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Protein

Kinetochore protein spc25

Gene

spc25

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore protein spc25
Gene namesi
Name:spc25
ORF Names:SPCC188.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC188.04c.
PomBaseiSPCC188.04c. spc25.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome kinetochore Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • Ndc80 complex Source: PomBase
  • NMS complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001168811 – 238Kinetochore protein spc25Add BLAST238

Proteomic databases

MaxQBiQ10430.
PRIDEiQ10430.

Interactioni

Subunit structurei

Component of the NDC80 complex, which consists of ndc80, nuf2, spc24 and spc25. Can self-associate. Component of the NMS super complex which consists of mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25.2 Publications

Protein-protein interaction databases

BioGridi275771. 5 interactors.
IntActiQ10430. 2 interactors.
MINTiMINT-4699389.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili28 – 141Sequence analysisAdd BLAST114

Sequence similaritiesi

Belongs to the SPC25 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ10430.
KOiK11558.
OMAiKDWEREA.
OrthoDBiEOG092C4GXM.
PhylomeDBiQ10430.

Family and domain databases

InterProiIPR013255. Spc25.
[Graphical view]
PfamiPF08234. Spindle_Spc25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q10430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLANFPTIE LDYDSLKSKI SNFNSIFDRF LQEERKKLLN NKNEYLRQLS
60 70 80 90 100
EINEAQKKAE KSLEQTEARK QNFTELLEKE HEEQAITEQE IFSFQEKLDA
110 120 130 140 150
MLKRKQKLSE ELDHYRAIIS SKRELRAQEM EAKRKQDSYN NPELKFWEDY
160 170 180 190 200
LGLKMEGVHD EVIRFIFTNI DEKDWNKQFS FQINLAERDY KVVHCHPPLP
210 220 230
HVDDLVNKVN RTRDFYQFLK DMRKGFRELH RKDLSQLI
Length:238
Mass (Da):28,811
Last modified:October 1, 1996 - v1
Checksum:i7351F2E8CDFC2659
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB41224.1.
PIRiT41184.
RefSeqiNP_588208.1. NM_001023198.2.

Genome annotation databases

EnsemblFungiiSPCC188.04c.1; SPCC188.04c.1:pep; SPCC188.04c.
GeneIDi2539200.
KEGGispo:SPCC188.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB41224.1.
PIRiT41184.
RefSeqiNP_588208.1. NM_001023198.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275771. 5 interactors.
IntActiQ10430. 2 interactors.
MINTiMINT-4699389.

Proteomic databases

MaxQBiQ10430.
PRIDEiQ10430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC188.04c.1; SPCC188.04c.1:pep; SPCC188.04c.
GeneIDi2539200.
KEGGispo:SPCC188.04c.

Organism-specific databases

EuPathDBiFungiDB:SPCC188.04c.
PomBaseiSPCC188.04c. spc25.

Phylogenomic databases

InParanoidiQ10430.
KOiK11558.
OMAiKDWEREA.
OrthoDBiEOG092C4GXM.
PhylomeDBiQ10430.

Miscellaneous databases

PROiQ10430.

Family and domain databases

InterProiIPR013255. Spc25.
[Graphical view]
PfamiPF08234. Spindle_Spc25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPC25_SCHPO
AccessioniPrimary (citable) accession number: Q10430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.