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Protein

Eukaryotic translation initiation factor 3 subunit B

Gene

SPAC25G10.08

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-72689 Formation of a pool of free 40S subunits
R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SPO-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit BUniRule annotation
Short name:
eIF3bUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 90 kDa subunit homologUniRule annotation
Short name:
eIF3 p90UniRule annotation
Translation initiation factor eIF3 p90 subunit homolog
spPrt1
Gene namesi
ORF Names:SPAC25G10.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC25G10.08
PomBaseiSPAC25G10.08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001235341 – 725Eukaryotic translation initiation factor 3 subunit BAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineUniRule annotation1 Publication1
Modified residuei135PhosphoserineUniRule annotation1 Publication1
Modified residuei136Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10425
PaxDbiQ10425
PRIDEiQ10425

PTM databases

iPTMnetiQ10425

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex appears to include tif32/eif3a, SPAC25G10.08/eif3b, tif33/eif3c, SPBC4C3.07/eif3f, tif35/eif3g and sum1/eif3i. This set of common subunits may also associate exclusively with either moe1/eif3d and int6/eif3e, or with SPAC821.05/eif3h and SPAC1751.03/eif3m. The eIF-3 complex may also include SPAC3A12.13c/eif3j.UniRule annotation2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278567, 18 interactors
STRINGi4896.SPAC25G10.08.1

Structurei

3D structure databases

ProteinModelPortaliQ10425
SMRiQ10425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 129RRMUniRule annotationAdd BLAST91
Repeati190 – 229WD 1Add BLAST40
Repeati304 – 344WD 2Add BLAST41
Repeati347 – 386WD 3Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili630 – 671UniRule annotationAdd BLAST42

Sequence similaritiesi

Belongs to the eIF-3 subunit B family.UniRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000265546
InParanoidiQ10425
KOiK03253
OMAiNFAWEPK
OrthoDBiEOG092C0KCM
PhylomeDBiQ10425

Family and domain databases

CDDicd12278 RRM_eIF3B, 1 hit
Gene3Di2.130.10.10, 1 hit
3.30.70.330, 1 hit
HAMAPiMF_03001 eIF3b, 1 hit
InterProiView protein in InterPro
IPR011400 EIF3B
IPR034363 eIF3B_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR14068 PTHR14068, 1 hit
PfamiView protein in Pfam
PF08662 eIF2A, 1 hit
PIRSFiPIRSF036424 eIF3b, 1 hit
SMARTiView protein in SMART
SM00361 RRM_1, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q10425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILIEEIK DQIVVKDEEI DVSELEVKLN VTKPVGYDTV VVIEGAPVVE
60 70 80 90 100
EAKQQDFFRF LSSKVLAKIG KVKENGFYMP FEEKNGKKMS LGLVFADFEN
110 120 130 140 150
VDGADLCVQE LDGKQILKNH TFVVRKLNQL EKAFSTPDEF SFEEREFKER
160 170 180 190 200
EHLRSWLTDY YGRDQFISYY GNRVSVNWNR KSDVPEQIVD RENWTETYVQ
210 220 230 240 250
WSPMGTYLVS LHLRGIQLWG GESWGMCARF LHPYVKFVDF SPNEKYLVSW
260 270 280 290 300
SYEPVRLPPI GHPARETMPF TDDDEGKHCF VWDIASGRIL RSFKIPPQPE
310 320 330 340 350
GSKDGKKVIW PIFKWSADDK YLARVTVGQS ISVYETPSLA LVDKKTIKID
360 370 380 390 400
GVQNFEWCPV SDALGRDSKE QLLAYWTPEI TNQPARVALI SIPSKSTIRT
410 420 430 440 450
KNLFNVSDCK LYWQSNGDYL CVKVDRHTKT KKSTFSNLEI FRIREKNIPV
460 470 480 490 500
EVVDLKDVVL NFAWEPKSDR FAIISANDQV LNSTNVKTNL SFYGFEQKKN
510 520 530 540 550
TPSTFRHIIT FDKKTCNSLF MAPKGRFMVA ATLGSSTQYD LEFYDLDFDT
560 570 580 590 600
EKKEPDALAN VQQIGSAEHF GMTELEWDPS GRYVTTSSTI WRHKLENGYR
610 620 630 640 650
LCDFRGTLLR EEMIGEFKQF IWRPRPPSPL TKEDMKKIRK KLKDYNRLFD
660 670 680 690 700
EEDIAEQSSA NRELAARRRQ LISEWQKYRD EVIARVAEER AITGQPAITV
710 720
PAEEEEIIQE TVEEVISEEI EPVED
Length:725
Mass (Da):84,035
Last modified:October 1, 1996 - v1
Checksum:iD4725583F7F9EE34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA94637.1
PIRiT38379
RefSeqiNP_594528.1, NM_001019957.2

Genome annotation databases

EnsemblFungiiSPAC25G10.08.1; SPAC25G10.08.1:pep; SPAC25G10.08
GeneIDi2542090
KEGGispo:SPAC25G10.08

Similar proteinsi

Entry informationi

Entry nameiEIF3B_SCHPO
AccessioniPrimary (citable) accession number: Q10425
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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