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Q10432 (CCQ1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil quantitatively-enriched protein 1
Alternative name(s):
Structural maintenance of chromosomes protein ccq1
Short name=SMC protein ccq1
Gene names
Name:ccq1
ORF Names:SPCC188.07
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length735 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC). Ref.2 Ref.4 Ref.5

Subunit structure

Interacts (during meiosis) with pcp1. Interacts with clr3, pot1, taz1 and tpz1. Ref.2 Ref.4 Ref.5

Subcellular location

Nucleusnucleoplasm. Chromosometelomere. Note: Associates with major heterochromatin, sub-telomeres, rDNA and the mat locus. Ref.2 Ref.3 Ref.4 Ref.5

Ontologies

Keywords
   Biological processChromosome partition
   Cellular componentChromosome
Nucleus
Telomere
   DomainCoiled coil
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular protein localization

Inferred from genetic interaction Ref.4. Source: PomBase

chromatin silencing at telomere

Inferred from mutant phenotype Ref.4. Source: PomBase

meiotic chromosome segregation

Inferred from mutant phenotype Ref.2. Source: PomBase

meiotic telomere clustering

Inferred from mutant phenotype Ref.2. Source: PomBase

negative regulation of DNA recombination at telomere

Inferred from mutant phenotype Ref.5. Source: PomBase

positive regulation of telomere maintenance

Inferred from mutant phenotype Ref.5. Source: PomBase

positive regulation of telomere maintenance via telomerase

Inferred from genetic interaction PubMed 24013504. Source: PomBase

telomere capping

Inferred from genetic interaction Ref.5. Source: PomBase

telomere maintenance

Inferred from mutant phenotype Ref.2. Source: PomBase

   Cellular_componentStn1-Ten1 complex

Inferred from direct assay Ref.5. Source: PomBase

chromosome, telomeric region

Inferred from direct assay Ref.2Ref.5. Source: PomBase

meiotic spindle pole body

Inferred from direct assay Ref.2. Source: PomBase

nucleoplasm

Inferred from direct assay Ref.2. Source: PomBase

nucleus

Inferred from direct assay Ref.3. Source: PomBase

telomeric heterochromatin

Inferred from direct assay Ref.4. Source: PomBase

   Molecular_functionprotein binding

Inferred from physical interaction Ref.2Ref.5. Source: PomBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 735735Coiled-coil quantitatively-enriched protein 1
PRO_0000116882

Regions

Coiled coil514 – 719206 Potential

Sequences

Sequence LengthMass (Da)Tools
Q10432 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 14193682700A2634

FASTA73583,301
        10         20         30         40         50         60 
MSEINDFTNS IIINESDTKY EVYSEVNSSN RWIAKEDCPS PLEDVWLLKL AGHKRKLEEP 

        70         80         90        100        110        120 
LSCMRNEEPA SKQREIEKFL RTDLDHSEND FLTQEVDEFP STQQLFPIPL QNDTAFDSSE 

       130        140        150        160        170        180 
ESITKSSKSS FSVLDIGLPM SALQRKMMHR LVQYFAFCID HFCTGPSDSR IQEKIRLFIQ 

       190        200        210        220        230        240 
SAHNIAKHPS LYDTEVRNPS AAESTNSHVS LDASNFSSYA ENSSKFLFLQ ELFKNLSPSY 

       250        260        270        280        290        300 
SKTFFLFISN QFLANTLTQW LKSQNIDAEL WAEEDAKTSQ HPAIWICVSK KAPSASHFLQ 

       310        320        330        340        350        360 
SCPDLSATIF YDIEAYMSVT SSLPSIQSLV LRLIHLGSIE HAIKCFQSSY NASFLVNIVG 

       370        380        390        400        410        420 
VVATLSSSSE ENSEASNLST LFEKSGNFEE ILGSESHSSI TEKTRDIAKN VATWLKNGEN 

       430        440        450        460        470        480 
FSSWPLPPLM DLASLSVAEP RDSQPSVSQV NDTFVKSSDS TFPSSQSMQS PSKLHSLTSN 

       490        500        510        520        530        540 
ATDLLSSSSL KKNFFSQQEA DEVELSNNYD LQGAAVQYLQ RRLRMVEDEL HEAINSKNVQ 

       550        560        570        580        590        600 
QSRSEELEQQ ISKLTDNLQE YRNTVRELKL DLEKSKKKNE DLSKLEVEKV EEIANLKKEL 

       610        620        630        640        650        660 
THLAKQQEFG FKYVQEFSNE DLQGKLIEAN EKNYKLTQLL KTQKEDADFI TNQYQNASTF 

       670        680        690        700        710        720 
AAEQSKEVAK LQAECKRLQA INSKVMEEVK VYNDSRVEAL LAKVSSLEET LKILEQKSLP 

       730 
KFTPHNQSPR IIDSN 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome."
Flory M.R., Carson A.R., Muller E.G., Aebersold R.
Mol. Cell 16:619-630(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 57-79, FUNCTION, INTERACTION WITH PCP1 AND TAZ1, SUBCELLULAR LOCATION.
[3]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"SHREC, an effector complex for heterochromatic transcriptional silencing."
Sugiyama T., Cam H.P., Sugiyama R., Noma K., Zofall M., Kobayashi R., Grewal S.I.S.
Cell 128:491-504(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CLR3, SUBCELLULAR LOCATION.
[5]"Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length."
Miyoshi T., Kanoh J., Saito M., Ishikawa F.
Science 320:1341-1344(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH POT1 AND TPZ1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAB41227.1.
PIRT41187.
RefSeqNP_588210.1. NM_001023200.2.

3D structure databases

ProteinModelPortalQ10432.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275918. 67 interactions.
DIPDIP-59444N.
MINTMINT-4699402.
STRING4896.SPCC188.07-1.

Proteomic databases

MaxQBQ10432.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC188.07.1; SPCC188.07.1:pep; SPCC188.07.
GeneID2539352.
KEGGspo:SPCC188.07.

Organism-specific databases

PomBaseSPCC188.07.

Phylogenomic databases

eggNOGNOG240409.
OrthoDBEOG7J9VZ1.

Family and domain databases

InterProIPR021006. HDA_complex_subunit-2/3.
[Graphical view]
PfamPF11496. HDA2-3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800517.

Entry information

Entry nameCCQ1_SCHPO
AccessionPrimary (citable) accession number: Q10432
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names