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Q10453 (H331_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone H3.3 type 1
Gene names
Name:his-71
ORF Names:F45E1.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length136 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Ref.2

Subunit structure

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Tissue specificity

Highly expressed in all adult nuclei. Ref.2

Post-translational modification

Acetylation is generally linked to gene activation By similarity.

Methylation at Lys-5 is linked to gene activation. Methylation at Lys-10 is linked to gene repression By similarity.

Sequence similarities

Belongs to the histone H3 family.

Ontologies

Keywords
   Cellular componentChromosome
Nucleosome core
Nucleus
   LigandDNA-binding
   PTMAcetylation
Methylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnucleosome assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleosome

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 136135Histone H3.3 type 1
PRO_0000221298

Amino acid modifications

Modified residue51N6,N6,N6-trimethyllysine; alternate By similarity
Modified residue51N6,N6-dimethyllysine; alternate By similarity
Modified residue51N6-acetyllysine; alternate By similarity
Modified residue51N6-methyllysine; alternate By similarity
Modified residue101N6,N6,N6-trimethyllysine; alternate By similarity
Modified residue101N6,N6-dimethyllysine; alternate By similarity
Modified residue101N6-acetyllysine; alternate By similarity
Modified residue111Phosphoserine By similarity
Modified residue151N6-acetyllysine By similarity
Modified residue241N6-acetyllysine By similarity
Modified residue281N6,N6,N6-trimethyllysine; alternate By similarity
Modified residue281N6,N6-dimethyllysine; alternate By similarity
Modified residue281N6-methyllysine; alternate By similarity
Modified residue291Phosphoserine By similarity
Modified residue371N6,N6,N6-trimethyllysine; alternate By similarity
Modified residue371N6-methyllysine; alternate By similarity
Modified residue801N6-methyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q10453 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 57E8809145022E77

FASTA13615,342
        10         20         30         40         50         60 
MARTKQTARK STGGKAPRKQ LATKAARKSA PTTGGVKKPH RYRPGTVALR EIRRYQKSTE 

        70         80         90        100        110        120 
LLIRKLPFQR LVREIAQDFK TDLRFQSAAI GALQEASEAY LVGLFEDTNL CAIHAKRVTI 

       130 
MPKDIQLARR IRGERA 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans."
Ooi S.L., Priess J.R., Henikoff S.
PLoS Genet. 2:883-895(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080773 Genomic DNA. Translation: CCD66641.1.
PIRT16361.
RefSeqNP_509344.1. NM_076943.4.
UniGeneCel.17947.

3D structure databases

ProteinModelPortalQ10453.
SMRQ10453. Positions 17-136.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid45980. 3 interactions.
DIPDIP-26634N.
MINTMINT-1117076.
STRING6239.F45E1.6.1.

Proteomic databases

PaxDbQ10453.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF45E1.6; F45E1.6; WBGene00001945.
GeneID181057.
KEGGcel:CELE_F45E1.6.
UCSCF45E1.6.2. c. elegans.

Organism-specific databases

CTD181057.
WormBaseF45E1.6; CE01943; WBGene00001945; his-71.

Phylogenomic databases

eggNOGCOG2036.
GeneTreeENSGT00750000117538.
HOGENOMHOG000155290.
InParanoidQ10453.
KOK11253.
OMATIIVDSE.
OrthoDBEOG7HB5C2.
PhylomeDBQ10453.

Family and domain databases

Gene3D1.10.20.10. 1 hit.
InterProIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR000164. Histone_H3.
[Graphical view]
PANTHERPTHR11426. PTHR11426. 1 hit.
PfamPF00125. Histone. 1 hit.
[Graphical view]
PRINTSPR00622. HISTONEH3.
SMARTSM00428. H3. 1 hit.
[Graphical view]
SUPFAMSSF47113. SSF47113. 1 hit.
PROSITEPS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio912206.
PROQ10453.

Entry information

Entry nameH331_CAEEL
AccessionPrimary (citable) accession number: Q10453
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase