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Protein

Translationally-controlled tumor protein homolog

Gene

p23fy

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein homolog
Short name:
TCTP
Alternative name(s):
p23fyp
Gene namesi
Name:p23fy
ORF Names:SPAC1F12.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F12.02c
PomBaseiSPAC1F12.02c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113101 – 168Translationally-controlled tumor protein homologAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10344
PaxDbiQ10344
PRIDEiQ10344

PTM databases

iPTMnetiQ10344

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278935, 7 interactors
STRINGi4896.SPAC1F12.02c.1

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Turni7 – 10Combined sources4
Turni16 – 18Combined sources3
Beta strandi20 – 22Combined sources3
Beta strandi24 – 31Combined sources8
Beta strandi34 – 38Combined sources5
Beta strandi62 – 66Combined sources5
Helixi67 – 71Combined sources5
Helixi81 – 101Combined sources21
Helixi106 – 122Combined sources17
Turni123 – 128Combined sources6
Beta strandi143 – 147Combined sources5
Beta strandi149 – 152Combined sources4
Beta strandi154 – 160Combined sources7
Beta strandi164 – 166Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H6QNMR-A1-168[»]
1H7YNMR-A1-168[»]
ProteinModelPortaliQ10344
SMRiQ10344
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ10344

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 168TCTPPROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000203361
InParanoidiQ10344
OMAiFKDFEFY
OrthoDBiEOG092C4YQJ
PhylomeDBiQ10344

Family and domain databases

Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumor
IPR034737 TCTP
IPR018103 Translation_control_tumour_CS
IPR018105 Translational_control_tumour_p
PANTHERiPTHR11991 PTHR11991, 1 hit
PfamiView protein in Pfam
PF00838 TCTP, 1 hit
PRINTSiPR01653 TCTPROTEIN
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS01002 TCTP_1, 1 hit
PS01003 TCTP_2, 1 hit
PS51797 TCTP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q10344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLYKDVISG DELVSDAYDL KEVDDIVYEA DCQMVTVKQG GDVDIGANPS
60 70 80 90 100
AEDAEENAEE GTETVNNLVY SFRLSPTSFD KKSYMSYIKG YMKAIKARLQ
110 120 130 140 150
ESNPERVPVF EKNAIGFVKK ILANFKDYDF YIGESMDPDA MVVLMNYRED
160
GITPYMIFFK DGLVSEKF
Length:168
Mass (Da):19,049
Last modified:October 1, 1996 - v1
Checksum:i52F749AF994C917F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93806.1
PIRiT38060 S67445
RefSeqiNP_594328.1, NM_001019749.2

Genome annotation databases

EnsemblFungiiSPAC1F12.02c.1; SPAC1F12.02c.1:pep; SPAC1F12.02c
GeneIDi2542475
KEGGispo:SPAC1F12.02c

Similar proteinsi

Entry informationi

Entry nameiTCTP_SCHPO
AccessioniPrimary (citable) accession number: Q10344
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health