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Q10415

- PMIP_SCHPO

UniProt

Q10415 - PMIP_SCHPO

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Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi544 – 5441Zinc; catalyticPROSITE-ProRule annotation
Active sitei545 – 5451PROSITE-ProRule annotation
Metal bindingi548 – 5481Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi551 – 5511Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: PomBase

GO - Biological processi

  1. cellular iron ion homeostasis Source: PomBase
  2. protein processing involved in protein targeting to mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:SPAC1F3.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1F3.10c.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
BLAST
Chaini29 – 762734Mitochondrial intermediate peptidasePRO_0000028582Add
BLAST

Proteomic databases

MaxQBiQ10415.

Interactioni

Protein-protein interaction databases

MINTiMINT-4699250.
STRINGi4896.SPAC1F3.10c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
InParanoidiQ10415.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.
PhylomeDBiQ10415.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10415 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVRTLLTLG KKKVIGNRQC ILSLYRKYSN VQSRKAEDQL LRQIFDDQNI
60 70 80 90 100
AVNQITKRNG IQGVGLFRNH FLSDKDTGFL RLAETASEKC KAVIEDLLLE
110 120 130 140 150
DTEDGSIVVS KFDRISNLLC SVIDLFEFVR CAHPDKMVVM KAEEAYSYLF
160 170 180 190 200
ELMNTLNTHQ GLYEKLKCSL QQTPTLKDTD PEAYTVGRVF LQDFEKSGVN
210 220 230 240 250
LESSKRNSFV KKSSESATLG RAFFNNSMNR PQRYLTISKQ RLAGSDPYFV
260 270 280 290 300
RSLSKNDKNF IMIPTVGYEG TQALISVANP DVRKEIYMEG HKGTVEEVEL
310 320 330 340 350
LNSYLRSKAE VAKLVGKSSF ADLQLIDKMA NAPKHVVEFL ENLSLKNSSV
360 370 380 390 400
LKKILNNLAL MKKKELNLNF LPSFDVWDRE YYTARYKQSL INQKPSLNPS
410 420 430 440 450
ITNYRRFFSV GTVIQGLSRL FSSLYGLRFV PADISPGEVW HPDVNKVNVY
460 470 480 490 500
NENDHVMGVI YFDLFARTGK TDGAAHFTIR SSRELDLTSF DDSISLGFDD
510 520 530 540 550
ATNIRVKDNK RYQIPVISLL CNFVRSSGMD PTFLDLWDVK TLFHEMGHAM
560 570 580 590 600
HSILGHTKYQ NLAGTRCATD FVELPSIIME FFMSNPAVLP LYARYEGTEI
610 620 630 640 650
PLPVQVLNHH NMVENSSAPL DLQSQICMAM VDQLFHSKVV LDPSFNSIDE
660 670 680 690 700
VTNVTRKFSG FESAPPAAWY LQFSHLYGYS ATYYSYIFDT VLASLIFSKL
710 720 730 740 750
FAGNPLSREA GEKFRKAILR WGGSRSPWEC VAEALEQPIL ATGGEEAMRR
760
IGSEGIKATS TF
Length:762
Mass (Da):86,286
Last modified:October 1, 1996 - v1
Checksum:iC6420C1F99001EFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA94628.1.
PIRiT38081.
RefSeqiNP_593013.1. NM_001018412.2.

Genome annotation databases

EnsemblFungiiSPAC1F3.10c.1; SPAC1F3.10c.1:pep; SPAC1F3.10c.
GeneIDi2541640.
KEGGispo:SPAC1F3.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA94628.1 .
PIRi T38081.
RefSeqi NP_593013.1. NM_001018412.2.

3D structure databases

ProteinModelPortali Q10415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4699250.
STRINGi 4896.SPAC1F3.10c-1.

Protein family/group databases

MEROPSi M03.006.

Proteomic databases

MaxQBi Q10415.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1F3.10c.1 ; SPAC1F3.10c.1:pep ; SPAC1F3.10c .
GeneIDi 2541640.
KEGGi spo:SPAC1F3.10c.

Organism-specific databases

PomBasei SPAC1F3.10c.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
InParanoidi Q10415.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.
PhylomeDBi Q10415.

Miscellaneous databases

NextBioi 20802733.
PROi Q10415.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPMIP_SCHPO
AccessioniPrimary (citable) accession number: Q10415
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3