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Q10415 (PMIP_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial intermediate peptidase

Short name=MIP
EC=3.4.24.59
Alternative name(s):
Octapeptidyl aminopeptidase
Gene names
Name:oct1
ORF Names:SPAC1F3.10c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length762 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activity

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactor

Binds 1 zinc ion By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the peptidase M3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2828Mitochondrion Potential
Chain29 – 762734Mitochondrial intermediate peptidase
PRO_0000028582

Sites

Active site5451 By similarity
Metal binding5441Zinc; catalytic By similarity
Metal binding5481Zinc; catalytic By similarity
Metal binding5511Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q10415 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: C6420C1F99001EFC

FASTA76286,286
        10         20         30         40         50         60 
MQVRTLLTLG KKKVIGNRQC ILSLYRKYSN VQSRKAEDQL LRQIFDDQNI AVNQITKRNG 

        70         80         90        100        110        120 
IQGVGLFRNH FLSDKDTGFL RLAETASEKC KAVIEDLLLE DTEDGSIVVS KFDRISNLLC 

       130        140        150        160        170        180 
SVIDLFEFVR CAHPDKMVVM KAEEAYSYLF ELMNTLNTHQ GLYEKLKCSL QQTPTLKDTD 

       190        200        210        220        230        240 
PEAYTVGRVF LQDFEKSGVN LESSKRNSFV KKSSESATLG RAFFNNSMNR PQRYLTISKQ 

       250        260        270        280        290        300 
RLAGSDPYFV RSLSKNDKNF IMIPTVGYEG TQALISVANP DVRKEIYMEG HKGTVEEVEL 

       310        320        330        340        350        360 
LNSYLRSKAE VAKLVGKSSF ADLQLIDKMA NAPKHVVEFL ENLSLKNSSV LKKILNNLAL 

       370        380        390        400        410        420 
MKKKELNLNF LPSFDVWDRE YYTARYKQSL INQKPSLNPS ITNYRRFFSV GTVIQGLSRL 

       430        440        450        460        470        480 
FSSLYGLRFV PADISPGEVW HPDVNKVNVY NENDHVMGVI YFDLFARTGK TDGAAHFTIR 

       490        500        510        520        530        540 
SSRELDLTSF DDSISLGFDD ATNIRVKDNK RYQIPVISLL CNFVRSSGMD PTFLDLWDVK 

       550        560        570        580        590        600 
TLFHEMGHAM HSILGHTKYQ NLAGTRCATD FVELPSIIME FFMSNPAVLP LYARYEGTEI 

       610        620        630        640        650        660 
PLPVQVLNHH NMVENSSAPL DLQSQICMAM VDQLFHSKVV LDPSFNSIDE VTNVTRKFSG 

       670        680        690        700        710        720 
FESAPPAAWY LQFSHLYGYS ATYYSYIFDT VLASLIFSKL FAGNPLSREA GEKFRKAILR 

       730        740        750        760 
WGGSRSPWEC VAEALEQPIL ATGGEEAMRR IGSEGIKATS TF 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA94628.1.
PIRT38081.
RefSeqNP_593013.1. NM_001018412.2.

3D structure databases

ProteinModelPortalQ10415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4699250.
STRING4896.SPAC1F3.10c-1.

Protein family/group databases

MEROPSM03.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC1F3.10c.1; SPAC1F3.10c.1:pep; SPAC1F3.10c.
GeneID2541640.
KEGGspo:SPAC1F3.10c.

Organism-specific databases

PomBaseSPAC1F3.10c.

Phylogenomic databases

eggNOGCOG0339.
HOGENOMHOG000076521.
KOK01410.
OMALQVFYSA.
OrthoDBEOG71GB4R.
PhylomeDBQ10415.

Family and domain databases

Gene3D1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802733.
PROQ10415.

Entry information

Entry namePMIP_SCHPO
AccessionPrimary (citable) accession number: Q10415
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Peptidase families

Classification of peptidase families and list of entries