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Protein

Probable proteasome subunit alpha type-4

Gene

pre6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-4 (EC:3.4.25.1)
Gene namesi
Name:pre6
ORF Names:SPBC106.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC106.16
PomBaseiSPBC106.16 pre6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241641 – 259Probable proteasome subunit alpha type-4Add BLAST259

Proteomic databases

MaxQBiQ10329
PaxDbiQ10329
PRIDEiQ10329

PTM databases

iPTMnetiQ10329

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi276708, 6 interactors
STRINGi4896.SPBC106.16.1

Structurei

3D structure databases

ProteinModelPortaliQ10329
SMRiQ10329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091085
InParanoidiQ10329
KOiK02731
OMAiEVAIMEN
OrthoDBiEOG092C47D8
PhylomeDBiQ10329

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR037560 Proteasome_alpha_7-like
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF15 PTHR11599:SF15, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q10329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYDRALSV FSPDGRLLQV EYGQEAVRRG TTAIALRGNE CIVIGVERKN
60 70 80 90 100
VPKLQNVSNF QKIAMVDNHV CLAFAGLNAD ARILIDKARV EAQNHKLNLA
110 120 130 140 150
DPVSIEYLTR YVAGVQQKYT QSGGVRPFGV STLIAGFDVG DNTPRVYQTE
160 170 180 190 200
PAGIYNAWKA TAIGRASKAA REYLEKNWKE GLSRDETIHL AVSSLLEVVQ
210 220 230 240 250
TASGNIELAI MDPGKDVEFL HSDKIDTIVK EIQDEKEAEA ARKKSGRSAP

GVSTTSTIQ
Length:259
Mass (Da):28,277
Last modified:October 1, 1996 - v1
Checksum:i6F36070FEF531380
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB53732.1
PIRiT37985
RefSeqiNP_595165.1, NM_001021074.2

Genome annotation databases

EnsemblFungiiSPBC106.16.1; SPBC106.16.1:pep; SPBC106.16
GeneIDi2540175
KEGGispo:SPBC106.16

Similar proteinsi

Entry informationi

Entry nameiPSA4_SCHPO
AccessioniPrimary (citable) accession number: Q10329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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