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Protein

Protein mom-2

Gene

mom-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:9288750, PubMed:9288749, PubMed:16678095, PubMed:25344071). Involved in cleavage axis determination (PubMed:9288750). Binds to receptor tyrosine kinase cam-1 (PubMed:17942487). Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18 (PubMed:15369677). May act redundantly with other Wnt ligands such as cwn-1 and cwn-2 to control seam cell polarity (PubMed:22022276).6 Publications

GO - Molecular functioni

  • frizzled binding Source: WormBase
  • receptor tyrosine kinase binding Source: WormBase

GO - Biological processi

  • asymmetric protein localization involved in cell fate determination Source: WormBase
  • embryonic digestive tract morphogenesis Source: UniProtKB
  • embryonic morphogenesis Source: WormBase
  • endodermal cell fate specification Source: WormBase
  • establishment of cell polarity Source: WormBase
  • establishment of mitotic spindle orientation Source: UniProtKB
  • interneuron migration Source: UniProtKB
  • left/right axis specification Source: UniProtKB
  • motor neuron migration Source: UniProtKB
  • neuroblast migration Source: UniProtKB
  • neuron differentiation Source: GO_Central
  • neuron migration Source: UniProtKB
  • positive regulation of motor neuron migration Source: UniProtKB
  • Wnt signaling pathway Source: WormBase
  • Wnt signaling pathway involved in digestive tract morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-CEL-3238698. WNT ligand biogenesis and trafficking.
SignaLinkiQ10459.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mom-2
Gene namesi
Name:mom-2
ORF Names:F38E1.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF38E1.7; CE17806; WBGene00003395; mom-2.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular region Source: WormBase
  • extracellular space Source: GO_Central
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal with severely defective embryonic morphogenesis with the formation of unspecified differentiated tissues, no endoderm and excess mesoderm (PubMed:9288749). In addition, embryos have defective mitotic spindle orientation in the 8-cell stage ABar blastomere (PubMed:9288749, PubMed:16678095). RNAi-mediated knockdown results in irregular distribution of the mitotic spindle orientating factor sdn-1 and wnt signaling protein mig-5, with premature accumulation of sdn-1 on the cell surface of the ABar blastomere during the prophase stage of mitosis, and reduced accumulation of mig-5 at cell contact sites between the Abar and C blastomere cells, respectively (PubMed:25344071).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004147525 – 362Protein mom-2Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 91By similarity
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi129 ↔ 137By similarity
Disulfide bondi139 ↔ 167By similarity
Disulfide bondi217 ↔ 231By similarity
Disulfide bondi219 ↔ 226By similarity
Lipidationi223O-palmitoleyl serine; by mom-1By similarity1
Disulfide bondi313 ↔ 322By similarity
Disulfide bondi337 ↔ 352By similarity
Disulfide bondi339 ↔ 349By similarity
Disulfide bondi344 ↔ 345By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ10459.

Expressioni

Tissue specificityi

Expressed by anchor cell and vulva precursor cell descendants P5.ppa, P5.ppp, P7.paa and P7.pap (PubMed:15369677). Expressed in the tail and weakly expressed in the vulva and body wall muscles (PubMed:20711352).2 Publications

Gene expression databases

BgeeiWBGene00003395.

Interactioni

GO - Molecular functioni

  • frizzled binding Source: WormBase
  • receptor tyrosine kinase binding Source: WormBase

Protein-protein interaction databases

BioGridi44258. 33 interactors.
DIPiDIP-26433N.
IntActiQ10459. 2 interactors.
MINTiMINT-1041589.
STRINGi6239.F38E1.7.

Structurei

3D structure databases

ProteinModelPortaliQ10459.
SMRiQ10459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039528.
InParanoidiQ10459.
KOiK00408.
OMAiALHTCEY.
OrthoDBiEOG091G0OFF.
PhylomeDBiQ10459.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHINTPVLLA IIYFLVFAPK SADAWWLLSK TDTSSANSGS SPILCKNVPG
60 70 80 90 100
LTPQQKRMCH ENPNIIKYLI SGLRSALHTC EYTFQREAWN CTLTLPGVGT
110 120 130 140 150
SPLQIASRES AYVYAISAAG VSHSLARACS KGLIDDCGCG ETPQGSGSVA
160 170 180 190 200
VSQASSRSSS DFVWAGCSDN VKFGNTFGRK FVDQYDRQHA TEPRSQMNLH
210 220 230 240 250
NNRVGRRLLV NAMNKECKCH GVSGSCVTKT CWKVMPKFDE FASRLHQKYQ
260 270 280 290 300
LAKLVTNNDQ KLTVRSSPSA GSSGRSERFA RNMDASSKQM RNELIYLDAS
310 320 330 340 350
PNYCAIDVKD RECGENCPNI CCGRGWRTTR EIVDEPCHCQ FVWCCEVKCK
360
TCKKLVERNY CL
Length:362
Mass (Da):40,191
Last modified:December 1, 2000 - v2
Checksum:iED69435F1F4F40DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013952 mRNA. Translation: AAC47749.1.
FO080433 Genomic DNA. Translation: CCD63659.1.
PIRiT34254.
T42049.
RefSeqiNP_505154.1. NM_072753.5.
UniGeneiCel.19628.

Genome annotation databases

EnsemblMetazoaiF38E1.7; F38E1.7; WBGene00003395.
GeneIDi179217.
KEGGicel:CELE_F38E1.7.
UCSCiF38E1.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013952 mRNA. Translation: AAC47749.1.
FO080433 Genomic DNA. Translation: CCD63659.1.
PIRiT34254.
T42049.
RefSeqiNP_505154.1. NM_072753.5.
UniGeneiCel.19628.

3D structure databases

ProteinModelPortaliQ10459.
SMRiQ10459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44258. 33 interactors.
DIPiDIP-26433N.
IntActiQ10459. 2 interactors.
MINTiMINT-1041589.
STRINGi6239.F38E1.7.

Proteomic databases

PaxDbiQ10459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF38E1.7; F38E1.7; WBGene00003395.
GeneIDi179217.
KEGGicel:CELE_F38E1.7.
UCSCiF38E1.7. c. elegans.

Organism-specific databases

CTDi179217.
WormBaseiF38E1.7; CE17806; WBGene00003395; mom-2.

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039528.
InParanoidiQ10459.
KOiK00408.
OMAiALHTCEY.
OrthoDBiEOG091G0OFF.
PhylomeDBiQ10459.

Enzyme and pathway databases

ReactomeiR-CEL-3238698. WNT ligand biogenesis and trafficking.
SignaLinkiQ10459.

Miscellaneous databases

PROiQ10459.

Gene expression databases

BgeeiWBGene00003395.

Family and domain databases

InterProiIPR005817. Wnt.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOM2_CAEEL
AccessioniPrimary (citable) accession number: Q10459
Secondary accession number(s): O16146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.