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Protein

Putative alanine aminotransferase

Gene

SPBC582.08

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pathwayi: L-alanine degradation via transaminase pathway

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative alanine aminotransferase (SPBC582.08)
This subpathway is part of the pathway L-alanine degradation via transaminase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from L-alanine, the pathway L-alanine degradation via transaminase pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-SPO-70614 Amino acid synthesis and interconversion (transamination)
UniPathwayiUPA00528; UER00586

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alanine aminotransferase (EC:2.6.1.2)
Alternative name(s):
Glutamate pyruvate transaminase
Short name:
GPT
Glutamic--alanine transaminase
Glutamic--pyruvic transaminase
Gene namesi
ORF Names:SPBC582.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPBC582.08
PomBaseiSPBC582.08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239381 – 505Putative alanine aminotransferaseAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei326N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiQ10334
PaxDbiQ10334
PRIDEiQ10334

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi277407, 15 interactors
STRINGi4896.SPBC582.08.1

Structurei

3D structure databases

ProteinModelPortaliQ10334
SMRiQ10334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000215020
InParanoidiQ10334
KOiK00814
OMAiAPGTEWV
OrthoDBiEOG092C291F
PhylomeDBiQ10334

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q10334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTDYPNDIN CESPRMSDLD GFCQNAFSDL NSLNQQVFKA NYAVRGALAI
60 70 80 90 100
LADEIQDDLL ENPSSYPFSE IVYANIGNPQ QMGQSPITFV RQVLSLCQYP
110 120 130 140 150
TLLDHAEEKW FQNLFPTDVV QRSKMLLKES GSLGAYSASQ GIPLVRRHVA
160 170 180 190 200
DFIRARDGFD CEPSDIYLTS GASHAARLIM TLIIARPTDG VMVPAPQYPL
210 220 230 240 250
YGAQIDLMSG SMVSYSLSEE NNWDIDFDQF KKSFDEASKK GINVRLCVVI
260 270 280 290 300
NPGNPTGACI SENSMEKVLR FAKAKGIVLL ADEVYQNNIY QNKFHSFRRK
310 320 330 340 350
LGELREKEPD NHWDQVSLIS VNSVSKGQFG ECGQRGGYLD VVNIPEPAKD
360 370 380 390 400
QILKLATIDI CPPVAGQLLV DMLVNPPKPG DPSYDLFIKE VDEIHEALRL
410 420 430 440 450
QCRQLYEGTK RMKRVSCLEP HGAMYLHPSV SLPEKLITTA KAQKIQPDEF
460 470 480 490 500
YAIELLKRSG ICVVPGSGFG QPEGDYHIRI TFLAKGTEYI ERFVKAHNEI

MDLYE
Length:505
Mass (Da):56,628
Last modified:October 1, 1996 - v1
Checksum:i6F6A0756A0458FAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB46671.1
PIRiT37975
RefSeqiNP_595176.1, NM_001021084.2

Genome annotation databases

EnsemblFungiiSPBC582.08.1; SPBC582.08.1:pep; SPBC582.08
GeneIDi2540891
KEGGispo:SPBC582.08

Similar proteinsi

Entry informationi

Entry nameiALAT_SCHPO
AccessioniPrimary (citable) accession number: Q10334
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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