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Protein

Coiled-coil quantitatively-enriched protein 1

Gene

ccq1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).3 Publications

GO - Biological processi

  1. cellular protein localization Source: PomBase
  2. chromatin silencing at telomere Source: PomBase
  3. meiotic chromosome segregation Source: PomBase
  4. meiotic telomere clustering Source: PomBase
  5. negative regulation of DNA recombination at telomere Source: PomBase
  6. positive regulation of telomere maintenance Source: PomBase
  7. positive regulation of telomere maintenance via telomerase Source: PomBase
  8. telomere capping Source: PomBase
  9. telomere maintenance Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil quantitatively-enriched protein 1
Alternative name(s):
Structural maintenance of chromosomes protein ccq1
Short name:
SMC protein ccq1
Gene namesi
Name:ccq1
ORF Names:SPCC188.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC188.07.

Subcellular locationi

Nucleusnucleoplasm. Chromosometelomere
Note: Associates with major heterochromatin, sub-telomeres, rDNA and the mat locus.

GO - Cellular componenti

  1. meiotic spindle pole body Source: PomBase
  2. nuclear chromosome, telomeric region Source: PomBase
  3. nuclear telomeric heterochromatin Source: PomBase
  4. nucleoplasm Source: PomBase
  5. nucleus Source: PomBase
  6. protein complex Source: PomBase
  7. Stn1-Ten1 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Coiled-coil quantitatively-enriched protein 1PRO_0000116882Add
BLAST

Proteomic databases

MaxQBiQ10432.

Interactioni

Subunit structurei

Interacts (during meiosis) with pcp1. Interacts with clr3, pot1, taz1 and tpz1.3 Publications

Protein-protein interaction databases

BioGridi275918. 69 interactions.
DIPiDIP-59444N.
MINTiMINT-4699402.
STRINGi4896.SPCC188.07-1.

Structurei

3D structure databases

ProteinModelPortaliQ10432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili514 – 719206Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG240409.
InParanoidiQ10432.
OrthoDBiEOG7J9VZ1.

Family and domain databases

InterProiIPR021006. HDA_complex_subunit-2/3.
[Graphical view]
PfamiPF11496. HDA2-3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10432-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEINDFTNS IIINESDTKY EVYSEVNSSN RWIAKEDCPS PLEDVWLLKL
60 70 80 90 100
AGHKRKLEEP LSCMRNEEPA SKQREIEKFL RTDLDHSEND FLTQEVDEFP
110 120 130 140 150
STQQLFPIPL QNDTAFDSSE ESITKSSKSS FSVLDIGLPM SALQRKMMHR
160 170 180 190 200
LVQYFAFCID HFCTGPSDSR IQEKIRLFIQ SAHNIAKHPS LYDTEVRNPS
210 220 230 240 250
AAESTNSHVS LDASNFSSYA ENSSKFLFLQ ELFKNLSPSY SKTFFLFISN
260 270 280 290 300
QFLANTLTQW LKSQNIDAEL WAEEDAKTSQ HPAIWICVSK KAPSASHFLQ
310 320 330 340 350
SCPDLSATIF YDIEAYMSVT SSLPSIQSLV LRLIHLGSIE HAIKCFQSSY
360 370 380 390 400
NASFLVNIVG VVATLSSSSE ENSEASNLST LFEKSGNFEE ILGSESHSSI
410 420 430 440 450
TEKTRDIAKN VATWLKNGEN FSSWPLPPLM DLASLSVAEP RDSQPSVSQV
460 470 480 490 500
NDTFVKSSDS TFPSSQSMQS PSKLHSLTSN ATDLLSSSSL KKNFFSQQEA
510 520 530 540 550
DEVELSNNYD LQGAAVQYLQ RRLRMVEDEL HEAINSKNVQ QSRSEELEQQ
560 570 580 590 600
ISKLTDNLQE YRNTVRELKL DLEKSKKKNE DLSKLEVEKV EEIANLKKEL
610 620 630 640 650
THLAKQQEFG FKYVQEFSNE DLQGKLIEAN EKNYKLTQLL KTQKEDADFI
660 670 680 690 700
TNQYQNASTF AAEQSKEVAK LQAECKRLQA INSKVMEEVK VYNDSRVEAL
710 720 730
LAKVSSLEET LKILEQKSLP KFTPHNQSPR IIDSN
Length:735
Mass (Da):83,301
Last modified:October 1, 1996 - v1
Checksum:i14193682700A2634
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB41227.1.
PIRiT41187.
RefSeqiNP_588210.1. NM_001023200.2.

Genome annotation databases

EnsemblFungiiSPCC188.07.1; SPCC188.07.1:pep; SPCC188.07.
GeneIDi2539352.
KEGGispo:SPCC188.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB41227.1.
PIRiT41187.
RefSeqiNP_588210.1. NM_001023200.2.

3D structure databases

ProteinModelPortaliQ10432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275918. 69 interactions.
DIPiDIP-59444N.
MINTiMINT-4699402.
STRINGi4896.SPCC188.07-1.

Proteomic databases

MaxQBiQ10432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC188.07.1; SPCC188.07.1:pep; SPCC188.07.
GeneIDi2539352.
KEGGispo:SPCC188.07.

Organism-specific databases

PomBaseiSPCC188.07.

Phylogenomic databases

eggNOGiNOG240409.
InParanoidiQ10432.
OrthoDBiEOG7J9VZ1.

Miscellaneous databases

NextBioi20800517.

Family and domain databases

InterProiIPR021006. HDA_complex_subunit-2/3.
[Graphical view]
PfamiPF11496. HDA2-3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "An SMC-domain protein in fission yeast links telomeres to the meiotic centrosome."
    Flory M.R., Carson A.R., Muller E.G., Aebersold R.
    Mol. Cell 16:619-630(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 57-79, FUNCTION, INTERACTION WITH PCP1 AND TAZ1, SUBCELLULAR LOCATION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. "SHREC, an effector complex for heterochromatic transcriptional silencing."
    Sugiyama T., Cam H.P., Sugiyama R., Noma K., Zofall M., Kobayashi R., Grewal S.I.S.
    Cell 128:491-504(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CLR3, SUBCELLULAR LOCATION.
  5. "Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length."
    Miyoshi T., Kanoh J., Saito M., Ishikawa F.
    Science 320:1341-1344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH POT1 AND TPZ1.

Entry informationi

Entry nameiCCQ1_SCHPO
AccessioniPrimary (citable) accession number: Q10432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.