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Protein

BRCT-containing protein 1

Gene

brc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for mitotic fidelity, specifically in the G2 phase of the cell cycle. Plays a role in chromatin organization.1 Publication

GO - Biological processi

  • postreplication repair Source: PomBase
  • regulation of DNA recombination Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
BRCT-containing protein 1
Gene namesi
Name:brc1
ORF Names:SPBC582.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC582.05c.
PomBaseiSPBC582.05c. brc1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, centromeric region Source: PomBase
  • nuclear rDNA heterochromatin Source: PomBase
  • nuclear telomeric heterochromatin Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
  • site of double-strand break Source: PomBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649831 – 878BRCT-containing protein 1Add BLAST878

Proteomic databases

MaxQBiQ10337.
PRIDEiQ10337.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hta1P049094EBI-7764855,EBI-7764873

Protein-protein interaction databases

BioGridi277586. 48 interactors.
IntActiQ10337. 1 interactor.
MINTiMINT-4698908.
STRINGi4896.SPBC582.05c.1.

Structurei

Secondary structure

1878
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi667 – 671Combined sources5
Helixi681 – 686Combined sources6
Beta strandi688 – 690Combined sources3
Turni694 – 696Combined sources3
Beta strandi698 – 701Combined sources4
Helixi709 – 714Combined sources6
Helixi715 – 717Combined sources3
Beta strandi720 – 722Combined sources3
Helixi724 – 733Combined sources10
Helixi740 – 742Combined sources3
Helixi747 – 753Combined sources7
Helixi757 – 767Combined sources11
Turni771 – 774Combined sources4
Beta strandi775 – 780Combined sources6
Helixi786 – 788Combined sources3
Helixi789 – 798Combined sources10
Beta strandi803 – 806Combined sources4
Helixi811 – 819Combined sources9
Beta strandi822 – 826Combined sources5
Helixi828 – 830Combined sources3
Helixi831 – 834Combined sources4
Turni835 – 837Combined sources3
Helixi838 – 841Combined sources4
Beta strandi847 – 851Combined sources5
Helixi852 – 861Combined sources10
Helixi872 – 874Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L40X-ray1.55A/B659-877[»]
3L41X-ray1.45A659-878[»]
ProteinModelPortaliQ10337.
SMRiQ10337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ10337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 104BRCT 1PROSITE-ProRule annotationAdd BLAST91
Domaini105 – 196BRCT 2PROSITE-ProRule annotationAdd BLAST92
Domaini311 – 399BRCT 3PROSITE-ProRule annotationAdd BLAST89
Domaini654 – 744BRCT 4PROSITE-ProRule annotationAdd BLAST91
Domaini767 – 872BRCT 5PROSITE-ProRule annotationAdd BLAST106

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiQ10337.
OMAiFLCAMAV.
OrthoDBiEOG092C0BFA.
PhylomeDBiQ10337.

Family and domain databases

CDDicd00027. BRCT. 4 hits.
Gene3Di3.40.50.10190. 6 hits.
InterProiView protein in InterPro
IPR001357. BRCT_dom.
PfamiView protein in Pfam
PF00533. BRCT. 1 hit.
PF12738. PTCB-BRCT. 1 hit.
PF16770. RTT107_BRCT_5. 1 hit.
SMARTiView protein in SMART
SM00292. BRCT. 6 hits.
SUPFAMiSSF52113. SSF52113. 4 hits.
PROSITEiView protein in PROSITE
PS50172. BRCT. 5 hits.

Sequencei

Sequence statusi: Complete.

Q10337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIKLLNVK TPNHYTIIFK VVAYYSALQP NQNELRKKEL FIKNDGKALS
60 70 80 90 100
FPYDWKLATH VICDDFSSPN VQEGSKRSLR LAKTNWIRDC VDKNTLLNYS
110 120 130 140 150
FYSCNPYLLF KGICASSCQI DSYQSSLIDD ALETFGGRFS KGLMKSMTHL
160 170 180 190 200
FTYSGMGAKC KKVLDKPSLS IKLIHPQWLL DCLQFGQLID QDPYLFPNPS
210 220 230 240 250
YKKNDSSISK AEPTSLFRNV LHGKRIYFSN DLNLPTNFRH SLQKFSVGIG
260 270 280 290 300
AKIAESINDC DIFIGLKRDT IEFNLASNKN TTIGTISWLL NLFVLGSWKS
310 320 330 340 350
PLLNALHYPF PSVGFLKDQM VAVTNYTDAA RIYLEKLLLA CGATYTKDLK
360 370 380 390 400
PTNTLLIAAS SYGQKYGAAK VWNIPTVHHS WLYSSFKNLS SQAFTDFPVP
410 420 430 440 450
LDDSYMDFIF PCPLNVEKGS FEDTLKSSLT KGNSEVLLDD LSDPSVSSIK
460 470 480 490 500
GNKTNEELEK EFKSTSDNFG KHIILTSSFS NQSADKGSSL AAEDDRNDEG
510 520 530 540 550
STITGVNREL QDEGRLEIDA KSSKTNTPPS PLLVGTPSKE SLKEASSDDE
560 570 580 590 600
LPVLATKLVD NVIKEKSPLS LTPKVVVPSH KETYTDEKKL IDELDRVNPL
610 620 630 640 650
NSSQLLRSKR KSAATALSML QNVIMPDVLA FEREKKRRQT HRSVSSGEVS
660 670 680 690 700
RESSESRNTN AKASKRVYIT FTGYDKKPSI DNLKKLDMSI TSNPSKCTHL
710 720 730 740 750
IAPRILRTSK FLCSIPYGPC VVTMDWINSC LKTHEIVDEE PYLLNDPEKE
760 770 780 790 800
LELGCTLESA LKRARAQGPS LLEDYVVYLT SKTVAPENVP AVISIVKSNG
810 820 830 840 850
GVCSTLNVYN KRLARHLEDG NVVLITCNED SHIWTNFLDN ASQNKTIFLQ
860 870
NYDWLIKTVL RQEIDVNDRI ADEFARAV
Length:878
Mass (Da):98,436
Last modified:October 1, 1996 - v1
Checksum:iAFCAFBEF800CBFC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB46668.1.
PIRiT37978.
RefSeqiNP_595173.1. NM_001021081.1.

Genome annotation databases

EnsemblFungiiSPBC582.05c.1; SPBC582.05c.1:pep; SPBC582.05c.
GeneIDi2541071.
KEGGispo:SPBC582.05c.

Entry informationi

Entry nameiBRC1_SCHPO
AccessioniPrimary (citable) accession number: Q10337
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 5, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names