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Q10415

- PMIP_SCHPO

UniProt

Q10415 - PMIP_SCHPO

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Protein
Mitochondrial intermediate peptidase
Gene
oct1, SPAC1F3.10c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi544 – 5441Zinc; catalytic By similarity
Active sitei545 – 5451 By similarity
Metal bindingi548 – 5481Zinc; catalytic By similarity
Metal bindingi551 – 5511Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: PomBase
Complete GO annotation...

GO - Biological processi

  1. cellular iron ion homeostasis Source: PomBase
  2. protein processing involved in protein targeting to mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:SPAC1F3.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1F3.10c.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828Mitochondrion Reviewed prediction
Add
BLAST
Chaini29 – 762734Mitochondrial intermediate peptidase
PRO_0000028582Add
BLAST

Proteomic databases

MaxQBiQ10415.

Interactioni

Protein-protein interaction databases

MINTiMINT-4699250.
STRINGi4896.SPAC1F3.10c-1.

Structurei

3D structure databases

ProteinModelPortaliQ10415.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.
PhylomeDBiQ10415.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10415-1 [UniParc]FASTAAdd to Basket

« Hide

MQVRTLLTLG KKKVIGNRQC ILSLYRKYSN VQSRKAEDQL LRQIFDDQNI    50
AVNQITKRNG IQGVGLFRNH FLSDKDTGFL RLAETASEKC KAVIEDLLLE 100
DTEDGSIVVS KFDRISNLLC SVIDLFEFVR CAHPDKMVVM KAEEAYSYLF 150
ELMNTLNTHQ GLYEKLKCSL QQTPTLKDTD PEAYTVGRVF LQDFEKSGVN 200
LESSKRNSFV KKSSESATLG RAFFNNSMNR PQRYLTISKQ RLAGSDPYFV 250
RSLSKNDKNF IMIPTVGYEG TQALISVANP DVRKEIYMEG HKGTVEEVEL 300
LNSYLRSKAE VAKLVGKSSF ADLQLIDKMA NAPKHVVEFL ENLSLKNSSV 350
LKKILNNLAL MKKKELNLNF LPSFDVWDRE YYTARYKQSL INQKPSLNPS 400
ITNYRRFFSV GTVIQGLSRL FSSLYGLRFV PADISPGEVW HPDVNKVNVY 450
NENDHVMGVI YFDLFARTGK TDGAAHFTIR SSRELDLTSF DDSISLGFDD 500
ATNIRVKDNK RYQIPVISLL CNFVRSSGMD PTFLDLWDVK TLFHEMGHAM 550
HSILGHTKYQ NLAGTRCATD FVELPSIIME FFMSNPAVLP LYARYEGTEI 600
PLPVQVLNHH NMVENSSAPL DLQSQICMAM VDQLFHSKVV LDPSFNSIDE 650
VTNVTRKFSG FESAPPAAWY LQFSHLYGYS ATYYSYIFDT VLASLIFSKL 700
FAGNPLSREA GEKFRKAILR WGGSRSPWEC VAEALEQPIL ATGGEEAMRR 750
IGSEGIKATS TF 762
Length:762
Mass (Da):86,286
Last modified:October 1, 1996 - v1
Checksum:iC6420C1F99001EFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA94628.1.
PIRiT38081.
RefSeqiNP_593013.1. NM_001018412.2.

Genome annotation databases

EnsemblFungiiSPAC1F3.10c.1; SPAC1F3.10c.1:pep; SPAC1F3.10c.
GeneIDi2541640.
KEGGispo:SPAC1F3.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA94628.1 .
PIRi T38081.
RefSeqi NP_593013.1. NM_001018412.2.

3D structure databases

ProteinModelPortali Q10415.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4699250.
STRINGi 4896.SPAC1F3.10c-1.

Protein family/group databases

MEROPSi M03.006.

Proteomic databases

MaxQBi Q10415.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1F3.10c.1 ; SPAC1F3.10c.1:pep ; SPAC1F3.10c .
GeneIDi 2541640.
KEGGi spo:SPAC1F3.10c.

Organism-specific databases

PomBasei SPAC1F3.10c.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.
PhylomeDBi Q10415.

Miscellaneous databases

NextBioi 20802733.
PROi Q10415.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPMIP_SCHPO
AccessioniPrimary (citable) accession number: Q10415
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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