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Protein

Probable arginine kinase F46H5.3

Gene

F46H5.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei226ATPPROSITE-ProRule annotation1
Binding sitei266SubstrateBy similarity1
Binding sitei270ATPPROSITE-ProRule annotation1
Binding sitei312SubstrateBy similarity1
Binding sitei354SubstrateBy similarity1
Binding sitei364ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 166ATPPROSITE-ProRule annotation5
Nucleotide bindingi321 – 325ATPPROSITE-ProRule annotation5
Nucleotide bindingi349 – 354ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-71288. Creatine metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine kinase F46H5.3 (EC:2.7.3.3)
Short name:
AK
Gene namesi
ORF Names:F46H5.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF46H5.3a; CE37112; WBGene00018519.
F46H5.3b; CE33098; WBGene00018519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002119881 – 396Probable arginine kinase F46H5.3Add BLAST396

Proteomic databases

EPDiQ10454.
PaxDbiQ10454.
PeptideAtlasiQ10454.
PRIDEiQ10454.

2D gel databases

World-2DPAGEi0020:Q10454.

PTM databases

iPTMnetiQ10454.

Expressioni

Gene expression databases

BgeeiWBGene00018519.

Interactioni

Protein-protein interaction databases

BioGridi45911. 4 interactors.
DIPiDIP-26821N.
IntActiQ10454. 1 interactor.
MINTiMINT-1069044.
STRINGi6239.F46H5.3a.2.

Structurei

3D structure databases

ProteinModelPortaliQ10454.
SMRiQ10454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 129Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini159 – 396Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 106Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3581. Eukaryota.
COG3869. LUCA.
GeneTreeiENSGT00550000074561.
HOGENOMiHOG000232165.
InParanoidiQ10454.
KOiK00934.
OMAiDKHPASN.
OrthoDBiEOG091G0HZ0.
PhylomeDBiQ10454.

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiView protein in InterPro
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR036802. ATP-guanido_PTrfase_N_sf.
IPR014746. Gln_synth/guanido_kin_cat_dom.
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiView protein in Pfam
PF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
SUPFAMiSSF48034. SSF48034. 1 hit.
SSF55931. SSF55931. 1 hit.
PROSITEiView protein in PROSITE
PS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q10454-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLHRCSRVLS QFLGRGNSKM LREAYSTSLH CVQAQEGMSV SPDVIAKIEE
60 70 80 90 100
GYAKLQAAPE CHSLLKKYLT KEVVDQLKDK KTKLGANLLD VIQSGVANLD
110 120 130 140 150
SGVGVYAPDA EAYTLFKPLF DPLIQDYHNG FAPDAKQPNT DLGEGKTSAL
160 170 180 190 200
VDLDPEGKFI NSTRIRCGRS LQGYPFNPCL SEANYLEMES KVKAIFDNIT
210 220 230 240 250
DPELAGKYFP LDGMTKEIQD QLIKDHFLFK EGDRFLQAAN ACRYWPKGRG
260 270 280 290 300
IFHNNQKTFL IWCNEEDHLR IISMQEGGNV GQVLERLIKG VKTIEKQAPF
310 320 330 340 350
SRDDRLGWLT FCPSNLGTTV RASVHIRLPK ISAKPDFKSI CDGLKLQIRG
360 370 380 390
IHGEHSESEG GVYDISNKAR LGLTEFEAVK QMYDGIAHLI ALEKAA
Note: No experimental confirmation available.
Length:396
Mass (Da):44,168
Last modified:February 1, 2005 - v2
Checksum:i0DF10283D3FEA45B
GO
Isoform b (identifier: Q10454-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.
Show »
Length:359
Mass (Da):39,991
Checksum:i7EC508115BDF086F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0127501 – 37Missing in isoform b. CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081399 Genomic DNA. Translation: CCD71355.1.
FO081399 Genomic DNA. Translation: CCD71356.1.
PIRiT34272.
RefSeqiNP_509217.2. NM_076816.2. [Q10454-1]
NP_872253.1. NM_182453.5. [Q10454-2]
UniGeneiCel.17036.

Genome annotation databases

EnsemblMetazoaiF46H5.3a.1; F46H5.3a.1; WBGene00018519. [Q10454-1]
F46H5.3a.2; F46H5.3a.2; WBGene00018519. [Q10454-1]
F46H5.3a.3; F46H5.3a.3; WBGene00018519. [Q10454-1]
GeneIDi180986.
KEGGicel:CELE_F46H5.3.
UCSCiF46H5.3b.2. c. elegans. [Q10454-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKARG1_CAEEL
AccessioniPrimary (citable) accession number: Q10454
Secondary accession number(s): Q86NG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 1, 2005
Last modified: October 25, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families