	34,862
	10 20 30 40 50 60 MPSHLLVLSL LVALLVVVSC GPGSDHGWGY DENNGPDTWQ GKCQNHLKQS PIDIRAPDVD 70 80 90 100 110 120 YALLHRMHFL NYDMDGKIEL SNTGRTLFAG GFESWQHKQP MIQGGGLKHR YKLAQFHLHW 130 140 150 160 170 180 GQNDAVGSEH AMGSLHYPAE LHLVHVREGL TLKEALSRPD GLAVVGVFLA KTNDPVANKF 190 200 210 220 230 240 SPISERLHDL RHSGNKTELK NFRTKYVLPL DTEAFYRYEG SLTTPDCSEA VIWTVLAEPM 250 260 270 280 290 300 AISSHQLHLL RQLHNKELVK SDKNYRPLQP LNGRRIQYRP SKLDRAMICS SFATTSVIIT 310 YVAILSAMLI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080190 Genomic DNA. Translation: CCD61848.1.
PIR	T16772.
RefSeq	NP_509186.3. NM_076785.3.
UniGene	Cel.20861.
3D structure databases
ProteinModelPortal	Q10462.
SMR	Q10462. Positions 25-280.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	R173.1; R173.1; R173.1.
GeneID	180972.
KEGG	cel:R173.1.
NMPDR	fig|6239.3.peg.23672.
UCSC	R173.1. c. elegans.
Organism-specific databases
CTD	180972.
WormBase	R173.1; CE36560; WBGene00000283; cah-5.
Phylogenomic databases
eggNOG	meNOG08272.
GeneTree	EMGT00050000007231.
HOGENOM	HBG717384.
InParanoid	Q10462.
OMA	NGRRIQY.
PhylomeDB	Q10462.
Gene expression databases
ArrayExpress	Q10462.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
KO	K01674.
PANTHER	PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	911796.

Entry information

Entry name

CAH5_CAEEL

Accession

Primary (citable) accession number: Q10462

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project