Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q10415

- PMIP_SCHPO

UniProt

Q10415 - PMIP_SCHPO

Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi544 – 5441Zinc; catalyticPROSITE-ProRule annotation
    Active sitei545 – 5451PROSITE-ProRule annotation
    Metal bindingi548 – 5481Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi551 – 5511Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: PomBase

    GO - Biological processi

    1. cellular iron ion homeostasis Source: PomBase
    2. protein processing involved in protein targeting to mitochondrion Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:oct1
    ORF Names:SPAC1F3.10c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1F3.10c.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: PomBase
    2. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
    BLAST
    Chaini29 – 762734Mitochondrial intermediate peptidasePRO_0000028582Add
    BLAST

    Proteomic databases

    MaxQBiQ10415.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4699250.
    STRINGi4896.SPAC1F3.10c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10415.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    KOiK01410.
    OMAiLQVFYSA.
    OrthoDBiEOG71GB4R.
    PhylomeDBiQ10415.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q10415-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVRTLLTLG KKKVIGNRQC ILSLYRKYSN VQSRKAEDQL LRQIFDDQNI    50
    AVNQITKRNG IQGVGLFRNH FLSDKDTGFL RLAETASEKC KAVIEDLLLE 100
    DTEDGSIVVS KFDRISNLLC SVIDLFEFVR CAHPDKMVVM KAEEAYSYLF 150
    ELMNTLNTHQ GLYEKLKCSL QQTPTLKDTD PEAYTVGRVF LQDFEKSGVN 200
    LESSKRNSFV KKSSESATLG RAFFNNSMNR PQRYLTISKQ RLAGSDPYFV 250
    RSLSKNDKNF IMIPTVGYEG TQALISVANP DVRKEIYMEG HKGTVEEVEL 300
    LNSYLRSKAE VAKLVGKSSF ADLQLIDKMA NAPKHVVEFL ENLSLKNSSV 350
    LKKILNNLAL MKKKELNLNF LPSFDVWDRE YYTARYKQSL INQKPSLNPS 400
    ITNYRRFFSV GTVIQGLSRL FSSLYGLRFV PADISPGEVW HPDVNKVNVY 450
    NENDHVMGVI YFDLFARTGK TDGAAHFTIR SSRELDLTSF DDSISLGFDD 500
    ATNIRVKDNK RYQIPVISLL CNFVRSSGMD PTFLDLWDVK TLFHEMGHAM 550
    HSILGHTKYQ NLAGTRCATD FVELPSIIME FFMSNPAVLP LYARYEGTEI 600
    PLPVQVLNHH NMVENSSAPL DLQSQICMAM VDQLFHSKVV LDPSFNSIDE 650
    VTNVTRKFSG FESAPPAAWY LQFSHLYGYS ATYYSYIFDT VLASLIFSKL 700
    FAGNPLSREA GEKFRKAILR WGGSRSPWEC VAEALEQPIL ATGGEEAMRR 750
    IGSEGIKATS TF 762
    Length:762
    Mass (Da):86,286
    Last modified:October 1, 1996 - v1
    Checksum:iC6420C1F99001EFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA94628.1.
    PIRiT38081.
    RefSeqiNP_593013.1. NM_001018412.2.

    Genome annotation databases

    EnsemblFungiiSPAC1F3.10c.1; SPAC1F3.10c.1:pep; SPAC1F3.10c.
    GeneIDi2541640.
    KEGGispo:SPAC1F3.10c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA94628.1 .
    PIRi T38081.
    RefSeqi NP_593013.1. NM_001018412.2.

    3D structure databases

    ProteinModelPortali Q10415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4699250.
    STRINGi 4896.SPAC1F3.10c-1.

    Protein family/group databases

    MEROPSi M03.006.

    Proteomic databases

    MaxQBi Q10415.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1F3.10c.1 ; SPAC1F3.10c.1:pep ; SPAC1F3.10c .
    GeneIDi 2541640.
    KEGGi spo:SPAC1F3.10c.

    Organism-specific databases

    PomBasei SPAC1F3.10c.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    KOi K01410.
    OMAi LQVFYSA.
    OrthoDBi EOG71GB4R.
    PhylomeDBi Q10415.

    Miscellaneous databases

    NextBioi 20802733.
    PROi Q10415.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPMIP_SCHPO
    AccessioniPrimary (citable) accession number: Q10415
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3