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Q10432

- CCQ1_SCHPO

UniProt

Q10432 - CCQ1_SCHPO

Protein

Coiled-coil quantitatively-enriched protein 1

Gene

ccq1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).3 Publications

    GO - Molecular functioni

    1. protein binding Source: PomBase

    GO - Biological processi

    1. cellular protein localization Source: PomBase
    2. chromatin silencing at telomere Source: PomBase
    3. meiotic chromosome segregation Source: PomBase
    4. meiotic telomere clustering Source: PomBase
    5. negative regulation of DNA recombination at telomere Source: PomBase
    6. positive regulation of telomere maintenance Source: PomBase
    7. positive regulation of telomere maintenance via telomerase Source: PomBase
    8. telomere capping Source: PomBase
    9. telomere maintenance Source: PomBase

    Keywords - Biological processi

    Chromosome partition

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil quantitatively-enriched protein 1
    Alternative name(s):
    Structural maintenance of chromosomes protein ccq1
    Short name:
    SMC protein ccq1
    Gene namesi
    Name:ccq1
    ORF Names:SPCC188.07
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC188.07.

    Subcellular locationi

    Nucleusnucleoplasm. Chromosometelomere
    Note: Associates with major heterochromatin, sub-telomeres, rDNA and the mat locus.

    GO - Cellular componenti

    1. meiotic spindle pole body Source: PomBase
    2. nuclear chromosome, telomeric region Source: PomBase
    3. nuclear telomeric heterochromatin Source: PomBase
    4. nucleoplasm Source: PomBase
    5. nucleus Source: PomBase
    6. protein complex Source: PomBase
    7. Stn1-Ten1 complex Source: PomBase

    Keywords - Cellular componenti

    Chromosome, Nucleus, Telomere

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 735735Coiled-coil quantitatively-enriched protein 1PRO_0000116882Add
    BLAST

    Proteomic databases

    MaxQBiQ10432.

    Interactioni

    Subunit structurei

    Interacts (during meiosis) with pcp1. Interacts with clr3, pot1, taz1 and tpz1.3 Publications

    Protein-protein interaction databases

    BioGridi275918. 67 interactions.
    DIPiDIP-59444N.
    MINTiMINT-4699402.
    STRINGi4896.SPCC188.07-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili514 – 719206Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG240409.
    OrthoDBiEOG7J9VZ1.

    Family and domain databases

    InterProiIPR021006. HDA_complex_subunit-2/3.
    [Graphical view]
    PfamiPF11496. HDA2-3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q10432-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEINDFTNS IIINESDTKY EVYSEVNSSN RWIAKEDCPS PLEDVWLLKL    50
    AGHKRKLEEP LSCMRNEEPA SKQREIEKFL RTDLDHSEND FLTQEVDEFP 100
    STQQLFPIPL QNDTAFDSSE ESITKSSKSS FSVLDIGLPM SALQRKMMHR 150
    LVQYFAFCID HFCTGPSDSR IQEKIRLFIQ SAHNIAKHPS LYDTEVRNPS 200
    AAESTNSHVS LDASNFSSYA ENSSKFLFLQ ELFKNLSPSY SKTFFLFISN 250
    QFLANTLTQW LKSQNIDAEL WAEEDAKTSQ HPAIWICVSK KAPSASHFLQ 300
    SCPDLSATIF YDIEAYMSVT SSLPSIQSLV LRLIHLGSIE HAIKCFQSSY 350
    NASFLVNIVG VVATLSSSSE ENSEASNLST LFEKSGNFEE ILGSESHSSI 400
    TEKTRDIAKN VATWLKNGEN FSSWPLPPLM DLASLSVAEP RDSQPSVSQV 450
    NDTFVKSSDS TFPSSQSMQS PSKLHSLTSN ATDLLSSSSL KKNFFSQQEA 500
    DEVELSNNYD LQGAAVQYLQ RRLRMVEDEL HEAINSKNVQ QSRSEELEQQ 550
    ISKLTDNLQE YRNTVRELKL DLEKSKKKNE DLSKLEVEKV EEIANLKKEL 600
    THLAKQQEFG FKYVQEFSNE DLQGKLIEAN EKNYKLTQLL KTQKEDADFI 650
    TNQYQNASTF AAEQSKEVAK LQAECKRLQA INSKVMEEVK VYNDSRVEAL 700
    LAKVSSLEET LKILEQKSLP KFTPHNQSPR IIDSN 735
    Length:735
    Mass (Da):83,301
    Last modified:October 1, 1996 - v1
    Checksum:i14193682700A2634
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB41227.1.
    PIRiT41187.
    RefSeqiNP_588210.1. NM_001023200.2.

    Genome annotation databases

    EnsemblFungiiSPCC188.07.1; SPCC188.07.1:pep; SPCC188.07.
    GeneIDi2539352.
    KEGGispo:SPCC188.07.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB41227.1 .
    PIRi T41187.
    RefSeqi NP_588210.1. NM_001023200.2.

    3D structure databases

    ProteinModelPortali Q10432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275918. 67 interactions.
    DIPi DIP-59444N.
    MINTi MINT-4699402.
    STRINGi 4896.SPCC188.07-1.

    Proteomic databases

    MaxQBi Q10432.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC188.07.1 ; SPCC188.07.1:pep ; SPCC188.07 .
    GeneIDi 2539352.
    KEGGi spo:SPCC188.07.

    Organism-specific databases

    PomBasei SPCC188.07.

    Phylogenomic databases

    eggNOGi NOG240409.
    OrthoDBi EOG7J9VZ1.

    Miscellaneous databases

    NextBioi 20800517.

    Family and domain databases

    InterProi IPR021006. HDA_complex_subunit-2/3.
    [Graphical view ]
    Pfami PF11496. HDA2-3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome."
      Flory M.R., Carson A.R., Muller E.G., Aebersold R.
      Mol. Cell 16:619-630(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 57-79, FUNCTION, INTERACTION WITH PCP1 AND TAZ1, SUBCELLULAR LOCATION.
    3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. "SHREC, an effector complex for heterochromatic transcriptional silencing."
      Sugiyama T., Cam H.P., Sugiyama R., Noma K., Zofall M., Kobayashi R., Grewal S.I.S.
      Cell 128:491-504(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CLR3, SUBCELLULAR LOCATION.
    5. "Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length."
      Miyoshi T., Kanoh J., Saito M., Ishikawa F.
      Science 320:1341-1344(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH POT1 AND TPZ1.

    Entry informationi

    Entry nameiCCQ1_SCHPO
    AccessioniPrimary (citable) accession number: Q10432
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names

    External Data

    Dasty 3