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Q10453

- H331_CAEEL

UniProt

Q10453 - H331_CAEEL

Protein

Histone H3.3 type 1

Gene

his-71

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleosome assembly Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H3.3 type 1
    Gene namesi
    Name:his-71
    ORF Names:F45E1.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiF45E1.6; CE01943; WBGene00001945; his-71.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. nucleosome Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleosome core, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 136135Histone H3.3 type 1PRO_0000221298Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei5 – 51N6,N6,N6-trimethyllysine; alternateBy similarity
    Modified residuei5 – 51N6,N6-dimethyllysine; alternateBy similarity
    Modified residuei5 – 51N6-acetyllysine; alternateBy similarity
    Modified residuei5 – 51N6-methyllysine; alternateBy similarity
    Modified residuei10 – 101N6,N6,N6-trimethyllysine; alternateBy similarity
    Modified residuei10 – 101N6,N6-dimethyllysine; alternateBy similarity
    Modified residuei10 – 101N6-acetyllysine; alternateBy similarity
    Modified residuei11 – 111PhosphoserineBy similarity
    Modified residuei15 – 151N6-acetyllysineBy similarity
    Modified residuei24 – 241N6-acetyllysineBy similarity
    Modified residuei28 – 281N6,N6,N6-trimethyllysine; alternateBy similarity
    Modified residuei28 – 281N6,N6-dimethyllysine; alternateBy similarity
    Modified residuei28 – 281N6-methyllysine; alternateBy similarity
    Modified residuei29 – 291PhosphoserineBy similarity
    Modified residuei37 – 371N6,N6,N6-trimethyllysine; alternateBy similarity
    Modified residuei37 – 371N6-methyllysine; alternateBy similarity
    Modified residuei80 – 801N6-methyllysineBy similarity

    Post-translational modificationi

    Acetylation is generally linked to gene activation.By similarity
    Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression By similarity.By similarity

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ10453.

    Expressioni

    Tissue specificityi

    Highly expressed in all adult nuclei.1 Publication

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Protein-protein interaction databases

    BioGridi45980. 3 interactions.
    DIPiDIP-26634N.
    MINTiMINT-1117076.
    STRINGi6239.F45E1.6.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10453.
    SMRiQ10453. Positions 17-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H3 family.Curated

    Phylogenomic databases

    eggNOGiCOG2036.
    GeneTreeiENSGT00750000117538.
    HOGENOMiHOG000155290.
    InParanoidiQ10453.
    KOiK11253.
    OMAiTIIVDSE.
    OrthoDBiEOG7HB5C2.
    PhylomeDBiQ10453.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR000164. Histone_H3.
    [Graphical view]
    PANTHERiPTHR11426. PTHR11426. 1 hit.
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00622. HISTONEH3.
    SMARTiSM00428. H3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    PROSITEiPS00322. HISTONE_H3_1. 1 hit.
    PS00959. HISTONE_H3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10453-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARTKQTARK STGGKAPRKQ LATKAARKSA PTTGGVKKPH RYRPGTVALR    50
    EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY 100
    LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA 136
    Length:136
    Mass (Da):15,342
    Last modified:January 23, 2007 - v2
    Checksum:i57E8809145022E77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080773 Genomic DNA. Translation: CCD66641.1.
    PIRiT16361.
    RefSeqiNP_509344.1. NM_076943.4.
    UniGeneiCel.17947.

    Genome annotation databases

    EnsemblMetazoaiF45E1.6; F45E1.6; WBGene00001945.
    GeneIDi181057.
    KEGGicel:CELE_F45E1.6.
    UCSCiF45E1.6.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080773 Genomic DNA. Translation: CCD66641.1 .
    PIRi T16361.
    RefSeqi NP_509344.1. NM_076943.4.
    UniGenei Cel.17947.

    3D structure databases

    ProteinModelPortali Q10453.
    SMRi Q10453. Positions 17-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 45980. 3 interactions.
    DIPi DIP-26634N.
    MINTi MINT-1117076.
    STRINGi 6239.F45E1.6.1.

    Proteomic databases

    PaxDbi Q10453.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F45E1.6 ; F45E1.6 ; WBGene00001945 .
    GeneIDi 181057.
    KEGGi cel:CELE_F45E1.6.
    UCSCi F45E1.6.2. c. elegans.

    Organism-specific databases

    CTDi 181057.
    WormBasei F45E1.6 ; CE01943 ; WBGene00001945 ; his-71.

    Phylogenomic databases

    eggNOGi COG2036.
    GeneTreei ENSGT00750000117538.
    HOGENOMi HOG000155290.
    InParanoidi Q10453.
    KOi K11253.
    OMAi TIIVDSE.
    OrthoDBi EOG7HB5C2.
    PhylomeDBi Q10453.

    Miscellaneous databases

    NextBioi 912206.
    PROi Q10453.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR000164. Histone_H3.
    [Graphical view ]
    PANTHERi PTHR11426. PTHR11426. 1 hit.
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00622. HISTONEH3.
    SMARTi SM00428. H3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    PROSITEi PS00322. HISTONE_H3_1. 1 hit.
    PS00959. HISTONE_H3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans."
      Ooi S.L., Priess J.R., Henikoff S.
      PLoS Genet. 2:883-895(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.

    Entry informationi

    Entry nameiH331_CAEEL
    AccessioniPrimary (citable) accession number: Q10453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3