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Q10444

- EXG2_SCHPO

UniProt

Q10444 - EXG2_SCHPO

Protein

Glucan 1,3-beta-glucosidase 2

Gene

exg2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei338 – 3381Proton donorBy similarity
    Active sitei439 – 4391NucleophileBy similarity

    GO - Molecular functioni

    1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. regulation of cell shape Source: PomBase

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Protein family/group databases

    CAZyiGH5. Glycoside Hydrolase Family 5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucan 1,3-beta-glucosidase 2 (EC:3.2.1.58)
    Alternative name(s):
    Exo-1,3-beta-glucanase 2
    Gene namesi
    Name:exg2
    ORF Names:SPAC12B10.11
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC12B10.11.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. extracellular region Source: UniProtKB-SubCell
    3. integral component of membrane Source: PomBase

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 47Sequence AnalysisPRO_0000007895
    Signal peptidei1 – ?Sequence Analysis
    Chaini48 – 570523Glucan 1,3-beta-glucosidase 2PRO_0000007896Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi525 – 5251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi552 – 5521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    BioGridi279425. 1 interaction.
    STRINGi4896.SPAC12B10.11-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2730.
    HOGENOMiHOG000114462.
    KOiK01210.
    OMAiDDSVQAN.
    OrthoDBiEOG7ZPNTV.
    PhylomeDBiQ10444.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10444-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNLLEAESS CDSKSLGVDD FTSKRCREID KKALLITILL TFFVSLCVFL    50
    SIILPLIFLV IIPHAQSDRK IKDTNMETTN LGVNIIDEIF NSTQVPEWAK 100
    NSLLDTNTWL DTSDFNTSFT NETFAGLYTM GIFDKYDDSV QANPNVPPLN 150
    EPFPYGRLPI RGVNLGGWLS MEPFITPSFF QVKNETAYLV KDELSLHAYL 200
    GENATSVIEN HYNTFVTKQT FYEIREAGLD HVRITFPYWI LYSNEITNVS 250
    GIGWRYLLRS IEWAREQGLR VNLDLHAAPG NQNSWNHGGY LNQMEWLDGT 300
    VKGEENSQFT LKIHERLASF FSQKRYRNVV TIYGALNEPN FFVLDEHKIT 350
    DWHKQAYAVI RQSNFTGLIS LSDGFRGPGN WEDHFDPFHF PNILIDVHRY 400
    IIFNDFLIGL RPKDKLNVIC KSWNEEMKLK AKLPTIIGEW SLADTDCAKF 450
    LNNVGEGARW DGTFTPNGGV ASCSEKVGCR CDFANQDPEN YEDSYRKFLY 500
    ALATSQIETF DKTWGWFYWN WDTENATQWS YKKSWLAGLL PRLAYSTTKD 550
    FNCSMLDSKS FMEFDEQSEF 570
    Length:570
    Mass (Da):65,687
    Last modified:October 1, 1996 - v1
    Checksum:i2B6E66A35AA7E1E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA94701.1.
    PIRiT37578.
    RefSeqiNP_594643.1. NM_001020071.1.

    Genome annotation databases

    EnsemblFungiiSPAC12B10.11.1; SPAC12B10.11.1:pep; SPAC12B10.11.
    GeneIDi2542987.
    KEGGispo:SPAC12B10.11.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA94701.1 .
    PIRi T37578.
    RefSeqi NP_594643.1. NM_001020071.1.

    3D structure databases

    ProteinModelPortali Q10444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279425. 1 interaction.
    STRINGi 4896.SPAC12B10.11-1.

    Protein family/group databases

    CAZyi GH5. Glycoside Hydrolase Family 5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC12B10.11.1 ; SPAC12B10.11.1:pep ; SPAC12B10.11 .
    GeneIDi 2542987.
    KEGGi spo:SPAC12B10.11.

    Organism-specific databases

    PomBasei SPAC12B10.11.

    Phylogenomic databases

    eggNOGi COG2730.
    HOGENOMi HOG000114462.
    KOi K01210.
    OMAi DDSVQAN.
    OrthoDBi EOG7ZPNTV.
    PhylomeDBi Q10444.

    Miscellaneous databases

    NextBioi 20804020.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiEXG2_SCHPO
    AccessioniPrimary (citable) accession number: Q10444
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3