Q10432 (CCQ1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil quantitatively-enriched protein 1

Alternative name(s):
Structural maintenance of chromosomes protein ccq1
Short name=SMC protein ccq1

Gene names

Name:	ccq1
ORF Names:	SPCC188.07

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	735 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC). Ref.2 Ref.4 Ref.5
Subunit structure	Interacts (during meiosis) with pcp1. Interacts with clr3, pot1, taz1 and tpz1. Ref.2 Ref.4 Ref.5
Subcellular location	Nucleus › nucleoplasm. Chromosome › centromere. Chromosome › telomere. Note: Associates with major heterochromatin, centromeres, sub-telomeres, rDNA and the mat locus. Ref.2 Ref.3 Ref.4 Ref.5

Ontologies

Keywords
Biological process	Chromosome partition
Cellular component	Centromere Chromosome Nucleus Telomere
Domain	Coiled coil
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein localization Inferred from genetic interaction Ref.4. Source: PomBase chromatin silencing at telomere Inferred from mutant phenotype Ref.4. Source: PomBase meiotic chromosome segregation Inferred from mutant phenotype Ref.2. Source: PomBase meiotic telomere clustering Inferred from mutant phenotype Ref.2. Source: PomBase negative regulation of DNA recombination at telomere Inferred from mutant phenotype Ref.5. Source: PomBase positive regulation of telomere maintenance Inferred from mutant phenotype Ref.5. Source: PomBase telomere capping Inferred from genetic interaction Ref.5. Source: PomBase
Cellular_component	Stn1-Ten1 complex Inferred from direct assay Ref.5. Source: PomBase chromosome, centromeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Inferred from direct assay Ref.2. Source: PomBase spindle pole body Inferred from direct assay Ref.2. Source: PomBase telomeric heterochromatin Inferred from direct assay Ref.4. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 735	735	Coiled-coil quantitatively-enriched protein 1		PRO_0000116882
Regions
	Coiled coil	514 – 719	206	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q10432 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 14193682700A2634	FASTA	735	83,301
	10 20 30 40 50 60 MSEINDFTNS IIINESDTKY EVYSEVNSSN RWIAKEDCPS PLEDVWLLKL AGHKRKLEEP 70 80 90 100 110 120 LSCMRNEEPA SKQREIEKFL RTDLDHSEND FLTQEVDEFP STQQLFPIPL QNDTAFDSSE 130 140 150 160 170 180 ESITKSSKSS FSVLDIGLPM SALQRKMMHR LVQYFAFCID HFCTGPSDSR IQEKIRLFIQ 190 200 210 220 230 240 SAHNIAKHPS LYDTEVRNPS AAESTNSHVS LDASNFSSYA ENSSKFLFLQ ELFKNLSPSY 250 260 270 280 290 300 SKTFFLFISN QFLANTLTQW LKSQNIDAEL WAEEDAKTSQ HPAIWICVSK KAPSASHFLQ 310 320 330 340 350 360 SCPDLSATIF YDIEAYMSVT SSLPSIQSLV LRLIHLGSIE HAIKCFQSSY NASFLVNIVG 370 380 390 400 410 420 VVATLSSSSE ENSEASNLST LFEKSGNFEE ILGSESHSSI TEKTRDIAKN VATWLKNGEN 430 440 450 460 470 480 FSSWPLPPLM DLASLSVAEP RDSQPSVSQV NDTFVKSSDS TFPSSQSMQS PSKLHSLTSN 490 500 510 520 530 540 ATDLLSSSSL KKNFFSQQEA DEVELSNNYD LQGAAVQYLQ RRLRMVEDEL HEAINSKNVQ 550 560 570 580 590 600 QSRSEELEQQ ISKLTDNLQE YRNTVRELKL DLEKSKKKNE DLSKLEVEKV EEIANLKKEL 610 620 630 640 650 660 THLAKQQEFG FKYVQEFSNE DLQGKLIEAN EKNYKLTQLL KTQKEDADFI TNQYQNASTF 670 680 690 700 710 720 AAEQSKEVAK LQAECKRLQA INSKVMEEVK VYNDSRVEAL LAKVSSLEET LKILEQKSLP 730 KFTPHNQSPR IIDSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome." Flory M.R., Carson A.R., Muller E.G., Aebersold R. Mol. Cell 16:619-630(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 57-79, FUNCTION, INTERACTION WITH PCP1 AND TAZ1, SUBCELLULAR LOCATION.
[3]	"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"SHREC, an effector complex for heterochromatic transcriptional silencing." Sugiyama T., Cam H.P., Sugiyama R., Noma K., Zofall M., Kobayashi R., Grewal S.I.S. Cell 128:491-504(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CLR3, SUBCELLULAR LOCATION.
[5]	"Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length." Miyoshi T., Kanoh J., Saito M., Ishikawa F. Science 320:1341-1344(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH POT1 AND TPZ1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329672 Genomic DNA. Translation: CAB41227.1.
PIR	T41187.
RefSeq	NP_588210.1. NM_001023200.2.
3D structure databases
ProteinModelPortal	Q10432.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59444N.
STRING	4896.SPCC188.07-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC188.07.1; SPCC188.07.1:pep; SPCC188.07.
GeneID	2539352.
KEGG	spo:SPCC188.07.
Organism-specific databases
PomBase	SPCC188.07.
Phylogenomic databases
eggNOG	NOG240409.
OrthoDB	EOG4R2733.
Family and domain databases
InterPro	IPR021006. HDA_complex_subunit-2/3. [Graphical view]
Pfam	PF11496. HDA2-3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20800517.

Entry information

Entry name

CCQ1_SCHPO

Accession

Primary (citable) accession number: Q10432

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program