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Q10334

- ALAT_SCHPO

UniProt

Q10334 - ALAT_SCHPO

Protein

Putative alanine aminotransferase

Gene

SPBC582.08

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    GO - Molecular functioni

    1. L-alanine:2-oxoglutarate aminotransferase activity Source: PomBase
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate biosynthetic process Source: PomBase
    2. L-alanine catabolic process Source: UniProtKB-UniPathway
    3. L-alanine metabolic process Source: PomBase

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00528; UER00586.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative alanine aminotransferase (EC:2.6.1.2)
    Alternative name(s):
    Glutamate pyruvate transaminase
    Short name:
    GPT
    Glutamic--alanine transaminase
    Glutamic--pyruvic transaminase
    Gene namesi
    ORF Names:SPBC582.08
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC582.08.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. mitochondrion Source: PomBase
    4. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Putative alanine aminotransferasePRO_0000123938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei326 – 3261N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    MaxQBiQ10334.
    PaxDbiQ10334.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi277407. 15 interactions.
    MINTiMINT-4698867.
    STRINGi4896.SPBC582.08-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ10334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000215020.
    KOiK00814.
    OMAiFPANPQD.
    OrthoDBiEOG7GXPMR.
    PhylomeDBiQ10334.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q10334-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTDYPNDIN CESPRMSDLD GFCQNAFSDL NSLNQQVFKA NYAVRGALAI    50
    LADEIQDDLL ENPSSYPFSE IVYANIGNPQ QMGQSPITFV RQVLSLCQYP 100
    TLLDHAEEKW FQNLFPTDVV QRSKMLLKES GSLGAYSASQ GIPLVRRHVA 150
    DFIRARDGFD CEPSDIYLTS GASHAARLIM TLIIARPTDG VMVPAPQYPL 200
    YGAQIDLMSG SMVSYSLSEE NNWDIDFDQF KKSFDEASKK GINVRLCVVI 250
    NPGNPTGACI SENSMEKVLR FAKAKGIVLL ADEVYQNNIY QNKFHSFRRK 300
    LGELREKEPD NHWDQVSLIS VNSVSKGQFG ECGQRGGYLD VVNIPEPAKD 350
    QILKLATIDI CPPVAGQLLV DMLVNPPKPG DPSYDLFIKE VDEIHEALRL 400
    QCRQLYEGTK RMKRVSCLEP HGAMYLHPSV SLPEKLITTA KAQKIQPDEF 450
    YAIELLKRSG ICVVPGSGFG QPEGDYHIRI TFLAKGTEYI ERFVKAHNEI 500
    MDLYE 505
    Length:505
    Mass (Da):56,628
    Last modified:October 1, 1996 - v1
    Checksum:i6F6A0756A0458FAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB46671.1.
    PIRiT37975.
    RefSeqiNP_595176.1. NM_001021084.2.

    Genome annotation databases

    EnsemblFungiiSPBC582.08.1; SPBC582.08.1:pep; SPBC582.08.
    GeneIDi2540891.
    KEGGispo:SPBC582.08.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB46671.1 .
    PIRi T37975.
    RefSeqi NP_595176.1. NM_001021084.2.

    3D structure databases

    ProteinModelPortali Q10334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277407. 15 interactions.
    MINTi MINT-4698867.
    STRINGi 4896.SPBC582.08-1.

    Proteomic databases

    MaxQBi Q10334.
    PaxDbi Q10334.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC582.08.1 ; SPBC582.08.1:pep ; SPBC582.08 .
    GeneIDi 2540891.
    KEGGi spo:SPBC582.08.

    Organism-specific databases

    PomBasei SPBC582.08.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000215020.
    KOi K00814.
    OMAi FPANPQD.
    OrthoDBi EOG7GXPMR.
    PhylomeDBi Q10334.

    Enzyme and pathway databases

    UniPathwayi UPA00528 ; UER00586 .

    Miscellaneous databases

    NextBioi 20802006.
    PROi Q10334.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiALAT_SCHPO
    AccessioniPrimary (citable) accession number: Q10334
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3