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Q10334

- ALAT_SCHPO

UniProt

Q10334 - ALAT_SCHPO

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Protein

Putative alanine aminotransferase

Gene

SPBC582.08

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. L-alanine:2-oxoglutarate aminotransferase activity Source: PomBase
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate biosynthetic process Source: PomBase
  2. L-alanine catabolic process Source: UniProtKB-UniPathway
  3. L-alanine metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00528; UER00586.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alanine aminotransferase (EC:2.6.1.2)
Alternative name(s):
Glutamate pyruvate transaminase
Short name:
GPT
Glutamic--alanine transaminase
Glutamic--pyruvic transaminase
Gene namesi
ORF Names:SPBC582.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC582.08.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. mitochondrion Source: PomBase
  4. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Putative alanine aminotransferasePRO_0000123938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei326 – 3261N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

MaxQBiQ10334.
PaxDbiQ10334.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi277407. 15 interactions.
MINTiMINT-4698867.
STRINGi4896.SPBC582.08-1.

Structurei

3D structure databases

ProteinModelPortaliQ10334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000215020.
InParanoidiQ10334.
KOiK00814.
OMAiFPANPQD.
OrthoDBiEOG7GXPMR.
PhylomeDBiQ10334.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q10334-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFTDYPNDIN CESPRMSDLD GFCQNAFSDL NSLNQQVFKA NYAVRGALAI
60 70 80 90 100
LADEIQDDLL ENPSSYPFSE IVYANIGNPQ QMGQSPITFV RQVLSLCQYP
110 120 130 140 150
TLLDHAEEKW FQNLFPTDVV QRSKMLLKES GSLGAYSASQ GIPLVRRHVA
160 170 180 190 200
DFIRARDGFD CEPSDIYLTS GASHAARLIM TLIIARPTDG VMVPAPQYPL
210 220 230 240 250
YGAQIDLMSG SMVSYSLSEE NNWDIDFDQF KKSFDEASKK GINVRLCVVI
260 270 280 290 300
NPGNPTGACI SENSMEKVLR FAKAKGIVLL ADEVYQNNIY QNKFHSFRRK
310 320 330 340 350
LGELREKEPD NHWDQVSLIS VNSVSKGQFG ECGQRGGYLD VVNIPEPAKD
360 370 380 390 400
QILKLATIDI CPPVAGQLLV DMLVNPPKPG DPSYDLFIKE VDEIHEALRL
410 420 430 440 450
QCRQLYEGTK RMKRVSCLEP HGAMYLHPSV SLPEKLITTA KAQKIQPDEF
460 470 480 490 500
YAIELLKRSG ICVVPGSGFG QPEGDYHIRI TFLAKGTEYI ERFVKAHNEI

MDLYE
Length:505
Mass (Da):56,628
Last modified:October 1, 1996 - v1
Checksum:i6F6A0756A0458FAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB46671.1.
PIRiT37975.
RefSeqiNP_595176.1. NM_001021084.2.

Genome annotation databases

EnsemblFungiiSPBC582.08.1; SPBC582.08.1:pep; SPBC582.08.
GeneIDi2540891.
KEGGispo:SPBC582.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB46671.1 .
PIRi T37975.
RefSeqi NP_595176.1. NM_001021084.2.

3D structure databases

ProteinModelPortali Q10334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277407. 15 interactions.
MINTi MINT-4698867.
STRINGi 4896.SPBC582.08-1.

Proteomic databases

MaxQBi Q10334.
PaxDbi Q10334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC582.08.1 ; SPBC582.08.1:pep ; SPBC582.08 .
GeneIDi 2540891.
KEGGi spo:SPBC582.08.

Organism-specific databases

PomBasei SPBC582.08.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000215020.
InParanoidi Q10334.
KOi K00814.
OMAi FPANPQD.
OrthoDBi EOG7GXPMR.
PhylomeDBi Q10334.

Enzyme and pathway databases

UniPathwayi UPA00528 ; UER00586 .

Miscellaneous databases

NextBioi 20802006.
PROi Q10334.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiALAT_SCHPO
AccessioniPrimary (citable) accession number: Q10334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3