ID   PUR6_CAEEL              Reviewed;         423 AA.
AC   Q10457;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 68.
DE   RecName: Full=Probable multifunctional protein ADE2;
DE   Includes:
DE     RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE              EC=6.3.2.6;
DE     AltName: Full=SAICAR synthetase;
DE   Includes:
DE     RecName: Full=Phosphoribosylaminoimidazole carboxylase;
DE              EC=4.1.1.21;
DE     AltName: Full=AIR carboxylase;
DE              Short=AIRC;
GN   ORFNames=B0286.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate +
CC       (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamido)succinate.
CC   -!- CATALYTIC ACTIVITY: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-
CC       formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 3/5.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-
CC       formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5.
CC   -!- INTERACTION:
CC       Self; NbExp=2; IntAct=EBI-311886, EBI-311886;
CC   -!- SIMILARITY: In the N-terminal section; belongs to the SAICAR
CC       synthetase family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the AIR
CC       carboxylase family.
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DR   EMBL; U39848; AAA80690.1; -; Genomic_DNA.
DR   PIR; T15309; T15309.
DR   RefSeq; NP_494771.1; -.
DR   UniGene; Cel.16061; -.
DR   DIP; DIP:24510N; -.
DR   IntAct; Q10457; 1.
DR   Ensembl; B0286.3; Caenorhabditis elegans.
DR   GeneID; 173772; -.
DR   KEGG; cel:B0286.3; -.
DR   NMPDR; fig|6239.3.peg.5157; -.
DR   WormBase; WBGene00015116; B0286.3.
DR   WormPep; B0286.3; CE03863.
DR   OMA; Q10457; SQCRVVV.
DR   BRENDA; 4.1.1.21; 672.
DR   BRENDA; 6.3.2.6; 672.
DR   NextBio; 881027; -.
DR   ArrayExpress; Q10457; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase ac...; IEA:EC.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxam...; IEA:EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0040007; P:growth; IMP:WormBase.
DR   GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR   InterPro; IPR000031; AIR_COase_core.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR001636; SAICAR_synt.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Gene3D; G3DSA:3.40.50.7700; AIR_carboxyl; 1.
DR   Gene3D; G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
DR   PANTHER; PTHR11609; SAICAR_synt; 1.
DR   Pfam; PF00731; AIRC; 1.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   ProDom; PD002193; AIR_carboxyl; 1.
DR   ProDom; PD003043; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR01162; purE; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Complete proteome; Decarboxylase; Ligase; Lyase;
KW   Multifunctional enzyme; Nucleotide-binding; Purine biosynthesis.
FT   CHAIN         1    423       Probable multifunctional protein ADE2.
FT                                /FTId=PRO_0000075034.
FT   REGION        1    263       SAICAR synthetase.
FT   REGION      264    423       AIR carboxylase.
SQ   SEQUENCE   423 AA;  46978 MW;  101CD65318C4804A CRC64;
     MSSLAEIASR PENLELLAEG KTKQIFDIKG EKDYVLIRSK DSLTAFNAVR KNELEGKSRI
     ASKTTSNVFE YLQLLGLPTH FEKSISETEF VARKCTMIPI EWVARRVATG SFLKRNPGVK
     EGFRFNDLKL ETFFKDDAND DPQWTDEQIV SNGLMIDHLK IGREEISLMK KMTKLVFRAL
     EKGWALSNSA LIDMKIEFGV TVEGEILLAD VIDNDSWRVW PENDRRLQLD KQVYRDMKEV
     TEEGLALVLK NYTKVMDITA TFSKHQQKCH VLVIMGSGSD GVFARKISDE AKKFGLETTL
     KVSSAHKTTS DTLEVIADFE ESGVPTVVIA VAGRSNGLGP VIAGNSSLPV INCPPPSEST
     SLDIWSSLRM PNGIGCTTVL DPSEAALAAA KILASHNHIV FGKVLTAQLK NQINIYNANR
     KLE
//