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Protein

Probable tubulin--tyrosine ligase C12B10.04

Gene

SPAC12B10.04

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable tubulin--tyrosine ligase.By similarity

Catalytic activityi

ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • K+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

Magnesium, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tubulin--tyrosine ligase C12B10.04 (EC:6.3.2.25)
Gene namesi
ORF Names:SPAC12B10.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC12B10.04.
PomBaseiSPAC12B10.04.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Probable tubulin--tyrosine ligase C12B10.04PRO_0000212447Add
BLAST

Proteomic databases

MaxQBiQ10438.

Interactioni

Protein-protein interaction databases

BioGridi279365. 31 interactions.
MINTiMINT-4699462.

Structurei

3D structure databases

ProteinModelPortaliQ10438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 386378TTLPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin--tyrosine ligase family.Curated
Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ10438.
OMAiKFHLRAY.
OrthoDBiEOG7SV14T.
PhylomeDBiQ10438.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR027746. TTL.
IPR004344. TTL/TTLL_fam.
[Graphical view]
PANTHERiPTHR12241:SF1. PTHR12241:SF1. 2 hits.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTKKDIKV YVNYRDEYAE PKIISALKNS GKELTFTNSA KEANFQWAQY
60 70 80 90 100
EDIDFDEVYK NPKTKLCCSY VIRKALIRKE YLWRTVITYL AKHPDSILSK
110 120 130 140 150
SVPEAYSLEL DYAEFLDDSL MEAYELRQEL EENATKNISE KQWYILKPSM
160 170 180 190 200
CDRAQGIRLF STIEELQAIF DSFDDEESES EEAGLEEKGD ITVAFNNKIV
210 220 230 240 250
ISQIRNFLVQ KYISKPLLLD HRKFHIRAYV LATGALSVYL FNEMLCLLAR
260 270 280 290 300
DKYKKPTPDP DLLFSHLSNT CLQGDNVEQS SIRDFWNTSI ENKDDIFKSI
310 320 330 340 350
LNIIGDVFEA AATTQGIHFQ PLENCFEIFG VDFLVDCESQ VYLLEVNSYP
360 370 380 390 400
DFKQTGKNLS NIIENLFSAV VETAIIPFFE SSTKRNVDSK LTLAKKLQLF

GFR
Length:403
Mass (Da):46,524
Last modified:October 1, 1996 - v1
Checksum:iB122F71756A0B108
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA94694.1.
PIRiT37571.
RefSeqiNP_594636.1. NM_001020064.2.

Genome annotation databases

EnsemblFungiiSPAC12B10.04.1; SPAC12B10.04.1:pep; SPAC12B10.04.
GeneIDi2542924.
KEGGispo:SPAC12B10.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA94694.1.
PIRiT37571.
RefSeqiNP_594636.1. NM_001020064.2.

3D structure databases

ProteinModelPortaliQ10438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279365. 31 interactions.
MINTiMINT-4699462.

Proteomic databases

MaxQBiQ10438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC12B10.04.1; SPAC12B10.04.1:pep; SPAC12B10.04.
GeneIDi2542924.
KEGGispo:SPAC12B10.04.

Organism-specific databases

EuPathDBiFungiDB:SPAC12B10.04.
PomBaseiSPAC12B10.04.

Phylogenomic databases

InParanoidiQ10438.
OMAiKFHLRAY.
OrthoDBiEOG7SV14T.
PhylomeDBiQ10438.

Miscellaneous databases

PROiQ10438.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR027746. TTL.
IPR004344. TTL/TTLL_fam.
[Graphical view]
PANTHERiPTHR12241:SF1. PTHR12241:SF1. 2 hits.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTL_SCHPO
AccessioniPrimary (citable) accession number: Q10438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.