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Q10432

- CCQ1_SCHPO

UniProt

Q10432 - CCQ1_SCHPO

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Protein

Coiled-coil quantitatively-enriched protein 1

Gene
ccq1, SPCC188.07
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).3 Publications

GO - Molecular functioni

  1. protein binding Source: PomBase

GO - Biological processi

  1. cellular protein localization Source: PomBase
  2. chromatin silencing at telomere Source: PomBase
  3. meiotic chromosome segregation Source: PomBase
  4. meiotic telomere clustering Source: PomBase
  5. negative regulation of DNA recombination at telomere Source: PomBase
  6. positive regulation of telomere maintenance Source: PomBase
  7. positive regulation of telomere maintenance via telomerase Source: PomBase
  8. telomere capping Source: PomBase
  9. telomere maintenance Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil quantitatively-enriched protein 1
Alternative name(s):
Structural maintenance of chromosomes protein ccq1
Short name:
SMC protein ccq1
Gene namesi
Name:ccq1
ORF Names:SPCC188.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC188.07.

Subcellular locationi

Nucleusnucleoplasm. Chromosometelomere
Note: Associates with major heterochromatin, sub-telomeres, rDNA and the mat locus.4 Publications

GO - Cellular componenti

  1. chromosome, telomeric region Source: PomBase
  2. meiotic spindle pole body Source: PomBase
  3. nucleoplasm Source: PomBase
  4. nucleus Source: PomBase
  5. Stn1-Ten1 complex Source: PomBase
  6. telomeric heterochromatin Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Coiled-coil quantitatively-enriched protein 1PRO_0000116882Add
BLAST

Proteomic databases

MaxQBiQ10432.

Interactioni

Subunit structurei

Interacts (during meiosis) with pcp1. Interacts with clr3, pot1, taz1 and tpz1.3 Publications

Protein-protein interaction databases

BioGridi275918. 67 interactions.
DIPiDIP-59444N.
MINTiMINT-4699402.
STRINGi4896.SPCC188.07-1.

Structurei

3D structure databases

ProteinModelPortaliQ10432.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili514 – 719206 Reviewed predictionAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG240409.
OrthoDBiEOG7J9VZ1.

Family and domain databases

InterProiIPR021006. HDA_complex_subunit-2/3.
[Graphical view]
PfamiPF11496. HDA2-3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10432-1 [UniParc]FASTAAdd to Basket

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MSEINDFTNS IIINESDTKY EVYSEVNSSN RWIAKEDCPS PLEDVWLLKL    50
AGHKRKLEEP LSCMRNEEPA SKQREIEKFL RTDLDHSEND FLTQEVDEFP 100
STQQLFPIPL QNDTAFDSSE ESITKSSKSS FSVLDIGLPM SALQRKMMHR 150
LVQYFAFCID HFCTGPSDSR IQEKIRLFIQ SAHNIAKHPS LYDTEVRNPS 200
AAESTNSHVS LDASNFSSYA ENSSKFLFLQ ELFKNLSPSY SKTFFLFISN 250
QFLANTLTQW LKSQNIDAEL WAEEDAKTSQ HPAIWICVSK KAPSASHFLQ 300
SCPDLSATIF YDIEAYMSVT SSLPSIQSLV LRLIHLGSIE HAIKCFQSSY 350
NASFLVNIVG VVATLSSSSE ENSEASNLST LFEKSGNFEE ILGSESHSSI 400
TEKTRDIAKN VATWLKNGEN FSSWPLPPLM DLASLSVAEP RDSQPSVSQV 450
NDTFVKSSDS TFPSSQSMQS PSKLHSLTSN ATDLLSSSSL KKNFFSQQEA 500
DEVELSNNYD LQGAAVQYLQ RRLRMVEDEL HEAINSKNVQ QSRSEELEQQ 550
ISKLTDNLQE YRNTVRELKL DLEKSKKKNE DLSKLEVEKV EEIANLKKEL 600
THLAKQQEFG FKYVQEFSNE DLQGKLIEAN EKNYKLTQLL KTQKEDADFI 650
TNQYQNASTF AAEQSKEVAK LQAECKRLQA INSKVMEEVK VYNDSRVEAL 700
LAKVSSLEET LKILEQKSLP KFTPHNQSPR IIDSN 735
Length:735
Mass (Da):83,301
Last modified:October 1, 1996 - v1
Checksum:i14193682700A2634
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB41227.1.
PIRiT41187.
RefSeqiNP_588210.1. NM_001023200.2.

Genome annotation databases

EnsemblFungiiSPCC188.07.1; SPCC188.07.1:pep; SPCC188.07.
GeneIDi2539352.
KEGGispo:SPCC188.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB41227.1 .
PIRi T41187.
RefSeqi NP_588210.1. NM_001023200.2.

3D structure databases

ProteinModelPortali Q10432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275918. 67 interactions.
DIPi DIP-59444N.
MINTi MINT-4699402.
STRINGi 4896.SPCC188.07-1.

Proteomic databases

MaxQBi Q10432.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC188.07.1 ; SPCC188.07.1:pep ; SPCC188.07 .
GeneIDi 2539352.
KEGGi spo:SPCC188.07.

Organism-specific databases

PomBasei SPCC188.07.

Phylogenomic databases

eggNOGi NOG240409.
OrthoDBi EOG7J9VZ1.

Miscellaneous databases

NextBioi 20800517.

Family and domain databases

InterProi IPR021006. HDA_complex_subunit-2/3.
[Graphical view ]
Pfami PF11496. HDA2-3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome."
    Flory M.R., Carson A.R., Muller E.G., Aebersold R.
    Mol. Cell 16:619-630(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 57-79, FUNCTION, INTERACTION WITH PCP1 AND TAZ1, SUBCELLULAR LOCATION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. "SHREC, an effector complex for heterochromatic transcriptional silencing."
    Sugiyama T., Cam H.P., Sugiyama R., Noma K., Zofall M., Kobayashi R., Grewal S.I.S.
    Cell 128:491-504(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CLR3, SUBCELLULAR LOCATION.
  5. "Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length."
    Miyoshi T., Kanoh J., Saito M., Ishikawa F.
    Science 320:1341-1344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH POT1 AND TPZ1.

Entry informationi

Entry nameiCCQ1_SCHPO
AccessioniPrimary (citable) accession number: Q10432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

External Data

Dasty 3

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