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Protein

Electron transfer protein 1, mitochondrial

Gene

etp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi541 – 5411Iron-sulfur (2Fe-2S)By similarity
Metal bindingi547 – 5471Iron-sulfur (2Fe-2S)By similarity
Metal bindingi550 – 5501Iron-sulfur (2Fe-2S)By similarity
Metal bindingi587 – 5871Iron-sulfur (2Fe-2S)By similarity

GO - Molecular functioni

GO - Biological processi

  • electron transport chain Source: PomBase
  • heme a biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-189451. Heme biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer protein 1, mitochondrial
Gene namesi
Name:etp1
ORF Names:SPAC22E12.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22E12.10c.
PomBaseiSPAC22E12.10c. etp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST
Transmembranei440 – 46021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 616Electron transfer protein 1, mitochondrialPRO_0000006079
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiQ10361.

Interactioni

Protein-protein interaction databases

BioGridi278330. 1 interaction.
MINTiMINT-4699099.

Structurei

Secondary structure

1
616
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi519 – 5246Combined sources
Beta strandi530 – 5356Combined sources
Turni540 – 5434Combined sources
Beta strandi551 – 5544Combined sources
Helixi556 – 5616Combined sources
Helixi567 – 5737Combined sources
Beta strandi583 – 5853Combined sources
Turni586 – 5883Combined sources
Helixi593 – 5953Combined sources
Beta strandi598 – 6014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WLBX-ray2.60A/B516-603[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ10361.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini502 – 6061052Fe-2S ferredoxin-typeAdd
BLAST

Sequence similaritiesi

Belongs to the COX15/CtaA family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000214943.
InParanoidiQ10361.
KOiK02259.
OrthoDBiEOG73V6VZ.
PhylomeDBiQ10361.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. Beta-grasp_dom.
IPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
PF00111. Fer2. 1 hit.
[Graphical view]
PRINTSiPR00355. ADRENODOXIN.
SUPFAMiSSF54292. SSF54292. 1 hit.
PROSITEiPS00814. ADX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNISRSSGLM RQFLLQPLRK GCDISCLGRS SWRMSRSFSG SSVLNEINLS
60 70 80 90 100
RTKNLFLNDC KFNKNSFEKF FARRLSNSVA PTPGGILQET EKIPSKKVAF
110 120 130 140 150
WLLGSSALVL AIVVVGGITR LTESGLSITE WKPITGVIPP LTDEQWNQEF
160 170 180 190 200
ELYKKSPEFE KLNSHMTVDE FKNIFFWEWF HRVLGRGIGL TILLPSIYMI
210 220 230 240 250
VTKRASPWLS KRLIGLTGLV GLQGVIGWWM VKSGLSEELF SDGSHPRVSH
260 270 280 290 300
YRLATHLAAA VALYIGLVWT GHGILQRHAF LKSMKSGSTS QLTSMVSSVQ
310 320 330 340 350
KMKGFRTSVN SFVGLVLITL LSGAFVAGLD AGMIYCTFPE MGEGRLAPSK
360 370 380 390 400
SELFDQRFCR KDDKSDLIWR NMIDNPSLVQ LEHRILAITT FVAACGLFIF
410 420 430 440 450
SRAKRNILPK KIKTSINVVT GVVTAQATLG IMTLIYVVPV PLAALHQAGS
460 470 480 490 500
LVTLTAALSL AQRLHPEYAL KNIRSWTKLI SSPPKSSISS SILTQQRQFH
510 520 530 540 550
TFRPSFHSEI KKPLPGTGIK VFFVTPEGRE IMIEGNEEGA CEGSVACSTC
560 570 580 590 600
HVIVDPEHYE LLDPPEEDEE DMLDLAFGLE ETSRLGCQVL LRKDLDGIRV
610
RIPAQTRNIR LERPKA
Length:616
Mass (Da):68,584
Last modified:September 22, 2009 - v2
Checksum:iD5E3846A28789691
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941P → S no nucleotide entry (PubMed:11841224).Curated
Sequence conflicti112 – 1121I → T no nucleotide entry (PubMed:11841224).Curated
Sequence conflicti443 – 4431A → V no nucleotide entry (PubMed:11841224).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93897.2.
PIRiT38167.
RefSeqiNP_594836.2. NM_001020265.3.

Genome annotation databases

EnsemblFungiiSPAC22E12.10c.1; SPAC22E12.10c.1:pep; SPAC22E12.10c.
GeneIDi2541839.
KEGGispo:SPAC22E12.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA93897.2.
PIRiT38167.
RefSeqiNP_594836.2. NM_001020265.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WLBX-ray2.60A/B516-603[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278330. 1 interaction.
MINTiMINT-4699099.

Proteomic databases

MaxQBiQ10361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC22E12.10c.1; SPAC22E12.10c.1:pep; SPAC22E12.10c.
GeneIDi2541839.
KEGGispo:SPAC22E12.10c.

Organism-specific databases

EuPathDBiFungiDB:SPAC22E12.10c.
PomBaseiSPAC22E12.10c. etp1.

Phylogenomic databases

HOGENOMiHOG000214943.
InParanoidiQ10361.
KOiK02259.
OrthoDBiEOG73V6VZ.
PhylomeDBiQ10361.

Enzyme and pathway databases

ReactomeiR-SPO-189451. Heme biosynthesis.

Miscellaneous databases

EvolutionaryTraceiQ10361.
PROiQ10361.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001055. Adrenodoxin.
IPR018298. Adrenodoxin_Fe-S_BS.
IPR012675. Beta-grasp_dom.
IPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
PF00111. Fer2. 1 hit.
[Graphical view]
PRINTSiPR00355. ADRENODOXIN.
SUPFAMiSSF54292. SSF54292. 1 hit.
PROSITEiPS00814. ADX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1."
    Bureik M., Schiffler B., Hiraoka Y., Vogel F., Bernhardt R.
    Biochemistry 41:2311-2321(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiETP1_SCHPO
AccessioniPrimary (citable) accession number: Q10361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 22, 2009
Last modified: June 8, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.